Decrease In Thickness Research Articles

Characteristics of submacular hemorrhage with bacillary layer detachment and intrabacillary hemorrhage.

To study the outcomes of patients presenting with submacular hemorrhage (SMH) and bacillary layer detachment (BALAD) following intervention. This retrospective study examined fundus photographs and optical coherence tomography (OCT) scans to identify treatment-naive SMH and BALAD cases. Two groups were formed: SMH cases with and without BALAD. The treatment outcomes of these cases were assessed. Thirteen (65%) of the 20 eyes with SMH had BALAD. Blunt trauma was the most common cause of SMH (n = 10, 50%). Median age was 46 years (IQR range: 28-70). Demographic, clinical, or OCT imaging findings between the groups (p > 0.05) were comparable. Nine (45%) patients each underwent intravitreal gas injection alone or along with PPV and TpA injection. At 1-month post-treatment, VA improved (logMAR VA - 0.89; p = 0.017). BALADs and intrabacillary hemorrhage had resolved in eight (61%) cases. Intraretinal, subretinal, and sub-RPE fluids resolved in 100%, 70%, and 43% of cases, respectively. Eyes with resolved BALAD showed greater improvement in VA (logMAR VA - 0.98) than eyes with persisting BALAD (logMAR VA - 1.1) and resulted in significant decrease in central macular (p = 0.016) and retinal thicknesses (p = 0.031). SMH eyes without pre-treatment BALAD also observed statistically significant improvement in visual acuity following intervention (p = 0.031). BALAD and intrabacillary hemorrhage in SMH are relatively common. A significant proportion of cases had their BALAD and intrabacillary haemorrhage resolved following treatment. Persistence of BALAD had no effect on VA.

Ultrasound assessment of muscle and fascia properties and the effects of spasticity and botulinum toxin injections on spastic muscles in chronic stroke survivors

Abstract Objective To objectively quantify changes in muscle properties in chronic stroke survivors and the effects of spasticity and botulinum toxin injections (BoNTi) on muscle properties using ultrasonography. Design In this cross-sectional observational study, 24 stroke subjects with history of BoNTi to biceps brachii muscles (BB) but without BoNTi to the triceps (TRI) were included. Results 12 subjects had spastic TRI, the other half did not. 20 subjects had spasticity in wrist flexors, and 11 subjects received BoNTi to the flexor carpii ulnaris (FCU). On average, a significant decrease in muscle thickness (16.5% loss in TRI), a thicker fascia with higher echo intensity were noted on muscles in the paretic limb. Percent muscle loss (PML) was significantly less (11.0%) in spastic TRI than in non-spastic TRI (22.1%). There was no statistically significant difference in muscle and fascia properties in spastic FCU with and without BoNTi. Spasticity did not correlate significantly with muscle loss, fascia thickness or echo intensity. Conclusion Our results provided evidence that muscles on the spastic-paretic side had less muscle mass, thicker fascia and greater echo intensity. Our results showed that spasticity helped maintain muscle mass, but failed to reveal additional muscle loss after botulinum toxin injection.

Fabrication of Ultrathin Ferroelectric Al0.7Sc0.3N Films under Complementary-Metal-Oxide-Semiconductor Compatible Conditions by using HfN0.4 Electrode.

Aluminum scandium nitride (AlScN) has emerged as a promising candidate for next-generation ferroelectric memories, offering a much higher remanent charge density than other materials with a stable ferroelectric phase. However, the inherently high coercive field requires a substantial decrease in film thickness to lower the operating voltage. Significant leakage currents present a severe challenge during the thickness scaling, especially when maintaining compatibility with complementary-metal-oxide-semiconductor (CMOS) fabrication standards. This study adopts a HfN0.4 bottom electrode, which minimizes lattice mismatch with Al0.7Sc0.3N (ASN), forming a coherent bottom interface that effectively reduces leakage currents even at thickness <5nm. CMOS-compatible HfN0.4/ASN/TiN stack, deposited without vacuum break between each layer, demonstrates exceptional scalability, confirming the ferroelectricity of ASN films at thicknesses down to 3nm. The coercive voltage is decreased to 4.35V, significantly advancing low-voltage AlScN devices that align with CMOS standards.

