Digit Span Backward Test Research Articles

Neuro-cognition in patients of bipolar affective disorder (currently in remission) and their first degree healthy relatives

Background: Bipolar patients do complain of persistent difficulties in concentration, memory, inability to perform optimally in challenging tasks or even, in day-to-day functioning, whereas variety of factors may be responsible for persistent functional impairments, at least a subgroup of patients are likely to experience poor psychosocial outcomes as a result of cognitive dysfunction. Objective: To assess the neurocognitive functions in patients of bipolar affective disorder currently in remission phase and their first-degree relatives. Materials and Methods: This study was carried out on a total of 60 subjects. Of which, 30 subjects belonged to patient group, who were patients of BPAD (currently in remission phase) attending outpatient department and remaining 30 were their first-degree healthy relatives who were included in healthy relative groups. Result: Mean age in both groups which was almost same, range between 42 and 45 years. Mean Hindi mini mental state examination (HMSE) test score obtained in patient group was 26.93 (SD = 2.066), in the healthy relative group 28.76 (SD = 1.278), and that in the control group was 29.133 (0.973). The performance of patient group and healthy relative group on the test of cognitive functions such as attention/psychomotor speed processing (Trail Making Test A), there was statistically significant difference in the TMT-A with patient. The performance of patient group and healthy relative group on the test of auditory verbal measure of simple span of attention (Digit Span Forward Test), there was statistically significant difference in the digit span forward test with patient group. The comparison of mean (2.60 ± 0.621 and 3.57 ± 0.568) between patients and healthy relative group was statistically significant (p = 0.00) in test of working memory (Digit span backward test). The comparison of mean (16.167 ± 1.839 and 19.00 ± 1.619) between patients and healthy relative group was statistically significant (p = 0.00) in test of immediate verbal memory and learning (VL and MT). Conclusion: Patients of BPAD currently in remission phase performed poorly on measure of all domains of neurocognition such as executive functions, working memory, verbal memory, visuospatial memory than healthy relatives.

Cognitive Function in Parkinson's Disease Patients with and without Anxiety.

Research on the implications of anxiety in Parkinson's disease (PD) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. This study compared cognitive performance across 50 PD participants with and without anxiety (17 PDA+; 33 PDA−), who underwent neurological and neuropsychological assessment. Group performance was compared across the following cognitive domains: simple attention/visuomotor processing speed, executive function (e.g., set-shifting), working memory, language, and memory/new verbal learning. Results showed that PDA+ performed significantly worse on the Digit Span forward and backward test and Part B of the Trail Making Task (TMT-B) compared to the PDA− group. There were no group differences in verbal fluency, logical memory, or TMT-A performance. In conclusion, anxiety in PD has a measurable impact on working memory and attentional set-shifting.

Stress recovery and restorative effects of viewing different urban park scenes in Shanghai, China

ObjectivesMany studies have found that natural environments benefit human health and wellbeing, but few have measured restorativeness of specific landscape components, especially in Chinese settings. Because the rapid urbanization of China is accompanied by increasing predomination of hardscape components in cities, the restorative quality of urban green space is a crucial issue. This study explored the stress recovery effects of different videotaped scenes, using six urban parks and one urban roadway scene. Potentially restorative urban park scenes were controlled for nature-based vs. hardscape components, presence/absence of people, and level of openness. MethodsSubjects were Chinese university students (N=140) aged 18–24. After completing an oral exam as a stressor, an equal number of males and females were randomly assigned to watch one of the seven videotaped scenes during a stress recovery stage, while data were collected on changes in stress and attentional levels. Physiological responses were measured by Electrocardiography (ECG) and Skin Conductance Response (SCR). Psychological responses were measured by the state (short-term) version of the State-Trait Anxiety Inventory (STAI-S), the Digit Span Backwards (DSB) test, and the Perceived Restorativeness Scale (PRS). ResultsIn a Chinese sample, this study confirmed previous findings that nature-based urban park scenes relieved stress and restored attentional levels, while viewing an urban roadway increased negative feelings. Overall perceived restorativeness was significantly higher in two scenes depicting a Lawn without people and a Small Lake, compared with a paved Plaza with or without people, confirming previous findings that restorativeness is associated with predominance of nature-based landscape components. This study also confirmed previous findings that outdoor scenes without people were more restorative than scenes depicting people. DiscussionThis study found different levels of restorativeness associated with different landscape features, and helped confirm that nature-based components are more likely to reduce stress than hardscape components, using Chinese urban scenes with a Chinese population. Findings can be used in future planning and design of urban spaces in China, emphasizing the value of parks and green spaces in relevant contexts.

