The following case illustrates clearly that absorption of a contrast agent Reno-M-60® (Meglumine diatrizoate), indeed, can occur. CASE REPORT A 42 year old woman was referred for the evaluation of recurrent bouts of midepigastric pain. Cholecys tectomy had been performed 4 years previously for cholecys titis and cholelithiasis. The serum and urine amylase, as well as serum lipase determinations, were normal. Intravenous cholangiography performed during the present hospitaliza tion revealed a common bile duct 12 mm in diameter with relatively poor distal visualization but suggestive of a distal stricture or small stone. In this context, ERCP was performed. After the pharynx was anesthetized with Cetacaine® (Ben zocaine) topical anesthetic, the patient was sedated with 10 mg of intravenous Valium ® (Diazepam). The Olympus )FB side-viewing duodenoscope was then passed into the duodenum. Glucagon, 1 mg intravenously, established duodenal paralysis. The ampulla was identified, and free cannulation was accomplished. Reno-M-60® was injected by hand pressure, and opacification of the main pancreatic duct was obtained. With slow withdrawal and continuous gentle injection, opacification of the common bile duct was accom plished. Both ductal systems were interpreted as being nor mal. During the injection the patient experienced mild, midepigastric discomfort while an intense pancreatic acinari