Solution Strengthening and Short-Range Order in Cold-Drawn Pearlitic Steel Wires

Pearlitic steel rods are subjected to cold-drawing processes to produce pearlitic steel wires with true strains ranging from 0.81 to 2.18. Tensile tests are utilized to attain mechanical properties of cold-drawn pearlitic steel wires. TEM and XRD investigations were performed on the microstructure of the cold-drawn steel wires. With an increasing cold-drawn strain, both the interlamellar spacing and cementite lamellae thickness decrease, while the dislocation density significantly increases. The drawn wire has a tensile strength of 2170 MPa when the true stain reaches 2.18. Deformation-induced cementite dissolution occurs during cold-drawing progress, which releases many C atoms. The findings indicate that the supersaturation of C is heterogeneously distributed in the ferrite matrix. The ordered distribution of the released C in ferrite phases creates short-range order (SRO). SRO clusters and disordered Cottrell atmospheres contribute to solution strengthening, which, together with dislocation strengthening and interlamellar boundary strengthening, form an effective strengthening mechanism in cold-drawn pearlitic steel wires. Our work provides new insights into carbon redistribution and the mechanism of solution strengthening within ferrous phases.

Volumetric changes of porcine collagen matrix and free gingival grafts for soft-tissue grafting to increase the width of keratinized tissue around dental implants: a retrospective clinical study.

To compare three-dimensional changes of aporcine derived collagen matrix (CM) and free gingival grafts (FGG) for increasing keratinized tissue (KT) at dental implants over a 24-month follow-up period. This retrospective study enrolled 25 patients exhibiting 41 implants with deficient KT width (i.e., < 2mm) who underwent soft tissue augmentation using either CM (11 patients/15 implants) or FGG (14 patients/26 implants). The primary outcome was tissue thickness change (mm) at treated implant sites between 1- (S0), 12- (S1), and 24-months (S2). Secondary outcome was the changes of KT width over a 24-month follow-up period. Dimensional analyses from S0 to S1 and from S0 to S2 revealed a mean decrease in tissue thickness of -0.05 ± 0.35mm and - 0.31 ± 0.41mm in the CM group, and - 0.23 ± 0.38mm and - 0.22 ± 0.81mm in the FGG group, with no significant differences found between the groups (S0-S1: p = 0.14, S0-S2: p = 0.58). Within S1 and S2, the CM and FGG groups displayed comparable tissue thickness reduction (CM: -0.32 ± 0.53mm, FGG: -0.02 ± 0.21mm; p = 0.07). The FGG group exhibited a significantly greater KT gain 24-months compared to the CM group (CM: 1.50 ± 1.14mm, FGG: 4.04 ± 1.65mm; p < 0.001). CM and FGG were associated with comparable three-dimensional thickness changes over a period of 24 months. A significantly wider KT band could be established in the FGG group.

Abstract 4137267: A novel reproducible low-cost model of acute myocardial infarction in swine