Treating attention deficit hyperactivity disorder with acupuncture: A randomized controlled trial

IntroductionAttention deficit hyperactivity disorder (ADHD) is the most common childhood behavioral problem. The purpose of this study was to evaluate the effectiveness and safety of acupuncture in patients with ADHD. MethodsThe study was randomized, waitlist-controlled, and unblinded. A total of 93 participants with ADHD were enrolled. The acupuncture group received acupuncture treatment twice per week for 6 weeks. The waitlist group did not receive acupuncture during the first six weeks, and then underwent acupuncture treatment during the next six weeks. The primary outcome measure was the ADHD-rating scale. The computerized neurocognitive function tests (CNTs) was conducted as an objective measurement. ResultsThe results of the primary analyses were equivocal. Additional analyses were conducted after data were stratified according to ADHD medication. The acupuncture group not taking ADHD medications demonstrated significantly better performance in the CNTs compared to the waitlist group: the backward digit span test (p=0.026), backward visual span test (p=0.044), correct hit/omission error of auditory continuous performance test (CPT) (p=0.021), standard deviation of response time of visual CPT (p=0.048). The clinical global impression-severity score decreased significantly in the acupuncture group after treatment compared to that in the waitlist group (p=0.000). There was no statistically significant difference between both groups taking ADHD medications, except for verbal learning test in which waitlist group experienced a higher increase than acupuncture group. No adverse effect was reported. ConclusionsAcupuncture positively influences cognitive function in patients who are not on ADHD medication.

Profiling cognitive impairment in treatment-resistant schizophrenia patients

The aim of this study was to compare cognitive performance between schizophrenia patients with and without treatment resistance (TRS and non-TRS patients) taking into account psychopathological symptoms and antipsychotic treatment. The following cognitive tests were administered to 53 TRS patients and 32 non-TRS subjects: Rey Auditory Verbal Learning Test (RAVLT), Trail Making Tests (TMT-A and TMT-B), verbal fluency tests (FAS test and Supermarket), as well as selected Wechsler Adults Intelligence Scale (WAIS-R-PI) subtests: Digit Symbol Coding Test, Digit Span Forward and Backward and Similarities. TRS patients performed significantly worse in comparison with non-TRS patients on the measures of processing speed (TMT-A, Stroop test, FAS test, Supermarket test, Digit Symbol Coding test), verbal fluency (FAS test, Supermarket test), cognitive flexibility and executive functions (Stroop test) after controlling for age, illness duration, clinical symptoms severity, the number of years of completed education and antipsychotics’ dose. Cognitive performance was associated with negative and general symptomatology. Anticholinergic activity of antipsychotics had debilitating effect on cognitive functioning in non-TRS patients (FAS test) and in TRS patients (TMT-B test, Stroop test, RAVLT subtests, Digit Coding test and Similarities test), while low anticholinergic activity of antipsychotics was associated with better cognitive performance in non-TRS patients (Backward Digit Span test) and in TRS patients (Similarities test). Results of this study indicate that cognitive deficits are more robust in TRS patients than in non-TRS subjects, and are associated with clinical symptoms as well as the treatment with antipsychotics that exert high anticholinergic activity.

Intra-individual lap time variation of the 400-m walk, an early mobility indicator of executive function decline in high-functioning older adults?

