Total quality management and corporate sustainability: the mediating role of innovative culture in healthcare

This study examines the role of organizational culture in mediating the influence of critical thinking and digital leadership on employee performance at the University of Muhammadiyah Aceh. Digital transformation demands that organizations have adaptive and innovative human resources, where critical thinking and digital leadership are key competencies expected to improve performance directly or through strengthening organizational culture. This study used a quantitative approach with a survey design and Structural Equation Modeling (SEM) analysis of 205 respondents who were all permanent employees of the university. The variables tested included critical thinking and digital leadership as independent variables, organizational culture as a mediating variable, and employee performance as a dependent variable. The results showed that critical thinking and digital leadership did not have a significant direct effect on employee performance, but both had a significant positive effect on organizational culture, which in turn had a significant effect on performance. Organizational culture was proven to partially mediate the relationship between critical thinking and digital leadership with employee performance. This finding emphasizes the importance of strengthening an adaptive and innovative organizational culture as a key pillar of performance improvement in the digital era. Practically, the research recommends the development of critical thinking training programs, improving digital leadership competencies, and strengthening a work culture that aligns with the university's vision and mission, as well as providing theoretical contributions to digital-based human resource management in higher education.

This case study explores the transformative role of a student-staff partnership (SSP) in redesigning assessment and learning experiences for the core master’s-level course, Global Challenges in Agriculture (AGRC7047). At the heart of this initiative was a diverse team of student and staff partners who co-developed new learning materials and assessment structures to better engage a heterogeneous cohort. A key outcome of this collaboration was the design and implementation of a reflexive ePortfolio assessment. This innovation emerged from the SSP’s commitment to inclusivity, pedagogical alignment, and global citizenship education. Rather than positioning the ePortfolio as the central course, this paper foregrounds the SSP process: how students and staff worked as co-creators, how diverse disciplinary and cultural perspectives enriched the project, and how this model can inform broader efforts to co-create curriculum in agricultural sciences and beyond. By documenting the application of SSP within agricultural sciences, an area where partnership-based pedagogical research remains limited, this study contributes new insights into how co-creation can reshape teaching practices in applied and interdisciplinary STEM-adjacent fields. The findings offer valuable insights into how SSPs can lead to sustainable pedagogical innovation and shift disciplinary cultures toward more reflective and student-centred practices.

This research is motivated by the demands of digital transformation in the banking sector, which require an adaptive, innovative, and collaborative work culture to enhance sustainable employee performance. Although Bank BJB has shown improvement during 2022–2024, challenges remain, including uneven cultural implementation, low employee participation, and limited knowledge sharing. This research aims to analyze the influence of organizational culture and innovation on employee performance with knowledge sharing as an intervening variable in Bank BJB.. This study uses a quantitative approach with causal design to examine the cause-and-effect relationship between organizational culture (X1) and innovation (X2) variables on employee performance (Y), either directly or indirectly through knowledge sharing (Z). The data analysis technique uses multiple linear regression to test the direct influence and mediation between variables. The results of the study are expected to show that organizational culture and innovation have a positive and significant influence on employee performance, both directly and through knowledge sharing as an intervening variable. Knowledge sharing plays an important role in strengthening the relationship between organizational culture and innovation on employee performance, thereby creating a productive, adaptive, and learning-oriented work environment. The implications of this study provide recommendations for the management of Bank BJB to strengthen an adaptive organizational culture, improve the innovation ecosystem, and optimize a digital-based knowledge sharing system to support the improvement of employee performance and company competitiveness in the digital era.