Background: Traditional open- and closed-chest methods for inducing acute myocardial infarction (AMI) in pigs typically require extensive and expensive instrumentation, including ventilators and inhalation anesthesia. This study aims to evaluate a reproducible and low-cost model for AMI in pigs using lower hemisternotomy. Methods: Twenty Yorkshire swine (15-20 kg, 45-50 days of age) underwent permanent ligation of the roots of the first and second diagonal branches of the left anterior descending coronary artery. The procedure was performed under intramuscular anesthesia (1ml 0.5mg/kg Zoletil™ and 2ml 10mg/kg xylazine hydrochloride) with spontaneous respiration. Cardiac function was assessed via echocardiography and cardiac PET/MRI scans at 1 and 4 weeks post-MI. Heart tissue was collected for pathological analysis to evaluate the establishment of the AMI model. Results: All animals exhibited ECG changes, including premature ventricular complexes and ST-segment elevation immediately after ligation. No ventricular tachycardia and fibrillation was observed during the operation. No animals (0%) died during infarct creation. The "Skin-to-Skin" procedure time was 18±3.3 minutes. this procedure produced an infarction that occupies ~10% of the left ventricular mass accompanied with the decrease of LV heart function and LV anterior wall thickness 4 weeks post-MI. Conclusions: This novel low-cost technique provides reproducible acute coronary artery occlusion at a selected location with subsequent AMI. It avoids ventilation, inhalation anesthesia, major surgery and does not require expensive instrumentation for intracoronary intervention.

Quantitative Evaluation of Enamel Thickness in Maxillary Central Incisors in Different Age Groups Utilizing Cone Beam Computed Tomography a Retrospective Analysis

Background/Objectives: The presence of enamel on the tooth surface is crucial for the long-term success of minimally invasive adhesive restorations such as dental veneers. Our study aims to evaluate the enamel thickness in the incisal, middle, and cervical portions of the labial surface of the upper central incisors using cone beam computed tomography (CBCT). This imaging method provides detailed and accurate three-dimensional images with a low radiation dose, allowing an accurate assessment of enamel thickness. The analysis aims to identify variations in enamel thickness depending on the age and different levels of the labial tooth surface. Methods: 800 CBCT scans performed for diagnostic or therapeutic purposes on patients aged 18–60 years were analyzed. The data were gathered from the imaging archives of private practitioners from Targu Mures and the “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Targu Mures. Enamel thickness measurements were conducted using the OnDemand3D Communicator CBCT evaluation program, with subsequent statistical analysis performed using GraphPad Instat Prism software. Results: Results showed significant variation in enamel thickness between the incisal, middle, and cervical segments of the labial surface of the upper central incisors. A decrease in enamel thickness with age has been observed. In patients aged 18–40, mean values of enamel thickness 1 mm and 3 mm above the cementoenamel junction (CEJ) were 0.48 ± 0.092, respectively, 0.819 ± 0.158. In patients over 40, the mean values were 0.454 ± 0.116 and 0.751 ± 0.067 at 1 mm, respectively, 3 mm above the CEJ. Statistically significant differences were found between the two age groups at 1 mm and 3 mm above the CEJ, with p &lt; 0.0001 and p = 0.0214. Conclusions: A statistically significant decrease can be observed in enamel thickness in almost the entire labial surface of the upper central incisors with aging. The varied thickness of the enamel at different tooth levels requires individualized planning for each patient to maximize the long-term aesthetic and functional results.

Topical 5-fluorouracil as monotherapy for ocular surface squamous neoplasia

Ocular surface squamous neoplasia (OSSN) comprises a gamut of diseases, which encompass conjunctival intraepithelial neoplasia, conjunctival carcinoma in situ, and squamous cell conjunctival neoplasia. Gold standard treatment for OSSN entails excision with cryotherapy. A lot of progress has been made recently that shows that chemotherapeutic drugs, such as mitomycin C, 5-fluorouracil (5-FU), and interferon alfa2b, can be just as effective. This is a case report that includes two cases: An 81-year-old Filipino female and a 65-year-old Filipino male who presented with a pinkish lesion on the bulbar conjunctiva. Documentation was done through clinical observation, slit-lamp examination, and the use of anterior segment optical coherence tomography (OCT). 1% topical 5-FU was given as chemotherapy administered at 1 drop 4×/day for 1 week with a 3-week drug holiday. During the course of treatment, we noted clinical resolution of the lesions grossly on slit-lamp examination. On anterior segment OCT, a decrease in diameter and thickness was noted, but with remaining areas of hyperreflectivity and thickened epithelium at the site of the lesion. No decrease in visual acuity was noted during the course of treatment, as well as any adverse effects such as eye pain or inflammation. Considering its safety and efficacy profile, 5-FU has great potential to be considered as a first-line therapy in the topical treatment of OSSN. Topical chemotherapy can target microscopic diseases that may be missed surgically and decrease adverse effects. As seen in this case report, 5-FU shows much promise as a possible alternative in the treatment of OSSN.

