Cosmetic Effect Research Articles

Whole-Course Intraperitoneal Robot-Assisted Choledochal Cyst Excision with a Hidden Incision in Children Under 1 Year Old.

Background: Whole-course intraperitoneal robot-assisted choledochal cyst resection in children under 1 year of age is controversial due to its technical challenges. Current Pfannenstiel incision is widely used in adults for its cosmetic effects but is rarely used in children. Materials and Methods: We conducted a prospective, single-center study to assess the feasibility, safety, and cosmesis of whole-course intraperitoneal robot-assisted choledochal cyst resection with Pfannenstiel incision in children under 1 year of age. Results: Ten patients were treated with our surgical protocol, and there was no conversion to laparotomy. The average total operation time was 223 minutes. The average duration of anesthesia was 260.2 minutes. The average docking time between the robot arm and Trocar was 17.5 minutes. The average intraoperative blood loss was 16 mL. No postoperative complications occurred in the 10 patients. The mean time to start drinking water after surgery was 2.4 days. The mean postoperative drainage tube removal time was 2.6 days. The average length of stay was 8.5 days. The scar assessment scale total scores of the 2 observers were (6.8 ± 1.23) and (7.4 ± 1.84), respectively. For every patient, there are only four abdominal surgery scars of which 75% of scars were hidden by underpants and 25% of scars were not covered. Conclusion: It is feasible and safe to perform whole-courses intraperitoneal robot-assisted choledochal cyst resection with Pfannenstiel incision in children under 1 year old. It also has a hidden incision effect and is worthy of promotion.

Encapsulation of Leptadenia pyrotechnica (Khip) Extract in Carbomer Based Emulgel for Its Enhanced Antioxidant Effects and Its In Vitro Evaluation.

The use of natural products in skin care has been valued for their tremendous therapeutic benefits since ancient times. The current study was aimed at exploring the Leptadenia pyrotechnica plant extract and development of a stable emulgel loaded with the same extract to assess its cosmeceutical potentials. A stable emulgel loaded with methanolic plant extract along with its control gel was prepared by homogenization. The antioxidant potential of extracts prepared in different solvents (methanol MLP, ethanol ELP, n-hexane nLP, ethyl acetate EALP, and petroleum ether PLP) was determined by DPPH scavenging activity. The presence of phytochemicals was confirmed by total phenolic and flavonoid content analysis (TPC/TFC). HPLC was used for quantification of bioactive components. FTIR analysis was performed for confirmation of functional groups. SPF was calculated via spectroscopic analysis for extract, control gel, and extract loaded emulgel. Stability studies included physical evaluation, pH, conductivity, spreadability, and rheological testing of both control and test emulgels at different temperatures, i.e., 8 °C ± 1, 25 °C ± 1, 40 °C ± 1, 40 °C ± 1 with RH of 75% for a period of 90 days. DPPH radical scavenging activity showed the highest antioxidant activity of 85.5% ± 2.78 for MLP. TPC and TFC were also found to be highest for the methanolic fraction, i.e., 190.98 ± 0.40 mgGAE/g and 128.28 ± 2.64 mgQE/g, respectively. The SPF of methanolic extract, placebo gel, and LPEG was 13.43 ± 0.46, 2.37 ± 0.33, and 7.28 ± 0.56, respectively. HPLC assay confirmed the presence of catechin, vanillic acid, caffeic acid, and sinapinic acid. Rheological analysis showed that formulation has pseudo-plastic flow behavior. Other stability tests also revealed that prepared emulgel is a stable one. A stable emulgel loaded with Leptadenia pyrotechnica plant extract was successfully prepared and characterized for its cosmetic effects.

