Decision making for the complex patient is challenging for doctors because of increased complexity, such as multiple coâmorbidities and interprofessionality for which evidenceâbased literature and guidelines are currently lacking. The consequent uncertainty causes vagueness, threatening patient safety and the quality of care. This article is motivated by the design science paradigm and describes the interprofessional decisionâmaking model for the complex patient, namely, INDECO along with an example instantiation. Drawing on our experience in an intensive care unit of a tertiary hospital in Israel, the biâdimensional view of this model includes the medicalâ and the interprofessional perspective. Retrospective assessment of 3 case studies of complex patients is used for assessing the usefulness of INDECO in decision making. The study reported here draws support from relevant literature, including the information science, information systems, and the medical domains. The findings resonate with emerging research developments focusing on healthcare decision making.