Higher intra-individual lap time variation (LTV) of the 400-m walk is cross-sectionally associated with poorer attention in older adults. Whether higher LTV predicts decline in executive function and whether the relationship is accounted for by slower walking remain unanswered. The main objective of this study was to examine the relationship between baseline LTV and longitudinal change in executive function. We used data from 347 participants aged 60 years and older (50.7% female) from the Baltimore Longitudinal Study of Aging. Longitudinal assessments of executive function were conducted between 2007 and 2013, including attention (Trails A, Digit Span Forward Test), cognitive flexibility and set shifting (Trails B, Delta TMT: Trials B minus Trials A), visuoperceptual speed (Digit Symbol Substitution Test), and working memory (Digit Span Backward Test). LTV and mean lap time (MLT) were obtained from the 400-m walk test concurrent with the baseline executive function assessment. LTV was computed as variability of lap time across ten 40-m laps based on individual trajectories. A linear mixed-effects model was used to examine LTV in relation to changes in executive function, adjusted for age, sex, education, and MLT. Higher LTV was associated with greater decline in performance on Trails B (β = 4.322, p < 0.001) and delta TMT (β = 4.230, p < 0.001), independent of covariates. Findings remained largely unchanged after further adjustment for MLT. LTV was not associated with changes in other executive function measures (all p > 0.05). In high-functioning older adults, higher LTV in the 400-m walk predicts executive function decline involving cognitive flexibility and set shifting over a long period of time. High LTV may be an early indicator of executive function decline independent of MLT.

Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome.

The 2003 Canadian Consensus Criteria for chronic fatigue syndrome (CFS) are often assumed to suggest low-grade systemic inflammation, but have never been formally validated. This study explored the content validity of the Criteria in a sample of adolescents with CFS selected according to a wide case definition. A total of 120 patients with CFS with a mean age of 15.4years (range 12-18years) included in the NorCAPITAL project were post hoc subgrouped according to the Canadian Consensus Criteria. Those who satisfied the criteria (Criteria positive) and those who did not (Criteria negative) were compared across a wide range of disease markers and markers of prognosis. A total of 46 patients were classified as Criteria positive, 69 were classified as Criteria negative, and five could not be classified. All disease markers were equal across the two groups, except the digit span backward test of cognitive function, which showed poorer performance in the Criteria-positive group. Also, the prognosis over a 30-week period was equal between the groups. This study questions the content validity of the Canadian Consensus Criteria, as few differences were found between adolescent patients with CFS who did and did not satisfy the Criteria.

Neurobehavioral effects of arsenic exposure among secondary school children in the Kandal Province, Cambodia

The research was carried out at 3 study sites with varying groundwater arsenic (As) levels in the Kandal Province of Cambodia. Kampong Kong Commune was chosen as a highly contaminated site (300–500μg/L), Svay Romiet Commune was chosen as a moderately contaminated site (50–300μg/L) and Anlong Romiet Commune was chosen as a control site. Neurobehavioral tests on the 3 exposure groups were conducted using a modified WHO neurobehavioral core test battery. Seven neurobehavioral tests including digit symbol, digit span, Santa Ana manual dexterity, Benton visual retention, pursuit aiming, trail making and simple reaction time were applied. Children's hair samples were also collected to investigate the influence of hair As levels on the neurobehavioral test scores. The results from the inductively coupled plasma-mass spectrometry (ICP-MS) analyses of hair samples showed that hair As levels at the 3 study sites were significantly different (p<0.001), whereby hair samples from the highly contaminated site (n=157) had a median hair As level of 0.93μg/g, while the moderately contaminated site (n=151) had a median hair As level of 0.22μg/g, and the control site (n=214) had a median hair As level of 0.08μg/g. There were significant differences among the 3 study sites for all the neurobehavioral tests scores, except for digit span (backward) test. Multiple linear regression clearly shows a positive significant influence of hair As levels on all the neurobehavioral test scores, except for digit span (backward) test, after controlling for hair lead (Pb), manganese (Mn) and cadmium (Cd). Children with high hair As levels experienced 1.57–4.67 times greater risk of having lower neurobehavioral test scores compared to those with low hair As levels, after adjusting for hair Pb, Mn and Cd levels and BMI status. In conclusion, arsenic-exposed school children from the Kandal Province of Cambodia with a median hair As level of 0.93µg/g among those from the highly contaminated study site, showed clear evidence of neurobehavioral effects.

The Effect of Programmed Physical Exercise to Attention and Working Memory Score in Medical Students

Background : Attention and working memory are two cognitive domain crucial for activities of daily living. Physical exercise increases the level of BDNF, IGF-1, and VEGF which contributes in attention and working memory processes.This study was conducted to analyze improvement of attention and working memory after programmed physical exercise of Pendidikan Dasar XXI Atlas Medical Pioneer (Pendas XXI AMP). Methods : An analytic observational study was conducted on 47 students from Faculty of Medicine, Universitas Padjadjaran during September-November 2012. Attention was assessed using digit span backward test, stroop test, visual search task, and trail making test. Working memory was assessed using digit span forward test and digit symbol test. Assessment was done on the 11th and 19th week of Pendas XXI AMP. Data distribution was tested first using a test of normality, and then analyzed using T-Dependent Test and Wilcoxon Test Results : Significant improvement was noted for attention in males based on working time for stroop test (26.50±5.66 to 22.03±3.78 seconds), working memory in males based on digit symbol test score (43.96±6.14 to 53.36±5.26 points), attention in females based on reaction time of visual search task for target absent (0.92±0.07 to 0.87±0.07 seconds), and working memory in females based on digit span forward score (5.42±1.30 to 6.63±1.07 points) and digit symbol test score (42.47±5.95 to 53.84±5.33 points. Conclusions : Exercise in Pendas XXI AMP improves attention and working memory for college students in Faculty of Medicine Universitas Padjadjaran. [AMJ.2015;2(1):291–97]

Effect of n−3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials

n-3 PUFAs play an important role in cognitive function. The objective was to investigate the effect of n-3 PUFA supplements on cognitive development, function, and decline throughout the life span. The study included randomized controlled trials and provided ≥3 mo of treatment. Potential studies were independently screened in duplicate, and study characteristics and outcomes were extracted. A meta-analysis was performed by using fixed- or random-effects models. The results are presented as standardized mean differences (SMDs) with 95% CIs. Of the 3692 citations retrieved, 34 studies of a total of 12,999 participants (1031 infants, 1517 children, 3657 adults, and 6794 elderly individuals) were included. Compared with placebo, n-3 PUFA supplements significantly improved cognitive development in infants, including the Mental Development Index (SMD: 0.33; 95% CI: 0.15, 0.52), the Psychomotor Development Index (0.27; 95% CI: 0.09, 0.45), and language (0.27; 95% CI: 0.13, 0.42), motor (0.29; 95% CI: 0.14, 0.43), and cognitive (0.31; 95% CI: 0.16, 0.45) abilities. However, n-3 PUFAs did not promote cognitive function in terms of composite memory, executive function, and processing speed domains in children, adults, or the elderly, except for the attention domain. No association was found between n-3 PUFA intake and improvements in cognitive performance in terms of recognition, immediate and delayed word recall, digit span backward and forward tests, rapid visual information processing, verbal fluency, and simple and choice reaction times. In addition, n-3 PUFA supplements were not associated with improvements in cognitive decline or with any effects on Alzheimer disease in elderly people. n-3 PUFA supplements may significantly improve cognitive development in infants but do not improve cognitive performance in children, adults, or the elderly. n-3 PUFA intake, especially that of DHA supplements, may benefit cognitive development during infancy.

Associations between aspects of pain and cognitive performance and the contribution of depressive symptoms in mid-life women: A cross-sectional analysis

Pain has been associated with cognitive problems in pain patients. This study evaluated the extent to which experiences of pain are associated with cognitive performance in a community sample of mid-life women, and the contribution of depressive symptoms to this association. A cross-sectional analysis was used with data from the Study of Women's Health Across the Nation (SWAN). Associations between aspects of pain and cognitive performance were evaluated using statistical models with and without depressive symptoms. The cognitive performance score was a composite of three cognitive tests, the Digit Span Backward Test, the Symbol Digit Modalities Test and the East Boston Memory Test. Greater pain experiences that interfered with daily work were independently associated with poorer cognitive performance, [β (SE) −0.074 (0.021); p value<0.01] and this association was partially explained by depressive symptoms [β (SE) −0.061 (0.022); p value<0.01 after adjusting for depressive symptoms]. Additionally, an independent association between a greater composite pain score and poorer cognitive performance was identified without adjusting for depressive symptoms, [β (SE) −0.002 (0.0009); p value<0.05] but was no longer significant after adjusting for depressive symptoms. Our results suggest that in mid-life women, greater pain is associated with poorer cognitive performance, and depressive symptoms play an important role in this association. Clinicians should be aware of these relationships when evaluating patients.