Purpose This paper introduces the concept of holdership as a psychoanalytically informed explanatory framework that reconceptualises leadership not as an individual role, behavior, or style, but as a distributed organisational holding function. Drawing on D. W. Winnicott's notion of the holding environment, the study explicates how organizations design and sustain relational, structural, and emotional conditions that regulate anxiety, support developmental progression, and enable innovation and organisational resilience under conditions of uncertainty. Design/methodology/approach The study adopts an integrative conceptual review approach explicitly oriented toward theory development rather than empirical aggregation or hypothesis testing. It synthesizes Winnicott's psychoanalytic concepts with contemporary leadership, organisational behavior, and organisational psychodynamics literatures. Through structured comparative analysis of established leadership perspectives and a theory-driven synthesis, the paper develops a multi-level conceptual model of holdership, articulates its developmental logic, and derives organisational design implications. Illustrative organisational examples are employed to support interpretive clarity rather than empirical validation. Findings The analysis advances holdership as a distributed, relational, and system-level holding function through which organizations enable the developmental movement from dependence to mature autonomy. By sustaining holding environments characterized by emotional containment, psychological safety, authenticity, and shared responsibility, organizations foster conditions conducive to learning, creativity, and innovation in complex and uncertain contexts. Innovation and resilience are thus conceptualized as emergent developmental outcomes rather than as leader-driven interventions or static capabilities. Practical implications The framework offers diagnostic and design-oriented guidance for leaders, executives, and HR professionals seeking to cultivate effective holding environments. Rather than prescribing idealized leader behaviors, it highlights organisational practices and arrangements, including empathy, emotional containment, shared decision-making, and developmental support, that enhance engagement, reduce turnover, and sustain resilient and innovative organisational cultures over time. Social implications By foregrounding emotionally attuned, inclusive, and non-heroic modes of organizing, the study contributes to debates on ethical leadership, sustainable use of power, and human-centered organisational design. Holdership supports healthier workplaces and strengthens collective capacity to respond creatively and responsibly to social, environmental, and institutional challenges in contemporary societies. Originality/value This study contributes to organisation and leadership theory by extending existing post-heroic and distributed leadership scholarship through a systemic and psychodynamic account of organising under uncertainty. By conceptualising leadership as an embedded organisational holding function, the paper introduces previously under-theorized mechanisms of anxiety regulation, emotional containment, and developmental support, offering a novel theoretical lens and a coherent set of actionable design principles for resilient, innovative, and humanly sustainable organizing.

The coastal areas that depend on tourism are increasingly under pressure from environmental factors driven by rapid infrastructure development, large seasonal populations, and inadequate waste management systems. The United Nations World Tourism Organization estimates that almost 40% of global tourism income is generated by coastal areas, and the United Nations Environment Program estimates that nearly 80% of marine pollution is land-based. During peak tourist seasons, solid waste may increase by 30-50% at popular attractions, affecting water pollution, biodiversity loss, and reduced local productivity in fisheries and crop production. This paper explores the potential for optimizing productivity and environmental resilience through innovative cultural systems based on sustainable tourism, circular-economy models, and community-based environmental stewardship, alongside sophisticated pollution management strategies. It employed a mixed-methodology, which involved environmental impact analysis, stakeholder survey (n=450), and pilot testing of decentralized wastewater treatment plants and waste-to-resource plants in three coastal areas. A quantitative comparison of pre- and post-intervention water quality indicators, tourism revenue, and employment in the locality was conducted. The outcome shows that there should be a 25% decrease in water pollution along the coast, a 32% increase in waste recycling, and a 15% increase in tourism revenue within 2 years after implementation. More carbon reduction of 18% and destination competitiveness programs were achieved through the development of energy-efficient infrastructure and eco-certification programs. Community participation increased by 40%, thereby enhancing long-term local governance and sustainability. The results show that it is possible to combine new cultural structures with specific approaches to pollution regulation to increase economic productivity and sustain the environment. Policymakers are advised to embrace scalable, evidence-based models that are adaptable to support tourism development in parallel with ecological conservation, thereby achieving sustainable development of coastal areas.

Many products (goods and services) experience rapid adoption followed by decline, transformation, or absorption into broader technological and cultural systems. These phenomena, often described as innovation fads, provide valuable insight into the cultural mechanisms that shape the lifecycle of innovations. This article analyzes sixty-six cases of products (goods and services) that experienced explosive growth between the late 1990s and the mid-2020s across multiple sectors, including consumer electronics, media formats, communication technologies, lifestyle products, and digital platforms. The study applies the Cultural Innovation Construct Process Model that classify innovations according to four cultural drivers: Neowel (technology-driven), Beutel (aesthetic-driven), Moral (rule-driven), and Gnosil (knowledge-driven). Using comparative historical analysis and cross-sector case examination, the research identifies recurring patterns in how innovations emerge, diffuse, and decline. The findings suggest that aesthetic-driven innovations tend to generate rapid but short-lived diffusion, while technology-driven innovations frequently become absorbed by new technological platforms. Norm-driven innovations display greater stability when supported by institutional frameworks. The most durable cultural transformations, however, appear to be associated with knowledge-driven innovation, where new scientific or systemic understanding reshapes behavior and decision-making. The study proposes a strategic framework indicating that innovations integrating knowledge transformation, institutional alignment, technological enablement, and cultural symbolism are more likely to evolve from temporary fads into sustained cultural practices.