ՄԱԿՐՈՍԿՈՊԻԿ ՍՆԿԵՐԻ ԿԻՐԱՌՄԱՆ ՀԵՌԱՆԿԱՐՆԵՐԸ ԿՈՍՄԵՏՈԼՈԳԻԱՅՈՒՄ/PERSPECTIVES OF USAGE OF MACROFUNGI IN COSMETOLOGY

Macroscopic fungi, or macromycetes, which belong to the phylum Basidiomycota (class Agaricomycetes) and phylum Ascomycota (class Pezizomycetes), are well-known for their high nutritional value and pharmacological properties. Mycelium and fruiting bodies of wild and cultivated edible and medicinal mushrooms, as natural source of bioactive compounds (β-glucans, terpenoids, phenolics, alkaloids, thiamine, riboflavin, niacin, proteins, melanin, selenium, etc.) with medicinal and cosmetic effects (antiinflammatory, immunomodulatory, antimicrobial, antioxidant, anti-radiation, regenerating, moisturizing, nourishing, etc.) are widely used to develop various biotech products. Presently, edible and medicinal mushrooms from different taxonomic and ecological groups are of great interest in the production of anti-aging cosmetic products. Currently, 19 species of mushrooms , as potential source of cosmetic bioingredients were identified in the territory of Armenia. The study of mushroom resources, the creation and storage of pure cultures of mushroom collections open up wide opportunities for their biotechnological cultivation and the development of mycocosmetology in Armenia.

Botulinium toxin applications in the lower face and neck: A comprehensive review.

Botulinum toxin has been widely and mainly used for the treatment of conditions affecting the upper and middle face; however, recent efforts have expanded the indications of botulinum toxin injection to the lower face and neck areas for cosmetic and medical purposes. We have reviewed the latest updates on using botulinum toxin in the lower face and neck focusing on cosmetic purposes and have discussed the existing concerns as well as the adverse sequelae of these newer indications. A comprehensive literature search was performed using the following keywords [[botulinum] AND [[Toxin] OR [Neurotoxin]]] AND [[Lower AND Face] AND/OR [Neck]] within the main databases including Web of Science, PubMed, Embase and gray literature on and before February 2023. The data were screened using titles and abstracts and those relevant to the topic were included in the paper. Botulinum toxin injection has considerable cosmetic and therapeutic effect on facial contouring, masseteric hypertrophy, lower face and neck scars, gummy smile, drooping lip corner and even skin rejuvenation. BNT injection has been widely used for the treatment of different medical and cosmetic purposes. Low rates of side effects, which were self-limited in most cases, have been reported in the literature, making BNT a safe therapeutic medication in most cases. However, regulatory status needs to be updated and more accurately revised in many countries and more comprehensive research is required to address the existing gaps in this area including the site, dosage, and method of injection in each case.

Application of retroauricular sulcus incision in the operation of benign tumors in the deep lobe of parotid gland

Objective: To investigate the application of retroauricular groove incision in the resection of benign tumors in the deep lobe of parotid. Methods: From January 2017 to January 2022, 19 patients (11 males and 8 females, age ranged from 17 to 69 years, with a median age of 48) with benign tumor in the deep lobe of parotid gland underwent parotidectomy through retroauricular sulcus incision in Linyi People's Hospital. Among them, 17 cases with tumor diameter≤4.0 cm underwent simple retroauricular groove incision, and 2 cases were dumbbell type with tumor diameter>4.0 cm on the medial side of mandible protruding into the parapharyngeal space, in which the deep lobe and tumor of parotid gland were resected through retroauricular sulcus incision combined with intraoral incision. Results: Tumors were completely removed through retroauricular sulcus incision in 17 cases, and dumbbell type tumors were removed through retroauricular sulcus incision combined with intraoral incision in 2 cases. Postoperative pathological examinations showed pleomorphic adenoma in 13 cases, basal cell adenoma in 4 cases and Warthin's tumor in 2 cases. Temporary mandibular marginal branch paralysis occurred in 2 patients and returned to normal 3 weeks after operation. All incisions healed in Phase I. By following-up of 1-5 years with a median follow-up time of 3.1 years, none of the patients had Frey syndrome, salivary fistula, other complications and tumor recurrence. The patients and their families were satisfied with the postoperative facial appearances. Conclusion: The retroauricular groove approach can not only preserve the function of parotid superficial lobe and facial nerve, but also has less trauma, less tissue defect and hidden scar. As the advantages of less complication, low recurrence rate and good cosmetic effect, the incision is worthy of clinical application.

