Advances in hybrid hydrogels for diabetic wound healing.

ABSTRACT European policies to achieve No Net Land Take (NNLT) by 2050 require a fundamental shift in how land is allocated, redeveloped, and governed. While logistics has been increasingly scrutinized for its carbon footprint, its contribution to land take – particularly through the irreversible sealing of soils – remains largely overlooked in both research and planning practice. This article addresses this gap by assessing the potential of brownfield recycling to accommodate logistics activities without further soil consumption. Focusing on the Eurometropolis of Strasbourg, we apply a spatially explicit, multi-criteria method that integrates parcel size, zoning compatibility, road accessibility, and proximity to protected natural areas. The analysis identifies a limited but strategically significant stock of ‘usable brownfields for logistics’ and highlights regulatory, governance, and market constraints to their reuse. By linking logistics geography with land-use governance, our findings contribute to European debates on how sectoral development strategies can be aligned with environmental land-use targets. We argue that brownfield recycling must be explicitly integrated into NNLT policies if the logistics sector is to move from being a land-take driver to a lever for land conservation.

Development of the INDIGO partnership knowledge exchange strategy

Given the therapeutic challenges posed by the unique molecular genetic mechanisms and immune-privileged microenvironment of uveal melanoma, this review aims to systematically evaluate the latest research on the molecular genetics and immune microenvironment of uveal melanoma, providing insights for translational research and the development of clinical treatment strategies. In gene therapy, a recombinant adeno-associated viral vector engineered to target the oncogenic GNAQ Q209L mutation achieved single-base-pair precision knockdown, offering a novel approach to overcoming the complex therapeutic challenges posed by downstream signaling in this pathway. Regarding tumor metastasis, BAP1 inactivation induces a low-metabolic state by inhibiting the mTORC1/p70S6K1 pathway, enabling tumor cells to adapt to nutritional stress during metastasis. Concurrently, BAP1 mutations regulate cell adhesion molecules and suppress the nuclear factor-κB pathway, collectively establishing an immunosuppressive microenvironment that drives the highly metastatic nature of uveal melanoma. The predictive value of chromosome 8q amplification was shown to be context-dependent, with high-risk subgroups exhibiting extremely poor prognosis, particularly in BAP1-mutant cases. At the epigenetic level, miR-181a-5p demonstrates therapeutic potential by inducing uveal melanoma apoptosis through targeting GNAQ and AKT3. Clinically, the bispecific T-cell redirection drug Tebentafusp has achieved a major breakthrough in metastatic uveal melanoma immunotherapy. This review systematically elucidates key driver gene mutations, chromosomal abnormalities, epigenetic alterations, and the unique immunosuppressive microenvironment of uveal melanoma, providing new insights into mechanisms of treatment resistance and guiding the development of innovative therapeutic strategies.

Use of standardized order sets and associated outcomes in the Emergency Department: A scoping review.

Lithium for the global energy transition: how global forces and national legacies are driving resource-based development in South America

This study explores the association between district vitality and industrial structure in historic districts through a quantitative analysis of the Xuanen Xinglong Historic District. In this study, on the basis of multisource data, we constructed the framework of a quantitative analysis system for the association between historic district vitality and industrial structure to explore the reasons for the decline in historic district vitality and propose strategies and recommendations for creating vitality in historic districts. The findings reveal that (1) the vitality of the Xuanen Xinglong Historic District showed a higher middle area than the surrounding area and more rest days than working days; (2) in terms of functionality, the degree of aggregation of POIs in catering, shopping and consumption, living services, and recreation and sports in the Xuanen Xinglong Historic District is high; and (3) the impact of POI data on district vitality is more significant for shopping and consumption and catering, followed by company and enterprise, hotel and accommodation, and recreation and sports, with other types of POIs having a weaker impact. The results can guide strategies for industrial upgrading and cultural tourism development for Xuanen Xinglong and other historic districts facing similar challenges.

Design and validation of a bioethical assessment instrument for public health policies involving behavioral change: A mixed-methods study.

A multiscale approach to lipid nanoparticle engineering from molecular structure to in vivo performance.

The growing demand for plant-based alternatives to animal-derived foods has led to an increased availability of plant-based cheese analogues, particularly those mimicking mozzarella. However, these products often fail to replicate the functional and sensory properties of cheeses. This study evaluates the physical, structural, functional, and sensory characteristics of three commercial plant-based mozzarella analogues in comparison with two dairy references. Physicochemical and structural analyses included moisture content, pH, color, oscillatory rheology, differential scanning calorimetry (DSC), low-field 1 H NMR, and texture profile analysis. Meltability, browning, oiling-off, and stretchability tests were also conducted to assess functionality during cooking. Sensory acceptability and Just-About-Right (JAR) tests were combined to identify penalizing attributes of the samples melted on pizza. The structures of the plant-based samples showed inability to replicate the texture and the cooking properties of dairy products. Rheological and DSC data revealed different melting behaviors. Sensory data confirmed a lack of consumer acceptance for plant-based samples, mainly due to texture and flavor limitations. Stretchability was identified as a key penalizing attribute. The findings underline structural challenges in replicating casein functionality with plant ingredients and provide insights to guide formulation strategies for future development of plant-based mozzarella analogues. • Plant-based samples had lower protein and higher carbohydrate and salt levels • Dairy samples showed elastic, thermoreversible networks under heating • Plant-based samples showed rigid or brittle structures with limited heat response • Plant-based products showed diversified cooking behavior compared with dairy samples • Sensory data showed the need to improve stretchability, browning and flavor

Covalent lysine targeting is coming of age.

