Different Proportions Of Protein Research Articles

247 DIETARY INFLUENCES ON THEOPHYLLINE PHARMACOKINETICS IN CHILDREN

We have examined the influence of diet on theophylline (T) pharmacokinetics in 14 asthmatic children, receiving chronic oral T. Doses from 4.2-8.8 mg/kg were given in an amount determined to yield therapeutic serum levels. Each patient was placed on 3 separate diets with different proportions of protein and carbohydrate and with constant fat and calories. Sequential serum T levels were obtained following a single oral dose on day 12 of each test diet. T half-life (t½) decreased on high protein (P) diet to a mean of 4.75 hr. compared to 6.76 on normal (N) diet and increased to 18.10 on high carbohydrate (C) diet (both p < .001). The metabolic clearance rate rose from a mean of .045 L/kg/hr on N to .055 on P and decreased to .037 during C (both p < .001). The apparent volume of distribution remained unchanged, except for an increase from .423 L/kg to .988 on C (p < .01). Multiple linear regression function demonstrated t½ differences to correlate significantly only with dietary changes. No abnormal blood chemistries were detected during any test periods. These results clearly show the effect of diet on T pharmacokinetics in children.

Studies of the Influence of Various Dietary Conditions on Physiological Resistance: I. The Influence of Different Proportions of Protein in the Food on Resistance to the Toxicity of Ricin and on Recuperation from Hemorrhage

Studies of the Influence of Various Dietary Conditions on Physiological Resistance: I. The Influence of Different Proportions of Protein in the Food on Resistance to the Toxicity of Ricin and on Recuperation from Hemorrhage

Studies of the influence of various dietary conditions on physiological resistance. I. The influence of different proportions of protein in the food on resistance to the toxicity of ricin and on recuperation from hemorrhage.

It was planned to compare, in these experiments, the behavior of two sets of dogs under variously induced pathological conditions. The experiments were conducted on two pairs of dogs, each pair being kept under identical conditions, so far as they could be controlled, except with respect to the food. One animal of each pair was given liberal amounts of protein in the daily diet, the other received barely sufficient protein to provide for the necessary nitrogenous metabolism, the remaining ingredients of the food for each animal being uniformly equal to the daily amounts ordinarily given per kilo, in this laboratory, to perfectly healthy dogs. No attempt was made to maintain equal caloric values in the diets. In each experiment the animal was fed on a diet of hashed lean meat, cracker meal and lard, the meat being gradually increased or diminished to a high or low plane, according to the plan in each case and before the particular pathological condition was induced.