The immune system has evolved to protect the host from an ever-growing world of pathogenic microbes. The immune system also helps the host eliminate toxic or allergenic substances that enter the body. The host uses internal and adaptive mechanisms to recognize and eliminate pathogens. Pathogens have a variety of mechanisms by which they multiply, spread, and threaten the normal functioning of the host. At the same time, the immune system destroys pathological microbes and toxic or allergenic proteins. [1] The immune system is a complex network of cells, tissues and organs that work together to protect the body from harmful pathogens such as bacteria, viruses, fungi and parasites. So far, the dental fraternity not given much importance to the immune related dental diseases and their treatment. As such very less prosthodontic literature is available on this important topic, hence this narrative review aimed to focus on the importance of immune and its effect on different prosthodontic treatment modalities. Immunity refers to the body's ability to resist and fight off infection or disease. It involves a complex network of cells, tissues, and organs that work together to defend the body against harmful pathogens such as bacteria, viruses, fungi, and parasites. Different immunity systems are given below. (Fig-1) [2]