Attitudes toward death and satisfaction with life among professionals in residential care facilities: A correlational study.

The association between body water compartments and muscle mechanical properties: A correlational study using bioimpedance and myotonometry.

Multiple screen addiction and neurological complaints in adolescents: A machine learning-based classification model.

A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder

Correlation study of nutritional status, mental health, sleep quality, and prognosis in patients with acute myeloid leukemia: Construction of early warning combined with mindfulness awareness countermeasures.

Multi-analytical dataset on Lekhaniya Mahakashaya: HRLC-MS/MS Orbitrap profiling, HPTLC fingerprinting with marker estimation, and FTIR spectroscopy.

Echoes of discrimination: How ageism affects the mental health among older people living in nursing homes.

Restless legs syndrome and sleep quality in patients with multiple sclerosis: A moderated mediation model of anxiety, fatigue, and disease duration.

Exposure to environmental contaminants, such as halogenated flame retardants (HFRs) and trace elements, has been associated with a several health effects, including neurotoxicity. However, information on contaminant concentrations in brain tissue and factors influencing their accumulation and exposure-related effects are limited in wild birds. We quantified 45 HFRs and 16 trace elements in brain of ring-billed gulls (Larus delawarensis) breeding in a highly urbanized environment and related their concentrations to foraging habitat use and a range of coarse and fine-scale neuroanatomical measures. Ten polybrominated diphenyl ethers (PBDEs), hexabromobenzene (HBB), pentabromoethylbenzene (PBEB), and anti-dechlorane plus (anti-DP) were detected in over 80% of brain samples, as well as cobalt, nickel, copper, selenium, silver, cadmium, lead, and mercury. For certain compounds or elements, brain concentrations correlated with foraging habitat use, for example, PBDEs and lead increased with the proportion of time gulls spent foraging in waste management facilities. Additionally, we found correlations between brain contaminant concentrations and certain brain measures. For example, the number of immature neurons in the nucleus pretectalis principalis (Pt), a region in the visual system in birds, correlated negatively with brain concentrations of PBDEs and lead. Our results showed that urban-adapted ring-billed gulls accumulate a wide range of HFRs and trace elements in brain tissue, and that some of these contaminants might be associated with variations in selected neural measures. Although the present correlative study cannot establish causality, these findings highlight potential toxicity pathways in the avian brain that warrant mechanistic investigation under controlled conditions.

Teacher burnout is a well-documented issue that is becoming widespread in modern education, yet its effects on manifested classroom behavior have not been properly studied. The present research examined the connection between teacher burnout and pedagogical flexibility in classroom teaching in terms of the ability to adjust the process of teaching and respond to the needs of learners and contextual requirements. The correlational research design was used to gather data of 300 secondary school teachers in District Haripur. Teacher burnout was assessed using the Maslach Burnout Inventory, which included emotional exhaustion, depersonalization and diminished personal accomplishment whereas pedagogical flexibility was measured through a structured classroom observation tool that comprised of several facets of adaptive instruction. The results of descriptive statistics showed that the level of emotional exhaustion among teachers is moderate to high, the level of depersonalization is lower, and the variability of observed pedagogical flexibility is limited. Pearson correlation showed emotional exhaustion had a moderate negative relationship with pedagogical flexibility, while depersonalization had a significant negative relationship with responsive instructional behaviors. Reduced personal accomplishment was positively related to instructional adaptation. Multiple regression confirmed emotional exhaustion as a significant negative predictor of composite.

The rapid integration of digital technologies in the sphere of higher education has had an essential influence on the process of teaching and learning and imposed new psychological and cognitive requirements on students of universities. Even with the increasing technical infrastructure on the ground, student academic performance is increasingly reliant on internal factors, including their dispositions towards technology use and their self-beliefs on their capability to study. The proposed research aims at exploring the extent to which academic self-efficacy and technology attitudes of undergraduate students have a bearing on academic achievement at the University of Lahore, Pakistan. It is founded on the Self-Efficacy Theory developed by Bandura and Technology Acceptance Model (TAM). Quantitative correlational study was used to collect data on 404 undergraduate students in six academic departments using validated self-report questionnaires. The evaluation of academic success based on cumulative grade point average (CGPA) was used to assess academic performance of students. The multiple regression analysis, independent-samples t-tests, descriptive statistics and Pearson correlation were performed in SPSS (Version 27). Findings showed academic self-efficacy and technology attitudes explained 52% variance in academic attainment. Self-efficacy was the strongest predictor, while females showed higher self-efficacy and more favorable technology attitudes.. The results support the paramount importance of the psychological preparation in the technology-enhanced learning space and emphasize the urgency of the institutional intervention increasing student confidence levels and engagement rates with digital technologies. The present research, policy and practice implications on higher education are discussed.