1629. Acceptability and Trust in the Low-dose Intradermal Mpox Vaccine: a Knowledge, Attitudes and Practices Sub-analysis of the Observational Study of Mpox Immunity (OSMI) in NYC

Abstract Background In the 2022 Mpox outbreak, the US FDA issued an EUA for a low-dose intradermal (ID) vaccination regimen to increase vaccine supply by five-fold. The ID regimen had yet to be evaluated for immunogenicity or tolerability in persons with HIV or for general acceptability. Methods We conducted a Knowledge, Attitudes and Practices survey to evaluate ID Mpox vaccine acceptability, comparing responses between participants with and without HIV and by route received. Results Of 119 ethnically and racially diverse respondents, 83% identified as male, 91% as LGBTQ+, median age was 38 years. 26% had HIV. 21% received ID/ID, 57% mixed subcutaneous (SC)/ID or ID/SC, and 18% SC/SC regimens. Vaccination route was similarly distributed across age, race, ethnicity, educational status, household income and HIV status. Knowledge of Mpox vaccines was moderate, with a mean of 4.36 of 7 responses correct. 62% were satisfied with Mpox vaccine rollout and 20% were neutral. 77% agreed that they trusted information received about the Mpox ID route by healthcare providers. Respondents with HIV were less likely to fully support the policy change to the ID route to stretch vaccine supply (Mann-Whitney p=0.039), but otherwise there were no significant differences between respondents with and without HIV in satisfaction with Mpox vaccine rollout, trust in vaccine-related information, confidence about ID regimen’s safety, efficacy, concern about cosmetic side effects, or overall acceptability. There were no significant differences between respondents by vaccination regimen in satisfaction with vaccine rollout, approval of the change toward ID formulation, concern about cosmetic side effects or overall acceptability. Compared to those who received mixed or ID/ID dosing regimens, SC/SC participants exhibited less confidence in efficacy of the ID formulation (Kruskal-Wallis p=0.015) and lower trust in information received by the US government about the ID formulation (p=0.01). Overall, 88% scored their Mpox vaccination experience as “excellent or very good,” and there was no difference between groups. Conclusion Survey responses from this clinical study sample suggest high acceptability of the ID regimen for Mpox vaccination in all groups, including among people with HIV and those who had received this regimen. Disclosures Ellie Carmody, MD, MPH, AstraZeneca: Stocks/Bonds|Merck: Stocks/Bonds Lalitha Parameswaran, MD, Pfizer: Grant/Research Support Mark J. Mulligan, M.D., Lilly: Grant/Research Support|Meissa Vaccines, Inc.: Advisor/Consultant|Meissa Vaccines, Inc.: Board Member|Merck: Advisor/Consultant|Merck: Board Member|Pfizer: Advisor/Consultant|Pfizer: Board Member|Pfizer: Grant/Research Support|Sanofi: Grant/Research Support

Endoscopic thyroidectomy via areola approach for stage T1 papillary thyroid carcinoma: feasibility, safety, and oncologic outcomes.

To evaluate the feasibility, safety, and oncologic outcomes associated with endoscopic thyroidectomy via the areolar approach (ETAA), compared with conventional open thyroidectomy (COT) for the treatment of stage T1 papillary thyroid carcinoma (PTC). Between January 2021 and June 2022, a total of 1204 patients diagnosed with PTC underwent screening, out of which 138 patients were selected for inclusion in the study population after propensity score matching (92 patients in the ETAA group and 46 patients in the COT group). The study included the collection and analysis of clinicopathologic characteristics, intraoperative outcomes, postoperative outcomes, complications, and follow-up data using R software. The operative time for the ETAA group was longer than that for the COT group (160.42 ± 32.21 min vs. 121.93 ± 29.78 min, p < 0.0001). However, there were no significant differences between the two groups in terms of intraoperative blood loss, the extent of surgical resection, the number of dissected lymph nodes, the number of metastatic lymph nodes, and the rate of parathyroid autotransplantation. Postoperative drainage and C-reactive protein levels were higher in the ETAA group than in the COT group, but there were no significant differences in 24-hour visual analogue scale scores, white blood cell counts, drainage duration, or postoperative hospital stay. Complication rates were similar between the two groups, and no permanent recurrent laryngeal nerve palsy or hypoparathyroidism was observed. Patients who underwent ETAA reported greater cosmetic satisfaction and quality of life than those who underwent COT. During the follow-up phase, only one patient in the COT group developed lateral cervical lymph node involvement requiring reoperation. ETAA is a safe and feasible surgical method for patients with stage T1 PTC, providing results similar to COT in terms of oncologic completeness, while avoiding neck scars, with excellent cosmetic effects. Chinese Clinical Trial Registry center, identifier ChiCTR2300077109.

