Correction Of Disorders In Patients Research Articles

Nonmedical correction of lipid metabolism disorders in patients with chronic cerebral ischemia

The authors evaluated the effectiveness of the isolated use of iodine-bromine baths and ozone therapy, as well as their complex application in the correction of lipid metabolism disorders in chronic cerebral ischemia. Statistical analysis of biochemical parameters after the treatment made it possible to come to the conclusion about the sufficient effectiveness and feasibility of using the proposed methods.

Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus

The aim of the study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis (IM) caused by EBV.
 Materials and methods. We examined 110 patients with a mean age of 23.3±4.2 years with IM, among whom women accounted for 52.7 % (n=58). The material for the study was the serum of patients obtained during the disease course. The set of tests of patients with IM included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. Statistical processing of the obtained data was performed with “Statsoft Statistica v. 10.0 for Windows” using the methods of variation and correlation statistics.
 Results. The obtained results analysis revealed changes in the system of cellular and humoral parts of the immune system and the diversity of the immune response in patients with IM. The progressive nature of changes in immune parameters indicated the formation of secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. Significant changes in the cellular immune system were observed in the acute period and were characterized by the increase in the number of cells with killer activity, namely mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (IL-2 receptor), and by the Th1/Th2 ratio increase. The appointment of combination therapy including ribonucleic acid was accompanied by immunomodulatory and antiviral effects, that was reflected in a more pronounced positive dynamics of immunological parameters, namely in strengthening the proliferative response, compared with the group of patients receiving only basic therapy.
 Conclusion. The expediency of the combination therapy application: the drug Nuclex (ribonucleic acid) (250 mg) 2 capsules 3 times a day for 14 days and valacyclovir (500 mg) at a dose of 1000 mg (2 tablets) 3 times a day for 14 days, is justified for the correction of immune disorders in patients with IM caused by EBV.

The Role of Physical Therapy in the Combined Treatment of Patients with Lower Extremities Diabetic Angiopathies

One of the most disabling complications of diabetes mellitus is angiopathy of the lower extremities. Diabetic polyneuropathy and diabetic foot syndrome are closely associated with vascular complications of diabetes mellitus, which significantly aggravate the course of the disease and contribute to high mortality. Diabetic polyneuropathy and diabetic foot syndrome are closely associated with the diabetes mellitus vascular complications that significantly aggravate the course of the disease and contribute to high mortality. Despite the improvement in the results of pharmacotherapy of diabetes mellitus, the problem of treating its vascular complications is far from being solved. Traditionally, therapeutic physical training is used among the methods of non-drug treatment of diabetes mellitus and its complications. As a method of pathogenetic focus on many risk factors for the development of diabetes and its complications, physical therapy exercises contribute to the correction of the syndrome of hypodynamia, obesity, and muscle atrophy. At the same time, there is insufficient data on how exercise therapy affects the quality of life of patients, functional characteristics of walking and objective indicators of blood flow in the lower extremities. This review identifies the main approaches to the application, advantages and disadvantages of individual methods of therapeutic physical training in the correction of functional disorders in patients with lower extremities diabetic angiopathies. We can currently talk about the proven safety of the physical therapy use in patients with diabetic angiopathies. Meanwhile, the scientific data on the high efficiency of this method is still insufficient.

Complex approach to correction of emotional disorders in patients with type II diabetes using biosuggestive therapy