This correlational study examines the relationship between pre-service teachers’ affective dispositions towards genetics and their academic performance in genetics courses. The unit of analysis consists of 101 undergraduate pre-service science teachers enrolled in a public university. A descriptive correlational research design was employed to quantify the nature and strength of the association between variables. Data were collected through standardized assessments of genetic content knowledge and a 5-point Likert-scale questionnaire measuring perceptions and attitudes towards genetics. The reliability of the instruments was confirmed using Cronbach’s alpha, with perception and attitude scales achieving coefficients of 0.87 and 0.85, respectively. Data analysis involved the use of Pearson’s correlation coefficient to determine the strength and direction of relationships, complemented by multiple Linear regression analysis to identify the predictive power of affective dispositions on academic outcomes. The results indicated that only 5% of students’ perception and attitude was able to predict their performance with a p-value of 0.087 depicting the model’s insignificance at 0.05 significance level, despite the positive attitude (mean [M] = 3.95) and perception (M = 4.09). This highlight’s the gap between students’ affective dispositions and their academic performance as what one might perceive may not entirely reflect within the shortest possible time. The study’s findings further suggest that tailored instructional strategies focusing on affective factors can enhance genetics comprehension and teaching efficacy among pre-service teachers.

ABSTRACT Climate change has emerged as a global challenge with significant impacts on individuals’ mental and emotional well-being. Among young people, particularly students in health-related fields, climate-related anxiety-commonly referred to as ‘eco-anxiety’ is becoming increasingly prevalent. Understanding the relationship between healthcare students’ climate anxiety and their levels of hope for mitigating climate change is essential for guiding educational strategies and fostering sustainable healthcare practices. This study aimed to examine the influence of healthcare students’ hope on their climate change anxiety. This descriptive and correlational study was conducted among students enrolled in five programs (Physiotherapy, Geriatric Care, First and Emergency Aid, Medical Laboratory Techniques, and Operating Room Services) within the School of Health Services at a state university, comprising a total population of 1027 students. The sample size was calculated using the G*Power program and the minimum required sample was determined as 194 students. In total, data were collected from 501 students. Data were gathered through face-to-face interviews using the Personal Information Form, the Climate Change Hope Scale (CCHS), and the Climate Change Worry Scale (CCWS). The collected data were analyzed using the SPSS 24 statistical software package. The students exhibited high levels of climate change worry (mean CCWS score = 34.49 ± 6.64) and high levels of hope for preventing climate change (mean CCHS score = 28.75 ± 7.43). The participating healthcare students exhibited high levels of both hope and worry regarding climate change, suggesting that climate change worry may function as a factor that fosters hope among young individuals.

The impact of specific chromatin modifications on meiotic crossover frequency has typically been inferred from correlative studies, leaving the question of causality unresolved. To directly test this, we used a catalytically inactive CRISPR-associated protein 9 (dCas9)-based system to recruit the histone demethylase JMJ14 to defined genomic loci. Recruitment of JMJ14 led to a reduction in local histone H3 lysine 4 trimethylation (H3K4me3) levels and a decrease in crossover frequency within the targeted interval. This was accompanied by reduced expression of a long noncoding RNA (lncRNA) at the hotspot and altered crossover topology. Suppressed recombination was also observed at neighboring, untargeted hotspots. In contrast, targeting the transcriptional activator VP64 to the same region increased lncRNA expression, elevated crossover frequency, and raised H3K4me3 levels. Together, these findings establish a causal link between H3K4me3, transcription, and local crossover activity, demonstrating that H3K4me3 levels are closely associated with both transcriptional output and recombination frequency at specific genomic loci.

Both genetic and environmental factors affect human stature, including overall height and familial short stature (FSS), and it is associated with various health outcomes. However, the study of genetic connections between stature and health conditions remains lacking in East Asian populations. Hence, we conducted parallel genome-wide association studies (GWAS) of body height and FSS in the Han Taiwanese population, aiming to elucidate the genetic influences of stature on health and facilitate the formulation of precision-health strategies. We analyzed large-scale GWAS data on adult height (120,301 Han Taiwanese) and FSS (FSS; 2,050 cases, 27,966 controls) to examine cross-trait genetic correlations across five East Asian biobanks, and applied phenome-wide association studies (PheWAS) and polygenic risk score (PRS) analyses to assess clinical outcomes using Cox proportional hazard models and Kaplan-Meier analyses. We identified 293 loci for height and five for FSS, with cross-biobank genetic correlations linking stature to body size, lung function, and cardiovascular/reproductive traits (atrial flutter/fibrillation [AF], menarche, and endometriosis). PheWAS showed that height PRS increased risks of AF and endometriosis, while FSS PRS had a protective effect against endometriosis. MR analyses showed that taller stature increased AF risk independently and endometriosis risk through menarche/weight, while shorter stature had a weak protective effect against endometriosis. Survival analyses showed the association of higher height PRS with greater AF risk and an earlier divergence of cumulative incidence curves. These time-to-event patterns were consistently replicated using meta-analysis-derived PRSs. The findings highlight stature-related genetic determinants, associated health outcomes, and polygenic risk scores as effective tools for early risk prediction and precision health strategies in East Asian populations.