The influence of auditory short-term memory on behavior problem development

The purpose of this research was to determine the influence of two subcomponents of auditory short-term memory on the developmental trajectories of behavior problems. The sample included 7,058 children from the NLSY79 – Children and Young Adult survey between the ages 5 and 14 years. Results suggested that anxious/depressed behavior increases during childhood and hyperactive and antisocial behavior problems decrease over the course of childhood. Children who scored higher on the Digit Span Backwards test demonstrated lower initial anxious/depressed, antisocial, and hyperactive behaviors, and children who scored higher on the Digit Span Forwards test demonstrated lower initial hyperactive behaviors. Some effects varied by sex; boys who scored higher on the Digit Span Forwards test decreased in antisocial behaviors at a slower rate than those who scored lower on the test. Thus, short-term memory associated with rehearsal mechanisms appears to influence initial levels of various problem behaviors for both males and females, while storage capacity influences initial hyperactive behavior for both males and females and the course of antisocial behavior in males.

Age at implantation and auditory memory in cochlear implanted children

Early cochlear implantation, before the age of 3 years, provides the best outcome regarding listening, speech, cognition an memory due to maximal central nervous system plasticity. Intensive postoperative training improves not only auditory performance and language, but affects auditory memory as well. The aim of this study was to discover if the age at implantation affects auditory memory function in cochlear implanted children. A total of 50 cochlear implanted children aged 4 to 8 years were enrolled in this study: early implanted (1-3y) n = 27 and late implanted (4-6y) n = 23. Two types of memory tests were used: Immediate Verbal Memory Test and Forward and Backward Digit Span Test. Early implanted children performed better on both verbal and numeric tasks of auditory memory. The difference was statistically significant, especially on the complex tasks. Early cochlear implantation, before the age of 3 years, significantly improve auditory memory and contribute to better cognitive and education outcomes.

Associations between preterm birth, small-for-gestational age, and neonatal morbidity and cognitive function among school-age children in Nepal

BackgroundThe long term consequences of low birth weight (LBW), preterm birth, small-for-gestational age (SGA, defined as birth weight for given gestational age less than the 10th percentile of the reference), and early newborn morbidity on functional outcomes are not well described in low income settings.MethodsIn rural Nepal, we conducted neurocognitive assessment of children (n = 1927) at 7–9 y of age, for whom birth condition exposures were available. At follow-up they were tested on aspects of intellectual, executive, and motor function.ResultsThe prevalence of LBW (39.6%), preterm birth (21.2%), and SGA (55.4%) was high, whereas symptoms of birth asphyxia and sepsis were reported in 6.7% and 9.1% of children. In multivariable regression analyses, adjusted for confounders, LBW was strongly associated with scores on the Universal Nonverbal Intelligence Test (UNIT), tests of executive function, and the Movement Assessment Battery for Children (MABC). Preterm was not associated with any of the test scores. Conversely, SGA was significantly (all p < 0.005) associated with lower UNIT scores (−2.04 SE = 0.39); higher proportion failure on Stroop test (0.06, SE = 0.02); and lower scores on the backward digit span test (−0.16, SE = 0.04), MABC (0.98, SE = 0.25), and finger tapping test (−0.66, SE = 0.22) after adjusting for confounders. Head circumference at birth was strongly and significantly associated with all test scores. Neither birth asphyxia nor sepsis symptoms were significantly associated with scores on cognitive or motor tests.ConclusionIn this rural South Asian setting, intrauterine growth restriction is high and, may have a negative impact on long term cognitive, executive and motor function.

Hyperphosphorylated Tau is Elevated in Alzheimer's Disease with Psychosis

Psychosis occurs in 40-60% of Alzheimer's disease (AD) subjects, is heritable, and indicates a more rapidly progressive disease phenotype. Neuroimaging and postmortem evidence support an exaggerated prefrontal cortical synaptic deficit in AD with psychosis. Microtubule-associated protein tau is a key mediator of amyloid-β-induced synaptotoxicity in AD, and differential mechanisms of progressive intraneuronal phospho-tau accumulation and interneuronal spread of tau aggregates have recently been described. We hypothesized that psychosis in AD would be associated with greater intraneuronal concentration of phospho-tau and greater spread of tau aggregates in prefrontal cortex. We therefore evaluated prefrontal cortex phospho-tau in a cohort of 45 AD cases with and without psychosis. Intraneuronal phospho-tau concentration was higher in subjects with psychosis, while a measure of phospho-tau spread, volume fraction, was not. Across groups both measures were associated with lower scores on the Mini-Mental State Examination and Digit Span Backwards test. These novel findings indicate that tau phosphorylation may be accelerated in AD with psychosis, indicating a more dynamic, exaggerated pathology in AD with psychosis.

