Abstract Introduction/Objective SARS-CoV-2, the causative agent for COVID-19 disease, has very recently developed an Omicron subvariant BA.2.12.1. The English literature is extremely sparse in discussing the clinical importance of BA.2.12.1 and in fact there are no reports for the unique veteran population which is different than the general population. Since the original Omicron variant, there has been multiple evolutionary branches. BA.2.12.1 specifically is the 12th sublineage to branch off from the second BA.2 branch from the original Omicron and is clade 22C. BA.2.12.1 has been described as having increased transmissibility compared to other subvariants of Omicron and even resistance to neutralization by antibodies elicited by a prior Omicron infection with a different subvariant, thus leading to a significant potential for reinfection. BA.2.12.1 is currently responsible for an increasing number of cases in the North American continent. This study was undertaken to explore the sequencing associated with the COVID-19 disease outbreak at a Veteran Affairs Community Living Center (CLC). Methods/Case Report Samples were sent for the sequencing for patients affected during an outbreak of COVID-19 at a CLC from May to June 2022. All samples had a cycle threshold or number below 30 by reverse transcriptase polymerase chain reaction, which was required for the sequencing analysis. The sequencing results and prior immunity history was obtained. Results (if a Case Study enter NA) A total of 9 CLC patient specimens were sent for sequencing. Of these 9, 7 had sequencing results and in the remaining 2, no sequencing results could be obtained due to lack of amplification. 6 of these 7 demonstrated Pango Lineage BA.2.12.1 or clade 22C. Only 1 of the 7 patients had a different subvariant (BA.2.9, clade 21L). Interestingly, all seven patients had either been previously vaccinated with a 3rd booster shot (6 of 7) or previously infected with COVID-19 without vaccination (1 of 7), indicating the ability of the two detected subvariants to cause breakthrough reinfection despite prior vaccination or infection earlier in the pandemic. Conclusion The only recently described BA.2.12.1 has resistance to neutralization by antibodies produced by a prior infection or vaccination, leading to reinfection. This lineage was detected in nearly all cases of COVID-19 outbreak within a veteran nursing home CLC despite the presence of prior immunity.