Background and Objective: Iron overload remains a significant clinical concern in patients with transfusion-dependent beta-thalassemia (TDT). This study aims to characterize the iron load and endocrine profile of adult transfusion-dependent beta-thalassemia patients and to evaluate their correlation with growth retardation. Methods: A cross-sectional study was conducted at PIMS Hospital, Islamabad, involving 62 adult patients with homozygous or HbE beta-thalassemia receiving regular blood transfusions. Iron overload was assessed using serum ferritin (SF) and transferrin saturation (TS), while endocrine function was evaluated through measurements of thyroid-stimulating hormone-sensitive (TSH), free thyroxine (FT4), and insulin-like growth factor-1 (IGF-1). Data was analyzed using SPSS v26.0 and R v4.3.1, which included Pearson correlation, chi-square testing, and multivariable regression to explore associations between iron indices and endocrine dysfunction. Results: Serum ferritin demonstrated significant negative correlations with FT4 (r = −0.348, p = 0.005) and IGF-1 (r = −0.302, p = 0.015). MRI T2* pancreas values correlated positively with FT4 (r = 0.268, p = 0.037) and IGF-1 (r = 0.312, p = 0.015). Patients with ferritin > 5000 ng/mL exhibited a higher prevalence of low IGF-1 levels (89.2% vs. 64.0%, p = 0.018). No significant gender-based differences were observed in endocrine parameters. Conclusion: Pancreatic iron burden and elevated serum ferritin were significantly associated with impaired thyroid and growth axis function, highlighting the value of integrating MRI T2* and biochemical markers for early endocrine risk stratification in adult TDT patients.

This study explored the relationship between burnout and spirituality among nurses working in an academic medical center (N = 408). Negative correlations were revealed between burnout and feeling deep inner peace or harmony (-0.35, p < .001), guided by God in daily activities (-0.24, p < .0001), God's love directly (-0.25, p < .0001), and God's love through others (-0.24, p < .0001). Feeling God's presence, connection to all life, strength, comfort in spirituality, and expressing gratitude for blessings exhibited moderate negative correlations (-0.21 to -0.19, p < .05). Findings support that nurses experiencing higher levels of spirituality report lower burnout levels.

Cognitive flexibility, resilience, and anger management are critical for health care workers operating in high-stress environments such as intensive care units (ICUs). This study examined the levels of cognitive flexibility, resilience, and anger management among ICU health care workers and explored the relationships among these variables. This descriptive, cross-sectional, correlational study was conducted between July and October 2022 in the ICUs of a training and research hospital in Türkiye (N = 147). Data were collected via the Cognitive Flexibility Inventory, the Brief Resilience Scale, and the Trait Anger and Anger Expression Scale. Descriptive statistics were calculated, and Pearson correlation analyses were performed. The participants showed high cognitive flexibility (mean ± SD; Cognitive Flexibility Inventory = 78.79 ± 10.13) and moderate resilience (Brief Resilience Scale = 20.76 ± 4.49). Cognitive flexibility was positively correlated with resilience (r = .574, p < .001). Resilience and cognitive flexibility were negatively associated with trait anger and maladaptive anger expression styles (p < .05), whereas resilience was positively associated with anger control (p < .05). Cognitive flexibility and resilience may function as protective factors against maladaptive anger responses among ICU health care workers. Strengthening these competencies may support emotional regulation, reduce burnout risk, and improve the quality of clinical and assistive care in intensive care settings.

This paper examines the intersection of attention-deficit/hyperactivity disorder (ADHD) and boredom. We begin with a short overview of ADHD, describing its core symptoms, cognitive features, and biological underpinnings, followed by discussion of boredom as a psychological construct, with an emphasis on individual differences in boredom propensity. Next, we review existing empirical studies and present new meta-analytic findings concerning the link between ADHD and boredom. Across 18 mostly correlational studies (total N = 22,365), an overall effect ofr = 0.40 (95% CI: 0.35-0.46) was observed, indicating a statistically significant positive association between boredom and ADHD. Building on these findings, we propose an integrated theoretical frameworkexplaining why individuals with ADHD may be particularly susceptible to boredom and how this susceptibility may affect motivation, emotion regulation, and goal-directed behavior. Finally, we discuss clinical implications and describe key directions for future research. The current work highlights boredom as a central, rather than peripheral, experience in ADHD, with important implications for theory building, assessment practices, and intervention.

Nurses' medication knowledge and confidence levels play a large role in patient safety, but few studies have examined the relationship. We used a certainty scale to compare Bachelor of Science in Nursing students' medication knowledge with their perceived confidence scores. We found that confidence of certainty was 71 percent when correct and 43 percent when incorrect. We discovered a statistically significant positive correlation between correctness and certainty, a statistically significant negative correlation between correctness and uncertainty, and a statistically significant negative correlation between incorrect answers and certainty. Accordingly, confidence of certainty did not align with knowledge, revealing potential risk of error during medication administration.