This research is entitled: “Strategic Management of the Educational Center through the Integration of Technological Tools at Liceo Sabana Alta, District 02-05 San Juan Este, School Year 2025–2026.” The main objective is to evaluate the strategic management of the educational center through the integration of technological tools at Liceo Sabana Alta. A quantitative approach was employed, with a descriptive study and a non-experimental, cross-sectional design. The study population consisted of 25 participants, including 8 members of the management team and 17 teachers. The instrument was validated through expert judgment, who assessed the clarity, relevance, coherence, and alignment of the items with the study’s objectives and variables. The experts had experience in educational management, educational technology, and research methodology. The findings indicate that Liceo Sabana Alta is making positive progress in integrating technological tools as support for its strategic management, showing improvements in institutional organization, operational efficiency, and educational innovation. The favorable disposition of both the management team and teaching staff represents a key strength for the institution’s digital transformation. However, to consolidate a fully innovative and collaborative institutional culture oriented toward continuous improvement, it is necessary to strengthen ICT training, optimize technological infrastructure, and ensure ongoing technical support to sustain and deepen the progress achieved.

ABSTRACT Purpose Entrepreneurship Infrastructure Organizations (EIOs) include chambers of commerce, startup incubators, accelerators, and consulting companies. There are very limited studies on the activities and effectiveness of EIOs. The potential of digitizing EIOs activities has received particularly little attention. The purpose of this study is to investigate the potential of generative AI to improve the work of B2B-focused EIOs, both internally and in their relationships with external market actors. The paper also evaluates key constraints, including data security, regulatory restrictions, and workforce challenges. Methodology/approach The study used a qualitative research design including semi-structured interviews with 23 professionals from 18 German EIOs that operate in B2B ecosystems. The data was analyzed using the Gioia methodology, allowing for the integration of existing theoretical constructs on generative AI in B2B markets with new insights from EIOs practice. Five propositions guided the study, focusing on the impact of generative AI on operational efficiency, expert roles, customer personalization, innovation culture, and the strategic positioning of EIOs in B2B networks. Findings The results show that generative AI tools improve EIOs efficiency by automating repetitive tasks (e.g. document creation, customer queries, or market analytics) and improved personalization in B2B service offerings. Contrary to the assumption that generative AI reduces the need for human expertise, this research shows that AI moves expert roles toward higher-value tasks, especially in strategic consulting and customer interactions. Successful adoption is more common in EIOs with strong innovation cultures, digital maturity, and B2B customer-centricity. However, challenges remain, such as data protection, gaps in staff AI skills, and the integration of AI with older systems. Research implications This study extends our understanding of the digital transformation of B2B ecosystems by proposing a conceptual framework that represents how generative AI is changing organizational processes, human-machine interaction, and B2B value co-creation. It emphasizes that, in complex B2B environments, generative AI complements, rather than replaces, EIOs. It also links theories of collaborative intelligence, organizational readiness, and business model innovation in B2B contexts. Practical implications B2B-focused EIOs can use generative AI increasingly to optimize workflows, provide real-time information to companies and startups, and create scalable, personalized support services. The proposed four-step roadmap – awareness, pilot testing, full deployment, and long-term optimization – offers a strategic path for B2B EIOs to responsibly and effectively integrate AI. EIO management teams are encouraged to invest in digital skills development, create AI-friendly cultures, and ensure compliance with evolving legal frameworks such as the EU AI Act. Originality/value/contribution This research is one of the first to explore generative AI in the context of B2B entrepreneurship infrastructure organizations. It provides empirical evidence and practical insights on how generative AI enables B2B service innovation, knowledge-intensive customer interactions, and improved strategic decision making. The results offer a balanced perspective on the additional role of generative AI in enabling EIOs future-proofing and strengthening their relevance in B2B digital ecosystems.

