This study investigates developments in involved fatherhood in Hungary. Drawing on the concepts of involved fatherhood and caring masculinities and recent findings on Hungarian caring fathering practices, the analysis employs multinomial logistic regression to examine Hungarian register data from 2011 and 2022. The dependent variable distinguishes between three categories: GYES (childcare allowance paid at a fixed rate), GYED Extra (childcare benefit combined with employment), and GYED Home (childcare benefit without a work commitment). Independent variables include educational attainment, marital status, regional context, employment type, and household status. A key contribution of this study was the emergence of a new group: fathers who interrupt their paid employment to care for their child, demonstrating the pluralisation of paternal roles. The sample shows that the norms of caring fatherhood have differentiated: In addition to the classical role of head of the family, there is more space for forms of care independent of work. The analysis revealed that this form of care has been spreading in Hungarian society independently of other contextual variables (region and educational attainment). These results underscore the interaction between institutional policies and evolving norms, highlighting the diversification of fatherhood models in contemporary Hungarian society.

Mortality trends and disparities associated with aortic aneurysm and aortic dissection in the United States from 1999 to 2023: a CDC WONDER database analysis.

Outcomes and Practice Patterns of Long-Acting Injectable Versus Oral Antipsychotics Among Patients With Bipolar I Disorder in the United States: A Hospital Database Analysis.

Inhibiting Arachidonate-5-lipoxygenase expression ameliorates osteoarthritis progression by suppressing ferroptosis via the JAK2/STAT3 signaling pathway.

Healthcare resource utilization in adults with focal onset seizures before and after initiating cenobamate: A US database analysis.

P0042 Real-world access to genotype-matched therapy through comprehensive cancer genomic profiling test in patients with metastatic prostate cancer: Analysis of the nationwide genomic database in Japan

Textbook Outcomes After Esophagectomy with Gastric Conduit for Cancer: A 2016-2021 National Surgical Quality Improvement Program Analysis.

Impact of ban and ordinances against indoor smoking on the proportion of smoke-free establishments in restaurants, izakaya, and bars in Japan: Interrupted time-series analysis of restaurant database.

Water pollution remains a critical public health and development challenge in Sierra Leone, driven by inadequate sanitation, agricultural runoff, weak solid waste management, and limited governmental capacity. Community participation models including WASH Committees, Community-Led Total Sanitation (CLTS), Community-Based Monitoring (CBM), and low-cost water treatment initiatives have become essential tools for enhancing water safety and promoting sustainable water management. This study examines the mechanisms through which community participation improves water quality outcomes, using evidence from Bombali District and supplementary national data. This paper employs mixed method approaches and data was collected through questionnaire surveys, and analysis of water pollution reports, NGO databases, and government records. Results show that community participation enhances water quality through five main pathways: (1) improved governance and accountability; (2) strengthened operation and maintenance of water systems; (3) behavior change in sanitation and hygiene practices; (4) increased environmental protection of water sources; and (5) enhanced monitoring and rapid response to contamination. Results show active community participation significantly reduces fecal contamination (by ~60-70% in intervention areas), increases protected water points (from 18% to 94%), and decreases childhood diarrhea (from 31% to 11%). Local accountability, user fees, and community monitoring drive success. Barriers are poverty, flooding, and weak institutions. Policy recommendations scale community water governance.

P0447 The prevalence of BRCA1 and BRCA2 gene deleterious alterations in advanced prostate cancer: Analysis of the nationwide cancer genomic database in Japan

Study design: A retrospective cohort study. Objective: To evaluate the association between preoperative use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and postoperative outcomes following thoracic and/or lumbar fusion for spinal deformity, stratified by body mass index (BMI). Summary of background data: Thoracic and lumbar fusion surgeries are increasingly performed to treat spinal deformities, particularly among older and obese populations. GLP-1 RAs, originally developed for diabetes management, are now commonly prescribed for weight loss across a wide BMI range. Although these agents have shown systemic metabolic and anti-inflammatory benefits, their effects on spine surgery outcomes remain poorly characterized. Methods: A retrospective analysis of a national claims database (2010–2023) was conducted. Patients undergoing thoracic and/or lumbar fusion for spinal deformity were identified and stratified into six BMI categories. GLP-1 RA users were identified through preoperative pharmacy claims and matched 1:4 to nonusers based on age, sex, and Charlson Comorbidity Index. Primary endpoints included 90-day medical complications and 2-year and 10-year surgical outcomes. Cox proportional hazards models were used to assess long-term risks, with Bonferroni correction applied for multiple comparisons. Results: Of 214,922 patients, 14,047 GLP-1 RA users were matched to 56,056 controls. GLP-1 RA use was associated with significantly lower rates of 90-day complications—including infections, pneumonia, venous thromboembolism, and sepsis—in patients with BMI ≥25. No significant differences were observed in 2-year or 10-year rates of revision for infection, pseudoarthrosis, or mechanical failure. However, GLP-1 RA users exhibited a consistently increased risk of decompressive laminectomy at both 2 and 10 years across all BMI categories. Conclusion: Preoperative use of GLP-1 RAs is associated with improved short-term postoperative outcomes following thoracic and/or lumbar fusion, particularly in overweight and obese patients. The observed increase in long-term rates of decompressive laminectomy warrants further investigation to elucidate potential skeletal effects and underlying mechanisms. Level of Evidence: Level III.

