Date Of Receipt Research Articles

Evaluación de los aspectos formales de las revistas pediátricas españolas

Standardization of scientific journals is indispensable for accurate transmission of knowledge, since it guarantees the universality and reproducibility of research. The objective of this study was to evaluate the formal elements of Spanish pediatrics journals. In 2005, we studied the characteristics of Spanish biomedical journals with special emphasis on Spanish pediatrics journals. The form used for the selection of journals for inclusion in the database Indice Médico Español (IME) was employed to evaluate 65 distinct characteristics in each journal. The parameters were grouped in the following five categores: journal presentation, presentation of the articles, scientific and editorial committees, content characteristics, and dissemination parameters. The journals with the highest overall scores were Anales de Pediatría (63 points out of a maximum of 82), followed by Pediatría de Atención Primaria (53 points), Acta Pediátrica Española and Cirugía Pediátrica (55 points each), Pediatrika (53 points), and Revista Española de Pediatría (48 points). The score obtained by Anales de Pediatría places this journal in the top 10 Spanish journals included in IME. Spanish pediatrics journals meet most of the formal elements required of biomedical journals, although some aspects could be improved, such as deficiencies in the frequency and regularity of publication, mention of the dates of manuscript receipt and acceptance, the lack of a clear description of the editorial process of manuscript selection and peer review, the absence of committee members' institutional affiliations, and the absence of articles by non-Spanish authors.

Outcomes of Patients with Prostate Cancer Receiving Zoledronic Acid or Pamidronate for Prevention of Skeletal‐Related Events

To determine the relative effectiveness of two bisphosphonates--pamidronate and zoledronic acid--for preventing skeletal-related events (SREs) in patients with prostate cancer metastatic to bone. Retrospective cohort study. Large, tertiary care cancer center. One hundred thirty-seven patients with a diagnosis of prostate cancer who received either pamidronate or zoledronic acid between January 1, 1998, and December 31, 2004, were identified in the electronic medical records; 24 of these patients met all prespecified eligibility criteria, and 105 patients met relaxed eligibility criteria. Using a binary logistic regression model, we explored the effect of the bisphosphonate received on development of an SRE. Whether the patient was receiving chemotherapy as of the date of first receipt of a study drug, the number of bisphosphonate doses received, time since the diagnosis of prostate cancer, and the number of previous SREs were included as covariates. The odds ratio for developing an SRE after receiving zoledronic acid was 0.80 (95% confidence interval 0.08-7.50) compared with the reference group that received pamidronate. This difference did not reach statistical significance (p=0.84). Because of the limited number of patients who met all prespecified eligibility criteria, various post hoc analyses were performed in the 105 patients with use of relaxed eligibility criteria. None provided definitive evidence of the superiority of one agent versus the other. No definitive evidence of a difference in the efficacy for preventing the development of an SRE was found between pamidronate and zoledronic acid, although a smaller-than-expected sample size impairs the interpretability of this finding. In the absence of additional research, it seems reasonable to assume that no clinically important difference exists between the two agents.

Reports of Death with Use of Propofol (Diprivan) for Nonprocedural (Long-term) Sedation and Literature Review

Reports of Death with Use of Propofol (Diprivan) for Nonprocedural (Long-term) Sedation and Literature Review

Errata

Tissue AntigensVolume 68, Issue 2 p. 192-192 Free Access Errata First published: 06 July 2006 https://doi.org/10.1111/j.1399-0039.2006.00647.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In the following article [1], the date of receipt was incorrect. The article was received on 18 November 2005. The publisher apologizes for the error and any confusion it may have caused. Reference 1 Joyner DE, Damron TA, Aboulafia A, Bokor W, Bastar JD, Randall RL. Heterogeneous expression of melanoma antigen (hMAGE) mRNA in mesenchymal neoplasia. Tissue Antigens 2006: 68: 19– 27. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Since the publication of the following article [1], the authors have noticed an error in the legend to Figure 2. SNPs have been defined as single nucleotide proteins. The correct definition is single nucleotide polymorphisms. The publisher apologizes for the error and any confusion it may have caused. Reference 1 Murdoch S, Seoud M, Kircheisen R, Mazhar B, Slim R. Detailed gene and allele content analysis of three homozygous KIR haplotypes. Tissue Antigens 2006: 68: 72– 77. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar In the following article [1], the dates of receipt and revision were incorrect. The article was received on 20 January 2006 and revised on 21 February 2006. The publisher apologizes for the errors and any confusion they may have caused. Reference 1 Melum E, Karlsen TH, Broomé U et al. The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Δ32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. Tissue Antigens 2006: 68: 78– 81. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume68, Issue2August 2006Pages 192-192 ReferencesRelatedInformation

