Destination Location Research Articles

Molecular mechanism of parental H3/H4 recycling at a replication fork

In chromatin replication, faithful recycling of histones from parental DNA to replicated strands is essential for maintaining epigenetic information across generations. A previous experiment has revealed that disrupting interactions between the N-terminal tail of Mcm2, a subunit in DNA replication machinery, and a histone H3/H4 tetramer perturb the recycling. However, the molecular pathways and the factors that regulate the ratio recycled to each strand and the destination location are yet to be revealed. Here, we performed molecular dynamics simulations of yeast DNA replication machinery, an H3/H4 tetramer, and replicated DNA strands. The simulations demonstrated that histones are recycled via Cdc45-mediated and unmediated pathways without histone chaperones, as our in vitro biochemical assays supported. Also, RPA binding regulated the ratio recycled to each strand, whereas DNA bending by Pol ε modulated the destination location. Together, the simulations provided testable hypotheses, which are vital for elucidating the molecular mechanisms of histone recycling.

An Impact Assessment of Cordon Pricing Relaxation on Modal Shift During the COVID-19 Pandemic

ABSTRACT The COVID-19 pandemic brought significant disruptions to transportation patterns worldwide, with a notable increase in Private Vehicle (PV) usage. Many studies have focused on travel restrictions, while neglecting to consider potential changes in transportation-related policies implemented during COVID-19 that may have improved public health. The present study explores the motivations for modal shifts to PVs and tries to analyze which of the risks of exposure and modifications in transportation policies has caused these modifications. Focusing on the case study of Tehran, Iran, where cordon pricing was relaxed during the pandemic, the study collected data through online and paper-based surveys from 1475 respondents. Binary logit models were employed to analyze the data and understand the impact of destination location, residency area, trip purpose, trip frequency, and vehicle characteristics on modal shift behavior. In addition to COVID-19 exposure as a primary reason for the modal shift, respondents also identified the relaxation of cordon pricing restrictions as a factor that increased the utility of PVs. The study's findings contribute to better understanding the dynamics of travel behavior during pandemics, guiding policymakers in devising effective strategies to address both public health concerns and traffic conditions.

Implementasi dan Perkembangan Halal Tourism pada Destinasi Pariwisata Lombok

Lombok has long been touted as a "new Bali" tourism destination. Along with the changing times, changes in tourist trends also develop and begin to recognize various new types of tourism. Lombok has a uniqueness that is thick with Islamic nuances. Therefore, Lombok applies a type of Muslim-friendly tourism / halal tourism. Muslim-friendly tourism types have been implemented indirectly by tourism actors in Lombok. Visits to various tourism destinations in Lombok were taken as samples representing the city. With qualitative descriptive research methods, the author wants to present observations supported by exposure to documentation and interviews. The author also bases research on a theory tested in reality, especially in Lombok tourism destinations. Based on the study results, several Lombok tourism destinations still need help implementing Muslim-friendly tourism. Problems are known both from destination location factors and market segmentation factors. However, some locations have been found to have long-term development opportunities that make it possible to implement Muslim-friendly tourism as a whole through certain efforts. The fulfillment of the minimum requirements for Muslim-friendly tourism does not have a coercive nature but has the opportunity to influence tourists' interest in visiting. Therefore, the Lombok government, with Muslim-friendly tourism branding together with stakeholders, maintains and improves the quality of tourism services for the sustainability of Lombok's tourism economy.

Pick and Place Control of a 3-DOF Robot Manipulator Based on Image and Pattern Recognition

Board games like chess serve as an excellent testbed for human–robot interactions, where advancements can lead to broader human–robot cooperation systems. This paper presents a chess-playing robotic system to demonstrate controlled pick and place operations using a 3-DoF manipulator with image and speech recognition. The system identifies chessboard square coordinates through image processing and centroid detection before mapping them onto the physical board. User voice input is processed and transcribed into a string from which the system extracts the current and destination locations of a chess piece with a word error rate of 8.64%. Using an inverse-kinematics algorithm, the system calculates the joint angles needed to position the end effector at the desired coordinates actuating the robot. The developed system was evaluated experimentally on the 3-DoF manipulator with a voice command used to direct the robot movement in grasping a chess piece. Consideration was made involving both the own pieces as well as capturing the opponent’s pieces and moving the captured piece outside the board workspace.