Chronic low-grade inflammation contributes to aging, metabolic dysfunction, and age-related diseases. High-sensitivity C-reactive protein (HsCRP) is widely used but limited by short-term variability. DNA methylation-based CRPMort derived from GrimAge2 may provide a more stable measure of chronic inflammatory burden, yet its predictive value for mortality and association with lipid metabolism remain unclear. Associations of CRPMort and HsCRP with all-cause and cardiovascular mortality and lipid traits were evaluated using weighted cox regression and linear regression, Kaplan-Meier curves, restricted cubic splines (RCS), and time-dependent receiver operating characteristic curve (timeROC) analyses within the NHANES database, with subgroup, mediation, sensitivity, and Mendelian randomization analyses. Higher CRPMort was significantly associated with all-cause mortality (hazard ratio [95% confidence interval]: 1.65 [1.10, 2.46], p = 0.015) and showed near-significant positive associations with triglycerides (p = 0.051) and residual cholesterol (p = 0.056). RCS analyses demonstrated a linear positive relationship between CRPMort and both all-cause mortality and lipid traits, including triglycerides and residual cholesterol. HsCRP showed no significant associations with mortality or lipid traits (all p > 0.05). TimeROC curves revealed that compared to HsCRP, CRPMort had more superior long-term predictive performance and partially mediated the effect of chronological age on all-cause mortality. Importantly, concurrent elevations of CRPMort and HsCRP were associated with the highest risks of all-cause mortality and dyslipidemia. GrimAge2-derived CRPMort is a robust predictor of long-term all-cause mortality and may capture chronic inflammation linked to triglyceride-rich lipoproteins beyond HsCRP. Combined assessment of both inflammatory markers may enhance risk stratification and inform aging-related cardiometabolic research.

TCN1 knockdown inhibits the progression and glycolysis of non-small cell lung cancer via regulating B3GNT3.

P0872 Time to treatment initiation and survival in patients with muscle-invasive bladder cancer: A national cancer database (NCDB) analysis

Interstitial lung disease (ILD) is a diverse group of pulmonary disorders characterized by inflammation and fibrosis of the lung parenchyma. Previous studies have linked acute exacerbation (AEx) events in patients with idiopathic pulmonary fibrosis to frequent hospitalizations, increased health care resource utilization (HCRU), and high mortality. However, limited information exists regarding the impact of AEx in other forms of fibrosing ILD. To assess HCRU and the associated costs of managing AEx in patients within a large population of patients with fibrosing ILD. This retrospective cohort study used a large US claims database to identify adults (aged ≥18years) with fibrosing ILD who experienced at least 1 AEx event between January 2017 and September 2022. AEx events were identified using an algorithm based on clinical guidelines, symptoms, imaging, and prescriptions. Using propensity score matching, patients with AEx were matched to those without AEx. Baseline data were evaluated for 12 months before the date of first AEx or assigned proxy equivalent (index date), with follow-up until death, loss to follow-up, or study conclusion. Outcomes included health care costs, inpatient stay frequency and length, emergency department and outpatient visits, and prescriptions. Two-part regression models compared health care utilization and costs during follow-up. A total of 8,929 patients were identified as having at least 1 qualifying AEx event. After matching for clinical and demographic characteristics, 8,104 were retained in both the AEx and comparator cohorts (average age, 63years; average Charlson Comorbidity Index, 8.18-8.33). An evaluation of postmatch baseline characteristics indicated cohorts to be well-balanced. Patients were followed for a mean of 616 days in the AEx group and 648 days in the comparator group. Regression analysis found all-cause inpatient HCRU to be 53% (risk ratio [95% CI] = 1.53 [1.45-1.62]) and outpatient HCRU to be 13% (risk ratio 1.13 [1.09-1.17]) higher for AEx cohort patients. For ILD-related utilization, the inpatient and outpatient rates were 98% and 63% higher, respectively, in the AEx cohort. Total per-patient per-month health care costs were $17,549 for AEx and $11,715 for comparator cohorts (P < 0.001). Per-patient per-month outpatient pharmacy costs were not significantly different between the cohorts ($1,327 vs $1, 302). This study found that patients with ILD experiencing AEx events incur significantly greater health care utilization and total costs than matched patients without AEx events. This study fills a key gap in understanding the broader health care burden of AEx beyond idiopathic pulmonary fibrosis.

Exploring the characteristics of the SKP2-CDK6 axis in pancreatic cancer cell metastasis and its clinical significance.

Comparative evaluation of 18S rDNA V4 and 28S rDNA D1-2 regions for resolving Alexandrium species diversity to improve its use for metabarcoding.

Epidemiology of interstitial lung diseases in Japan: A nationwide database analysis.

A0860 Metastatic profile and survival outcomes of metastatic non-muscle invasive bladder cancer in comparison with metastatic muscle invasive bladder cancer: A national cancer database analysis

RhoA deletion in macrophages/microglia aggravates blood-brain barrier disruption after ischemic stroke reperfusion injury by promoting endothelial cell apoptosis and pyroptosis.