Abundance anomalies in hot horizontal branch stars of the Galactic globular cluster NGC 2808

the date of receipt and acceptance should be inserted later Abstract. We present metallicity measurements of 25 stars in the blue horizontal branch of the Galactic globular cluster NGC 2808. Our measurements are based on moderate-resolution spectra taken with the multi-object fiber facility FLAMES- UVES, mounted on Kueyen at the Very Large Telescope. We confirm that stars hotter than a threshold temperature have super-solar abundance, while the cooler ones respect the nominal metallicity of the cluster, i.e. (Fe/H)≃-1.1. The threshold temperature is estimated to be about 12 000 K, corresponding to the so called u-jump, and coincides with the sudden departure of the cluster horizontal branch from the models. The metallicity increases with temperature for star hotter than the ju mp, confirming the hypothesis that the process responsible for t his abrupt metallic enhancement is the levitation due to the strong radiation field in absence of a significative convective enve lope. A metallicity dependence of the abundance enhancement is also suggested, with more metal poor clusters having a higher increase in metal content. The slope in the temperature vs. abundance diagram is higher than the errors involved, and the metal content of the cluster plays possibly a role in determining the a mplitude of the jump (more metal poor clusters show more enhancement after the jump), although other parameters, such as clusters ' characteristics and even the atomic species involved, may also someway contribute.

A microquasar model applied to unidentified gamma-ray sources

the date of receipt and acceptance should be inserted later Abstract. Among unidentified gamma-ray sources in the galactic plane, there are some that present significant variability and have been proposed to be high-mass microquasars. To deepen the study of the possible associa- tion between variable low galactic latitude gamma-ray sources and microquasars, we have applied a leptonic jet model based on the microquasar scenario that reproduces the gamma-ray spectrum of three unidentified gamma- ray sources, 3EG J1735 1500, 3EG J1828+0142 and GRO J1411 64, and is consistent with the observational constraints at lower energies. We conclude that if these sources were generated by microquasars, the particle acceleration processes could not be as efficient as in other objects of this type that present harder gamma-ray spectra. Moreover, the dominant mechanism of high-energy emission should be synchrotron self-Compton (SSC) scattering, and the radio jets may only be observed at low frequencies. For each particular case, further predictions of jet physical conditions and variability generation mechanisms have been made in the context of the model. Although there might be other candidates able to explain the emission coming from these sources, microquasars cannot be excluded as counterparts. Observations performed by the next generation of gamma-ray instruments, like GLAST, are required to test the proposed model.

Seventeen new very low-mass members in Taurus

the date of receipt and acceptance should be inserted later Abstract. Recent studies of the substellar population in the Taurus cloud have revealed a deficit of brown dwarfs compared to the Trapezium cluster population (Briceno et al. 1998; Luhman 2000; Luhman et al. 2003a; Luhman 2004). However, these works have concentrated on the highest stellar density regions of the Taurus cloud. We have performed a large scale optical survey of this region, covering a total area of ≃ 28deg 2 , and encompassing the densest parts of the cloud as well as their surroundings, down to a mass detection limits of 15 MJ. In this paper, we present the optical spectroscopic follow-up observations of 97 photometrically selected potential new low-mass Taurus members, of which 27 are strong late-M spectral type (SpT ≥ M4V ) candidates. Our spectroscopic survey is 87 % complete down to i ' =20 for spectral types later than M4V, which corresponds to a mass completeness limit of 30 MJ for ages ≤ 10 Myr and Av ≤ 4. We derive spectral types, visual absorption and luminosity class estimates and discuss our criteria to assess Taurus membership. These observations reveal 5 new VLM Taurus members and 12 new BDs. Two of the new VLM sources and four of the new substellar members exhibit accretion/outflow signatures similar to the higher mass classical T Tauri stars. From levels of Hemission we derive a fraction of accreting sources of 42 % in the substellar Taurus population. Combining our observations with previously published results, we derive an updated substellar to stellar ratio in Taurus of Rss = 0.23 ± 0.05. This ratio now appears consistent with the value previously derived in the Trapezium cluster under similar assumptions of 0.26±0.04. We find indication that the relative numbers of BDs with respect to stars is decreased by a factor 2 in the central regions of the aggregates with respect to the more distributed population. Our findings are best explained in the context of the embryo-ejection model where brown dwarfs originate from dynamical interactions in small N unstable multiple systems.