Upaya Pengelolaan Sarana Pada Objek Wisata Air Soda di Desa Parbubu I Kecamatan Tarutung Kabupaten Tapanuli Utara

The Parbubu I soda water tourist attraction is one of the areas located in North Sumattra Province, Tarutung District, which is known as the Gospel tourism city, and also has the advantage of agricultural products such as yagung, sawa, coffee, and also has a variety of natural beauty and diversity. culture so that it can give rise to various potential tourist attraction destinations. Local communities also take the initiative to actively manage it into a potential tourist attraction. So tourist options are varied, and so are they. The Tourism Office in North Tapanuli district still has many problems that must be paid attention to, such as facilities, facilities for tourist visitors, in each tourist attraction destination location which are not yet adequate and still have not yet optimized management efforts, which still lacks professional human resources. Formulation The problem in this research is how to manage the facilities of a manager of the Parbubu I soda water tourist attraction, Tarutung District, as well as for the foundation of a researcher who wants to conduct research, in other tourist motorcycle taxi destinations and in their respective areas in North Tapanuli Province. The method used is a qualitative methodology which is descriptively oriented by having informants and also using data collection techniques, you can use observation techniques, interviews, document analysis. From this research, the researcher feels that the government of the tourism office and the district of Tarutung sub-district, and also especially the government of the village of Parbubu I, is establishing a cooperative relationship with the management of the Parbubu I soda water tourist attraction, because the management of the tourist attraction destination comes from the local community or is Individually, in terms of regional income, the Tarutung District Government has not implemented regulations so that tourism income goes into the coffers of a manager and Parbubu village or is distributed to the community who manages the soda water tourist attraction destination.

Quantum-Accelerated Flight Selection: Probing Grover's Algorithm and Quantum Device Efficiency

Current flight search platforms primarily consider four essential factors when planning a trip: departure/arrival dates, as well as the origin and destination locations. However, when additional parameters are added to this search, the problem shifts from a simple to a complex search, as the engine must sift through a massive dataset of flights, including information on airlines, flight routes, fees, and more. To address this challenge and improve flight search efficiency amidst data-intensive and resource-demanding environments, this paper proposes the use of Grover's search algorithm. This algorithm is demonstrated as the optimal solution for searches with increased constraints. The paper highlights the practical application of Grover's search algorithm across three datasets of assorted sizes, as well as various quantum hardware and simulators available in the NISQ era. Furthermore, this paper provides an in-depth understanding of the complexity of quantum circuit design, including the key phases of state encoding and amplitude amplification. The effectiveness of these approaches is evaluated through analysis of execution times and quantum measurement results. The aim is to showcase the potential of quantum computing in revolutionizing real-world search tasks, particularly in the realm of flight selection.

Commuting mode choice and work from home in the later stages of COVID-19: Consolidating a future focussed prediction tool to inform transport and land use planning

As COVID-19 slowly dissipated after 30 months since March 2020, working from home (WFH) continues to be popular, with support from notable numbers of employees and employers. There is growing evidence that we have either reached, or appear to be close to, a level of WFH − to some extent − that might be described as an equilibrium outcome going forward. Hence, there is a need to update any travel behaviour response models that have been developed during the passage of the pandemic. This paper sets out a commuter model for each day of the week for the Greater Sydney Metropolitan Area as of September 2022; where the alternative responses are to not work, WFH, or commute by one of ten modes available. Given the probability of WFH obtained from a mixed logit model, we construct a mapping equation to establish the sources of statistical variance by origin and destination locations that influence the incidence of WFH. The evidence is used as the basis of commenting on what this means for longer-term structural changes in network performance, the likely move to a greater focus on living locally, and the need (or otherwise) for employers to retain office space. A significant return to the office has recently been promoted by some employers, and we comment on this as to what it might mean for the future of a hybrid working location model.

