Novel non-electrolytic di- and tri-organotin(IV) derivatives of the general formula R 2Sn(L/HL′) and Ph 3Sn(HL/H 2L′), where R is n-Bu and Ph, and L/HL is dianion/monoanion of d-penicillamine (H 2L-1) and l-carnosine (H 2L-2), and HL′/H 2L′ is dianion/monoanion of triglycine (H 3L-3) have been synthesized in 1:1 molar ratio either at pH 7.0 or pH<2.0. All n-Bu 2Sn(IV) derivatives have been synthesized by the reaction of Bu 2SnO with amino acid/peptides under azeotropic removal of water. Ph 2Sn(IV)/Ph 3Sn(IV) derivatives have been synthesized by either sodium chloride method or alkoxide method. The dibutyltin(IV) complexes synthesized at pH<2.0 possess chlorine in the coordination sphere (as revealed from molar conductance measurement in methanol) and a molecule of water in the crystal lattice. The structures of the complexes are discussed on the basis of IR, far-IR, multinuclear ( 1H-, 13C- and 119Sn-) NMR and 119Sn-Mössbauer spectroscopic studies. All the diorganotin(IV) derivatives possess a distorted trigonal bipyramidal structure in which D-penicillamine/peptides are tridentate coordinating through N amino, C(O)O carboxyl and S thiol/N peptide. The NH 2 group bridging/hydrogen bonding may lead to the associated structure. Whereas a linear polymeric structure with a distorted trigonal bipyramidal environment around tin has been tentatively proposed for Ph 3Sn(IV) derivatives in which the ligands may act as bidentate coordinating through N amino and C(O)O carboxyl. n-Bu 2SnCl(HL-1)·H 2O, synthesized at low pH, is dimeric. The anti-inflammatory activity, ALD 50 and blood pressure lowering activity of the synthesized derivatives are reported. Some complexes exhibit good anti-inflammatory activities comparable to that of phenylbutazone (a comparative analysis is presented through plots). The triorganotin(IV) derivatives exhibit significantly better activities than the diorganotin(IV) derivatives.