Introduction. Cough is the most common symptom for consultation with a family doctor in many European countries. Its persistence for a long time affects the patient’s quality of life. Case report. We present the case of a 13-year-old adolescent hospitalized for frequent, emitting, all day long, spastic cough started 7 months earlier and who did not recover from antibiotic and symptomatic treatment. The clinical examination of the respiratory tract was within normal limits. Asthma, the most common cause of chronic cough in adolescents, was ruled out by spirometry and evaluation of athopy. Posteronasal drops have been also ruled out by ENT examination, and bronchoscopy and the determination of Quantiferon TB allowed the refutation of a pulmonary tuberculosis, but also of foreign body aspiration. Upper digestive endoscopy confirmed the presence of minimal gastroesophageal reflux and identified a polypoid formation with a broad base of implantation in the cardia, later confirmed by thoracoabdominal CT and esogastric barium transit. Under treatment with a proton pump inhibitor, the evolution was favorable, with the remission of the polyp and of cough exacerbations. Conclusions. Chronic cough may be the single manifestation of gastroesophageal reflux potentiated by an inflammatory formation in the cardia.