Decrease In Cerebrospinal Fluid Pressure Research Articles

Decrease in cerebrospinal fluid pressure following the pressure injection technique.

Decrease in cerebrospinal fluid pressure following the pressure injection technique.

TERMINATION OF MIGRAINE HEADACHE BY A NEW ANTI-INFLAMMATORY VASOCONSTRICTOR AGENT.

Indomethacin, a new nonsteroid anti‐inflammatory agent causes headache, a marked decrease in cerebrospinal fluid pressure, and an increase in retinal arterial pressure, while it produces little and inconstant change in the pressure of the carotid and brachial arteries. Despite the headache, indomethacin was investigated in sub;ects with vascular headache because of its vasoconstrictor action. Clinical improvement similar or slightly inferior to that with ergotamine was observed.

Effect of Vitamin A and Vitamin A Acid on Cerebrospinal Fluid Pressure and Blood and Liver Vitamin A Concentrations in the Pig

Thirty-six pigs, weaned at 3 weeks of age, were depleted until their blood plasma vitamin A concentrations had decreased to less than 12 µg/100 ml. They were then supplemented for 75 ± 1 days with vitamin A or vitamin A acid, or both. Blood plasma vitamin A increased with vitamin A intake but decreased and was unrelated to any level of vitamin A acid fed. Liver vitamin A increased with vitamin A and vitamin A acid intake although values for the pigs fed vitamin A acid were low. In addition, those pigs fed a combination of vitamin A and vitamin A acid had considerably higher liver vitamin A concentrations than those pigs fed vitamin A alone, indicating that vitamin A acid had a sparing effect on liver vitamin A in the pig. No vitamin A acid could be detected in the plasma or liver. A similar decrease in cerebrospinal fluid pressure occurred with an increase in vitamin A or vitamin A acid intake, suggesting that vitamin A acid was effective in meeting this physiological requirement. Cerebrospinal fluid pressure proved to be an adequate criterion in measuring the vitamin A status of the pig when fed either vitamin A or vitamin A acid.

Long-term follow-up of patients who received 10,098 spinal anesthetics; syndrome of decreased intracranial pressure (headache and ocular and auditory difficulties).

• The headache that frequently follows spinal anesthesia is sometimes associated with visual and auditory difficulties and dizziness. This syndrome was studied in connection with 9,277 anesthetizations by the spinal technique, and the data were compared with those from 1,000 other patients who were given general anesthesia over the same period of time. The over-all incidence of the headache, which occurred in 9,277 anesthetizations, was 1,011, or 11%. The oldest patients were least susceptible to it, and men were less susceptible than women. Its incidence when needles of small diameter were used was much less than that with needles of large diameter; the 22-gauge needle was found best for routine use. Headache could be virtually eliminated by the employment of a 24-gauge needle. The data on duration and time of onset of the headache, on the effects of postural changes, and on the visual and auditory phenomena indicate that this syndrome results from a decrease in cerebrospinal fluid pressure and that the decrease is caused by leakage of the fluid.