Prescribing patterns and appropriateness of dietary supplements in pediatric outpatients by age, nutritional status, and clinical diagnoses.

FEMA GRAS assessment of natural flavor complexes: Pepper, ginger, coniferous-derived and related flavoring ingredients.

Development and characterization of a liposome-based collagen delivery system with sustained release and preserved antioxidant activity.

Fibromyalgia and menopause often share common symptomatology, including musculoskeletal pain, fatigue, brain fog and sleep disturbances. The menopausal transition can represent a critical time at which fibromyalgia symptoms often worsen. This study examined the relationship between fibromyalgia and menopause using validated instruments. The Revised Fibromyalgia Impact Questionnaire (FIQR) was administered to 169 patients with fibromyalgia, and sociodemographic data and data on medication use were collected. Menopausal status was recorded, and the Greene Climacteric Scale (GCS) was administered. Linear regression analyses were performed to identify the predictors of more severe fibromyalgia impact and worse climacteric symptoms. Participants' mean age was 49.3±9.6years. Treatments for fibromyalgia included antidepressants (42.0% daily use), paracetamol, nonsteroidal anti-inflammatory drugs, and dietary supplements. Among the peri-/post-menopausal women, 6.25% were on hormone replacement therapy (HRT). The FIQR score was a significant predictor of the severity of menopausal symptoms (β=0.38, 95% CI 0.26-0.51, p<0.001), indicating that individuals with worse fibromyalgia tended to experience aggravated menopause symptomatology. Additionally, higher body mass index (BMI) was significantly associated with greater GCS scores (β=0.84, 95% CI 0.35-1.33, p=0.001) and more severe fibromyalgia impact (β=1.1, 95% CI 0.61-1.57, p<0.001, R2=0.11). Fibromyalgia preceded menopause in 51.0% of the sample and occurred concurrently in 21.9% of the sample. The findings suggest that fibromyalgia and menopausal symptoms overlap, worsening the symptom burden for patients in menopause. Higher FIQR scores were observed among patients with a greater BMI, indicating a greater overall disease impact and poorer quality of life.

Evaluation of labeled and actual contents in dietary supplements: Analysis of quercetin and hesperidin

Green synthesis of ferulic acid-grafted xylooligosaccharides with enhanced antioxidant and anti-inflammatory activities.

FEMA GRAS assessment of natural flavor complexes: Vanilla extract, Bitter almond oil, Wintergreen oil and related flavoring ingredients.

Dietary Supplements in the Perinatal Period.

Evaluation of inorganic element content and safety of Selaginellae Herba Carbonisata based on different processing heating durations

The complex relationship between cardiologists and lipid-lowering dietary supplements: Hate or love?

Natural bioactive compounds in dietary supplements and functional foods are valued for their role in health and disease prevention, leading to global demand. This has led to increased interest in cost-effective, scalable, and sustainable food and plant matrix chemical extraction technologies. This review contrasts classical and innovative bioactive extraction methods and demonstrates how eco-innovative approaches can be beneficial for food sustainability. Conventional techniques are widely used, but they frequently require substantial amount of solvent and energy as well as time, and they often harm the environment. On the other hand, new green technologies, such as ICD (instant controlled pressure drop) technology and PEF (pulsed electric field), SFE with CO2, UAE (power ultrasound assisted extractions) and MAE assist the efficiency of the extraction by reducing solvent consumption and waste/energy use. This review is original as it considers these strategies from technological and sustainability viewpoints, with focusing on extraction yield, process efficiency, eco-design and resource recovery. The present study emphasizes the necessity of combining technological performance with environmental and economic conditions to implement circular bioeconomy configurations in the nutraceutical and functional food sector. The biologically active compound extraction by the environmentally friendly techniques such as SFE, UAE, MAE, PEF and DIC improved the recovery of bioactive compounds with better quality in shorter duration and lesser consumption of resources than conventional methods. Nevertheless, expensive equipment cost, process optimization and absence of standardized evaluation criteria are the barriers for the development of this field. The integrated technology supported by online monitoring and multi-step operations under green solvent systems would be in high demand in the future. These sustainable global food systems are always the object of policies that consider regulatory frameworks, techno-economic study and life cycle assessment as key factors for industry to adopt them.

Click chemistry-based bioconjugates for direct immunochemical analysis of the mycotoxin citrinin.

Consuming Primarily Egg Dishes and Eggs as Ingredients among United States Adolescents Is Associated with Greater Usual Nutrient Intakes Compared with Not Consuming Eggs.

Distinct structural features of neutral and acidic flaxseed gum polysaccharides confer complementary anti-hyperuricemic effects via multi-dimensional regulation of urate metabolism.

Eggshell membrane (ESM) is a poultry egg-processing by-product increasingly recognized as a valuable food-relevant bioresource and a potential food-grade functional ingredient due to its rich composition (collagen, keratin, glycosaminoglycans) and inherent bioactivities. This comprehensive review examines the structural composition and key functional properties of ESM, including antioxidant, anti-inflammatory, and antimicrobial activities. Recent advances in ESM separation and modification techniques are systematically evaluated, spanning physical (mechanical separation, ultrasonication), chemical (acid/base treatments), and biological (enzymatic hydrolysis) methods, with particular emphasis on green, sustainable processing approaches that preserve functionality. Interdisciplinary applications of ESM are critically discussed across the food, health, and packaging sectors. For example, ESM is being explored as a functional ingredient in nutraceuticals and functional foods, as a functional ingredient in nutraceuticals and functional foods (including dietary supplements), and as an active component in biodegradable/edible packaging materials; selected non-food biomedical uses are briefly noted for context. This review also addresses current challenges in scaling up ESM utilization-including improving extraction efficiency, ensuring quality consistency, and meeting regulatory requirements-and highlights future directions for precision modification and multi-sector collaboration. Overall, the integrative analysis provides scientific insights and technical guidance for the sustainable high-value utilization of ESM across multiple disciplines.

A functional medicine approach to diabetes control and quality of life: an open-label randomized pilot study.

Green tea extract disrupts gonadal differentiation in a model avian system.

This study explored the integral use of imperfect red guava by extracting carotenoids from the pulp, employing the peel and seed as natural wall materials for nanoencapsulation. Ultrasound-assisted extraction with cereal ethanol was maximized using a 24 full factorial design, yielding 31.40±5.04μg/g and an extraction efficiency of 90.90%. The extract was nanoencapsulated using poly(lactic-co-glycolic acid) (NPPLGA), guava peel (NPGP), and guava seed (NPGS), producing nanoparticles with sizes ranging from 171.50±10.69 (NPPLGA) to 219.52±33.98 (NPGP) nm, an acidic pH, and measurable antioxidant activity. NPGS exhibited the highest encapsulation efficiency and carotenoid content and was found to be non-cytotoxic to HT22 cells at concentrations ≤0.07μg/mL. In a liquid dietary supplement model system, NPGS exhibited minimal changes in yellow color over 22days of refrigerated storage (ΔE*<2), indicating a possible application as a food dye and demonstrating a strategy for valorizing guava by-products.

Ginseng in exercise training and injury recovery: Composition, mechanism of action, dosage recommendations, and safety analysis.

Physicochemical characterization, lipid-metabolism effects and transcriptomics insights of perilla seed oil in high-fat-diet induced rats.