PERANCANGAN SISTEM INFORMASI LOCATION BASED SERVICE (LBS) OBJEK WISATA MENGGUNAKAN METODE INKREMENTAL BERBASIS ANDROID DI KOTA BEKASI

Tourist attractions are a necessity for people to go on holiday with their families. Tourist attractions in Bekasi also have great potential for regional income if they are managed well. Data from the Central Statistics Agency (BPS) shows that the population of Bekasi Regency currently reaches 3.3 million people and Bekasi City 2.6 million, an increase of around 1 million in the last 5 years. In the modern era, technology is developing so rapidly that it has become one of society's main needs. Technology that is always developing, such as smartphones and Android, can be easily utilized in carrying out various activities. Location Based Service (LBS) is a location service that uses GPS (Global Positioning Service) which functions to find a destination location to make it easier for users. Many people travel to a certain place to enjoy their holiday, this is a necessity in life to refresh the mind while working or studying. For this reason, it is necessary to present an information system that provides tourist attraction location services to make it easier for people to find these tourist attractions. The Location Based Service (LBS) information system can help the public in showing directions. This information system can help the public to carry out holiday activities to tourist attractions. This Location Based Service (LBS) system provides information services regarding tourist attractions and travel preparation tips. This tourist attraction's Location Based Service (LBS) system is also equipped with a location route feature.

Jointly modelling activity start time, travel mode, companionship, and destination location choices

Activity-travel decisions, including time use (i.e. activity start time), travel choices (i.e. mode and companionship), and destination location choices are interdependent and complex in nature. They are often controlled by observed factors such as sociodemographic, vehicle ownership, built environment, land use, and unobserved factors like attitude, preference, or habits which typically are not captured in the survey data. To accommodate these complex interactions and capture trade-offs among the time use-travel-land use choices, this study proposes a joint discrete choice model by introducing unobserved factors that are common to them. The model results confirm the presence of complex interdependencies among these choice dimensions. In addition, this study highlights the contribution of observed and unobserved factors introduced in the model by calculating the total variance of utility differences. Lastly, this study provides behavioural insights on the activity-travel patterns, which can be further used to develop robust travel demand management policies.

IMPLEMENTATION OF ENERGY EFFICIENT SECURITY MECHANISMS FOR WIRELESS SENSOR NETWORKS

Designing energy-efficient security mechanisms is critical for WSNs due to their limited power resources. Techniques like low-power cryptography, duty cycling, and energy-aware security protocols can help in achieving security without significantly impacting the energy consumption of sensor nodes. In this paper, we propose an energy aware geographical multipath routing scheme for WSNs. The distance to the destination location, remaining battery capacity, and queue size of candidate sensor nodes in the local communication range are taken into consideration for next hop relay node selection, and Analytical Hierarchy Process (AHP) and Geographical Routing Algorithm (GRA) are applied for decision making. Simulation results show that these schemes can extend the network lifetime longer than the original geographical routing scheme which only considers distance to the destination location. KEYWORDS: WSN, linear discriminate packet flow analysis system, optimized rout path switch, Analytical Hierarchy Process (AHP) and Geographical Routing Algorithms(GRA).

