Identifying pollution sources and measuring their impact is essential for protecting groundwater. Groundwater pollution sources in the Guanzhong region were identified using the positive matrix decomposition (PMF) model, and their contributions were quantified. The spatial distribution of socio-economic factors (population, GDP, fertilizer use, farmland, and livestock) was analyzed. Redundancy and correlation analyses were used to assess the impact of land use on groundwater quality. The results showed that the primary groundwater physicochemical constituents exceeding the standard limits were, in descending order, NO3 −, Na+, TDS, F−, SO4 2−, and Cl−, and the most polluted areas were found in the eastern and southern parts of the study area. Land use and socio-economic factors can have diverse impacts on groundwater quality. Five main sources responsible for groundwater quality deterioration in the Guanzhong were comprehensively identified, i.e., agricultural nonpoint sources, domestic pollution from urban and rural development, natural release of fluorine from stratigraphic minerals as well as coal mine storage and combustion, industrial discharges, and water-rock reactions. Natural release from minerals and industrial discharges are the major causes of groundwater degradation in the study area, which is followed by water-rock reactions, agriculture, and domestic pollution.
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