An urgent necessity in socio-economic regional development strategy specification is being substantiated for the purpose of reconstructing and adjusting the TEA (Types of Economic Activity) structure, which is able to speed up the development of GRP (Gross Regional Product), GS (Gross Surplus) per person and steadily grade current interregional differentiation and asymmetry. To reach the target a special algorithm for Soft Computing has been created. On the example of the selected region it was proved that the present economic system is not self-organized and it requires an efficient public management. If the regional management strategy is not optimally chosen then in the system some uncontrolled fluctuations can be observed, that may lead to an economic crisis and the collapse of the economy system. Mathematical models of optimization of strategies building of 3 types have been constructed and their effectiveness has been quantitatively researched. It is proved, that the dynamic management strategy with the maximizing of the objective function at the end of the period under investigation, turned out to be the most effective. It is established that public administration which is based on a scientifically grounded quantitative approach, using advanced mathematical models of Soft Computing, allows building a strong economic foundation, which will be the basis for a further rapid growth of the regional economy.
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