Effective therapy of psychosomatic diseases in the classical sense of this term (bronchial asthma, diabetes mellitus, arterial hypertension, etc.) is an important problem due to the high frequency of chronic course, increase in the incidence and prevalence of this pathology. Patients with diabetes mellitus and anxiety-depressive disorders primarily need psychotherapeutic correction of the emotional state in connection with the possibility of a more significant positive effect on the quality of life, performance of patients and facilitating the further course of psychosomatic diseases. A comprehensive clinical, psychopathological and psychodiagnostic examination was conducted in 109 patients with type II diabetes mellitus and comorbid emotional disorders, both sexes at the age of (35.9±10.1) years. The main group consisted of 65 patients, along with the standard treatment, according to clinical protocols, they received a course of biosuggestive therapy, the control group consisted of 44 patients, who received standard therapy, according to clinical protocols. Using biosuggestive therapy in the complex treatment of patients with emotional disorders in type II diabetes mellitus has a positive effect on the feeling of psychological well-being, improving interpersonal relationships, enhancing a sense of belonging and personal fulfillment, which, in turn, affects the general perception of the quality of life, and most importantly decreases the main symptoms and the level of neuropsychic stress. This study proved high efficiency of biosuggestive therapy using in the complex treatment approach of emotional disorders in patients with type II diabetes mellitus, namely, there is a decrease in anxiety-depressive symptoms, restoration of working capacity and social activity, a decrease in the level of neuropsychic stress, normalization of the sleep-wake cycle, improvement quality of life of the examined patients. Keywords: type II diabetes, emotional disorders, correction, psychotherapy.

Features of affective disorders correction in patients with epilepsy (therapy, rehabilitation, prevention)

For many decades, epilepsy has remained a serious medical and social problem that requires constant attention not only from neurologists, psychiatrists, but also from medical psychologists and social workers. The priority in the treatment of epilepsy is not only to prevent seizures, but also to help the patient maintain social functioning and restore quality of life. Achieving drug remission of epileptic seizures is only part of the management of the disease, it is necessary to help restore the patient's psychosocial adaptation and form a correct understanding of their disease and related limitations in daily functioning. A comprehensive examination which involved 65 patients with epilepsy of both sexes aged 18–40 years was conducted in compliance with the principles of bioethics and medical deontology. The mean age of the subjects ranged from (34.0±1.6) years, duration of the disease in patients did not exceed 10 years. All subjects had disorders of the emotional sphere of non-psychotic level, which were recorded in the interictal period of the disease. Selected comprehensive system of correction of affective disorders in patients with epilepsy helped to achieve following results, especially: reduction of anxiety and depressive disorders (73.5 %), reducing the level of motor and ideational inhibition (65.2 %), reducing the intensity and duration of depressive affect (72.5 %), restoration of interest in activities that previously interested patients (69.5 %), improvement of psychosocial adaptation (81.3 %), managed to achieve the transition of maladaptive types of attitudes to the disease to adaptive (66.5 %) and improve quality of life (83.2 %). A study of affective disorders in patients with epilepsy allowed us to make following conclusions: epilepsy is often combined with affective disorders. Depressive disorders are more common among all affective disorders. Epilepsy and affective disorders interact with each other and complicate clinical prognosis. Keywords: epilepsy, affective disorders, rehabilitation, psychoeducation.

Clinical and psychopathological features of course and correction of depressive disorders in patients with brain tumors, prevention and rehabilitation

The article studys the psychological characteristics in patients with brain tumors of different localization which allows to reduce the diagnostic period and, as a result, minimize the time of early detection and the consequences of the surgical treatment of this pathology, and to cause a positive effect on preventing the development of psychopathological disorders at the hospital stage. Analysis of the clinical manifestations of depressive disorders of the subclinical level revealed their polymorphism: depression was accompanied by various variants of asthenic (prevalence of dyssomnias, psychalgia, adynamia and anxiety component) and anxiety (prevalence of senestopathies, hypochondria, phobia) states. The revealed symptom complexes of psychopathological and pathopsychological characteristics of the patient's condition were the clinical justification for the choice of methods of psychotherapeutic correction. Adjuvant psycho­logical therapy, individual rational and family psychotherapy were used as the basic method of psycho­therapeutic influence. Pharmacological correction included: anxiolytics, antidepressants, atypical mild antipsychotics in low doses. The results of the SCL-90-R test demonstrate the effectiveness of the comprehensive treatment aimed at preventing and reducing the manifestations of psychopathological symptoms. Comparison of the mean values of the SCL-90-R test revealed significant differences in such indicators as somatization (p<0.05), depressiveness (p<0.01), anxiety (p<0.05); high statistical significance is noted in the “index of symptom severity” integral indicator (p<0.01). Obtained results of psychological and psychiatric research became the basis for the development of differential diagnostic criteria for the diagnosis and prevention of the development of mental disorders.