STRATEGI AKSELERASI DESTINASI EKOWISATA POTRE KONING DI DESA SUMBERCANTING, BONDOWOSO

This article is about the strategy to accelerate the development of the Potre Koning ecotourism destination in Sumbercanting Village, Wringin District, Bondowoso Regency which has the potential for attractive natural scenery, namely hills, teak and kedawung trees, niches in the form of paddy fields dividing the hills, siring terrace cultivation on the hillsides, waterfall, and Mustajab cave. The preparation stage including initial observation activities, mapping problems in the field, and drafting mentoring activities. Initial observations were carried out to understand the complexity and dynamics that occurred in the field. The data from initial observations was classified based on various problems, obstacles, and shortcomings faced by the Potre Koning ecotourism destination managers. In developing Potre Koning ecotourism, the management needs to pay attention to (1) management by Pokdarwis in managing the ecotourism destination; (2) management of a variety of attractions that can be developed to attract tourists; (3) spatial planning, comfort and ecotourism infrastructure, (4) promotion and marketing through conventional mass media, electronics and social media; (5) security of the ecotourism destination location, and (6) sustainability of the Potre Koning ecotourism destination. Based on the results of service in the field, it was known that the development management factor by Pokdarwis and the role of the village government, Muspika (District Head, Danramil, Kapolsek) were key factors in the success of destination development. Potre Koning ecotourism's development was expected to positively impact local economic growth in Sumbercanting Village, increasing the number of tourists, preserving ecotourism objects, and maximum community participation.

Selection of the Shortest Path of Gamalama Eruption Evacuation Using the Astar Method

Natural disasters have no time limit and can happen anywhere at any moment. They put human life at risk and can result in both property loss and casualties. Like those at Gamalama volcano, volcanic eruption disasters are constant and incur enormous losses. There are numerous evacuation sites for self-rescue against volcanic eruptions, and knowing the distance to the evacuation sites is necessary to expedite the self-rescue process to reduce the number of victims. Naturally, the areas surrounding the disaster center must be kept clear. To solve this issue, a mechanism for choosing the shortest path via the astar method must be implemented. As part of the astar method, the shortest path is chosen by first figuring out the starting and destination locations, initializing intersections by turning each intersection into a node, adding the node to the open list, calculating it with weights, adding it to the closed list, figuring out potential nodes that lead to the destination, and saving the results. As a consequence of the master method's application, the shortest route—a distance of 3,560 meters—connects the starting point (the Tubo village head office) with the gathering point (the Salerno field). Bypassing every pre-planned path, which is as follows: No. 1 (Jl. Ake Tubo, Tubo) - Node 2 (Ake et al.) - Node 7 (Jl. Batu Angus No.1, Dufa Dufa) - Node 8 (North Sangaji) - Node 9 (Toboleu, Kec. Kota Ternate Utara) - Assembly Point (Salero Field). Keywords: Astar, Volcanic Disaster, and Geographic Information System.

Why moving there? Spanish SIEs: factors and motivations involved in the choice of the host destination

PurposeThis paper aims to explore the Spanish Self-Initiated Expats’ (SIEs) motivations and factors involved in the choice of the host destination.Design/methodology/approachThrough an exploratory and qualitative study, drawing upon SIE literature on motivations and careers, 22 Spanish SIEs were interviewed in a semi-structured way.FindingsMost SIEs clearly detailed the line of reasoning behind the host destination choice (specific destination); a second group considered a limited number of potential countries to relocate to (alternative destinations), and the smallest one did not choose a specific location. Career motivations were the most mentioned ones and different degrees of career planning were found: those with a very defined career planning process relied upon one potential destination, while those with a less defined one considered several alternative host destinations. The European Region Action Scheme for the Mobility of University Students experience was one of the most mentioned factors influencing the choice of the host destination, which may be common to other European Union (EU) nationals. As to the limiting ones, the visa requirements outside the EU were identified. Other factors were particular to Spain, such as the perceived need for English proficiency for a successful global career and the degrees of career planning.Practical implicationsThese findings may assist Talent Management Managers to align organizational strategies with SIEs motivations. They may also help future Spanish and European SIEs in their individual career management process.Originality/valueThis study contributes to a better understanding of the expatriation motivations and factors influencing the destination location of Spanish SIEs, adding to the SIE and global career literature.

