Current Research Priorities Research Articles

The next stages of treatment-oriented research: Commentary on Wade et al. (2023).

Treatments for eating disorders have established benefits; yet, current psychotherapies focus specifically on the cognitions and behaviors of the eating disorder. Wade et al. (2023) propose that the myriad symptoms and disorders that occur together with eating disorders merit specific attention in treatment research protocols. We seek to amplify the authors' call to take a fresh look at the characterization of eating disorders, and the need for treatment research to consider both the role of symptoms that occur as part and parcel of an eating disorder (such as mood, anxiety, and obsessionality) and the role of co-occurring disorders (such as obsessive-compulsive disorder and substance use disorders). We discuss additional aspects in the care of patients with eating disorders that were beyond the scope of Wade et al., such as the impact of systems of care, and consideration of medication trials. We propose that current research priorities (mechanism-based treatment development, transdiagnostic symptoms, and patient perspectives) can be leveraged to advance treatment research and develop a systematic approach to evaluation and treatment planning.

National Institute on Drug Abuse (NIDA) research priorities to support the development of incentive-based treatments for substance use disorders

The purpose of this commentary is to highlight current research priorities of National Institute on Drug Abuse (NIDA) Division of Therapeutics and Medical Consequences (DTMC) regarding the development and testing of incentive-based interventions for the treatment of substance use disorders (SUDs). This manuscript summarizes the NIH Stage Model for behavioral intervention development, briefly reviews existing research on incentive-based treatments for SUDs that falls within the scope of DTMC at NIDA and highlights the development of digital therapeutics-based incentive interventions as an exemplar and high priority area. We briefly review how digital therapeutics approaches may address some common limitations to dissemination of incentive-based interventions and highlight opportunities for integrating incentive-based approaches into pharmacotherapy efficacy trials. Finally, we mention several related funding opportunities for researchers interested in developing incentive-based approaches for SUD treatment. The overall goal of this commentary is to inform the research community of current NIDA priority areas for intervention development and funding.

Physiology of Health and Performance: Enabling Success of Women in Combat Arms Roles.

The modern female soldier has yet to be fully characterized as she steps up to fill new combat roles that have only recently been opened to women. Both U.S. and U.K. military operational research efforts are supporting a science-based evolution of physical training and standards for female warfighters. The increasing representation of women in all military occupations makes it possible to discover and document the limits of female physiological performance. An informal Delphi process was used to synthesize an integrated concept of current military female physiological research priorities and emerging findings using a panel of subject matter experts who presented their research and perspectives during the second Women in Combat Summit hosted by the TriService Nursing Research Program in February 2021. The physical characteristics of the modern soldier are changing as women train for nontraditional military roles, and they are emerging as stronger and leaner. Capabilities and physique will likely continue to evolve in response to new Army standards and training programs designed around science-based sex-neutral requirements. Strong bones may be a feature of the female pioneers who successfully complete training and secure roles traditionally reserved for men. Injury risk can be reduced by smarter, targeted training and with attention directed to female-specific hormonal status, biomechanics, and musculoskeletal architecture. An "estrogen advantage" appears to metabolically support enhanced mental endurance in physically demanding high-stress field conditions; a healthy estrogen environment is also essential for musculoskeletal health. The performance of female soldiers can be further enhanced by attention to equipment that serves their needs with seemingly simple solutions such as a suitable sports bra and personal protective equipment that accommodates the female anatomy. Female physiological limits and performance have yet to be adequately defined as women move into new roles that were previously developed and reserved for men. Emerging evidence indicates much greater physical capacity and physiological resilience than previously postulated.

Re: Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting

Re: Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting

Spatiotemporal Variations in the Sensitivity of Vegetation Growth to Typical Climate Factors on the Qinghai–Tibet Plateau