Quantum correction of homeostatic disorders in patients with mechanical jaundice

Purpose . To study the effectiveness of low-level laser therapy (LLLT) for the correction of homeostatic disorders in severe mechanical jaundice of non-tumor origin at the early postoperative period. Material and methods . The authors present their results of treating 45 patients with mechanical jaundice (MJ) of non-neoplastic genesis and of various severity. Patients were randomized into three groups: Group 1 (n = 15) – patients with mild MJ who were prescribed standard treatment at the postoperative period; Group 2 (n = 15) – patients with severe MJ who were also prescribed standard treatment; Group 3 (n = 15) – patients' state similar to that of Group 2 but who were added laser therapy sessions to their standard treatment. Laser «Matrix» was used for this. The intensity of lipoperoxidation processes, phospholipase activity, microcirculation, hemostasis and liver functional state were assessed. Results . It was found that at the early postoperative period (up to day 8), patients with mechanical jaundice of non-tumor genesis have marked deviations in homeostasis, like oxidative stress, activation of phospholipase system, microcirculatory disorders, hepatic dysfunction and hemostatic disorders, the severity of which is associated with the severity of pathology. The therapeutic effectiveness of basic treatment at early stages in patients with mild MJ was enough, while in patients with severe MJ not always. Conclusion . Supravascular quantum irradiation added to standard therapy in patients with severe mechanical jaundice promotes more rapid restoration of hepatic dysfunction and more effective correction of the homeostatic system.

Structure and correction of psychoemothical disorders in patients with second type of diabetes

Structure and correction of psychoemothical disorders in patients with second type of diabetes

The potential for correction of depressive disorders in patients with chronic obstructive pulmonary disease

Background: The use of vitamin D in the treatment of depressive disorders in patients with chronic obstructive pulmonary disease (COPD) is justified by its pathophysiology, but it is not always feasible in clinical practice. This may be related to the lack of guidelines for implementation for this patient group, as well as to the inadequate sample of patients with baseline high vitamin D levels or mild psychoemotional distress.Objective: To assess the changes of psychoemotional status over time in COPD patients against the maintenance of vitamin D levels at>34.3 ng/ml for one year.Materials and methods: The study included 264 COPD patients randomized into the treatment and control groups (135 and 129 patients, respectively). The patients in both groups were divided into 4 subgroups according to their forced expiratory volume in 1 second (FEV1) values and vitamin D levels. All the patients were administered an inactive vitamin D (colecalciferol): in the main group, according to the scheme ensuring maintenance of the micronutrient value above the goal for 12 months, and in the control group according to the standard scheme of correction of vitamin D deficiency. Depression symptoms were assessed in Geriatric Depression Scale (GDS-15) at the beginning of the study and at its end.Results: After 12 months of vitamin D treatment, the main group showed a statistically significant decrease in the rate of severe depression (14.8% vs 6.7%, χ2=4.67, p=0.04) and an increase in the proportion of patients with normal psychoemotional status (28.2% vs 49.6%, χ2=13.11, p=0.03). In addition, there was a significant difference between the rates of severe depression in the main and control groups after 12 months of treatment: 6.7% vs 14.7% (χ2=4.52, p=0.02).Conclusion: Maintenance of vitamin D levels above 34.3 ng/ml in COPD patients for 12 months reduces the proportion of patients with severe depression.