In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus.

Assessment of operating strategies for airport future developments using optimized simulation

This study investigates how commerce students at a historically disadvantaged institution (HDI) in rural South Africa view and use Moodle (WiSeUp) and Microsoft Teams. Based on the extended Technology Acceptance Model (eTAM), the research employs a quantitative, descriptive approach with data collected through a self-administered online questionnaire completed by 209 students. The findings show that Microsoft Teams promotes communication and teamwork, while Moodle is mainly used for assessments and accessing academic content. Both platforms are used together, despite their different functions. Although some usability issues were noted, students generally reported satisfaction and found the platforms useful. Importantly, students were more likely to actively engage with the platforms if they valued their usefulness. The results highlight the role of perceived usefulness in maintaining interest and demonstrate how both platforms contribute uniquely yet importantly to the educational experience. The study also recommends ongoing institutional support for both tools, emphasising their complementary strengths. Moodle should be strengthened for structured academic delivery, while MS Teams should be improved to foster collaborative learning. Enhancing usability through better training, support, and orientation, especially for students with limited digital experience, is also advised to sustain engagement. These insights help inform the development of more effective digital learning strategies in resource-constrained higher education settings.

This review provides a summary of the evolving landscape of pediatric lung transplantation highlighting current trends, short and long-term outcomes, ongoing challenges in posttransplant survival, and unique considerations in pediatric populations. The annual volume of pediatric lung transplantation has declined over the past decade due to a decreased need among children with cystic fibrosis. Improvement in survival has paralleled advancements in bridge to transplant strategies, expanding what were once considered contraindications. Despite the ongoing shortage of donor organs, innovations in policy changes, surgical and immunologic strategies, and organ preservation technologies have expanded the donor lung pool. Chronic lung allograft dysfunction (CLAD) remains the primary limitation to long-term survival, with limited management strategies and emerging immunomodulatory therapies offering promise. As survival in pediatric lung transplantation improves, emphasis should shift to long-term outcomes including quality of life and equitable care, development of effective CLAD prevention strategies and pediatric-specific guidelines to optimize long-term survival.

Gender-related facilitators and barriers to participation in research on aging using fuzzy cognitive mapping.

Thalamocortical and corticostriatal pathways in the progression from acute to chronic musculoskeletal pain: An fMRI study.

Eating behaviour traits (EBTs), individuals' reactions to food, food-related cues, and food intake, play an important role in the development and maintenance of overweight and obesity. We provide population-based norms for cognitive restraint, uncontrolled eating, and emotional eating as measured by the Three Factor Eating questionnaire (short form, TFEQ-18) in a UK cohort of middle-aged adults (the Fenland Study). Participants included 7830 individuals recruited across Cambridgeshire General Practices; 51.8% identified as female and participants reported a mean BMI of 26.8. Unadjusted linear regression estimated demographic (sex, age) and anthropometric (Body Mass Index, BMI) associations with each EBT to identify subgroups to derive normative scores. Percentiles of each EBT were calculated for the overall population and subgroups. Males scored lower than females on cognitive restraint (β=-7.86, 95% CI [-8.69, -7.03], p<0.001), uncontrolled eating (β=-1.03, 95% CI [-1.80, -0.26], p=0.008), and emotional eating (β=-13.13, 95% CI [-14.28, -11.98], p<0.001). Older age was associated with higher scores on cognitive restraint (β=0.13, 95 % CI [0.07, 0.19], p < 0.001), and lower scores on uncontrolled eating (β=-0.34, 95% CI [-0.39, -0.28], p<0.001) and emotional eating (β=-0.13, 95% CI [-0.21, -0.04], p=0.002). Higher BMI was associated with higher emotional eating (β=1.71, 95% CI [1.59, 1.83], p<0.001) and uncontrolled eating (β=1.05, 95% CI [0.97, 1.12], p<0.001). BMI was not associated with cognitive restraint. Normative scores provide context for individual EBT scores and may inform development, refinement, and application of prevention strategies for overweight, obesity, and eating disorders.

CT Radiogenomics Provides a Novel Factor for cM0(i+) Risk Stratification in Localized Renal Cell Carcinoma: A Model Linked to a Circulating Tumor Cell-Related Gene Signature.

TAOK3 promotes ccRCC progression by phosphorylating ASAP2.