Purpose The aim of this study was to evaluate the effect of implanting MyoRing into a femtosecond-created corneal pocket on corneal asphericity in patients with keratoconus. Patients and methods This prospective, nonrandomized, interventional clinical study included 38 eyes with keratoconus. Femtosecond-assisted implantation of MyoRing was done for all cases. The intrastromal pocket was 7.4 mm in diameter and deep at a level equal to 80% of central corneal thickness. Corneal asphericity, curvature, thickness, and elevations were evaluated 3 months after surgery. Results The mean age of the patients was 24.53±5.18 years at the time of surgery. The same diameter of the MyoRing was used in all cases. Both uncorrected distance visual acuity and corrected distance visual acuity significantly improved after implantation of the MyoRing. Uncorrected distance visual acuity improved from 0.05±0.01 to 0.31±0.01 and corrected distance visual acuity improved from 0.29±0.14 to 0.34±0.10. The postoperative changes in all measured refractive parameters were significantly better in comparison with the preoperative measures. The mean preoperative spherical equivalent of the refractive error was −9.87±2.91 D, whereas the postoperative spherical equivalent was −0.89±0.30 D. The refractive sphere and cylinder improved also from a preoperative value of −8.31±2.55 and −3.11±1.93 D, respectively, to a postoperative value of −0.46±0.21 and −0.86±0.32 D, respectively. The Q value of anterior corneal surface significantly improved to a less prolate shape, from −0.49±0.11 preoperatively to 0.23±0.01 postoperatively. On the contrary, the Q value of the posterior surface of the cornea showed no statistically significant change after MyoRing implantation. Conclusion MyoRing implantation improved the asphericity of the anterior corneal surface from advanced prolate shape to the optimal prolate Q value of −0.52 and ‘spherical aberration free’ Q value of −0.46. This improvement in corneal asphericity may have a role in increasing the postoperative visual acuity.