Current State Of Research Research Articles

Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

A Review of Structural Damage Identification Research

Conducting damage identification and detection of engineering structures can help to identify the location of structural damage and assess the extent of the damage, providing a basis for the reinforcement and repair of the structures. This ensures the normal operation of engineering structures and, in turn, protects people's lives and property. Therefore, the research on structural damage identification methods has always been an important research topic in the field of civil engineering. The existing damage identification methods can be roughly classified into the following categories: damage identification based on structural dynamic response, structural damage identification based on model updating techniques, and structural damage identification based on artificial intelligence methods. This paper reviews the development history of existing methods, expounds on several common damage identification methods and their advantages and disadvantages, and makes a prospect for the development of structural damage identification methods according to the current research status at home and abroad. It can provide a reference for the research and application of damage identification methods.

Research on the current research status and future development trend of extreme ultraviolet

Extreme Ultraviolet (EUV) lithography is pivotal in semiconductor manufacturing and attosecond metrology. This paper delves into the current research status and future development trends of EUV, aiming to offer a comprehensive understanding and predictions for this technologys evolution. Considering the challenges in applying EUV in chip manufacture, we will discuss advanced methods such as metalenses, phase-shifting masks, EUV transient grating spectroscopy, and negative tone development (NTD) processes to address issues in photolithography. Additionally, this article employs a methodical literature review and analysis. Presently, EUV lithography machines with a numerical aperture (NA) of 0.33 have achieved mass production of 5nm logic chips. Nevertheless, generating a more stable EUV light source and enhancing the focusing ability and power of the light source remain critical challenges requiring resolution.

Global trends of laser bone ablation: bibliometric analysis of publications from 1979 to 2023

ObjectivesThe objective of the bibliometric analysis was to quantify and identify the current status and trends of laser bone ablation research from 1979 to 2023.Materials and methodsThe Web of Science (WOS) core collection database was used to search for articles on laser bone ablation published from 1979 to 2023. The collected data were then imported into Microsoft Excel, VOSviewer, and CiteSpace for detailed analysis and visualization.ResultsA total of 383 articles were included for analysis. The United States made the most significant contributions to the field in terms of both quantity and quality. Moreover, Cattin, Philippe C emerged as the author with the highest number of publications, while the University of Basel stood out as the institution with the greatest publication output. Lasers in Surgery and Medicine emerged as not only the journal with the most publications but also held considerable influence within its domain. Prominent keywords that surfaced frequently included “ablation,” “er:yag laser,” and “bone.”ConclusionThe annual number of publications in the field of laser bone ablation is showing an overall upward trend. Research on laser bone ablation primarily focuses on investigating the parameters of this technique, as well as its application in treating bone tumors, performing laser stapes surgery, and various applications of laser bone ablation. The laser osteotomy, laser ablation of bone tumors, animal experiments, and the interaction with biological tissues during laser bone ablation are expected to be the focal areas and future directions in this field.

The Contribution of Human Antimicrobial Peptides to Fungi

Various species of fungi can be detected in the environment and within the human body, many of which may become pathogenic under specific conditions, leading to various forms of fungal infections. Antimicrobial peptides (AMPs) are evolutionarily ancient components of the immune response that are quickly induced in response to infections with many pathogens in almost all tissues. There is a wide range of AMP classes in humans, many of which exhibit broad-spectrum antimicrobial function. This review provides a comprehensive overview of the mechanisms of action of AMPs, their distribution in the human body, and their antifungal activity against a range of both common and rare clinical fungal pathogens. It also discusses the current research status of promising novel antifungal strategies, highlighting the challenges that must be overcome in the development of these therapies. The hope is that antimicrobial peptides, as a class of antimicrobial agents, will soon progress through large-scale clinical trials and be implemented in clinical practice, offering new treatment options for patients suffering from infections.

