Doenjang (fermented soybean paste) is one of the traditional fermented foods in Korea which has various physiological effects. In this study, we investigated the antioxidant and neuroprotective activities of doenjang prepared fresh and aged for 6 weeks. Freeze‐dried doenjang was extracted with 80 % (v/v) ethanol. The 80% ethanol extract of doenjang was subjected to determination of antioxidant activity by 2,2‐diphenyl‐1‐pycrylhydrazyl (DPPH) radical scavenging capacity, ferric ion reducing antioxidant power, 2,2'‐azinobis (3‐ehylbenzthiazoline‐6‐sulphonic acid) cation radical scavenging activity, and oxygen radical absorbance capacity assays. In addition, the neuroprotective effect of doenjang extract was investigated using MTT cytotoxicity and 2´,7´‐dichlorofluorescein diacetate (DCF‐DA) assays. It was found that the 80% ethanol extract of doenjang protected from neuronal cell death induced by ROS or glutamate. The underlying mechanism for neuroprotective effect of doenjang will be discussed. (supported by a grant from IPET (High Value‐added Food Technology Development Program, 2012, 112066‐3), Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea)