Styrene was quantitatively determined by head space gas chromatography-selected ion monitoring using ethylbenzene as the internal standard. The lower limit of sensitivity of this procedure is 500 pg per milliliter of blood or gram of wet tissue and detector response (flame ionization or selected ion monitoring) was linear up to microgram concentrations without any interference from endogenous compounds. The kinetics of styrene distribution in blood and tissues (brain, heart, lungs, liver, kidneys, spleen, and perirenal fat) of CD 2F 1 mice receiving a single intraperitoneal administration of styrene (200 mg/kg) were also investigated.
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