A new adaptive excision approach for nonstationary interference excision in direct sequence spread spectrum (DS/SS) communications is introduced. The proposed excision approach is based on the attractive localization properties of the impulse responses of the multiple pole filters. These impulse responses have Gaussian-like shapes and decrease in bandwidth with higher pole multiplicities. When used as data windows, they field a large class of computationally efficient short-time Fourier transforms (STFTs). Localization measures can be applied to determine the optimum window that maximally concentrates the interference in the time-frequency (t.-f.) domain. Interference mitigation is then achieved by applying a binary excision mask to the corresponding STFT for each data bit. We show that the proposed interference excision method permits both data-dependent windowing and time-varying filtering and leads to improved BER performance of the DS/SS system. The paper also derives the general optimum receiver implementing the STFT-based interference excision system.