Gaining knowledge about vegetation sensitivity in response to climate change is a current research priority in the context of accelerated shifts generated by global warming, especially for the Qinghai–Tibet Plateau (QTP), where vegetation is known to be highly sensitive to ongoing climate change. However, the temporal variability of vegetation sensitivity in response to climate change is still poorly understood on the QTP. Here, we articulate the interannual variability of the vegetation sensitivity in response to typical climate factors, including temperature, solar radiation, and water availability, on the QTP during 2000–2021, using a variety of indicators characterizing vegetation dynamics, including the Leaf Area Index (LAI), the Normalized Difference Vegetation Index (NDVI), the Enhanced Vegetation Index (EVI), and solar-induced chlorophyll fluorescence (SIF) data. The results indicate that temperature exerted positive impacts on forests, grasslands, and barren or sparsely vegetated areas (BSVs). However, all the land-cover types showed decreasing sensitivity to temperature variability. Solar radiation had a positive impact on forests, while it had a negative impact on grasslands and BSVs. An increasing trend was observed for forests, while a decreasing trend was found for grasslands and BSVs regarding their sensitivity to solar radiation. Water availability exerted a positive impact on grasslands and BSVs, and no obvious impact direction could be determined for forests. Over the last two decades, forests and BSVs exhibited increasing sensitivity to water availability, and no obvious trend was observed for grasslands. Overall, temperature was the most important climate factor, followed by solar radiation and water availability, regarding the regulation of vegetation sensitivity on the QTP. Spatially, temperature and solar radiation jointly dominated the vegetation sensitivity in the central to eastern QTP. Conversely, water availability dominated the sensitivity of forests in the southeastern QTP and grasslands in the northeastern and southwestern QTP. This study provides theoretical support for the ecological conservation and management of the QTP in the context of ongoing climate change.

Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial

IntroductionChronic low back pain (CLBP) is a highly prevalent and disabling condition. Identifying subgroups of patients afflicted with CLBP is a current research priority, for which a classification system based...

Privacy during epidemic of COVID-19: a bibliometric analysis

1,226 articles on privacy and COVID-19 were published by authors from 69 countries in this year's issue. COVID 19's privacy is now the focus of many researchers' attention. The present body of knowledge on privacy for COVID-19 digital technologies has been thoroughly analyzed, and a concise overview of research status and future developments can be gleaned. This paper conducted a bibliometric examination of privacy using the Scopus dataset. Utilizing VOSviewer software, the relevant literature papers published on this topic were examined to determine the field's development history, research hotspots, and future directions. Over time, there has been a rise in the number of studies published in privacy for COVID-19, particularly after 2020, and the growth rate has been steadily increasing. Regarding published research, the United States and China lead the pack. These articles appeared in primarily English-language journals and conference proceedings. Privacy and COVID-19 research was mostly computer science. The most used terms in privacy and COVID-19 were data privacy and humans. This paper examines the evolution of privacy and COVID-19 research and indicates current research priorities and future research goals. Furthermore, the privacy and COVID-19 study seem to be a promising sphere as this study identifies 26 domains.

Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting

BackgroundActive surveillance (AS) is recommended for low-risk and some intermediate-risk prostate cancer. Uptake and practice of AS vary significantly across different settings, as does the experience of surveillance—from which tests are offered, and to the levels of psychological support. ObjectiveTo explore the current best practice and determine the most important research priorities in AS for prostate cancer. Design, setting, and participantsA formal consensus process was followed, with an international expert panel of purposively sampled participants across a range of health care professionals and researchers, and those with lived experience of prostate cancer. Statements regarding the practice of AS and potential research priorities spanning the patient journey from surveillance to initiating treatment were developed. Outcome measurements and statistical analysisPanel members scored each statement on a Likert scale. The group median score and measure of consensus were presented to participants prior to discussion and rescoring at panel meetings. Current best practice and future research priorities were identified, agreed upon, and finally ranked by panel members. Results and limitationsThere was consensus agreement that best practice includes the use of high-quality magnetic resonance imaging (MRI), which allows digital rectal examination (DRE) to be omitted, that repeat standard biopsy can be omitted when MRI and prostate-specific antigen (PSA) kinetics are stable, and that changes in PSA or DRE should prompt MRI ± biopsy rather than immediate active treatment. The highest ranked research priority was a dynamic, risk-adjusted AS approach, reducing testing for those at the least risk of progression. Improving the tests used in surveillance, ensuring equity of access and experience across different patients and settings, and improving information and communication between and within clinicians and patients were also high priorities. Limitations include the use of a limited number of panel members for practical reasons. ConclusionsThe current best practice in AS includes the use of high-quality MRI to avoid DRE and as the first assessment for changes in PSA, with omission of repeat standard biopsy when PSA and MRI are stable. Development of a robust, dynamic, risk-adapted approach to surveillance is the highest research priority in AS for prostate cancer. Patient summaryA diverse group of experts in active surveillance, including a broad range of health care professionals and researchers and those with lived experience of prostate cancer, agreed that best practice includes the use of high-quality magnetic resonance imaging, which can allow digital rectal examination and some biopsies to be omitted. The highest research priority in active surveillance research was identified as the development of a dynamic, risk-adjusted approach.