Landmark use by ghost crab (Ocypode quadrata) during wayfinding in a complex maze

Species of crab have been shown to spatially track and navigate to consequential locations through different processes, such as path integration and landmark orienting. Few investigations examine their ability to wayfind in complex environments, like mazes, with multiple intersections and how they may utilize specific features to benefit this process. Spatial learning potentially would lend a fitness advantage to animals living in complicated habitats, and ghost crab (Ocypode quadrata) is a semiterrestrial species that typically occupies extensive beach environments, which present many navigational challenges. Despite their potential, there are currently no studies that investigate forms of spatial cognition in these animals. To better diversify our knowledge of this trait, the current research exposed ghost crab to a maze with seven intersections. Animals were given multiple trials to learn the location of a reward destination to a specific criterion proficiency. In one condition several landmarks were distributed throughout the maze, and in another the environment was completely empty. Results showed that ghost crab in the landmark present group were able to learn the maze faster, they required significantly fewer trials to reach the learning criterion than those in the landmark absent group. However, only approximately half of the total sample met the learning criterion, indicating the maze was rather difficult. These findings are interpreted through theories of route learning that suggest animals may navigate by establishing landmark-turn associations. Such processes have implications for the cognitive ability of ghost crab, and spatial learning in this species may support the notion of convergent evolution for this trait.

Generous to a fault: Differential impact of CSR investments on financial gains in Indian market multinationals

To date, the extant Corporate Social Responsibility (CSR) literature has overlooked the performance consequences of different forms of CSR investments made by Emerging Market Multinational Corporations (EMNCs). Addressing this knowledge gap, and drawing on legitimacy theory, we examine the impact of external CSR investments (e.g., social and community philanthropic support activities) and internal CSR investments (e.g., working conditions, employee rights and equal employment opportunities) on financial performance of EMNCs, while also accounting for the moderating effects of internationalization location choices. We test our hypotheses on a panel consisting of 1513 unique Indian EMNCs, in the 2014–2019 time-period. On applying various estimation techniques, the findings reveal that both external and internal CSR investments are positively associated with financial performance of EMNCs, while the destination location of foreign investments and home-host geographic and institutional distance moderate these relationships. This study offers new empirical evidence on the financial implications of different types of CSR investments available to EMNCs and advances legitimacy theory by expanding its dimensional and contextual scope.

Enhancing Campus Connectivity: A Smart Intra-Transit Strategy for Efficient Vehicle Throughput

An advanced vehicle monitoring, and seat availability system is designed to monitor the vehicles from any source location A to destination location B in real time to the passengers. The proposed system would make good use of modern technologies via leveraging ultrasonic sensors, cloud API for example Thing Speak, and in-house Word Press software. The system track’s location, speed, and passenger count in real-time. This data fuels optimized scheduling and route planning, maximizing seat occupancy, and boosting overall productivity. A user-friendly dashboard visualizes vehicle activity within designated time slots, empowering faculty, and administrators with data-driven insights for improved resource allocation and scheduling. By comprehensively monitoring location, speed, and passenger count, the system ensures efficient Electric Vehicle operation within the campus confines, ultimately revolutionizing campus transportation and maximizing resource utilization.

Quantifying the probability of a successful marine bioinvasion due to source-destination risk factors.

The increasing spread of marine non-indigenous species (NIS) due to the growth in global shipping traffic is causing widespread concern for the ecological and economic impacts of marine bioinvasions. Risk management authorities need tools to identify pathways and source regions of priority concern to better target efforts for preventing NIS introduction. The probability of a successful NIS introduction is affected by the likelihood that a marine species entrained in a transport vector will survive the voyage between origin and destination locations and establish an independently reproducing population at the destination. Three important risk factors are voyage duration, range of environmental conditions encountered during transit and environmental similarity between origin and destination. In this study, we aimed for a globally comprehensive approach to assembling quantifications of source-destination risk factors from every potential origin to every potential destination. To derive estimates of voyage-related marine biosecurity risk, we used computer-simulated vessel paths between pairs of ecoprovinces in the Marine Ecoregions Of the World biogeographic classification system. We used the physical length of each path to calculate voyage duration risk and the cross-latitudinal extent of the path to calculate voyage path risk. Environmental similarity risk was based on comparing annual average sea surface temperature and salinity within each ecoprovince to those of other ecoprovinces. We derived three separate sets of risk quantifications, one each for voyage duration, voyage path and environmental similarity. Our quantifications can be applied to studies that require source-destination risk estimates. They can be used separately or combined, depending on the importance of the types of source-destination risks that might be relevant to particular scientific or risk management questions or applications.