Correction of metabolic disorders in patients with aneurysmal intracranial hemorrhages

The article presents data assessment of the severity of the clinical condition and a number of biochemical parameters in 51 patients with aneurysmal intracranial hemorrhage on the 10th day, on average, after the rupture of the arterial aneurysm and after treatment with the additional use of magnesium sulfate to standard therapy in the postoperative period. It is shown, that at the time of hospitalization, 75 % of patients in the control group and 50 % of patients in the main group had cerebral vascular spasm according to transcranial dopplerography; activation of lipid peroxidation processes, a decrease in superoxide dismutase activity, an increase in the content of vascular endothelial growth factor and highly sensitive C-reactive protein (CRP) with a decrease in the level of stable nitrogen monoxide exchange products were detected. A statistically significant improvement in the clinical condition of patients on the Hunt-Hess scale, the modified Fisher scale, and an increase in the score on the Glasgow coma scale with normalization of pro- and antioxidant status of the blood were revealed in the main group after neurosurgical treatment and course use of magnesium sulfate. At the same time, high levels of highly sensitive CRP and low levels of nitrates/nitrites in the patients blood of both groups are maintained. Consequently, the additional use of magnesium sulfate improves the clinical condition of patients with intracranial hemorrhage and increases the antioxidant potential of the blood in the postoperative period.

TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis

The aim of the study: to reveal peculiarities of the phagocytic activity of TLR4, TLR7/8-activated monocytes of peripheral blood, depending on the type of multiple sclerosis and clinical effectiveness of the treatment.Material and methods. E. coli or ssRNA40/LyoVec lipopolysaccharide as TLR4 and TLR7/8 agonists were added to the monocyte-enriched cell suspension, respectively, and incubated for 24 hours at t 37 °C under an atmosphere of 5 % CO2. In parallel series, ram erythrocytes (RE) sensitized with hemolytic serum and inactivated C. albicans cells were used as phagocytosis objects; the incubation time was 30 minutes. The phagocytic index was calculated as the percentage of phagocytic monocytes and the phagocytic number as the ratio of the total number of absorbed REs or C. albicans cells to the number of monocytes that entered into phagocytosis.The study presents the results of examination of 58 patients with recurring remitting (RRMS) and 36 patients with progressive (PMS) multiple sclerosis.Results. The differences in the activation mechanisms of peripheral blood monocytes in patients with PC, which consist in different phagocytic activity in response to stimulation of TLR4 and TLR 7/8 depending on the disease conditions, were presented.Phagocytic activity lesions of monocytes were observed both in patients with RRMS and PMS, associated mainly with FcR-mediated mechanisms of phagocytosis.IFN-β therapy in patients with RRMS led to the correction of such disorders in patients with high treatment efficacy (responders), and TLR7/8-mediated activation of monocytes was accompanied by an increase in the number of phagocytic cells. In patients with low efficacy of IFN-β therapy (nonresponders), the nature of changes in the phagocytic activity of stimulated monocytes indicated a decrease in the functional reserve with regard to FcR-mediated phagocytosis.Conclusions. The obtained results indicate differences in phagocytic activity indices during stimulation of TLR4 and TLR7/8 and may indicate the presence of functional and phenotypic alterations of peripheral blood monocytes depending on the effectiveness of MS treatment.

Modern approaches to the correction of hemodynamic disorders in patients with severe combined trauma