The rapid integration of generative and agentic artificial intelligence (AI) into higher education presents new opportunities for efficiency, accessibility, and personalised learning, particularly within resource-constrained contexts. However, this transformation also raises critical concerns regarding the erosion of human agency, including diminished critical thinking, weakened self-regulation, and growing dependence on automated systems. This study explores how AI-supported learning environments shape human agency in South African higher education and examines the implications for equitable human development and sustainable urban futures. Using a qualitative research design, semi-structured interviews were conducted with academic staff and postgraduate students who actively engage with AI in teaching, learning, and research. This study situates higher education within broader urban sustainability and innovation governance systems. The findings reveal a pattern of engagement: participants value AI’s cognitive and productivity benefits while actively resisting its substitution for human judgment, authorship, and accountability. Strong practices of verification, reflective use, and self-regulation demonstrate agentic resilience, yet these individual efforts are constrained by institutional gaps in AI governance, policy clarity, and capacity-building. Sustaining human agency in AI-supported higher education is essential not only for meaningful learning outcomes but also for cultivating the ethical competencies, governance norms, and innovation cultures required for sustainable cities. Participants adopted a cautious approach to AI in higher education due to uncertainty and its recent introduction into their work, highlighting that without adequate support, there is a significant risk of agency loss that could undermine intellectual capital essential for urban sustainability. The study contributes a context-sensitive framework for responsible AI integration that foregrounds human agency as a foundational condition for inclusive, ethical, and sustainable urban transformation.

This conceptual paper explores the critical relationship between organizational culture and entrepreneurial leadership, focusing on how fostering a culture of high achievement and innovation excellence empowers entrepreneurs to drive sustainable growth and competitive advantage. This research examines the most effective methods used by high-performing companies that foster an entrepreneurial culture by utilizing a conceptual framework grounded in qualitative research and backed by statistics from around the world, secondary sources and an extensive literature analysis. The findings highlight culture's pivotal role as a competitive advantage in entrepreneurial settings. Organizations that nurture high-performing and innovative cultures experience greater resilience, agility and financial success. Leadership with vision, psychological safety, purpose alignment, learning continuously and employee empowerment are essential components. Techniques like design thinking, agile structures and innovation labs accelerate organizational innovation. This study provides practical insights and frameworks for entrepreneurs and business leaders to build scalable, values-driven, innovation-oriented environments. The implications extend to HR practitioners, startup incubators and policymakers fostering entrepreneurial ecosystems. Through the strategic prioritization of culture, entrepreneurs may propel expansion and prosperity. Future study avenues are suggested in the paper's conclusion, including mixed-method techniques or longitudinal case studies for empirical validation. This study contributes to the understanding of organizational culture's impact on entrepreneurial leadership, offering actionable recommendations for building high-achieving and innovative cultures.

This study, titled “Design Thinking: Its Concept, Stages, Tools, and Role in Learning Experience Design,” explores Design Thinking as an innovative framework for addressing complex educational challenges and enhancing learning environments in alignment with Saudi Vision 2030. It examines the concept and five key stages of Design Thinking (empathize, define, ideate, prototype, and test) and highlights its role in Learning Experience Design (LXD). Using a descriptive-analytical approach based on a review of relevant literature and frameworks, the study found that Design Thinking promotes a learner-centered approach by prioritizing empathy and effectively develops 21st-century skills such as creativity, collaboration, and problem -solving. The findings also indicate that integrating Design Thinking with LXD supports the development of flexible, iterative learning models that improve learner engagement and outcomes. The study recommends training educators in Design Thinking tools and fostering an institutional culture of innovation.

Universities serve as pivotal institutions for knowledge creation, innovation, and national development, with research productivity increasingly recognised as a key indicator of academic excellence. In Nigerian private universities, research output among academic staff remains a concern due to structural challenges such as limited funding, heavy teaching loads, and inadequate research infrastructure. Beyond these constraints, organisational culture has emerged as a critical factor influencing research engagement, motivation, and scholarly performance. This study examines the relationship between organisational culture and research productivity of academic staff in Nigerian private universities. Employing a conceptual review research design, the study analyses secondary data from peer-reviewed journal articles, scholarly books, conference proceedings, and institutional reports. A structured thematic content analysis was used to identify key dimensions of organisational culture—including innovation, risk-taking, collaboration, outcome orientation, and institutional stability—and their influence on research productivity. The findings indicate that supportive, flexible, and innovation-oriented cultures foster higher research output, while rigid, bureaucratic, or excessively competitive cultures may limit scholarly engagement. The study also highlights that research productivity is a multi-dimensional construct, encompassing not only publications but also teaching effectiveness and community service, all of which are moderated by organisational culture in conjunction with structural and contextual factors. The research concludes that aligning organisational culture with institutional support, adequate resources, and workload management is essential to enhance academic productivity. The study contributes to the literature by providing a comprehensive framework linking organisational culture to research performance in Nigerian private universities, offering practical insights for policymakers and administrators to foster a research-oriented institutional environment