Adiponectin may play a crucial role in the metabolic effects of GLP-1RAs treatment in patients with Type 2 Diabetes Mellitus: a preliminary longitudinal study.

Type 2 diabetes mellitus (T2DM) stands as the most prevalent metabolic disorder globally. T2DM entails numerous cardiovascular complications, which contribute significantly to morbidity, mortality, and increased public spending worldwide. The real challenge for new diabetes drugs lies not only in reducing blood glucose levels and glycated hemoglobin but also in preventing cardiovascular risk. Emerging receptor agonists for glucagon-like peptide-1 (GLP-1RAs) have demonstrated a pivotal role in diabetes management and mitigating cardiovascular risk. We conducted a 12-month longitudinal investigation evaluating the cardio-metabolic effects of GLP-1RAs on a cohort of 65 Caucasian patients diagnosed with T2DM who were scheduled for treatment with GLP-1RAs. Fifty-four T2DM patients successfully completed the 12-month study period, with 30 receiving dulaglutide and 24 receiving semaglutide. In our study population, GLP-1RAs resulted in several positive changes beyond the observed weight loss: a shift in fat distribution, indicated by a reduction in the percentage of visceral fat (1.21 vs. 1.17, p < 0.05); a significant decrease in LDL cholesterol levels (p < 0.05) and triglycerides (p < 0.01); and a significant increase in serum adiponectin levels (p < 0.05), potentially indicating a reduction in insulin resistance and inflammation. Additionally, we observed a significant decrease in microalbuminuria and media-intimal thickness at the carotid vessel level (p < 0.05). In patients with T2DM 1-year therapy with GLP-1RAs has a positive effect on the main determinants of cardiovascular risk including body weight, visceral fat, dyslipidemia, and atherosclerosis. Moreover, the increase in adiponectin may play a pivotal role in controlling the inflammatory state and the mechanisms of vascular damage.

Influence depth of highway subgrade under heavy vehicle loads based on a theoretical model

A three-dimensional dynamic model of vehicle-road-unsaturated subgrade coupling is established. The semi-analytical and numerical solutions of three-dimensional dynamic response of highway subgrade under vehicle load are presented for the first time. Then, the accuracy of the theoretical model is verified by the field measurement data. Finally, the spatial distribution of dynamic stress and depth of working zone under different influencing factors are studied, and the calculation model of depth of working zone of highway subgrade is proposed. The results show that the dynamic stresses, σx, σy, σz, and τxz increase significantly with the increase of vehicle axle load and decrease significantly with the increase of road thickness under the same subgrade depth. In addition, with the increase of axle load and the decrease of road thickness, the peak values of dynamic stress σx, σy, σz, and τxz decrease more obviously along the depth of roadbed. In the process of vehicle movement, the traditional subgrade working area can be divided into a sensitive area and an influence area of dynamic load. The depth of these two areas is positively correlated with the axle load of the vehicle and negatively correlated with the thickness of the road surface. The advantage of the model in this paper is that the semi-analytical solution of the total stress component of the soil element in the course of traffic load is given.

