Zebrafish Research Articles

Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio).

Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio).

Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio).

Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio).

Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio).

Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio).

Enhancement of cognitive benefits and anxiolytic effects of scoparone (6,7-dimethoxycoumarin) in a zebrafish (Danio rerio) model of scopolamine-induced anxiety and memory impairment

Enhancement of cognitive benefits and anxiolytic effects of scoparone (6,7-dimethoxycoumarin) in a zebrafish (Danio rerio) model of scopolamine-induced anxiety and memory impairment

Zebrafish as a model for assessing biocide toxicity: A comprehensive review.

Zebrafish as a model for assessing biocide toxicity: A comprehensive review.

Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.

Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.

The effect and mechanisms of nano cerium dioxide (Nano-CeO2) on cardiovascular development in zebrafish (Danio rerio).

The effect and mechanisms of nano cerium dioxide (Nano-CeO2) on cardiovascular development in zebrafish (Danio rerio).

Chronic dimethomorph exposure induced behaviors abnormalities and cognitive performance alterations in adult zebrafish (Danio rerio).

Chronic dimethomorph exposure induced behaviors abnormalities and cognitive performance alterations in adult zebrafish (Danio rerio).

Transcriptome analysis of Berberine induced accelerated tail fin regeneration in Zebrafish larvae.

Transcriptome analysis of Berberine induced accelerated tail fin regeneration in Zebrafish larvae.

Effects of nano- and micro- fibers derived from surgical face masks in Danio rerio.

Effects of nano- and micro- fibers derived from surgical face masks in Danio rerio.

Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure.

Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure.

The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway.

The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway.

Autophagy and Endoplasmic Reticulum Stress-Related Protein Homeostasis Links Palmitic Acid to Hepatic Lipotoxicity in Zebrafish (Danio rerio), Counteracted by Linoleic Acid.

Autophagy and Endoplasmic Reticulum Stress-Related Protein Homeostasis Links Palmitic Acid to Hepatic Lipotoxicity in Zebrafish (Danio rerio), Counteracted by Linoleic Acid.

Toxicological screening of jambolan hydroalcoholic extract (Syzygium cumini (L.) Skeels) in zebrafish (Danio rerio).

Toxicological screening of jambolan hydroalcoholic extract (Syzygium cumini (L.) Skeels) in zebrafish (Danio rerio).

Further negative effect of fibrous microplastics to the bioaccumulation and toxicity of decabromodiphenyl ethane on zebrafish.

Further negative effect of fibrous microplastics to the bioaccumulation and toxicity of decabromodiphenyl ethane on zebrafish.

The developmental toxicity of bisphenol F exposure on the zebrafish larvae.

The developmental toxicity of bisphenol F exposure on the zebrafish larvae.

Polystyrene microplastics and cypermethrin exposure interfered the complexity of antibiotic resistance genes and induced metabolic dysfunction in the gut of adult zebrafish.

Polystyrene microplastics and cypermethrin exposure interfered the complexity of antibiotic resistance genes and induced metabolic dysfunction in the gut of adult zebrafish.

In-vitro sensing of traumatic brain tissue by electrochemical impedance for diagnosis and therapeutic

In-vitro sensing of traumatic brain tissue by electrochemical impedance for diagnosis and therapeutic

Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide.

Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide.

Assessing cisplatin-induced acute toxicity in zebrafish (Danio rerio): a multi-organ perspective at realistic concentrations.

Cisplatin, a widely used platinum-based chemotherapeutic agent, has been detected in hospital effluents and wastewater treatment plant discharges, raising concerns about its potential ecological impact, particularly on aquatic organisms. Despite its significant presence in environmental matrices, limited studies have investigated the effects of cisplatin at concentrations within the lower range of those reported in wastewater treatment plant effluents (< 150μg/L) on fish health. This study aimed to assess the impact of cisplatin (2, 5, 10μg/L) on zebrafish (Danio rerio) by evaluating oxidative stress responses and gene expression alterations in critical organs, including the liver, brain, gut, and gills. Results indicated distinct tissue-specific oxidative stress responses, with high negative correlations between antioxidant enzymes (SOD and CAT) and oxidative biomarkers in the gut and gills. Gene expression analysis, on the other hand, revealed marked upregulation of apoptotic markers (bax, p53, casp3) and stress-related genes (nrf1, nrf2) across all tissues, indicating a robust apoptotic response at low concentrations. Moreover, the expression of mapk8, prkaa2, ddit3, and stim1a was significantly elevated in all organs, reflecting the activation of multiple pathways, including DNA damage, mitochondrial dysfunction, endoplasmic reticulum stress, and calcium dysregulation. The study concludes that cisplatin exposure adversely affects zebrafish health, emphasizing the urgency of assessing the environmental implications of this widely used chemotherapeutic agent.