Context: The relationship which firms and schools establish around compulsory student internships is a key aspect of the Spanish vocational education system. The introduction of extended student internships (the so-called "dual Vocational Education and Training" or "dual VET") in recent years has received considerable attention. Whereas some authors have pointed out at positive results in terms of academic results and employability, others indicate that important challenges remain regarding formalisation of the in-company curriculum and diversity of student internship experiences. Most of recent studies look at education agents, and there is a need of further evidence coming from the firms. In particular, limited attention has been paid so far at the comparison between standard and extended ("dual") internship experiences. Approach: A survey-based quantitative study has been carried out with a sample of 254 industrial Small and Medium-sized Enterprises (SMEs) from the Basque Country (Northern Spain). The questionnaire looks at different aspects of the relationships which firms and schools develop around student internships, as experienced by the companies: Motives for receiving students, implementation of the internships, and outcomes. Special attention is paid to the impact of dual VET on firm-school relationships. Results: The evidence gathered shows that firms and schools have developed rich, reciprocal relationships around student internships (both standard and dual). Firms having experience of dual VET have a more intense relationship with schools in aspects such as training in competencies needed by the firm, selection and supervision of students, frequency and depth of communication with the school tutor, organisational width of the intern student experience, use of the training contract, better knowledge of the school curriculum, and hiring the student after graduation. However, other variables, related to the innovative culture of the firm, exert also a wide influence on the relationship in aspects like student selection and integration in the firm, long-term view of training (affecting all employees in the organisation), participation in intern student evaluation, formalisation of student training plans and contribution to the quality of the school curriculum. Conclusion: The key message emerging from the study is that dual VET has an effect on the intensity of firm-school relationships, but that it does not alter radically the character of the relationship which had been established before, based on standard student internships. Along with the dual experience, the innovative culture of the firm also has an important effect on the relationships.

The inclusion of digital technology in the teaching and learning process of Spanish as a Foreign Language is presented as the beginning of a deeper transformation process that should take into account the environment and social inequalities in order to continue reinventing itself and fulfilling its mission of preparing future generations for an uncertain and changing world. To succeed in digitization in rural areas, the main stakeholders in the teaching and learning of Spanish as a Foreign Language, in collaboration with the authorities, should develop transformation models and methodologies adapted to the rural environment and realities. A policy should be implemented that specifically addresses the appropriate and timely digitization of the teaching and learning of Spanish as a Foreign Language. The objective of this work is to investigate the digitization of the teaching and learning of Spanish as a Foreign Language as a sociocultural experience, emphasizing the inequalities and disconnections in the appropriation of new information and communication technologies by the actors within digital inclusion. The mixed-methods research methodology employed in this study offers a design that incorporates both quantitative and qualitative data. Data was collected from two hundred students and twenty teachers using a survey technique. The results were analyzed and interpreted using figures and diagrams, yielding a 100% response rate. Based on these findings, it is essential to establish a culture of innovation, commitment, and resilience that integrates sociocultural elements from rural areas to ensure the success of digital transformation.

This research study investigates the associations among supplier relationships, outsourcing decisions, IT investment, and innovative behavior in the healthcare industry. All measurement items used in the survey are based on existing test instruments. Survey questionnaires were distributed to the administrators of skilled nursing facilities which receive Medicare and Medicaid reimbursements. A total of 243 usable surveys were analyzed. Structural EquationModeling (SEM) was implemented to test five hypotheses in order to determine the relationships among supplier relationships, outsourcing decisions, information technology investment, and innovative behavior at the firm level. Strong significant positive associations among supplier relationships, outsourcing decisions, IT investment, and innovative behavior are identified through statistical analysis. Specifically, strong supplier relationships (e.g. partnerships with pharmacies that share knowledge) are associated with outsourcing decisions and encourage employees to engage in innovative behaviors, such as exploring alternative solutions and encouraging IT investments in the facility. Finally, investments in IT-based solutions for operations issues can motivate employees to explore new technologies regarding how tasks are performed within a culture of innovation. This study offers ways for healthcare administrators to enhance performance by cultivating transparent supplier partnerships, strategically outsourcing non-core functions, investing in IT for increased adaptability, and fostering staff innovation. Together, these practices reduce costs, increase efficiency, and improve patient care, thereby offering a practical framework for sustainable supply chain management and competitive advantage in the healthcare industry.