INTRA- AND EARLY POSTOPERATIVE RESULTS OF BIOPSY OF SIGNAL LYMPH NODE UNDER CONTROL OF ICG MAPPING IN PATIENTS WITH ENDOMETRIAL CANCER OF INITIAL STAGES

Biopsy of sentinel lymph nodes (SNL) with the use of indocyanine green (ICG) as an indicator is becoming a standard method for evaluating the lymphatic reservoir in endometrial cancer in patients in the early stages.&#x0D; The purpose of the study. To conduct a comparative assessment of іntra- and early postoperative results in patients with endometrial cancer of initial stages when performing systemic lymphadenectomy and ICG mapping for the detection of SLNs.&#x0D; Materials and methods. The study included 98 patients (2017-2022) with morphologically verified endometrial cancer with low and mediumintermediate risks of metastasis. Removal of lymph nodes was carried out in two ways: 1)systemic lymphadenectomy (group 1); 2) ICG mapping for detection of SLN in the pelvic area (group 2).&#x0D; Results. The time of the operation for 1 group is longer - (63.7 ± 14.8) min. than for the second - (36.4 ± 8.9) min. In group 1, intraoperative lesions of the obturator nerve were detected in 2 patients (4.5%), postoperative complications also were observed: lymphocysts 3 (7.5%), lymphostasis 2 (5.5%), prolonged lymphorrhea 4 (9.5%) and. There were no complications in group 2. In both groups, there were no bleedings and intraoperative injuries of the pelvic organs. In group 1, the average number of extracted LVs was 8.5±2 on each side; positive LNs were found in 3 (8%) patients, the remaining 38 (92%) were negative. Identification of the localization of LN was not carried out; since their evacuation from the abdominal cavity was carried out in a single block - 32 (80%), in 8 (20%) - fragmentary (which still does not allow identification of the position of the LN). No metastases were detected in group 2; in 40 (70 %) patients, SLN was detected on both sides, 11 (20 %) - on one side, and 6 (10 %) - not detected. In these 10% of patients, systemic lymph node dissection was performed. The most common localizations of LN are the external iliac vessels and the obturator area on both sides.&#x0D; Conclusions. SLN biopsy should be used more often in early-stage endometrial cancer. The SLN technique can be used in patients with low and intermediate risk of lymphatic metastases to reduce the frequency of complications associated with systemic lymph node dissection. This technique can be used for patients with a higher risk of metastasis (in particular, average and high-average) in the presence of concomitant comorbid pathology. Its advantages are: reducing the trauma of the procedure, surgical comorbidity (lymphorrhea, lymphocysts, vascular and nerve injury), reducing the time of surgical intervention (which reduces the risk of infectious complications), reduction of blood loss, shortening of hospitalization, faster recovery, improvement of cosmetic effect and equivalence of oncological results.

