The purpose of the study was to evaluate the reliability of the most common landmarks and variables in digital lateral cephalometric radiographies in fixed and natural head positions. Twenty-one patients with anterior or distal displacement of the mandible treated in the Postgraduate Orthodontic Clinic of the Aristotle University of Thessaloniki had a digital lateral cephalometric radiography in fixed and in natural head position. The images where digitized. The main investigator and 6 examiners, digitized 61 landmarks and analysed 34 variables. We examined the intra-observer and inter-observer variability. There was a significant difference in X-axis in the distribution (hence the mean results) according to the reliability of the landmarks and in only 2 variables in digital lateral cephalograms between fixed and natural head position. Cephalometric landmarks and variables showed reliability in digital lateral cephalometric radiography in fixed and natural head position. In lateral cephalograms taken in fixed head position an anterior inclination of the head was noticed compared to those in natural head position.
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