Research trends and highlights in PD-1/PD-L1 inhibitor immunotherapy in lung cancer: a bibliometric analysis

BackgroundLung cancer is one of the most common malignant tumors worldwide. This article aims to review the current research status and trends in PD-1/PD-L1 inhibitor immunotherapy.MethodOn the basis of the Web of Science Core Collection database, literature on PD-1/PD-L1 inhibitor immunotherapy in lung cancer patients was searched and analyzed for all years up to August 5, 2023. Bibliometric techniques were employed, including CiteSpace (6.1.R6), VOSviewer, and the Bibliometrix package in R, to examine publication counts, countries, institutions, authors, journals, cited literature, keywords, and research trends.ResultsA total of 1,252 documents were included following the screening process. The analysis revealed that China had the highest number of publications (512), whereas the institution with the most publications was the UDICE French Association of Research Universities Union (193). The journal with the most articles was the Journal for Immunotherapy of Cancer (48), and the most prolific author was Zhou Caixun from Tongji University in China (20). Co-citation analysis revealed that Borghaei H’s 2015 article in the New England Journal of Medicine had the highest citation frequency. The clustering results indicated that the most frequently referenced keywords included predictors, treatment monitoring, and hyperprogressive diseases. There is a growing trend toward combination therapies, such as dual immune checkpoint inhibitors, and research into molecular mechanisms within the tumor microenvironment, aimed at enhancing the efficacy of immunotherapy and reducing adverse effects.ConclusionBibliometric analysis indicates that PD-1/PD-L1 inhibitors are pivotal in lung cancer immunotherapy. Research in this domain focuses on identifying biomarkers within the tumor microenvironment, addressing immune evasion and resistance to maximize efficacy, and mitigating adverse effects.

Formation Mechanism and Response Strategies for Urban Waterlogging: A Comprehensive Review

With the intensification of climate change and the continuous advancement of urbanization, the pressure on urban drainage systems has increased, leading to the growing prominence of urban waterlogging issues. Besides the destruction of infrastructure, urban waterlogging also affects environmental quality, economy, and residents’ daily lives. Researchers have recently analyzed the causes of urban waterlogging from multiple perspectives, including land-use changes driven by urbanization, the inadequacy of urban drainage systems, and extreme rainfall events resulting from climate change. Various strategies have been proposed to address waterlogging, including optimizing urban green spaces, establishing forecasting systems, and creating effective emergency management systems. Additionally, some scholars highlight the significance of integrated urban planning and interdepartmental collaboration, suggesting that multi-party cooperation can help mitigate the risks of waterlogging. This paper conducts a comprehensive literature review to summarize the current research status of urban waterlogging, focusing on theoretical, experimental, numerical simulation, and artificial intelligence approaches. The review aims to provide a clearer understanding of the existing knowledge, identify gaps for future research and propose ideas that combine advanced technologies and interdisciplinary approaches.

Current status and future agenda of citizen journalism research: a computational analysis

Purpose This paper aims to provide a comprehensive overview of the current status and future research agenda of citizen journalism through a computational analysis lens. It explores how technological advancements and evolving media consumption patterns have shaped the rise of citizen journalism, democratizing news production via social media and digital technologies and impacting traditional journalism and societal discourse. Design/methodology/approach A bibliometric analysis was conducted on 1,325 peer-reviewed articles related to citizen journalism sourced from the Dimensions.ai database. The study used the Biblioshiny app of the bibliometrix software and VOSviewer for network visualization. The analysis examined publication trends, citation patterns, major contributors, influential journals and main research directions to map the intellectual landscape of citizen journalism research. Findings The analysis revealed significant growth in citizen journalism publications starting from 2004, with peak years in 2021–2023. Key researchers and journals were identified, highlighting both sustained and emerging contributions. Co-occurrence of keywords indicated a focus on qualitative methods and the credibility of citizen journalism. International collaboration varied, with robust intra-country publications in the USA and high intercountry collaboration rates in Austria and Australia. European and North American universities, particularly the University of Seville and the University of Vienna, were noted for their significant contributions. Originality/value To the best of the author’s knowledge, this study is one of the first to apply comprehensive bibliometric techniques to the field of citizen journalism, offering a quantitative assessment of global research trends.