Skin-Whitening Effect of a Callus Extract of Nelumbo nucifera Isolate Haman

The sacred lotus (Nelumbo nucifera Gaertn. Isolate Haman, in the family Nelumbonaceae) used in this study originated from the Haman region of Korea, and lotus seeds dating back to the Goryeo Dynasty (650–760 years ago) were accidentally discovered. Lotus is known to possess antioxidant, anti-inflammatory, and soothing properties. Instead of using the lotus alone, we obtained extracts using Haman region lotus-derived callus (HLC), which allowed for a controlled, quantitative, and infinite supply. Based on the reported effects of the lotus, we formulated a hypothesis to investigate the skin-whitening effect of the HLC extract (HLCE). The HLCE was first obtained by extraction with distilled water and using 5% propanediol as a solvent and subsequently verified for the whitening effect (melanin content tests) using mammalian cells in vitro. Its efficacy at the molecular level was confirmed through real-time polymerase chain reaction (PCR) using melanin-related genes. Furthermore, clinical trials with 21 volunteers confirmed the significant whitening effect of cosmetics containing the HLCE. In conclusion, we found that the HLCE not only has anti-inflammatory, antioxidant, and skin-soothing properties but also plays an essential role in skin whitening. Therefore, we propose that the HLCE has the potential to become a new raw material for the cosmetic industry.

Impact of a novel sugarcane straw extract-based ingredient on skin microbiota via a new preclinical in vitro model

During cosmetic product development, the impact on the skin microbiota needs to be evaluated, as it plays an important role in skin health. Clinical studies are frequently used to assess cosmetic effects, but are expensive, time-consuming and require finished ingredients, which may be a limiting factor. Thus, this study had two main objectives, the development of a preclinical in vitro model for the evaluation of the effect of cosmetic ingredients on the skin microbiota, and its use to evaluate a novel sugarcane straw extract-based ingredient. In the development of the preclinical in vitro model, the microbiota incubation time and atmospheric conditions were optimized. The model was validated using a benchmark ingredient with reported in vivo effects on skin microbiota. Then, the new sugarcane straw extract-based ingredient was tested in the model, using skin microbiota samples from 12 healthy female volunteers. The impact on microbial groups was analyzed using qPCR and next-generation sequencing. The best conditions for the in vitro model were 24 h incubation under aerobic conditions. Furthermore, the results obtained with the benchmark ingredient agreed with those obtained in vivo, thus validating our model. Sugarcane straw extract-based ingredient was found to have no effect on community α-diversity, however it appears to affect S. epidermidis. In conclusion, the developed model can be used as a tool to assess the impact of novel cosmetic ingredients on skin microbiota. Also, the novel ingredient seems to have an impact on commensal S. epidermidis.

A new Chinese crow’s feet grading scale based on the DermaTOP system

Many Chinese wrinkle studies continue to use non-Chinese scales because few Chinese-based wrinkle scales have been developed. The study aims to develop a crow’s feet grading scale for Chinese individuals. We enrolled 608 healthy Chinese subjects and measured data through the DermaTOP system. We chose exploratory factor analysis (EFA) to reduce the dimensions of the data. A three-factor structure was obtained by using EFA, and it explained a cumulative total of 89.551% of the variance. A computational formula was obtained by calculating the total factor tilt scores and taking the variance contribution rate of three factors as the weight. Based on the computational formula, a grading map was designed and tested. The model validation was conducted using both subjective assessments from the expert panel and objective results from the model calculations. The results showed that our grading scale model is stable. This study developed a Chinese crow’s feet (CCF) grading scale, which included a parameter, a grading map, and literal descriptions. The CCF grading scale is a validated tool for evaluating the effects of cosmetics or specific therapies. More importantly, the CCF scale was developed based on objective data, which may inspire new ideas for wrinkle grading scale development in the future.

Protective effect of the brown seaweed Padina boryana against UVB-induced photoaging in vitro in skin cells and in vivo in zebrafish