Background. The choice of a rational program of infusion therapy for severe trauma remains an urgent problem. Crystalloid solutions are used as the main infusion media, but data on the effect of balanced multicomponent solutions on the hemodynamic profile in patients with severe trauma in the literature are almost absent.
 The aim: to investigate the possibility of correction of hemodynamic disorders in patients with severe combined trauma with the use of a modern multicomponent drug based on a 6% solution of sorbitol (reosorbilact).
 Material and methods: a total of 60 patients with severe combined trauma and the clinic of degree I–II traumatic shock aged 18 to 46 years were examined. Patients were divided into two groups: 1st group (n = 30) – patients who included in the standard complex of intensive care (IС) reosorbilact at a dose of 8–10 ml/kg body weight; 2nd group (n = 30) – patients who underwent a standard IС complex.
 Results: administration of reosorbilact resulted in a decrease in extracellular fluid volume, an increase in BCC and a transition from hypokinetic to eukinetic circulation within 3 hours of infusion and persisted for up to 6 hours after infusion (p < 0.01). The introduction of adrenomimetics were required: before the study in groups 1 and 2 – 7 (23.3 %) and 6 (20.0 %) patients, after 6 hours – respectively 1 (3.3 %) and 4 (13.3 %), and one day after the introduction of reosorbilact no patient required the introduction of adrenomimetics, whereas in group 2 such patients were 3 (10.0 %, p < 0.05).
 Conclusions. The use of balanced multicomponent solutions based on sorbitol is accompanied by a change in the hypokinetic type of blood circulation to eukinetic, lack of interhydration hyperhydration, rapid stabilization of hemodynamic parameters and reduced need for adrenomimetic support. Conflict of interest: absent

Features of the use of choline alfoscerate in the complex correction of cognitive disorders in patients with alcohol dependence with encephalopathy

The results of studying the dynamics of clinical and psychopathological manifestations, cognitive disorders, brain electrogenesis in patients with alcohol dependence under the influence of therapy according to the treatment standards (I group) and using the drug "Cereglia" in complex correction (II group) are shown in the work. As a result of treatment revealed positive dynamics of psychopathological symptoms relief in both groups was revealed; in patients II group improving electrogenesis brain manifested a decrease of irritatie, regress polymorphic paroxysmal activity, the representation of slow-wave complexes, normalization of the ratio of alpha- and beta-rhythms, the emergence of regional differences and the reactions of absorption on the functional load clinically manifested by increase of functional activity of the brain and improving cognitive function (improving ability to work and steadfastness of focus, logic of judgments, the correctness and validity of generalizations, processes of semantic memorization, the ability to highlight the main meaning of the perceived material, the ability to analyze, understand and put into words the information received), before the performance standards, the test execution time was significantly shorter in group II patients than in group I patients (p<0.05) and was closer to the test execution time in the control group. It was found that the dynamics of cognitive functions under the influence of treatment is a marker of the degree of manifestations of encephalopathy and evaluation of the effectiveness of therapy with the use of the drug "Cereglia".

Possibilities of Early Combination Therapy with Sitagliptin and Metformin in the Correction of Metabolic Disorders in Patients with Type 2 Diabetes and Obesity

Diabetes mellitus is one of the most common diseases of the endocrine system that is encountered in the practice of any doctor in any specialty. Some features of type 2 diabetes are: a slow progressive development and a mild clinical picture in the early stages of the development of the disease. The main goal of diabetes treatment is to prevent the development of late complications that reduce the quality of life of patients, leading to their early disability and death. Despite the increase in the number of antihyperglycemic drugs in the pharmaceutical industry, we are still not successful enough to achieve good glycemic control. In addition, achieving good glycemic control does not always prevent macrovascular complications in patients with diabetes mellitus. The article presents the results of two studies. The first study examined the diurnal fluctuations in blood glucose levels during therapy with type 4 dipeptidyl peptidase inhibitor Sitagliptin, as well as its effect on oxidative stress markers in comparison with MV gliclazide. The second study examined the role of sitagliptin in the correction of disorders of fat metabolism.

Liver Disease and Hemostasis (Review) Part 2. Cholestatic Liver Disease and Hemostasis

The presence or development of liver disorders can significantly complicate the course of critical illness and terminal conditions. Systemic hemostatic disorders are common in Intensive Care Units patients with cholestatic liver diseases, so the study of the mechanisms of their development can contribute to the understanding of the development of multiorgan failure in critical illness.The review discusses current data on changes in hemostatic parameters in patients with cholestatic liver diseases, proposes a mechanism for the development of such disorders, which involve interactions of phospholipids with platelet and endotheliocyte membranes. It is suggested that a trend for thrombosis in patients with cholestatic liver disease is due to increased accumulation of bile acids in the systemic circulation. Available data demonstrate that the antiphospholipid syndrome may predispose to the formation of blood clots due to alterations of phospholipid composition of membranes of platelets and vascular endothelial cells by circulating antiphospholipid antibodies. Clarifying the mechanisms contributing to changes of the blood coagulation system parameters in liver disorders will aid to development of optimal correction of hemostatic disorders in patients with chronic liver diseases.

