We report the realization of a novel degenerate Fermi mixture with an SU(2)×SU(6) symmetry in a cold atomic gas. We successfully cool the mixture of the two fermionic isotopes of ytterbium 171Yb with the nuclear spin I=1/2 and 173Yb with I=5/2 below the Fermi temperature T_{F} as 0.46TF for 171Yb and 0.54TF for 173Yb. The same scattering lengths for different spin components make this mixture featured with the novel SU(2)×SU(6) symmetry. The nuclear spin components are separately imaged by exploiting an optical Stern-Gerlach effect. In addition, the mixture is loaded into a 3D optical lattice to implement the SU(2)×SU(6) Hubbard model. This mixture will open the door to the study of novel quantum phases such as a spinor Bardeen-Cooper-Schrieffer-like fermionic superfluid.