NeuroIS: A Systematic Review of NeuroIS Through Bibliometric Analysis

This study aims to provide a comprehensive knowledge mapping and extensive analysis of NeuroIS research, elucidating global trends and directions within this field from January 2007 to January 2024. A visual analysis of 256 research articles sourced from the Scopus database is conducted. The knowledge mapping, utilizing CiteSpace (CiteSpace 3.6 R1) and VOSviewer (VOSviewer 1.6.19), illustrates the current research landscape, encompassing collaboration networks, co-citation networks, references exhibiting citation bursts, and keyword analysis. The findings highlight the United States and Germany as leading nations in the exploration of NeuroIS, with the Karlsruher Institut für Technologie in Germany identified as a prominent institution in this domain. René Riedl, Pierre-Majorique Léger, Marc T. P. Adam, and Christof Weinhardt emerge as the most prolific authors in the field. Noteworthy themes that have garnered attention in recent years include customer experience, information systems, and information processing. Document analysis reveals that the study by Dimoka et al. in 2012 is the most cited work, providing a comprehensive overview of global NeuroIS research. Analysis of the document co-citation network identifies electroencephalography (EEG) in the context of technostress, the social impact of information in security alerts, and user experience in human–computer interaction as key areas of focus. René Riedl is recognized as the most cited researcher, while MIS Quarterly is distinguished as the leading journal in this field. Twelve NeuroIS papers exhibit high citation counts, with significant activity noted in 2021 and 2022. The timeline delineates the evolution of topics such as neuroscience, fMRI, cognitive neuroscience, social media, trust, eye tracking, and human–computer interaction. This study pioneers the examination of the current research status of NeuroIS through bibliometric analysis and the latest available data. It advocates for enhanced collaborations among scholars and institutions to improve information systems management and foster the development of NeuroIS. The study underscores the importance of ongoing research and cooperation in NeuroIS to deepen our understanding of how neuroscience can inform information systems design and management, thereby enhancing human–technology interaction. By identifying key trends, influential authors, and prominent themes, this analysis lays the groundwork for further exploration and innovation in this interdisciplinary domain. As technology continues to advance and our reliance on information systems intensifies, the insights derived from NeuroIS research can provide valuable perspectives on enhancing user experiences, optimizing information processing, and applying neuroscientific principles to develop more effective IT artifacts. Through sustained collaboration and knowledge sharing, the NeuroIS community can drive progress and shape the future of information systems management in an increasingly dynamic digital landscape.

Research and Demonstration of Operation Optimization Method of Zero-Carbon Building’s Compound Energy System Based on Day-Ahead Planning and Intraday Rolling Optimization Algorithm

The compound energy system is an important component of zero-carbon buildings. Due to the complex form of the system and the difficult-to-capture characteristics of thermo-electric coupling interactions, the operation control of the zero-carbon building’s energy system is difficult in practical engineering. Therefore, it is necessary to carry out relevant optimization methods. This paper investigated the current research status of the control and scheduling of compound energy systems in zero-carbon buildings at home and abroad, selected a typical zero-carbon building as the research object, analyzed its energy system’s operational data, and proposed an operation scheduling algorithm based on day-ahead flexible programming and intraday rolling optimization. The multi-energy flow control algorithm model was developed to optimize the operation strategy of heat pump, photovoltaic, and energy storage systems. Then, the paper applied the algorithm model to a typical zero-carbon building project, and verified the actual effect of the method through the actual operational data. After applying the method in this paper, the self-absorption rate of photovoltaic power generation in the building increased by 7.13%. The research results provide a theoretical model and data support for the operation control of the zero-carbon building’s compound energy system, and could promote the market application of the compound energy system.

Research Progress on the Surface Modification of Basalt Fibers and Composites: A Review

Fiber-reinforced resin composites (FRRCs) are widely used in several fields such as construction, automotive, aerospace, and power. Basalt fiber (BF) has been increasingly used to replace artificial fibers such as glass fiber and carbon fiber in the production of BF-reinforced resin matrix composites (BFRRCs). This preference stems from its superior properties, including high temperature resistance, chemical stability, ease of manufacturing, cost-effectiveness, non-toxicity, and its natural, environmentally friendly characteristics. However, the chemical inertness of BF endows it with poor compatibility, adhesion, and dispersion in a resin matrix, leading to poor adhesion and a weak BF–resin interface. The interfacial bonding strength between BF and resin is an important parameter that determines the service performance of BFRRC. Therefore, the interfacial bonding strength between them can be improved through fiber modification, resin–matrix modification, mixed enhancers, etc., which consequently upgrade the mechanical properties, thermodynamic properties, and durability of BFRRC. In this review, first, the production process and properties of BFs are presented. Second, the mechanical properties, thermodynamic properties, and durability of BFRRC are introduced. Third, the modification effect of the non-destructive surface-modification technology of BF on BFRRC is presented herein. Finally, based on the current research status, the future research direction of BFRRC is proposed, including the development of high-performance composite materials, green manufacturing processes, and intelligent applications.