Possibilities of correction of lipid-phospholipid disorders in patients with non-alcoholic steatohepatitis against obesity and pathology of the biliary tract.

Possibilities of correction of lipid-phospholipid disorders in patients with non-alcoholic steatohepatitis against obesity and pathology of the biliary tract.

The role of gut microbiota and nutrition features in the pathogenesis of multiple sclerosis and its course

The study of the role of microbiota in the pathogenesis of autoimmune and demyelinating diseases is of a particular importance. Experimental data obtained during the last 10 years shows a close connection between the immune system and the gut microbiota. In the analyzed literature, additional evidence was found that microbial involvement in immunoregulation and the influence of gut microbiota on the development of various immunomediated diseases: rheumatoid arthritis, psoriasis, Sjogren syndrome, multiple sclerosis, metabolic syndrome, autoimmune hepatitis, type 1 diabetes, spondylarthritis and inflammatory bowel disease. Studies from recent years have shown that intestinal microbiota with the help of numerical microbial compounds, autonomic nervous system of the allocation of neurometabolites, signaling molecules, neurotransmitters has an effect on the functioning of the central nervous system, in connection with which the model of the intestinal‑cerebral axis was proposed, which involves the interregulation between CNS and intestinal microbiota. Detection of the influence of microbiota on the functioning of the immune and nervous systems raised the interest in microbiota of the intestine as an etiopathogenetic factor in the development of autoimmune diseases such as multiple sclerosis. However, during studies analysis, it was established that because of the nature and composition of microbiota in patients with multiple sclerosis, it is impossible to say with certainty which type of microorganisms is associated with the onset of the disease and its course. Therefore further research is aimed at the study of microbiota and the interdependence of the species composition of microorganisms necessary for clarification of the influence on methods of correction of disorders in patients with multiple sclerosis. It has been established that an important element of the study of microbiota composition is the study of the nutrition, as the dietetic pattern determines the enterotype of a person and affects the concentration and distribution of microorganisms in the intestine. That is why it is necessary to combine modern methods of studying the composition of microbiota and to compare with the type of dietary pattern found in the patient.

DELAYED PUBERTY IN BOYS. MODERN ASPECTS

Pubertal impairment in adolescents is an urgent pediatric problem conditioned by progressive worsening of the population’s reproductive health in general. One of the variants of teenagers’ puberty disturbances is the delayed puberty (DP) as no secondary sexual maturation by the age of 14 years in boys. There are discriminated hypogonadism and constitutional DP, the latter being the most frequent form of the disorder of pubertal development in boys, accounting for 60-80% of all forms of DP. At the base of pathogenesis of constitutional DP there are lied deteriorations in the system of the regulation of impulse secretion of gonadotrophin-releasing hormone (Gn-RH) and such non-hormonal factors as monamines of adrenergic and dophaminergic system, melatonin, neuropeptide Y, estragens, insulin-like growth factor-1 (IGF-1), leptine, interacting with Gn-RH-secreting neurons. Pathology of the development and maturation of structures of the diencephalon, as the cause of constitutional APD, is a rather frequent consequence of antenatal and perinatal pathology, traumatic injury of the brain, microcirculatory disorders. DP proves to be an unfavorable factor in the formation of bone density and final growth, in psychological personality achievement of the adolescent, in the maturation of the reproductive system, thus is the subject to correct. The problem of the therapy of constitutional puberty arrest remains to be controversial up to recent time. Some authors adhere to the observation tactics. They believe that children with constitutional DP may have a favorable prognosis of final growth and pubertal development. However, obvious negative psychosocial and medical consequences of the delayed growth and puberty have not yet been taken into consideration. Lately, hormonal therapy with puberty-stimulating steroids, anabolic agents has been suggested. But both a number of questions concerning the effect of therapy with androgens on activation of the hypophyseal-gonadal system in adolescents, and the impact of this treatment on the final growth of the patients remain to be unsolved. The necessity to produce an effect on central mechanisms of regulation by applying physiotherapeutic transcranial techniques, particularly transcranial magnetic therapy also exists. The presented review showed the diversity of factors influencing on the pubertal development of adolescents, various tactical methods of treatment and correction of disorders in patients with constitutional PD.