INTEGRAL spectroscopy of the accreting millisecond pulsar XTE J1807-294 in outburst

the date of receipt and acceptance should be inserted later Abstract. The fourth transient accreting millisecond pulsar XTE J1807-294 was observed during its February/March 2003 outburst by INTEGRAL, partly simultaneously with the XMM-Newton and RXTE satel- lites. We present here the first study of the 0.5-200 keV broad-band spectra of the source. On February 28, the source spectrum was consistent with thermal Comptonization by electrons of temperature � 40 keV, considerably larger than the value (� 10 keV) previously derived from the low energy XMM-Newton data alone. The source is detected by INTEGRAL up to 200 keV with a luminosity in the energy band (0.1-200) keV of 1.3 × 10 37 erg s −1 (assuming a distance of 8 kpc). 22 days later the luminosity dropped to 3.6 × 10 36 erg s −1 . A re-analysis of XMM-Newton data yields the orbital Doppler variations of the pulse period and refines the previous ephemeris. For this source having shortest orbital period of any known binary radio or X-ray millisecond pulsar, we constrain the companion mass Mc < 0.022M⊙, assuming minimum mass transfer driven by gravitational radiation. Only evolved dwarfs with a C/O composition are consistent with the Roche lobe and gravitational radiation constraints, while He dwarfs require an unlikely low inclination.

Chemical evolution in the environment of intermediate mass young stellar objects

the date of receipt and acceptance should be inserted later Abstract. We have carried out a molecular survey of the Class 0 IM protostar NGC 7129 - FIRS 2 (hereafter FIRS 2) and the Herbig Be star LkH� 234 with the aim of studying the chemical evolution of the envelopes of intermediate-mass (IM) young stellar objects (YSOs). Both objects have similar luminosities (�500 L⊙) and are located in the same molecular cloud which minimizes the chemical differences due to different stellar masses or initial cloud conditions. Moreover, since they are located at the same distance, we have the same spatial resolution in both objects. A total of 17 molecular species (including rarer isotopes) have been observed in both objects and the structure of their envelopes and outflows is determined with unprecedent detail. Our results show that the protostellar envelopes are dispersed and warmed up during the evolution to become a pre-main sequence star. In fact, the envelope mass decreases by a factor >5 from FIRS 2 to LkH� 234, while the kinetic temperature increases from �13 K to 28 K. On the other hand, there is no molecular outflow associated with LkH� 234. The molecular outflow seems to stop before the star becomes visible. These physical changes strongly affect the chemistry of their envelopes. The N2H + and NH3 abundances seem to be quite similar in both objects. However, the H 13 CO + abundance is a factor of �3 lower in the densest part of FIRS 2 than in LkH� 234, very likely because of depletion. In contrast, the SiO abundance is larger by a factor of �100 in FIRS 2 than in LkH� 234. CS presents a complex behavior since its emission arises in different envelope components (outflow, cold envelope, hot core) and could also suffer from depletion. The CH3OH and H2CO column densities are very similar in FIRS 2 and LkH� 234 which implies that the beam averaged abundances are a factor >5 larger in LkH� 234 than in FIRS 2. The same case is found for the PDR tracers CN and HCN which have similar column densities in both objects. Finally, a complex behavior is found for the deuterated compounds. While the DCO + /H 13 CO + ratio decreases by a factor of �4 from FIRS 2 to LkH� 234, the D2CO/H2CO ratios is within a factor 1.5 in both objects. The detection of a warn CH3CN component with Tk>63 K shows the existence of a hot core in FIRS 2. Thus far, only a handful of hot cores have been detected in low and intermediate mass stars. Based on our results in FIRS 2 and LkH� 234, we propose some abundance ratios that can be used as chemical clocks for the envelopes of IM YSOs. The SiO/CS, CN/N2H + , HCN/N2H + , DCO + /HCO + and D2CO/DCO + ratios are good diagnostics of the protostellar evolutionary stage.