Determining the top research priorities in UK prehospital critical care: a modified Delphi study

BackgroundPrehospital critical care is a rapidly evolving field. There is a paucity of evidence relating to its practice, with limited progress in answering those research questions identified over a decade...

Bibliometric and visualization analysis of global research trends on immunosenescence (1970–2021)

BackgroundImmunosenescence, the aging of the immune system, leads to a decline in the body's adaptability to the environment and plays an important role in various diseases. Immunosenescence has been widely studied in recent years. However, to date, no relevant bibliometric analyses have been conducted. This study aimed to analyze the foundation and frontiers of immunosenescence research through bibliometric analysis. MethodsArticles and reviews on immunosenescence from 1970 to 2021 were obtained from the Web of Science Core Collection. Countries, institutions, authors, journals, references, and keywords were analyzed and visualized using VOSviewer and CiteSpace. The R language and Microsoft Excel 365 were used for statistical analyses. ResultsIn total, 3763 publications were included in the study. The global literature on immunosenescence research has increased from 1970 to 2021. The United States was the most productive country with 1409 papers and the highest H-index. Italy had the highest average number of citations per article (58.50). Among the top 10 institutions, 50 % were in the United States. The University of California was the most productive institution, with 159 articles. Kroemer G, Franceschi C, Goronzy JJ, Solana R, and Fulop T were among the top 10 most productive and co-cited authors. Experimental Gerontology (n = 170) published the most papers on immunosenescence. The analysis of keywords found that current research focuses on “inflammaging”, “gut microbiota”, “cellular senescence”, and “COVID-19”. ConclusionsImmunosenescence research has increased over the years, and future cooperation and interaction between countries and institutions must be expanded. The connection between inflammaging, gut microbiota, age-related diseases, and immunosenescence is a current research priority. Individualized treatment of immunosenescence, reducing its negative effects, and promoting healthy longevity will become an emerging research direction.

Review of Key Technologies for Offshore Floating Wind Power Generation

In recent years, due to the global energy crisis, increasingly more countries have recognized the importance of developing clean energy. Offshore wind energy, as a basic form of clean energy, has become one of the current research priorities. In the future, offshore wind farms will be developed in deep and distant sea areas. In these areas, there is a new trend of floating offshore wind platforms replacing fixed wind power platforms, due to their low cost, ease of installation, and independence from the water depth. However, the stability of offshore floating platforms is poor and their power fluctuations are significant; furthermore, they are more prone to failure because of sea wind, waves, and currents. This paper summarizes and analyzes the current research progress and critical technical issues of offshore floating wind power generation, such as stability control technology, integrated wind storage technology, wind power energy management, and long-distance transmission of electricity for floating wind power generation at sea. Finally, future research directions for key offshore wind power technologies are presented.

Past, present, and future of tourism and climate change research: bibliometric analysis based on VOSviewer and SciMAT

ABSTRACT The topic of tourism and climate change is a highly promising area. This paper attempts to review the relevant research and identify prospective opportunities. On the basis of 1,274 records in the Web of Science from 1998–2021, this paper develops visual maps of co-authorship networks and strategic diagrams using VOSviewer and SciMAT. Results indicate that the cooperation among different authors has accelerated the knowledge output. Panel data, ski tourism, outdoor recreation, national parks, pro-environmental behavior, and error correction are the current research priorities. On the basis of the strategic diagrams, the paper discovers future research trends.

Considering potential benefits, as well as harms, from the COVID-19 disruption to cancer screening and other healthcare services.

Since 2020, hundreds of thousands of more deaths than expected have been observed across the globe. Amid the coronavirus 2019 (COVID-19) pandemic, current research priorities are to control the spread of infection and minimise loss of life. However, there may be future opportunities to learn from the pandemic to build a better healthcare system that delivers maximum health benefits with minimum harm. So far, much research has focused on foregone benefits of healthcare services such as cancer screening during the pandemic. A more balanced approach is to recognise that all healthcare services have potential harms as well as benefits. In this way, we may be able to use pandemic 'natural experiments' to identify cases where a reduction in a healthcare service has not been harmful to the population and some instances where this may have even been beneficial.

Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities.

Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

Scientometric analysis of kidney disease and gut microbiota from 2001 to 2020 based on Web of Science

This study aims to demonstrate current research priorities and predict future trends in the link between kidney disease and gut microbiota by means of scientometric analysis. We collected nearly 20 years (2001-2020) of publications related to kidney disease and gut microbiota in the Web of Science database. CiteSpace was used to evaluate the knowledge mapping. There are 965 manuscripts about kidney disease and gut microbiota in total, and faster growth after 2016. The country, institution, and author who posted the most are the USA, Univ Calif Irvine, and DENISE MAFRA, respectively. The frequencies are 109, 16, and 17. The most important of them are FRANCE (0.23), Fed Univ Parana UFPR (0.13), and VAZIRI ND (1.14), owing to their highest centrality. In addition, the cited documents that have contributed the most to the co-citations are Wong J (2014); the most key cited reference is Rossi M (2016); the most commonly used keywords are chronic kidney disease, gut microbiota and indoxyl sulfate. Through scientometric analysis of the past 20 years, we obtained the knowledge map of this information, which has important guiding significance for accurately and quickly locating trends in this field.

Deactivation and Regeneration of Palladium Catalysts for Hydrogenation Debenzylation of 2,4,6,8,10,12-Hexabenzyl-2,4,6,8,10,12-Hexaazaisowurtzitane (HBIW)

2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (HNIW, also known as CL-20) is an important energetic compound. As one of the representatives of the third generation of energetic materials, it has an excellent performance, providing broad application prospects for the development of new weapons and equipment. The synthesis of CL-20 is usually obtained from 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (HBIW) through two catalytic hydrogenolysis and debenzylation reactions, followed by nitration. The most critical step is the hydrogenolysis debenzyl-acetylation process of HBIW because this process requires a large amount of expensive palladium-based catalyst, and the catalyst is completely deactivated after one use. In response to this problem, there is no suitable solution at present, resulting in the high cost of the entire synthesis process. Therefore, reducing the production cost of CL-20 by increasing the catalyst stability is one of the current research priorities. By using AAS, XRD, XPS, TEM, BET, TG and other characterization techniques, the reasons for catalyst deactivation were explored. Studies have shown that the main reason for catalyst deactivation is that a large number of blockages accumulate in the pores of the catalyst after the reaction, which greatly weakens the transfer of the reactant HBIW, intermediate substances, and product 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) in the catalyst pores, and the blockage may block the active site of the catalyst. A regeneration treatment method for catalyst deactivation was developed. This method uses chloroform and glacial acetic acid as reagents, which, when combined with stirring and ultrasonic operation, finally restores the activity of the Pd(OH)2/C catalyst. The BET and TG parameters of the regenerated catalyst indicate that catalyst textural and structural properties have greatly recovered, indicating that this treatment method can remove the blockages in the catalyst pores.

Vegetation responses to variations in climate: A combined ordinary differential equation and sequential Monte Carlo estimation approach

Vegetation responses to variation in climate are a current research priority in the context of accelerated shifts generated by climate change. However, the interactions between environmental and biological factors still represent one of the largest uncertainties in projections of future scenarios, since the relationship between drivers and ecosystem responses has a complex and nonlinear nature. We aimed to develop a model to study the vegetation's primary productivity dynamic response to temporal variations in climatic conditions as measured by rainfall, temperature and radiation. Thus, we propose a new way to estimate the vegetation response to climate via a non-autonomous version of a classical growth curve, with a time-varying growth rate and carrying capacity parameters according to climate variables. With a Sequential Monte Carlo Estimation to account for complexities in the climate-vegetation relationship to minimize the number of parameters. The model was applied to six key sites identified in a previous study, consisting of different arid and semiarid rangelands from North Patagonia, Argentina. For each site, we selected the time series of MODIS NDVI, and climate data from ERA5 Copernicus hourly reanalysis from 2000 to 2021. After calculating the time series of the a posteriori distribution of parameters, we analyzed the explained capacity of the model in terms of the linear coefficient of determination and the parameters distribution variation. Results showed that most rangelands recorded changes in their sensitivity over time to climatic factors, but vegetation responses were heterogeneous and influenced by different drivers. Differences in this climate-vegetation relationship were recorded among different cases: (1) a marginal and decreasing sensitivity to temperature and radiation, respectively, but a high sensitivity to water availability; (2) high and increasing sensitivity to temperature and water availability, respectively; and (3) a case with an abrupt shift in vegetation dynamics driven by a progressively decreasing sensitivity to water availability, without any changes in the sensitivity either to temperature or radiation. Finally, we also found that the time scale, in which the ecosystem integrated the rainfall phenomenon in terms of the width of the window function used to convolve the rainfall series into a water availability variable, was also variable in time. This approach allows us to estimate the connection degree between ecosystem productivity and climatic variables. The capacity of the model to identify changes over time in the vegetation-climate relationship might inform decision-makers about ecological transitions and the differential impact of climatic drivers on ecosystems.