Enhancing the discharge uniformity of atmospheric pressure DBD cold plasma for food efficient microbial inactivation

Identification and optimization of the discharge uniformity is worldwide problems in the plasma industry. In this study, a simple, practical, and economical alternative for quantitatively identifying discharge uniformity of DBD plasma was proposed using the gray-level histogram, discharge area curve, and gray level transformation characteristics of discharge images. The influences of discharge peak voltage, excitation frequency, dielectric material, and dielectric thickness on discharge uniformity on the time scale of seconds were discussed, and the intrinsic relationship and mechanism between discharge uniformity and microbial inactivation efficiency were revealed. Within a certain range, with the gradual increase of discharge peak voltage (13–17 kV), excitation frequency (9–11 kHz), relative dielectric constant (3.6–9.6), and the gradual decrease of dielectric thickness (1–5 mm), the discharge image corresponded to the relative discharge uniformity and the average inactivation of L. monocytogenes and S. typhimurium (0.12–1.40 log-reduction and 0.26–2.34 log-reduction) increased as a whole. Overall, the findings revealed disruption or improvement of the discharge uniformity was the main factor contributing to the inactivation of bacteria by cold plasma, facilitating the scaling-up of DBD reactors on an industrial scale.

Hydrodynamic theory of premixed flames propagating in closed vessels: flame speed and Markstein lengths

A hydrodynamic theory of premixed flame propagation within closed vessels is developed assuming the flame is much thinner than all other fluid dynamic lengths. In this limit, the flame is confined to a surface separating the unburned mixture from burned combustion products, and propagates at a speed determined from the analysis of its internal structure. Unlike freely propagating flames that propagate under nearly isobaric conditions, combustion in a closed vessel results in continuous increases in pressure, burning rate and flame temperature, and a progressive decrease in flame thickness. The flame speed is shown to depend on the voluminal stretch rate, which measures the deformation of a volume element of the flame zone, and on the rate of pressure rise. Both effects are modulated by pressure-dependent Markstein numbers that depend on heat release and mixture properties while capturing the effects of temperature-dependent transport and stoichiometry. The model applies to flames of arbitrary shape propagating in general flows, laminar or turbulent, within vessels of general configurations. The main limitation of hydrodynamic flame theories is the assumption that variations inside the flame zone due to chemistry or turbulence, which could potentially alter its internal structure, are physically unresolved. Nonetheless, the theory, deduced from physical first principles, identifies the various mechanisms involved in the combustion process as demonstrated in detailed discussions of planar flames propagating in rectangular channels and spherically expanding flames in spherical vessels. It also enables the construction of instructive models to numerically simulate the evolution of multi-dimensional and corrugated flames under confinement.

Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis

Pseudomonas aeruginosa (P. aeruginosa), a Gram-negative opportunistic pathogen, poses significant treatment challenges due to its antibiotic resistance and biofilm formation. This study investigates the anti-bacterial and anti-biofilm activities of chemically synthesized selenium nanoparticles (SeNPs) against P. aeruginosa. SeNPs were synthesized using ascorbic acid as a reducing agent and characterized. Biofilm formation was quantified using a modified microtiter plate method, and the anti-biofilm efficacy of SeNPs was evaluated using confocal microscopy and SEM. The P.aeruginosa isolates exhibited high resistance to piperacillin-tazobactam (60%) and ceftazidime (59%). SeNPs demonstrated a round shape with a diameter of 15-18 nm. UV-Vis spectra showed a peak at 275 nm, and XRD analysis revealed crystalline peaks corresponding to selenium. The FTIR spectra confirmed the presence of various functional groups. SeNPs significantly reduced biofilm formation in a dose-dependent manner, with MIC50 and MIC90 values of 60 μg/mL and 80 μg/mL, respectively. Confocal microscopy and SEM analysis showed a notable decrease in biofilm thickness and bacterial adherence post-SeNPs treatment. These findings suggest that SeNPs could be a promising alternative or adjunctive treatment option for combating antibiotic-resistant P. aeruginosa infections. Further research is warranted to explore the clinical applications of SeNPs in treating biofilm-associated infections.