A bibliometric analysis of current research, development status, and future development trends of soy and whey proteins

ObjectiveThis study aimed to analyse the current status and development of research on soy and whey proteins during the period 2004–2024 using bibliometric methods in order to reveal the research hotspots and development trends in this field.MethodsThe study used CiteSpace and VOSviewer software to visualise and analyse 1,888 articles in the core database of Web of Science, including collaboration mapping, co-occurrence mapping, and co-citation mapping, in order to detect the development of disciplinary knowledge areas, research hotspots, frontiers, and trends.ResultsThe study found an overall fluctuating increase in the publication of relevant literature, especially a significant increase between 2016 and 2023. China has the most prominent research contribution in this field and maintains close collaboration with several countries. Keyword analysis revealed that research hotspots include antioxidant properties, sodium caseinate, pH effects, and colorectal cancer, and that research is gradually changing from process physicochemical properties to nutritional health. However, there were some limitations in this study, such as the narrow subject matter of the dataset, some high-quality literature may not be valued due to low citation rates, and there was a delay in updating the database, which affected the timeliness of the analysis.ConclusionOver the past two decades, research on soy and whey proteins has witnessed a shift from processing aspects to nutrition and health, reflecting the emphasis and in-depth exploration of the nutritional and health values of proteins. Despite its limitations, this study provided a valuable reference for researchers in the field of soy and whey proteins, helping them to grasp the direction of their research and rationally allocate resources. At the same time, it also provided data support for policymakers to formulate relevant research policies and promote international cooperation, which will help to promote the further development and innovation of proteins in the field of nutrition. Therefore, it was recommended that research institutes strengthen their cooperation and work together to meet future research challenges and promote the sustainable development of proteins in nutrition.

Remediation of Micro- and Nanoplastics by Membrane Technologies

Micro- and nanoplastics (NPs) cannot be completely removed from water/wastewater in conventional wastewater treatment plants (WWTPs) and drinking water treatment plants (DWTPs). According to the literature analysis, membrane processes, one of the advanced treatment technologies, are the most effective and promising technologies for the removal of microplastics (MPs) from water and wastewater. In this article, firstly, the properties of MPs commonly found in water and wastewater treatment and their removal efficiencies are briefly reviewed. In addition, research on the use of microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), reverse osmosis (RO), and membrane bioreactors (MBR) for the remediation of MPs and NPs from water/wastewater is reviewed, and the advantages/disadvantages of each removal method are discussed. Membrane filtration is also compared with other methods used to remove MPs. Furthermore, the problem of membrane fouling by MPs during filtration and the potential for MPs to be released from the polymeric membrane structure are discussed. Finally, based on the literature survey, the current status and gaps in research on MPs removal by membrane technologies are identified, and recommendations for further research are made.

Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis

BackgroundGastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding of the mechanisms underlying gastric cancer deepens, in recent years, investigations on gastric cancer stem cells (GCSCs) have garnered significant interest. They are pivotal in the onset, progression, recurrence, and pharmacoresistance of GC. Comprehensive research on GCSCs is expected to provide new strategies for the diagnosis and treatment of GC. This article endeavors to comprehensively assess the current status and future trends of GCSCs research through bibliometric analysis, thereby providing a valuable reference for further in - depth studies in this field.MethodsEnglish - language academic journals related to GCSCs research in the Web of Science database were retrieved. Subsequently, VOSviewer was utilized to conduct network collinear analysis of the exported source institutions, literature authors, references, and keywords. And CiteSpace was used to perform statistical analysis of the annual publication count, keyword clustering, references, and keyword burst.ResultsA total of 3882 documents that met the criteria were incorporated. The quantity of published papers has shown a consistent upward trend annually since 2003. Among the authors of the literature, multiple stable core author groups represented by Zhu, Wei, Wang, Mei, Xu, Wenrong, etc. have been formed. There are 335 associated institutions in total. The Japan National Cancer Center has the strongest relevance and the largest number of published papers. There are 7 clustering labels formed among the keywords, including main clustering modules such as activation, cancer stem cells, DNA content aneuploidy, and expression. 25 burst keywords were generated, and the burst keywords in the past two years include mesenchymal stem cells, drug resistance, proliferation, etc. The emergence of references indicates that eight references have been cited up to now and are the focus of current research.ConclusionThe research overview of GCSCs in the past 30 years was visually presented by visual maps. In the past decade, scholars’ research in this field has gradually intensified, and the development trend is good. Through the deeper study of the GCSCs mechanism, intervention GCSCs in the future will be a new promising treatment approach for GC patients. This hot topic still deserves more attention in the future.

Conservation of island city heritage site: a study of the spatial practices of A-Ma Temple heritage site in Macau

ABSTRACT Island city heritage is a type of heritage in island cities with historical, cultural, and artistic value, including their buildings, neighborhoods, landscapes, and cultural traditions, and is a branch of architectural heritage research. It emphasizes the analysis of the construction process of urban heritage sites through the dual impacts of time and space, and it is conducive to breaking through the current static research status and restoring the intrinsic relationship between historical space, local landscape conditions, and the social economy. However, currently, some island urban heritage sites face considerable challenges due to land constraints caused by urban land expansion. This study takes the heritage site of A-Ma Temple, Macau, as the research object and reveals that the construction and evolution of the site reflect the protection process and practical logic of urban space construction. At the same time, with the help of cultural and historical materials such as documents, maps, inscriptions, and stone carvings, two research methods, namely, physical space samples from on-site surveys and personnel interviews, were combined. Finally, from a diachronic perspective, this study focused on the influence of private and official forces on the construction and development, evolution and reshaping, art, and expression of A-Ma Temple’s spaces. This research shows the following: (1) the heritage site of A-Ma Temple, Macau, was influenced by natural geography and humanity to form phases, situations, pavilions, and the environment, which is the main logic of its spatial practice; (2) based on the development of the external historical environment and the influence of its own divine personality, the heritage site of A-Ma Temple has obvious stage differences; (3) the interaction between the heritage site and the environment helps to actively integrate, adapt, and even support the development of island urban spaces. Systematically studying the historical construction of heritage sites and the internal and external factors that produced them in the rapid expansion of urban space around these three levels is of significance for promoting research on the protection and reuse of these sites in island cities.

Nanomaterials for targeted drug delivery for immunotherapy of digestive tract tumors

The incidence and mortality rates of digestive tract tumors, especially gastric and colorectal cancers, are high worldwide. Owing to their unique advantages, such as efficient drug loading, safety, and targeting properties, nanoparticles (NPs) have demonstrated great potential in the treatment of gastrointestinal tumors. However, their practical application is limited by several factors, such as high costs, few clinical trials, and long approval periods. In this review, we summarize three types of immunotherapeutic nanomaterial drugs for gastrointestinal tumors: organic, inorganic, and hybrid nanomaterials. This article also discusses the current status of research and development in this field and the advantages of each type of material to provide theoretical references for developing new drugs and advancing clinical research.

Effective Strategies in Covalent Organic Frameworks for Enhanced Photocatalytic Hydrogen Production.

Hydrogen as a significant green energy source, has emerged as one of the most promising candidates to solve serious environmental and energy problems. Photocatalytic water splitting is a prospective route to sustainable hydrogen production. Covalent organic frameworks (COFs) are considered as efficient photocatalysts due to their substantial specific surface areas, extended π-conjugated backbones, and robust chemical stability. This review summarizes the recent advances of COF-based materials in the field of photocatalytic hydrogen production, including the construction of donor-acceptor (D-A) structure, protonation of the N site, synthesis of zwitterionic COFs, introduction of co-catalysts, use of metal-containing monomers, and compositing COFs with other catalysts. The properties of the catalysts are meticulously adjusted through those structural and system design strategies, thereby significantly enhancing the hydrogen production performance of the COFs. Finally, the challenges and potential opportunities for future developments are discussed in terms of the current research status and practical applications of photocatalytic hydrogen production from COFs.