Effects of 12 Weeks High-Speed Elastic Band Training on Cognitive Function, Physical Performance and Muscle Strength in Older Women with Mild Cognitive Impairment: A Randomized Controlled Trial

Background: Exercise has shown to slow down the progression from mild cognitive impairment (MCI) to dementia. In particular, not only resistance exercise has been verified to improve physical performance and muscle strength, leading to the prevention of fall-related injuries in the frail elderly, but also cognitive function. In this study, we investigated how high-speed elastic band training, applied using a high-speed power training protocol, affects cognition, physical performance and muscle strength of female elderly individuals with MCI. Methods: Thirty-nine subjects diagnosed with MCI from one senior college using a Korean version of mini-mental state examination (MMSE-K) and a Korean version of the Montreal Cognitive Assessment (MoCA-K) were randomly divided into exercise group (n=20) and control group (n=19). The exercise group completed a 12-week high-speed resistance elastic band exercise program and was encouraged to exercise at home as well during the intervention period. Results: The results showed significant increases in cognitive function, physical performance and muscle strength assessed by digit span forward test (P<0.001), digit span backward test (P=0.003), the Stroop test B (P=0.031), SPPB scores (P=0.010), right knee 60° extensor peak torque (P=0.004), 60° flexor peak torque (P=0.001), 180° extensor peak torque (P=0.020) and grip strength (P=0.025) Conclusions: Our study showed that participants with MCI who continued the high-speed elastic band training program for 12 weeks showed improvements in cognitive function, physical performance and muscle strength.

Effect of virtual reality on cognitive dysfunction in patients with brain tumor.

ObjectiveTo investigate whether virtual reality (VR) training will help the recovery of cognitive function in brain tumor patients.MethodsThirty-eight brain tumor patients (19 men and 19 women) with cognitive impairment recruited for this study were assigned to either VR group (n=19, IREX system) or control group (n=19). Both VR training (30 minutes a day for 3 times a week) and computer-based cognitive rehabilitation program (30 minutes a day for 2 times) for 4 weeks were given to the VR group. The control group was given only the computer-based cognitive rehabilitation program (30 minutes a day for 5 days a week) for 4 weeks. Computerized neuropsychological tests (CNTs), Korean version of Mini-Mental Status Examination (K-MMSE), and Korean version of Modified Barthel Index (K-MBI) were used to evaluate cognitive function and functional status.ResultsThe VR group showed improvements in the K-MMSE, visual and auditory continuous performance tests (CPTs), forward and backward digit span tests (DSTs), forward and backward visual span test (VSTs), visual and verbal learning tests, Trail Making Test type A (TMT-A), and K-MBI. The VR group showed significantly (p<0.05) better improvements than the control group in visual and auditory CPTs, backward DST and VST, and TMT-A after treatment.ConclusionVR training can have beneficial effects on cognitive improvement when it is combined with computer-assisted cognitive rehabilitation. Further randomized controlled studies with large samples according to brain tumor type and location are needed to investigate how VR training improves cognitive impairment.

A Comparative Study of Immediate effects of Yogic Techniques on Human Memory

Regulating the breath is an important part of yogic techniques. A study was started with the selection of fifty normal subjects of both genders, age 25±5 years. The subjects were trained for forced nostril breathing, which is a type of yogic techniques; i.e. right nostril breathing, left nostril breathing, alternate nostril breathing and breath awareness for duration of 30 minutes daily for two week. The subjects were examined before and after two week yoga training for immediate effect of forced nostril breathing in memory performance using WECHSLER memory scale. The aim of this study was to compare the effects of yoga between male and female in memory performance. Measure ANOVA analysis revealed a significant increase in Digit Span Forward, Digit Span Backward and associate learning recall performance due to forced nostril breathing at P<0.001 level. Comparative data shows that increment of digit span forward and associate learning memory in both males and females was almost equal at P<0.001 level and findings of digit span backward revealed that forced nostril breathing influences differently in males and females. Data of digit span backward test shows better memory performance in females.

