Knowledge is one of the valuable assets owned by an organization or an enterprise. But unfortunately, not all organizations have this awareness. The Laboratory Unit of the Faculty of Applied Sciences (FIT) is a unit that was established with the aim of managing laboratories and all practicum activities within the Faculty of Applied Sciences, Telkom University. Since its establishment until now, the FIT Laboratory Unit has undergone several staff changes. This happened due to the rotation or shift from the FIT Laboratory Unit to other units or due to the expiration of the contract period. In addition, because those chosen to be laboratory assistants are final year students of the Faculty of Applied Sciences, laboratory assistants also experience changes every year. Without good knowledge management, it will cause a loss for the organization. Because the knowledge gained by the staff, while working in the Laboratory Unit will also be lost when the staff moves. To overcome this problem, the researcher proposed a knowledge management system design that can assist organizations in managing and storing their knowledge be it tacit or explicit knowledge. It Also can make it easier for staff to share and transfer knowledge. In this research process, 10 Step Knowledge Management Roadmap by Amrit Tiwana is used as guidance. However, of the ten steps, this research is limited to the sixth step, which is the designing of a knowledge management system blueprint. From the analysis of the strategic approach of KM, it is found that the codification approach has a larger portion of application than the personalization approach. Furthermore, the design process is based on seven layers of KMS. To produce a knowledge management blueprint that can be applied in the development of KMS in the FIT Laboratory Unit.
 
 
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