Optically transparent microwave metamaterial absorbers

Abstract Optically transparent microwave absorbers based on metamaterials demonstrate exceptional microwave absorption performance while maintaining high optical transmittance, showcasing significant potential for applications in modern communication, defense, and architectural fields. Transparency in the visible light spectrum is primarily achieved through material selection and structural optimization. The artificially designed metamaterials based on transparent resistive films can be used to achieve devices with excellent wave absorption characteristics in the microwave frequency band. In this paper, we systematically review the research progress in the domain of optically transparent microwave metamaterial absorbers. We first introduce the implementation principles of optically transparent microwave metamaterial absorbers from the perspectives of transparency and wave absorption, laying the foundation for the in-depth discussions in subsequent sections. Subsequently, we focus on the research progress of optically transparent microwave metamaterial absorbers. In this paper, microwave metamaterial absorbers are classified into three types: passive absorbers, tunable absorbers and adaptive absorbers. Passive and tunable absorbers are further discussed based on their structural classifications. This paper summarizes the current research status and technical bottlenecks of optically transparent microwave absorbers while envisioning their extensive applications in stealth technology, wireless communication, and multifunctional devices. While challenges persist in balancing thickness, bandwidth and transmittance, future advancements in novel material, innovative structural designs, and manufacturing processes are expected to enable the realization of efficient, intelligent, multifunctional absorbers.

A comprehensive review on applications of multi-criteria decision-making methods in healthcare waste management.

Effective management of healthcare waste (HCW) imposes a great challenge to all countries. Specially in the developing countries, it is often mixed with municipal waste, adversely affecting the health and safety of the medical personnel, general public and environment. Healthcare waste management (HCWM) basically deals with segregation, collection and storage, routing and transportation, treatment and safe disposal of HCW, while obeying some national legislation. In every stage of HCWM, there are several alternative choices/strategies to be evaluated against a set of conflicting criteria. Numerous multi-criteria decision-making (MCDM) methods have appeared to resolve the issue. This article reviews 101 articles available in Scopus and other scholarly databases on applications of MCDM techniques in solving HCWM problems. Those articles are classified into six groups: (a) selection of the most effective HCW treatment technology, (b) identification of the best HCW disposal site, (c) assessment of the best-performing healthcare unit adopting ideal HCWM strategies, (d) selection of third party logistics providers, (e) identification of HCWM barriers and (f) evaluation of specific HCWM plans. It is observed that the past researchers have mostly preferred to apply MCDM tools for solving HCW treatment technology selection problems, whereas analytic hierarchy process, decision-making trial and evaluation laboratory and best-worst method and fuzzy set theory have been the mostly favoured MCDM tool, criteria weight measurement techniques and uncertainty model, respectively. The outcomes of this article would help the healthcare personnel/policymakers in unveiling the current status of HCWM research, exploring extant research gaps and challenges and providing future directions leading to sustainable environment.

Expansion of Splice-Switching Therapy with Antisense Oligonucleotides

Since 2016, splice-switching therapy, in which splicing is controlled by antisense oligonucleotides, has been applied in clinical practice for spinal muscular atrophy and Duchenne muscular dystrophy. In the former disease, this therapy induces exon inclusion, while, in the latter, it induces exon skipping, leading expression of functional proteins. Basic and clinical studies of splice-switching therapy for many monogenic diseases have now been conducted. The molecular mechanisms of splice-switching therapy include not only the induction of exon inclusion and skipping, but also the induction of pseudoexon skipping and suppression of splicing sites generated by mutations. In addition, therapies that alter protein function by regulating splicing are being investigated not only for monogenic diseases but also for non-monogenic ones such as cancer and immune-related disorders. It is expected that many of these basic studies will be translated into clinical applications. This review describes the current status of basic research and clinical applications of splice-switching therapy to promote the development of treatments for noncurable diseases.