The ethanol extract of Padina boryana (PB-EtOH) containing phlorotannin effectively inhibits oxidative stress and melanin synthesis, suggesting the potential use of PB-EtOH in the cosmetics industry. To further investigate the cosmetic effects of PB-EtOH, its photoprotective effects against ultraviolet (UV) irradiation was investigated. The results displayed that PB-EtOH remarkably improved cell viability by suppressing the apoptosis via cleaning the intracellular reactive oxygen species (ROS) in UVB-exposed human keratinocytes. In addition, PB-EtOH effectively suppressed oxidative stress, increased collagen synthesis, and reduced the matrix metalloproteinase production in UVB-exposed human dermal fibroblasts in a concentration-dependent manner. Furthermore, the in vivo anti-photoaging effect was determined using the zebrafish model. The results displayed that PB-EtOH remarkably attenuated UVB-stimulated photodamage. The photoprotective effect was displays in reducing the levels of ROS, nitric oxide, lipid peroxidation, and cell death. These results demonstrate that PB-EtOH possesses anti-photoaging effects and suggest that PB-EtOH may be an ideal ingredient to develop a skincare product in the cosmetic industry.

Introduction of Stereotactic Vacuum-Assisted Breast Biopsy in Bulgaria

Summary Breast cancer is the most common cancer in women worldwide. The gold standard for biopsy is core needle biopsy. However, in certain cases, core needle biopsy cannot be applied, and the method of choice is vacuum-assisted biopsy. It is a minimally traumatic and precise method for diagnosing microcalcifications and small breast lesions. We aimed to present the initial experience with stereotactic vacuum-assisted biopsy in breast diseases at the Department of Surgical Oncology. We show indications and contraindications for this kind of biopsy and present our initial experience. From February 2020 to December 2022, 29 stereotactic vacuum-assisted biopsies were performed. Benign histology was found in 9 cases, malignant – in 15, and 5 cases were precancerous. Therefore, being an innovative, minimally invasive, and highly accurate method for diagnosing breast lesions with a good cosmetic effect, it allows early diagnosis of breast cancer, and, last but not least, the procedure can be curative for benign lesions.

A survey study on adverse effects of synthetic cosmetics

Background: Cosmetics are substances used to enhance the appearance or odour of the human body. The use of cosmetics in the present era has enormously increased and the chemicals present in them quite frequently cause adverse reactions like contact dermatitis, allergic reaction and so on. Therefore, a survey study was planned to evaluate awareness and knowledge about adverse effects of synthetic cosmetics among inmates of SDM Institute of Ayurveda and Hospital Bangalore. Methods: Descriptive survey study with self-administered questionnaire method sent to 500 participants selected randomly emailed through self-generated Google form. Results: Among 500 inmates of age between 18-50years, 427 (85.4%) responded as cosmetics are used for beautification, 454 (90.8%) inmates believe there will be long-term side effects by continuous use of synthetic cosmetics. 352 (70.4%) inmates are aware of harmful ingredients used in cosmetics. Conclusions: Majority of inmates have knowledge about adverse effects of cosmetics and are giving preference to herbal cosmetics. Inmates are even aware of hazardous toxic contents of cosmetics. The adverse effects caused by the cosmetics can be correlated to the toxicity signs and symptoms caused by of gara visha/artificial poisons and dushi visha/cumulative toxicity explained in ayurveda. The study forms the basis for future studies where in management of adverse effects of cosmetics could be tried in line of Garavisha and Dushivisha chikitsa.

Heminephrectomy in the pediatric population – single-center comparison of the open versus transperitoneal laparoscopic approach

IntroductionHeminephrectomy is considered the method of choice in the treatment of symptomatic or poorly working moiety of a duplex kidney as well as in oncology.AimThe study aims to retrospectively analyze the laparoscopic approach to heminephrectomy (LHN) in comparison with the open approach (OHN).Material and methodsFrom 2011 to 2020, 28 heminephrectomies were performed in the Clinical Ward of Pediatric Surgery and Urology of the Regional Specialized Children’s Hospital in Olsztyn: 10 with the laparoscopic transperitoneal method (LHN), and 18 with the open method (OHN). The mean age was 37.4 months (1–197 months). In total, 20 patients were female, and 8 were male. Loss of function of the moiety was a prerequisite for surgery. Hydronephrosis, dysplasia of the moiety, and vesicoureteral reflux were the most prevalent in both groups. Data regarding patients were collected based on available medical documentation and retrospectively analyzed.Results and discussionThere was no significant difference between the LHN and OHN groups regarding mean operating time (157 vs 128 minutes; &lt;i&gt;P&lt;/i&gt; = 0.226) and mean postoperative hospital stay (5.20 vs 6.53; &lt;i&gt;P&lt;/i&gt; = 0.64). The refeeding time is comparable and not statistically significant (1.90 vs 1.83 days; &lt;i&gt;P&lt;/i&gt; = 0.555). Postoperative analgesic intake was found to be significantly lower (10.4 vs 17.5 doses, &lt;i&gt;P&lt;/i&gt; = 0.004).ConclusionsBoth open and laparoscopic approaches are safe and feasible in the pediatric population. Both are comparable in operative time, hospital stay and refeeding time. LHN displays a better cosmetic effect and requires significantly lesser analgesic use.