Fragmentation behavior and velocity formula for secondary fragments from RC slabs during contact explosions

The failure process of reinforced concrete (RC) slabs under contact explosion is dominated by localized damages, accompanied by numerous flying fragments. These concrete fragments pose a significant threat to personnel and equipment, as well as causing dynamic deformation and failure of the retrofitting materials used to restrain the fragments. The behavior of concrete fragmentation during explosions has been seldom studied experimentally, and few fragment velocity formulas exist that incorporate multiple factors. In this paper, the fragmentation process is recorded using two high-speed cameras, revealing that concrete fragmentation during explosions exhibits notable zoning characteristics, with the maximum velocity observed at the center of the fragment cloud’s front. To predict this maximum velocity, a model is derived from dimensional analysis. Utilizing this model, velocity prediction formulas are proposed and validated by 29 contact explosion tests. The formulas consider the explosive-rebar position, slab thickness, explosive mass and explosive shape, and are further improved by considering the concrete cover. The results indicate that, when the slab is not breached, the deceleration of rebar on fragments is weak. However, once the slab is breached, this deceleration becomes increasingly significant as the defined scaled thickness (TS) decreases. In the limiting case, the fragment velocity when the charge is located above the rebar is 0.636 times that of when the charge avoids the rebar. Fragments when the charge avoids the rebar, should be regarded as the most unfavorable case in secondary fragment hazards assessment and structural design.

Effect of wall thickness on the precipitation behavior, microstructure, electrical conductivity and mechanical properties of copper alloy prepared by electron beam powder bed fusion

Electron beam powder bed fusion (EB-PBF) is one of the most promising technologies for preparing thin-walled copper alloy, because copper alloy have a high energy absorption rate for electron beam, and high preheating temperature can reduce the solidification temperature gradient and reduce the deformation of thin-walled parts. At present, there are few reports on the systematic research work on the EB-PBF of thin-walled CuCrZr alloy parts, and it's impossible to effectively supervise the production of complex thin-walled CuCrZr alloy parts. This work aims to investigate the effect of thickness on the microstructure and mechanical properties of CuCrZr alloy produced by EB-PBF. As the wall thickness decreases from 5.0 mm to 0.3 mm, the grain sizes of the XY and YZ planes decreased from 20.4 μm and 43.1 μm to 14.5 μm and 21.5 μm respectively, and the texture intensity decreased from 16.04 and 23.57 to 7.62 and 10.99. The analysis showed that Cr2O3 nanoprecipitates were precipitated in situ in the sample, and their average size decreased from 65.8 nm to 21.6 nm. Due to the reduction in grain and nanoprecipitate size, the performance of thin-walled samples is significantly enhanced, with yield strength (YS) increasing from 112 MPa to 165 MPa and conductivity increasing from 71.7 %IACS to 86.1 %IACS. Finally, the main contributions to the YS of specimens with different wall thicknesses was discussed. Precipitation strengthening and dislocation strengthening are the main strengthening mechanisms in thin-walled samples, and the gradual refinement of nano-precipitates is the main reason for the improvement of mechanical properties as the wall thickness decreases.

Early impairment of endothelial and myocardial function in patients with hidradenitis suppurativa