Clinico-functional assessment of the effectiveness of osteopathic correction of biliary disorders in patients with celiac disease

Ntroduction. Celiac disease is a genetically determined disease, which is often associated with the dysplasia of the connective tissue, and may be considered as one of the causes of the secondary biliary dysfunction. Functional alterations play a signifi cant role in the formation of chronic pathology. The basis for osteopathic treatment is the correction of functional alterations, aimed at amelioration of work of the basic elements of the biliary system.Goals of research - to evaluate the clinical effectiveness of osteopathic correction in treatment of biliary dysfunction in patients with celiac disease.Materials and methods. 48 patients (23 men and 25 women) diagnosed with celiac disease aged from 18 to 35 took part in the research. Their average age was 26,5±2,1 years old. All the patients underwent clinical and osteopathic examination, I. A. Alexeev-Berkman coprological examination, ultrasound examination «SonolinePrima LC» («Siemens», Germany) performed according to the standard methodology with the determination of the fraction and the coeffi cient of the evacuation. Patients received osteopathic treatment during two months. Results. The assessment of the diagnostic fi ndings showed that among 48 patients with biliary disorders with a background of different anomalies of the gall bladder 41 (85,4 %) patients suffered from clinical manifestations of the disease. During the osteopathic examination of patients typical somatic dysfunctions were found: regional biomechanical disorders (cervical, thoracic, lumbar and pelvic regions) and local biomechanical disordes (cupula of the diaphragm on the right, lower ribs on the right, ligamentous apparatus of the liver, gall bladder, duodenum). The ultrasound examination of the abdominal organs revealed different anomalies of gall bladder in combination with the alteration of the colloidness of the content of the gall bladder. Statistically signifi cant contingency between the presence of the biliary sludge and the type of anomalies of the gall bladder was determined (χ2=8,12; р=0,017; С=0,55). After the course of osteopathic treatment the main clinical manifestations signifi cantly reduced, the mobility improved in all the regions of the spine, and in the thoracic diaphragm, the importance and the manifestation of somatic dysfunctions decreased in the liver, in the bile ducts, in the stomach, in the duodenum, and in the bone structures of the pelvis (р<0,01). Also the process of digestion improved: creatorrhoea, steatorrhoea, amylorrhea were less expressed (p<0,05), the contractile function of the gall bladder improved (emptying coeffi cient 59,8±1,84 %) and the anechogenic effect was achieved.Conclusion. The use of osteopathic methods showed high effectiveness in treatment of biliary pathologies in patients with celiac disease.

Correction of Immunoendocrine Disorders in Patients with Ischemic Heart Disease Using Low-intensity Microwave Therapy

The article considers the possibility of correcting immunoendocrine disorders in patients with ischemic heart disease using low-intensity microwave radiation at a frequency of 1 GHz. The study showed that the Aquaton device for low-intensity microwave therapy could be used to stimulate production of bradykinin, NO, IL-24, antioxidants, and soluble tumor necrosis factor-alpha receptor II by whole blood cells. Exposure to microwave irradiation was accompanied by a decrease in the caspase-1 content in mononuclear leukocytes with a simultaneous increase in the nuclear transcription factor NFκB level, promoting thereby normalization of the subclinical inflammatory process and correction of endothelial dysfunction.