Clinical correlations of proton magnetic resonance spectroscopy findings in acute phase after mild traumatic brain injury

AbstaractIntroduction: Standard brain magnetic resonance imaging (MRI) is typically normal in most patients after mild traumatic brain injury (MTBI). Proton magnetic resonance spectroscopy (1H-MRS) is more sensitive to detect subtle post-traumatic changes. The aim of the study was to evaluate the clinical correlations of these changes in the acute phase (within 3 days) after MTBI.Methods: Twenty-one patients with MTBI and 22 controls were studied. Both groups underwent neuropsychological testing and single-voxel 1H-MRS examination of both frontal lobes and upper brainstem.Results: Significant decrease in NAA was found in both frontal lobes and in NAA/Cre ratio in the right frontal lobe (p < 0.05). Correlation analysis showed a correlation of NAA in the left frontal lobe with Backward Digit Span (p = 0.022) and Stroop test A (p = 0.0034) and a weak correlation with TMT B time (p = 0.046). The NAA/Cre in the right frontal lobe correlated with Stroop test A (p = 0.007) and with the total score of Digit Span (p = 0.016). Lower NAA was found in the upper brainstem (p = 0.0157) in the sub-group of patients with post-traumatic unconsciousness.Conclusions: This study found a correlation of 1H-MRS metabolite changes with cognitive decline and presence or absence of loss of consciousness in the acute phase after MTBI.

Some Factors Underlying Individual Differences in Speech Recognition on PRESTO: A First Report

Previous studies investigating speech recognition in adverse listening conditions have found extensive variability among individual listeners. However, little is currently known about the core underlying factors that influence speech recognition abilities. To investigate sensory, perceptual, and neurocognitive differences between good and poor listeners on the Perceptually Robust English Sentence Test Open-set (PRESTO), a new high-variability sentence recognition test under adverse listening conditions. Participants who fell in the upper quartile (HiPRESTO listeners) or lower quartile (LoPRESTO listeners) on key word recognition on sentences from PRESTO in multitalker babble completed a battery of behavioral tasks and self-report questionnaires designed to investigate real-world hearing difficulties, indexical processing skills, and neurocognitive abilities. Young, normal-hearing adults (N = 40) from the Indiana University community participated in the current study. Participants' assessment of their own real-world hearing difficulties was measured with a self-report questionnaire on situational hearing and hearing health history. Indexical processing skills were assessed using a talker discrimination task, a gender discrimination task, and a forced-choice regional dialect categorization task. Neurocognitive abilities were measured with the Auditory Digit Span Forward (verbal short-term memory) and Digit Span Backward (verbal working memory) tests, the Stroop Color and Word Test (attention/inhibition), the WordFam word familiarity test (vocabulary size), the Behavioral Rating Inventory of Executive Function-Adult Version (BRIEF-A) self-report questionnaire on executive function, and two performance subtests of the Wechsler Abbreviated Scale of Intelligence (WASI) Performance Intelligence Quotient (IQ; nonverbal intelligence). Scores on self-report questionnaires and behavioral tasks were tallied and analyzed by listener group (HiPRESTO and LoPRESTO). The extreme groups did not differ overall on self-reported hearing difficulties in real-world listening environments. However, an item-by-item analysis of questions revealed that LoPRESTO listeners reported significantly greater difficulty understanding speakers in a public place. HiPRESTO listeners were significantly more accurate than LoPRESTO listeners at gender discrimination and regional dialect categorization, but they did not differ on talker discrimination accuracy or response time, or gender discrimination response time. HiPRESTO listeners also had longer forward and backward digit spans, higher word familiarity ratings on the WordFam test, and lower (better) scores for three individual items on the BRIEF-A questionnaire related to cognitive load. The two groups did not differ on the Stroop Color and Word Test or either of the WASI performance IQ subtests. HiPRESTO listeners and LoPRESTO listeners differed in indexical processing abilities, short-term and working memory capacity, vocabulary size, and some domains of executive functioning. These findings suggest that individual differences in the ability to encode and maintain highly detailed episodic information in speech may underlie the variability observed in speech recognition performance in adverse listening conditions using high-variability PRESTO sentences in multitalker babble.