Abstract Background/Introduction Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating, inflammatory skin disease manifested by painful, deep-seated, inflamed lesions of the apocrine gland-bearing areas of the body (axillae, submammary folds, inguinal and anogenital region). HS has been associated, among others, with an increased cardiovascular risk. Purpose We aimed to investigate the endothelial, arterial and left ventricular (LV) myocardial function in patients with severe HS. Methods Twenty-eight, not previously treated patients (mean age: 36 ± 13 years) with Hurley stage III disease and a mean score of 19±8 on the International Hidradenitis Suppurativa Severity Score System (IHS4) scale, were studied. Twenty healthy sex-, age- and body mass index -matched individuals, who were also weighted for common cardiovascular risk factors, served as the control group. Both patients and controls were evaluated for: a) perfused boundary region (PBR) of the sublingual microvessels with a diameter of 5-25 μm (an increased PBR value is considered as an indicator of a decrease in thickness of the endothelial glycocalyx), using a dedicated camera (Microscan, GlycoCheck), b) carotid-femoral pulse wave velocity (PWV-Complior), c) flow-mediated dilation (FMD) of the brachial artery and d) LV global longitudinal strain (GLS) using the speckle-tracking echocardiography. Results Compared to healthy controls, HS patients had increased PBR value (2.32 ± 0.19 vs. 1.99 ± 0.14 μm, p &amp;lt; 0.001) and decreased FMD (5.7 ± 2.9 vs. 10.3 ± 1.9 %, p &amp;lt; 0.001) and GLS values (-18.6 ± 2.8 vs. -22.5 ± 2.3 %, p &amp;lt; 0.001). In contrast, similar PWV values (9.2 ± 2 vs. 9.1 ± 1.9 m/s, p = 0.937) were recorded between patients and controls (Table). Increased IHS4 score (more severe disease) was associated with increased PBR values (r = 0.42, p = 0.026) and decreased FMD values (r = -0.37, p = 0.045). Conclusion Patients with HS show early impairment of endothelial and LV myocardial function, which correlates with the severity of the underlying systemic inflammation.Table

Efficacy of Intravitreal Multi-Characteristic Opsin (MCO-010) Optogenetic Gene Therapy in a Mouse Model of Leber Congenital Amaurosis.

Purpose: Leber congenital amaurosis (LCA) is a sight-threatening inherited retinal disorder (IRD) caused by numerous genetic mutations. Multi-characteristic opsin (MCO)-based optogenetic therapy allows the recruitment of residual cells of the retina in LCA for alternative vision transduction while being mutation-agnostic. Using rd12 mice, we investigated the invivo efficacy of an adeno-associated virus2 (AAV2)-transduced ambient light-activatable MCO (MCO-010) containing a metabotropic glutamate receptor-6 bipolar cell-specific promoter/enhancer. Methods: Mice requiring > 40 s to reach and board a dimly lit hidden platform in a water-maze were selected and randomly divided into 2 cohorts. These mice were intravitreally (IVT) injected with either 1.7E9 gene copies/eye of MCO-010 or control AAV2 and re-tested in the water-maze. Spectral-domain optical coherence tomography (SD-OCT), hematoxylin and eosin staining of retinas, and electroretinographic (ERG) studies were also conducted. Results: Safety of MCO-010 in rd12 mice was confirmed by the lack of significant detrimental changes in the mouse behavior, b-wave amplitudes and in retinal thickness. rd12 control mice performed relatively poorly in the water-maze test requiring ≥ 30-60 s to find and board the platform. MCO-010-treated rd12 mice reached the platform much faster than the AAV2-treated rd12 mice, with some mice only requiring < 5 s to achieve this goal (P < 0.01-0.0024). Conclusions: IVT MCO-010 treatment was well tolerated by rd12 mice, and it prevented the decrease in retinal thickness, and preserved ERG parameters. It also significantly improved the vision in rd12 mice relative to control AAV2-injected mice. MCO-010 therefore represents a novel and efficacious optogenetic therapeutic to treat LCA and other IRDs irrespective of the genetic defect(s).

Dexamethasone implantation causing iatrogenic lens injury: a review of literature with case series