Adverse Health Events Associated with Antimicrobial Drug Resistance inCampylobacterSpecies: A Registry‐Based Cohort Study

Resistance to clinically important antimicrobial agents, particularly fluoroquinolones and macrolides, is increasing among Campylobacter isolates, but few studies have explored the human health consequences of such resistance. In a registry-based cohort study, we determined the risk of invasive illness and death associated with infection with quinolone- and erythromycin-resistant Campylobacter strains, while adjusting for comorbidity. We linked data from the Danish Surveillance Registry for Enteric Pathogens with data from the Civil Registration System and National Health Registries. Of 3471 patients with Campylobacter infection, 22 (0.63%) had an adverse event, defined as invasive illness or death, within 90 days of the date of receipt of samples. Patients infected with quinolone-resistant Campylobacter strains had a 6-fold increased risk of an adverse event within 30 days of the date of receipt of samples, compared with patients infected with quinolone- and erythromycin-susceptible Campylobacter strains (adjusted odds ratio [AOR], 6.17 [95% confidence interval {CI}, 1.62-23.47]). However, infection with erythromycin-resistant strains was associated with a >5-fold risk of an adverse event within 90 days of the date of receipt of samples (AOR, 5.51 [95% CI, 1.19-25.50]). The present study provides evidence of the human health consequences of resistance to clinically important agents among Campylobacter infections and the need for increased efforts to mitigate such resistance.

Velocity Spectrum Model for Turbulence Ingestion Noise from Computational-Fluid-Dynamics Calculations

TECHNICALNOTESareshortmanuscriptsdescribingnewdevelopmentsorimportantresultsofapreliminarynature.TheseNotescannotexceedsixmanuscriptpages and three ” gures; a page of text may be substituted for a ” gure and vice versa. After informal review by the editors, they may be published within a fewmonths of the date of receipt. Style requirements are the same as for regular contributions

Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia.

It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or monotherapy for P. aeruginosa bacteremia. We assembled a historical cohort of 115 episodes of P. aeruginosa bacteremia treated with empirical antipseudomonal therapy between 1988 and 1998. On the basis of susceptibility testing of the bacteremic P. aeruginosa isolate, we defined categories of empirical treatment, including adequate combination therapy, adequate monotherapy, and inadequate therapy, as well as corresponding categories of definitive therapy. Neither the adequacy of the empirical treatment nor the use of combination therapy predicted survival until receipt of the antibiogram. However, the risk of death from the date of receipt of the antibiogram to day 30 was higher for both adequate empirical monotherapy (adjusted hazard ratio [aHR], 3.7; 95% confidence interval [CI], 1.0 to 14.1) and inadequate empirical therapy (aHR, 5.0; 95% CI, 1.2 to 20.4) than for adequate empirical combination therapy. Compared to adequate definitive combination therapy, the risk of death at 30 days was also higher with inadequate definitive therapy (aHR, 2.6; 95% CI, 1.1 to 6.7) but not with adequate definitive monotherapy (aHR, 0.70; 95% CI, 0.30 to 1.7). In this retrospective analysis the use of adequate combination antimicrobial therapy as empirical treatment until receipt of the antibiogram was associated with a better rate of survival at 30 days than the use of monotherapy. However, adequate combination antimicrobial therapy given as definitive treatment for P. aeruginosa bacteremia did not improve the rate of survival compared to that from the provision of adequate definitive monotherapy.

