Cutaneous Miliary Tuberculosis Research Articles

Unusual cutaneous miliary tuberculosis manifesting as periorbital necrotizing fasciitis: Pitfalls and pearls

Unusual cutaneous miliary tuberculosis manifesting as periorbital necrotizing fasciitis: Pitfalls and pearls

Cutaneous miliary tuberculosis in a chronic kidney disease patient

Cutaneous miliary tuberculosis in a chronic kidney disease patient

Immune Reconstitution Inflammatory Syndrome Presenting as Cutaneous Miliary Tuberculosis in an HIV-Infected Patient

피부의 좁쌀결핵은 면역저하 상태에서 발생하는 결핵의 드문 감염형태로, 구진 농포성 발진과 피부를 포함한 여러 장기로의 결핵균의 혈행성 다장기 감염을 특징으로 한다. 저자들은 ART를 시작한 HIV 감염 환자에서 피부의 좁쌀결핵으로 발현한 IRIS 첫 예를 경험하여 이를 보고하는 바이다.

Cutaneous miliary resistant tuberculosis in a patient infected with human immunodeficiency virus: case report and literature review

We report the case of a patient infected with human immunodeficiency virus who presented with fever and a disseminated papulous eruption, diagnosed as cutaneous miliary tuberculosis. The diagnosis was made by histological examination of a skin biopsy, which showed numerous acid-fast bacilli. A culture grown from a skin biopsy isolated a resistant Mycobacterium tuberculosis strain. The papules disappeared within a few days after starting treatment with pyrazinamide, isoniazid and moxifloxacin.

Cutaneous miliary tuberculosis in two patients with hiv infection

Cutaneous manifestations of miliary tuberculosis are rare. We report two patients with previously unknown advanced human immunodeficiency virus (HIV) infection, who presented with respiratory collapse and an erythematous papulopustular skin eruption. Skin biopsies demonstrated focal dermal microabscess in one patient, and a subcorneal vesicle with an underlying dermal microabscess in the other. Despite the lack of granulomatous inflammation, acid-fast bacilli (AFB) and Fite stains demonstrated numerous acid-fast bacilli, and Mycobacterium tuberculosis was subsequently isolated in either skin and/or sputum cultures. Pulmonary involvement was present in both cases, but was sufficiently diffuse and atypical so as not to be specific for tuberculosis upon initial clinical and radiographic examination. Our two cases illustrate the importance of careful skin examination in patients with HIV infection, since cutaneous dissemination can be an easily overlooked sign of miliary tuberculosis.

Cutaneous tuberculosis: A clinical, histopathologic, and bacteriologic study

Background: In recent years cutaneous infections with Mycobacterium tuberculosis with an atypical clinical appearance have become more common because of the increasing number of immunocompromised patients. Objective: We report the clinical, histopathologic, and bacteriologic data of 11 patients with several forms of cutaneous tuberculosis seen during the past 14 years. Methods: Patients from whom M tuberculosis was isolated from culture of skin biopsy specimens, sinus drainage, or material aspirated from cutaneous abscesses were included. In all but two patients a biopsy specimen was obtained for histopathologic study. All but one patient received combined antituberculous therapy. Results: The clinical diagnoses were scrofuloderma (four cases), cutaneous miliary tuberculosis (two), lupus vulgaris (two), tuberculous gumma (two), and one unclassified. All but three patients had evidence of either previous or simultaneous tuberculous foci other than in the skin. Histopathologic findings varied according to the type of cutaneous tuberculosis. Conclusion: In some patients with cutaneous tuberculosis, lesions are atypical in appearance because of immunodeficiency. Culture for M. tuberculosis should be performed in all suspected cases, even in those in whom special stains for acid-fast bacilli are negative.

In vitro and in vivo cellular immunity in anergic miliary tuberculosis.

A patient with cutaneous anergy and miliary tuberculosis was studied with serial determinations in vivo of skin test responsiveness to natural antigens and to vesicant doses of dinitrochlorbenzene, and in vitro with buffy coat migration inhibition, indirect migration inhibition factor production, and lymphocyte transformation during the acute phase of the disease and during convalescence. During the anergic phase, the patient maintained good lymphocyte transformation to phytohemagglutinin and purified protein derivative of tuberculin and showed strong buffy coat migration inhibition that was partially dependent on autologous serum but not complement; however, indirect migration inhibition factor production to purified protein derivative was not demonstrable. the results suggest that the defect in anergic tuberculosis resides at least partially in the nonimmunologic inflammatory response and that lymphocyte function is at least partially intact.

Uncommon skin reactions after BCG vaccination

Background: In recent years cutaneous infections with Mycobacterium tuberculosis with an atypical clinical appearance have become more common because of the increasing number of immunocompromised patients.Objective: We report the clinical, histopathologic, and bacteriologic data of 11 patients with several forms of cutaneous tuberculosis seen during the past 14 years.Methods: Patients from whom M tuberculosis was isolated from culture of skin biopsy specimens, sinus drainage, or material aspirated from cutaneous abscesses were included. In all but two patients a biopsy specimen was obtained for histopathologic study. All but one patient received combined antituberculous therapy.Results: The clinical diagnoses were scrofuloderma (four cases), cutaneous miliary tuberculosis (two), lupus vulgaris (two), tuberculous gumma (two), and one unclassified. All but three patients had evidence of either previous or simultaneous tuberculous foci other than in the skin. Histopathologic findings varied according to the type of cutaneous tuberculosis.Conclusion: In some patients with cutaneous tuberculosis, lesions are atypical in appearance because of immunodeficiency. Culture for M. tuberculosis should be performed in all suspected cases, even in those in whom special stains for acid-fast bacilli are negative.