Aims: In this study, three cases of iatrogenic lens injuries during Dexamethasone (DXM) implantation will be discussed and current approaches will be reviewed with the literature. Methods: Three patients with iatrogenic lens injury during DXM implantation were evaluated retrospectively. Results: The three patients underwent DXM implantation for cystoid macular edema with central retinal vein occlusion and one patient for EALES disease. The surgical intervention was performed in all three patients in conjunction with cataract surgery. Intraocular lens implanted into the sulcus in all patients. The DXM could be directed to the vitreous in two patients with intact anterior hyaloid, while the other patient underwent anterior vitrectomy and DXM explanation. Anti-vascular endothelial growth factor was injected in the patient who could not implant DXM. The lens was stable in all patients in postoperative controls. There was a decrease in macular thickness at follow-up. Conclusion: Dexamethasone implant is a slow-release tablet for macular edema due to retinal vein occlusion, diabetic retinopathy and non-infectious uveitis. Lens injury during dexamethasone implantation is a rare complication. In our series, the implant occluded the visual axis and most of it was in the lens, managed with cataract surgery. If possible, DXM should be directed to the vitreous, if not, treatment modalities should be specificized on a patient-by-patient basis.

Analysis of Choroidal Thickness Changes in Recurrent Rhegmatogenous Retinal Detachment.

To analyze changes in choroidal thickness in patients with recurrent rhegmatogenous retinal detachment (RRD) before and after surgical intervention and to identify factors that influence changes in choroidal thickness. A retrospective observational study was conducted on patients who underwent surgery for recurrent RRD from November 2019 to March 2023. Choroidal thickness was measured using optical coherence tomography (OCT) at baseline, and then at 2 and 6 months postoperatively. The study analyzed the impact of various factors on choroidal thickness changes. The study included 33 patients, demonstrating a significant decrease in choroidal thickness in the surgical eye compared to the fellow eye over a 6-month period. In the univariate analysis, changes in choroidal thickness were significantly correlated with changes in central retinal thickness (p=0.048) between 0-2 months, and with proliferative vitreoretinopathy (PVR) grade between 2-6 months (p=0.009) and 0-6 months(p=0.02). In the multivariate analysis, an association was found between changes in choroidal thickness from 2 to 6 months and PVR grade(p=0.030). The findings indicate that surgical reattachment in eyes with recurrent RRD leads to a significant reduction in choroidal thickness. The extent of this reduction is influenced by the severity of PVR, highlighting the importance of considering PVR severity when evaluating surgical outcomes in patients with recurrent RRD.

Chemical composition, physical properties, and sensory evaluation of wheat-based cookies enriched with different proportions of corn silk

Incorporating dried corn silk powder (CSP) into food products is considered beneficial for health and suitable for individuals of all ages. Thus, our study is designed to evaluate the effects of adding CSP to prepared cookies as a nontraditional source of dietary fiber and natural antioxidants, focusing on the chemical composition, physical properties, color attributes, antioxidant activity, and sensory properties of fortified cookies. Different CSP proportions (5%, 10%, 15%, and 20%) replaced wheat flour (WF) with a 72% extraction rate. The results revealed that CSP had significant levels of total phenolic content (TPC) and flavonoid content (TFC), measuring 86.42 mg GAE/g and 112.68 mg QE/g, respectively. CSP contained higher quantities of protein and fiber than WF, with values of 14.81 g and 15.21 g per 100 g of flour weight basis, respectively. The amounts of phenolic compounds in cookie samples increased proportionally with the increasing substitution of CSP, while total carbohydrates decreased. Adding CSP at concentrations of 5%, 10%, 15%, and 20% resulted in corresponding increases in crude fiber of 0.52, 1.2, 2.04, and 2.7 times compared to the control cookie samples. As the amount of CSP supplementation increased (0–20%), TPC and TFC in the cookies increased to 3.06 and 4.08 mg GAE/g and 0.02 to 1.28 mg QE/g, respectively. Increasing CSP proportions led to a significant decrease in diameter, thickness, spread factor, volume, and density of fortified cookies. Furthermore, the L* value exhibited a substantial decline from 65.48 to 51.12 as the amount of CSP substitution increased from 5% to 20%. The sensory evaluation characteristics of the cookie samples indicated that the sample with 15% CSP had the highest overall acceptability score. Therefore, this study demonstrates that adding 15% CSP can effectively yield functional cookies without compromising their sensory acceptability.