The Influence of Clinical Factors on Treatment Outcome and a Recurrence of Surgically Removed Protruded Subungual Osteochondroma and Subungual Exostosis.

Subungual exostosis (SE) and subungual osteochondroma (SO) are benign solitary lesions that grow from the distal phalanx. The mass itself is typically painless, but pressure on the nail plate can result in pain and deformity of the involved digit. Tumors can be correctly diagnosed based on clinical, histological and radiographic appearance alone. Surgical resection of SE/SO is typically curative, with a small risk of recurrence. The study was retrospective and observational, involving 74 patients with subungual SE/SO. The surgical procedure consisted of the removal of the tumor from the dorsal approach under digital anesthesia. The procedure was assessed using a questionnaire and photo documentation after a minimum of 6 months after surgery. A total of 85% of respondents were satisfied with the procedure. Nearly 80% of patients rated the cosmetic effect as good or very good. Young age and pain intensity after surgery showed statistically significant associations with worse satisfaction. Age < 18 was associated with recurrence. Worse satisfaction is strongly associated with recurrence. Gender, duration of symptoms, pain before surgery and tumor size and destruction of the nail plate had no significant effect on recurrence. The technique using burr appeared to be a more effective treatment.

Limitations of ALA-PDT as a reliable therapy for AK in clinical practice

BackgroundNumerous clinical studies have demonstrated the effectiveness of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) in treating actinic keratosis (AK). This therapy has achieved an average lesion clearance rate of approximately 80 % and has also shown to produce satisfactory cosmetic outcomes. However, in our clinical practice, the utilization and adherence to ALA-PDT treatment among AK patients has been lower than anticipated, possibly due to various factors. ObjectiveThe objectives of this study are twofold: (1) To analyze the actual therapeutic effects of ALA-PDT treatment on AK lesions in clinical practice; and (2) To identify the factors that hinder acceptance of ALA-PDT therapy among AK patients with large area or multiple lesions situated on the head and face. MethodThis study included a group of 20 AK patients, comprising 15 females and 5 males, with an age range of 57–87 years. All patients received a complete course of ALA-PDT therapy, consisting of 3–6 treatments. The study analyzed various factors, including the cure rate, recurrence rate, cosmetic effects, and adverse reactions following treatment. To investigate the factors affecting the acceptance of ALA-PDT treatment among AK patients with large or multiple lesions on the head and face, we also examined a separate group of 43 AK patients. This group included individuals who either had incomplete courses of ALA-PDT treatment or declined the therapy for the first time. The factors potentially influencing patients’ acceptance of PDT were analyzed based on the outcomes of these investigations. ResultAmong the 20 patients who completed the full course of ALA-PDT treatment, the cure rate was 95 % (19/20). The recurrence rates at 1 month, 3 months, and 6 months were 0 %, 5 %, and 10 %, respectively. Out of the 19 cured patients, only 2 experienced heavy pigmentation, and no scarring was reported 1–3 months post-treatment. Based on the survey of 43 patients who either had an incomplete course of ALA-PDT treatment or declined the therapy initially, several factors were identified as limiting their choice of PDT therapy. These factors include: (1) Intolerable adverse effects of treatment. (2) Higher treatment cost than expected. (3) Inconvenient transportation. (4) Coexistence of other senile diseases. (5) Unsatisfactory clinical efficacy observed. (6) Inadequate understanding of AK. (7) Lost to follow-up. ConclusionThe study concludes that ALA-PDT is a beneficial and aesthetically pleasing treatment for AK patients, particularly those with extensive or multiple lesions on the head and face. However, various factors can impede the selection of ALA-PDT therapy, potentially depriving patients of the most suitable option. The study aims to assist dermatologists and AK patients in considering treatment plans and exploring alternative options. Overall, the findings of this study may provide valuable guidance for improving treatment outcomes and patient satisfaction.

