Abstract While rates of juvenile crime have declined over the past decade, public preoccupation with youth violence remains high, periodically fueling judicial and legislative “get-tough” policies and social movements. For most young people, criminal activity, if any, is mild, infrequent, peer-driven, and peaks in late adolescence and early adulthood, declining steadily thereafter. A small subset of persistently antisocial youths begin their criminal careers earlier, commit more frequent and more serious offenses, continue their offending throughout the life-course, and are characterized by a number of neurocognitive, personality, and diagnostic features. Individual, familial, and social forces all combine to influence juvenile criminal behavior, but another small subset of youths, with a characteristic cognitive and temperamental profile, appear to be staunchly resilient to the criminogenic influences around them. The success of intervention and treatment modalities for childhood antisocial behavior depends both on the type of subjects to which they are applied and the consistency and comprehensiveness with which they are implemented and carried out.