The European Medicines Agency (EMA) played a crucial role in responding to the COVID-19 pandemic by implementing various innovations that facilitated the development and approval of vaccines and treatments. This article analyses some of those innovations on the agency’s operations through literature on innovation in the public sector using a literature review, publications on EU policy along with internal knowledge by the authors. The agency’s innovative approaches such as the establishment of the COVID-19 Emergency Task Force and the effective use of real-world evidence enabled the agency to provide rapid advice to developers and ensure the provision of scientific feedback to the authorities and the public during crisis. The changes implemented led to new legislation allowing long-term effects within the agency. The EMA has emerged from the COVID-19 pandemic strengthened by innovative approaches leading to new legislation enabling an expanded mandate of the agency. To sustain innovation at the EMA, the agency might have to consider a structured and comprehensive approach to innovation, including the importance of fostering an innovation culture within the organization.

ABSTRACT To adapt to a swiftly evolving and unpredictable world, business leaders have strengthened their strategic planning approaches by incorporating corporate foresight to support innovation. However, questions remain regarding how effectively organizations utilize foresight to enhance product innovativeness. Further research is needed to explore this relationship. This manuscript seeks to fill this gap by answering the following research question: How does corporate foresight relate to new product portfolio innovativeness (NPI)? To address this question, this study formulates a model that connects corporate foresight to NPI. It also examines the mediating role of innovation culture and the moderating effect of environmental uncertainty, operationalized as perceived long‐horizon state uncertainty (EU), as these interacting factors provide further insights into this relationship. This empirical investigation employs a cross‐sectional quantitative, explanatory and predictive approach with a non‐experimental design. The hypotheses are evaluated through a survey of 113 companies in Colombia's food and beverage sector. The field results are analyzed using partial least squares structural equation modeling (PLS‐SEM). The results indicate a significant and positive association between corporate foresight and NPI, with innovation culture serving as a complementary but modest mediator. Moreover, corporate foresight is strongly and positively associated with innovation culture. However, no evidence was found for a moderating effect of EU. This study provides empirical evidence from a field setting that foresight‐driven capabilities, such as environmental scanning and strategic selection, are associated not only with NPI but also with an organizational culture that is willing to innovate. The paper concludes by proposing future research directions.

The integration of local wisdom into product design is becoming increasingly important in the digital era, especially as cultural heritage faces the risk of marginalization due to globalization and rapid technological advancements. The purpose of this study is to examine how local wisdom can be preserved, transformed, and reinterpreted through the implementation of practices in product design supported by digital technology, positioning design as a medium for sustainability and cultural innovation. This study adopted a qualitative research approach, which used a literature review and comparative analysis of selected case studies in contemporary product design. Data were collected from academic journals, scientific books, and design documentation focusing on cultural heritage, digital design processes, and sustainable design practices. Digital technologies, such as digital modelling parametric design, and digital fabrication, enable the reinterpretation of local wisdom into contemporary design products without diminishing their symbolic meaning. The integration of cultural values in digitally driven design processes can enhance product identity and cultural relevance. Furthermore, products that incorporate local wisdom demonstrate strong potential for long-term differentiation and resilience of national culture in the global market. In conclusion, product design based on local wisdom can serve as a sustainable cultural heritage strategy in the digital age if supported by ethical design principles and a strong sense of national culture.

The article examines institutional constraints on the development of the knowledge economy at the regional level in the context of Ukraine’s wartime economy. Based on the institutional theory of D. North and O. Williamson, as well as the theory of regional innovation systems by B. Cooke, the types of institutional constraints are systematised by level (national, regional, micro) and type (formal, informal, organisational). A matrix of institutional constraints has been developed, which reflects the systemic, mutually reinforcing nature of the identified dysfunctions and allows identifying the «key» constraints with the greatest structural impact: weak protection of intellectual property rights, fragmentation of the national innovation system, and mistrust between actors in the innovation process. The specifics of institutional deformations caused by full-scale armed aggression have been revealed: destruction of scientific and educational infrastructure, outflow of human capital, breakdown of network links between actors of regional innovation systems, redistribution of public funding in favour of defence spending. The asymmetric nature of the regional consequences of military aggression is substantiated: frontline regions are characterised by the destruction of innovation infrastructure, while regions receiving displaced persons have received additional resources for knowledge development. The conception of «institutional resilience» of regional knowledge systems is proposed, covering three dimensions: absorptive, adaptive and transformative capacity. The need for a «recovery with trajectory change» approach instead of a simple return to the pre-war status quo is argued. Five priorities for institutional reform to restore and develop the regional knowledge economy are substantiated: reforming the protection and commercialisation of intellectual property; decentralising the management of the science and innovation system; programmes to attract the diaspora and return scientific personnel; new formats for interregional and cross-border scientific and educational cooperation; and the formation of a culture of innovation and entrepreneurship.