Road Curbs Extraction from Mobile Laser Scanning Point Clouds with Multidimensional Rotation‐Invariant Version of the Local Binary Pattern Features

AbstractRoad curb is one of the important components of road information, and its high‐precision information is significant for the development of autonomous driving, intelligent transportation and smart cities. A mobile laser scanning (MLS) system can acquire high‐precision and high‐density road three‐dimensional (3D) point clouds data, which has the advantages of high efficiency, low cost and non‐contact. However, how to extract accurate road information from the massive and disordered point clouds is one of the current research priorities and difficulties. This paper presents a new method to extract the road curbs from the MLS point clouds. The proposed method mainly includes three steps: pre‐processing, road curbs extraction and vectorisation. Pre‐processing obtains the ground, including road subsection and ground identification. Road curbs are first quantitatively represented by the rotation‐invariant version of the local binary pattern (LBPROT) values in three dimensions, including spatial elevation mode, spatial dispersion mode and spatial shape mode, and then they are extracted by a multidimensional LBPROT features semantic recognition model. Vectorised road curb polylines are connected by accurate road curbs points, which are obtained through simplification and denoising. The proposed method was tested on two large‐scale datasets collected from arterial roads and expressways, respectively. The precision of the results was > 95%, recall was > 90% and the F1 score was > 0.93. The experimental results show that the proposed method can effectively extract road curbs in different environments and has robust adaptability.

Youth Services: Empowering Community, Inclusion, and Active Citizenship through Libraries

The ALISE Youth Services Special Interest Group (SIG) presents a panel that explores the ways in which youth services and programs in libraries empower community, inclusion, and active citizenship. The session will begin with presentations of six papers (10 minutes each) and conclude with a themed question and answer at the end of the session, transitioning to open conversation. Attendees will be invited to share their own works in progress and developing ideas on these topics and youth services more broadly during the open discussion portion of the panel. This panel and discussion will connect presenters and attendees in conversation about current trends, future goals, research and pedagogical priorities, and youth and community needs with regards to youth services. 
 The panel brings together six presentations reporting on work at a variety of stages, including late-breaking research as well as long term projects in later stages. These presentations include research from Cahill, Sartin Long, and Adkins focusing on library services for young children with disabilities, reporting findings from focus group interviews seeking to identify ways that libraries can and should be serving young children with disabilities and their families. Farmer’s presentation discusses how diverse populations are targeted by fake news and how librarians can help them express their voice to speak to power. Excitingly this year’s panel also has strong representation of doctoral students. Koren will present work developed with Dywer, Acosta, Bonsignore, and Santacruz focusing on how they used the design thinking process to co-design programs alongside young people from communities impacted by issues of power. Petrella will share the preliminary findings of her doctoral research on ways pre-service school librarians are taught about race, racism, and whiteness in their school library professional programs. Salib will share work developed with Abbas and Agosto, detailing their Institute of Museum and Library Services funded Navigating Screens project which seeks to understand the ways parents desire to connect with other parents in their communities to talk about managing family use of digital media. Finally, Zalot will discuss the mislabeling of the Seuss books’ removal as an act of censorship and how the term is often incorrectly deployed to describe books that are evaluated in new contexts.
 The breadth of these presentations, techniques, and goals demonstrate how wide ranging the relevance of youth services is to libraries, librarianship, and library and information science (LIS) research and education. This panel will examine how youth services programs and services can support inclusion, nurture active citizenship, and develop community, and prompt an open conversation about how the LIS field can better support these priorities with an emphasis on next steps, research trajectories, teaching innovation, and community building.

Klotho in Kidney Transplantation: A New and Important Target?

Klotho in Kidney Transplantation: A New and Important Target?