Recommendations for Reporting of Extra-Adrenal Paragangliomas

The Association of Directors of Anatomic and Surgical Pathology (ADASP) has proposed recommendations for surgical pathology reporting of malignant tumors. Recommendations for reporting of extra-adrenal paragangliomas are outlined herein. The Association of Directors of Anatomic and Surgical Pathology (ADASP) has requested various committees to propose recommendations for the content and scope of the surgical pathology report for common or uncommon tumors. The following recommendations were developed by an ad hoc committee composed of Ernest E. Lack, MD, (Chair), Ricardo V. Lloyd MD, PhD, J. Aidan Carney, MD, PhD, James M. Woodruff MD, and a group of pathologists with expertise or special interest in paragangliomas. These recommendations are reviewed and approved by the council of the ADASP and then circulated to the entire membership of the ADASP for their input. Thus, an interim consensus on reporting is reached among those with interest and expertise in a particular area or field of pathology; clearly, it is recognized that classification of tumors, diagnostic criteria, and terminology may undergo change in the future.

Location of H2O maser in the double-nuclei system of NGC 6240

the date of receipt and acceptance should be inserted later Abstract. We performed VLA observations of the 22 GHz H2O maser emission in the merging galaxy NGC6240, which hosts the well-known double active nuclei. In a previous paper, we reported on the first solid detection of the H2O maser emission in 2001. After two abortive attempts due to the weakness and probable variability of the emission, the maser was detected with the VLA in June 2002. The emission is unresolved at � 0.3 arcsecond and coincides with the southern 22 GHz continuum peak to � 0.007 arcsecond (� 3 pc: D = 97 Mpc). The detection of the maser in the southern nucleus indicates that nuclear activity of the galaxy, which is significant in X-ray and far-infrared (FIR) bands, lies mainly in the southern nucleus, and the nucleus without a high brightness peak could be explained by thick dust emitting FIR radiation. We favour the idea that the maser in NGC6240 is associated with the AGN-activity.

Save That Dye!

Abstract All laboratory workers face the ongoing requirement that all chemicals and solutions used in the lab be labeled with the date of receipt or preparation, together with the expiration date of the chemical and the initials of the preparer, as well as any known hazards associated with that chemical. Officials from accrediting agencies, sometimes unannounced, pick and poke around laboratories looking for outdated chemicals and solutions, including biological stains left unsuspectingly at the back of a fridge or on a seldom used shelf.

Models of Secondary Vorticity Evolution During Normal Vortex-Cylinder Interaction

TECHNICALNOTESare shortmanuscriptsdescribingnew developmentsor important results of a preliminary nature.TheseNotes cannot exceed sixmanuscript pages and three Ž gures; a page of text may be substituted for a Ž gure and vice versa. After informal review by the editors, they may be published within a few months of the date of receipt. Style requirements are the same as for regular contributions (see inside back cover).

Las revistas españolas de ciencias de la documentación: productos manifiestamente mejorables

After presenting the characteristic features of Spanish library and information science journals, both their information quality as means of communication and the quality of the editorial process is analysed. The characteristic profile of the Spanish LIS journal is that of a young journal, under the auspices of a LIS professional association or university unit, published in Madrid, of long periodicity (annual/biannual), of general scope and audience, and with a consolidated editorial structure although not professionalised which is also medium-sized, recruited locally and preferably of academic affiliation. In general, Spanish LIS journals do not comply with international standards pertaining to scientific publication. Their main deficiencies are: lack of detailed instructions to authors; lack of information on manuscript selection and evaluation processes; missing translations of titles, abstracts and keywords; missing dates of receipt, acceptance and publication of originals. The editorial process presents important gaps insofar as publication dates are disregarded, author instructions are not followed, the system for manuscript revision and evaluation is not rigorous in the least, a system for the control, auditing and selfevaluation of journals is not in place and the management of the editorial process is very little professionalised. To conclude, a number of specific measures for improvement are offered.