Эффективность радиоволновой хирургии доброкачественных новообразований век

Purpose. To evaluate the effectiveness of radiowave method for the treatment of benign neoplasms of the eyelids. Methods. The study involved 87 patients with various pathologies (operated in 2 ways): chalazions, xanthelasma, papillomas, non -pigmented nevis, atheromas, retention cysts of the eyelids. The diagnoses were confirmed by clinical and laboratory research methods (cytological and histological examination). In both groups of patients clinical effect of the treatment, healing time of the wound surface and the cosmetic results of classical surgical and radio wave treatment (“Surgitron”) were evaluated. Results.Radiosurgical method, in contrast to the classic surgical method, showed low traumatism, high cosmetic results in 100 % of cases, healing occurred by primary intention and no recurrence of the pathology was observed in any case. Conclusion.The use of radio wave method had demonstrated high efficiency, safety and good cosmetic effect in the treatment of benign neoplasms of the eyelids. Key words: eyelid neoplasm; radiowave surgery; cosmetic results.

Single-port robotic surgery using the EDGE SP1000 surgical system in gynaecology: Initial experience of a single institution.

The EDGE SP1000 is a newly developed single-port (SP) robotic surgical system whose clinical evaluation in gynaecology has not yet been addressed. This is a single-arm clinical trial evaluating the perioperative outcomes of patients receiving EDGE SP1000 assisted surgeries. Patients with either benign or malignant gynaecological diseases suitable for robotic surgery were included, and their data were prospectively collected. Eighteen patients were included and 8 of them had malignant conditions. The total operative time was 190.1±83.3min for benign diseases and 254.4±59.4min for malignant diseases. The mean estimated blood loss was 25mL (range, 5-100). No assistant ports or conversions were required. No perioperative complications occurred. Overall satisfaction with the umbilical wounds was expressed at the 1-month follow-up. EDGE SP1000 SP robotic surgical system is technically feasible and safe in various gynaecological surgeries with good cosmetic effects.

Clinical effect of Lymph Node Dissection in the Lateral Neck for the treatment of Papillary Thyroid Carcinoma: Endoscopic Thyroidectomy versus Open Surgery.

To compare the clinical effect, safety, and cosmetic effect of lymph node dissection via endoscopic thyroidectomy and open surgery in the treatment of papillary thyroid carcinoma (PTC). A retrospective analysis was performed on 86 patients with PTC admitted to Baoding No.1 Central Hospital from January 2020 to December 2021. The enrolled patients were divided into the endoscopic thyroidectomy (n = 34) and open surgery (n = 52) groups based on different surgical methods. Further comparison was conducted on the surgical indexes, postoperative complications, changes of oxidative stress indexes, numerical score system (NSS) score of postoperative cosmetic satisfaction, scar length, and recurrence rate between the two groups. The operation time was longer, and the intraoperative blood loss was lower for the endoscopic thyroidectomy group than those for the open surgery group (P < 0.05). The oxidative stress indexes of the endoscopic thyroidectomy group were significantly better than those of the open surgery group (P< 0.05). The postoperative complication rate of the endoscopic thyroidectomy group was lower than that of the open surgery group (P < 0.05). At six months after surgery, the scar length was shorter, and the NSS score was higher in the endoscopic thyroidectomy group than those in the open surgery group (P < 0.05). Endoscopic thyroidectomy for PTC is safe and effective, with mild stress response, fewer postoperative complications, and good cosmetic effect.