ANALISIS SENTIMEN TINGKAT KEPUASAN PELANGGAN TERHADAP LAYANAN KURIR J&T EXPRESS MENGGUNAKAN ALGORITMA SUPPORT VECTOR MACHINE (SVM) BERDASARKAN ULASAN PENGGUNA DI GOOGLE PLAYSTORE

Courier Service Is One Of The Services That Are Widely Used By The Public, Especially In The Current Digital Era. In This Context, Courier Services Allow Shippers To Deliver Goods Or Documents Without The Need To Be Present Directly To The Destination Location. J & T Express, As One Of The Shipping Expedition Service Providers In Indonesia, Is The First Choice For Many People. Although Technology Continues To Evolve And Competition Is Increasingly Fierce, The Quality Of Courier Services Is A Key Factor That Customers Need To Pay Attention To. However, It Should Be Noted That The J&T Express Application In The Google Play Store Received A Low Rating, And This Is The Background Of This Study. the main focus of this study was to identify the level of customer satisfaction with j&t express courier services through reviews available on the google play store. within the framework of this study, sentiment analysis was conducted using the support vector machine algorithm, by applying crisp-dm methodology. the results showed that from the business understanding stage to the modeling stage, the performance of the support vector machine can be considered good. in addition, this study also resulted in an implementation that can be accessed through a website with the address jnt-sentiment.streamlit.app. hopefully, this research can contribute to j & t express in understanding the views of customers and improving the quality of their services

Local firms spillovers from multinationals’ exports in Switzerland

This paper aims to examine how local firms can learn from the export activities of large multinational corporations (MNCs). Arguing that MNCs’ export activities could act as catalysts for local firms, allowing them to start exporting or intensify their export volume, we hypothesize that the size and extent of export spillovers depend on the linkage between local firms and MNCs, the geographical distance between them in the home country, and the foreign export market destination in terms of psychic distance from the home market. Using Swiss manufacturing firm-level data, we found support to this learning by exporting effect through which local firms benefit from the presence of MNCs’ exporter counterparts and the export activities of their upstream MNCs’ suppliers, with particular effects of the nature and the physical location of destinations. From these findings, several important academic and practical implications are exhibited and discussed

Travel pattern analysis and freight trip generation modeling of textile commodities. Case study: Thamrin City Shopping Center, Jakarta

One of the sectors supporting the country’s economic development is the commercial sector. With the increasing population, the demand for consumer goods will increase, impacting trip generation. Thus, it is necessary to conduct a study to predict the trip generation of freight transport in shopping centers, especially in DKI Jakarta, with textile stores as trip generators. This research aims to determine the travel pattern of freight transport and freight trip generation models produced and attracted at the Thamrin City shopping center and to analyze the factors influencing freight trip generation. The research was conducted using a quantitative research method with a cross-sectional. Data collection used a questionnaire given to 105 merchants. Data analysis used linear regression methods with the number of freight trip production and attraction as the dependent variable. The independent variables used are the number of employees and gross floor area. The study results show that the delivery of goods using expedition services is sent to the distribution center before being sent to the destination. While shipping goods using private vehicles, sent directly to the destination location. The gross floor area significantly influences the trips generation. Transportation planners can use this research to estimate the number of trip generation in shopping center areas in the future.