NCI-Funded Small Animal Imaging Programs

The use of small animal models as surrogates for humans in the study of normal and disease states has a long history. The models used have ranged from the simplest possible to those as complex as the investigator’s imagination and skills allow. Growing opportunities to apply methods of molecular and cellular biology to the study and treatment of human disease have increased demand for the creation of animal models with more humanlike diseases. Cultures of cancer cells growing in vitro, or as tumors on the flank of a small animal, no longer suffice because treatment agents and techniques that enjoy even great success in such milieus too frequently prove to be utter failures in phase I testing in humans. These failures propel investigators to understand disease, and its progression and treatment, by better means than observations of less-faithful models, such as a growing cell line. They see more fruitful approaches in molecular and cellular manipulations of animals to model the whole disease process more faithfully. Successful creations of live, whole animals that more faithfully model human diseases led to an obvious desire for a way to image disease progression in each animal, without resort to biopsy or sacrifice to answer every question. Most early animal imaging studies used instruments and techniques designed for human use, during hours when this equipment was not in clinical use. However, systems optimized for human use frequently yield suboptimal results for small animal studies. In addition, there are other problems associated with mixing animal and patient studies on clinical instruments. The growing need for dedicated small animal imaging systems was noticed by the Biomedical Imaging Program of the National Cancer Institute (NCI) and was included among other issues explored in series of workshops held to better define the needs for cancer imaging and areas in which special NCI initiatives might provide the most impetus for change and advancement. One subgroup addressing small animal imaging—the In vivo Molecular/Functional Imaging Subgroup (MIS), chaired by Elias Zerhouni, MD—recommended that the National Institutes of Health (NIH) and NCI should support dedicated small animal imaging facilities focusing on the study of genetically engineered tumor models (http://cancer.gov/bip/ISWG3.htm). They also recommended that the greater part of the efforts of the facilities be directed toward imaging, not the creation of new instruments. Workshop participants concluded that the facilities should provide imaging by more than one technique because they did not like the prospect of limiting the range of scientific questions open to investigation by having only one modality at hand. With this workshop recommendation in mind, the Biomedical Imaging Program developed a concept for Small Animal Imaging Resource Project (SAIRP) grants, which the May 1998 NCI Board of Scientific Advisors approved enthusiastically. The concept was for the Biomedical Imaging Program to budget support for approximately four SAIRPs under the R24 mechanism, which specifies the development of research resource centers. Each grantee would be expected to provide access to at least two different imaging modalities and serve at least six funded cancer research projects by the end of the 2nd year of operation. The Biomedical Imaging Program translated the concept into a request for applications, set a receipt date of November 1998, and defined the objectives and scope as follows: (a) multiple imaging technologies for small animals, emphasizing, but not limited to those technologies that can provide biochemical, genetic or Acad Radiol 2001; 8:372–374

Estado actual de la ventilación mecánica domiciliaria en España: resultados de una encuesta de ámbito nacional

Home mechanical ventilation (HMV) is used to treat chronic respiratory insufficiency in patients who are clinically stable and require partial or total support ventilation. To determine how HMV is being used in Spain, we mailed a questionnaire to the respiratory medicine departments of all hospitals in the public health system. The closing date for receipt of responses was April 1999. Forty-three hospitals in 14 autonomous communities of Spain responded. At the time of the survey, 1,821 patients were using HMV, which had been introduced in 1987. Volumetric respirations were being used by 856 patients and various models for delivering support pressure were being used by 965. Nasal masks connected to respirators were being used by 90%, while 6% were ventilated through a tracheotomy, 2% through face masks and fewer than 1% trough mouth devices. In conclusion, HMV has been widely applied in Spain and non invasive ventilation is usually provided through a face mask. HMV is prescribed for the usual reasons (chest and neuromuscular diseases) and for such conditions as hypoventilation due to obesity and chronic obstructive pulmonary disease.

Control of Noise from Civil Aircraft – New Proposals for Discussion

The UK has issued a Consultation Paper' seeking views on Introduction and enforcement of noise reduction schemes at aerodromes Dispute resolution between local authorities and aerodromes Changes in environmental regulations at Heathrow, Gatwick and Stanstead. The final date for receipt of comments is Friday October 13th 2000.