Danhong injection alleviates sepsis-induced acute lung injury by regulating AGE/RAGE/AKT pathway.

Multi-component synergy of safflower (Carthamus tinctorius L.) against hypertension-dyslipidemia: Network pharmacology and molecular docking study.

Systematic pharmacology-guided analysis of the therapeutic mechanism of Sedum sarmentosum against chronic liver injury.

Mechanisms of deoxynivalenol-induced multi-organ toxicity in broiler chickens: The central role of the Rap1/MAPK pathway revealed by network pharmacology and molecular docking.

Organophosphate flame retardants exposure and neuroaxonal injury in adults: A systematic study integrating human data and network toxicology.

Sinomenine treats Rheumatoid Arthritis by regulating IL-6 Gene Promoter Methylation.

Calycosin ameliorates high-altitude pulmonary edema by regulating macrophage polarization through the PPAR-γ/NF-κB pathway: a comprehensive analysis of network pharmacology, molecular docking, and experimental validation.

Fufang Banmao Capsule (FBC) is clinically applied in the treatment of non-small cell lung cancer (NSCLC), yet its underlying pharmacological mechanism remains to be fully elucidated. This study aimed to systematically elucidate the pharmacological actions of FBC against NSCLC by integrating network pharmacology and Mendelian randomization approaches. Active components and potential targets of FBC were retrieved from the BATMAN-TCM database, while NSCLC-related therapeutic targets were collected from OMIM, TTD, and DisGeNet. Enrichment analysis and a "Herbs-Ingredients-Targets-Pathways" network were constructed. Core targets were further identified through protein-protein interaction and Mendelian randomization analyses, followed by colocaliza tion tests and molecular docking validation. A total of 152 potential FBC targets for NSCLC were identified, with seven candidates shortlisted. Among these, TNF and PIK3CA emerged as key protective targets (P<0.0025, OR<1). Colocalization analysis suggested possible shared genetic causality of TNF and PIK3CA single nucleotide polymorphisms with increased NSCLC risk. Molecular docking confirmed strong binding interactions between these targets and active FBC compounds such as resveratrol. The findings provide a theoretical foundation and new research directions for further investigation into the anti-NSCLC mechanism of FBC, supporting future innovation in therapeutic strategies.

This study investigated the chemical profile and therapeutic mechanisms of the Yishen Ningxin Formula (YSNXF) in treating hypertension comorbid with insomnia through an integrated approach involving UPLC-QE-MS/MS, network pharmacology, and molecular docking. Chemical profiling identified a total of 870 components within YSNXF, with 13 compounds confirmed as blood-entering components in rat plasma, corresponding to 133 potential targets. Intersection analysis with disease-related targets revealed 46 core targets, notably ACE, HTR2A, HTR2B, and HTR1A. Network pharmacology and enrichment analyses indicated that key bioactive components-including hirsutine, geissoschizine methyl ether, hypaphorine, and N-acetylleucine-exert their effects via critical pathways such as the renin-angiotensin system, neuroactive ligand-receptor interactions, and serotonergic synapses. Molecular docking further validated the strong binding affinities of geissoschizine methyl ether and hypaphorine to the identified core targets. These findings suggest that YSNXF alleviates hypertension and insomnia through a multi-component, multi-target, and multi-pathway synergistic mechanism, highlighting geissoschizine methyl ether and hypaphorine as pivotal active constituents for further pharmacological validation.

Anti-HIV bioactive components in Pinus yunnanensis cones and their in vivo absorption-metabolism profiles based on sequential metabolism theory.

Platycodin D alleviates idiopathic pulmonary fibrosis by targeting PPP2R1A and regulating the PP2A-mediated PI3K/Akt pathway to inhibit fibroblast transdifferentiation.

Therapeutic potential of Dahuang Mudan Decoction for severe acute pancreatitis: targeting oxidative stress and MAPK pathways through network pharmacology and experimental verification1.

Mechanisms of bisphenols-induced cervical cancer: A multidimensional bioinformatics analysis.

Identification of therapeutic targets and potential phytochemicals for UTI treatment from Myristica fragrans through CADD.

Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the synergy between susceptibility factor TNF-α and Polygonum multiflorum-induced idiosyncratic liver injury in mice.

Biochanin A exerts neuroprotective effects in Parkinson's disease both in vivo and in vitro by improving mitochondrial dysfunction through the Sirt1 signaling pathway.

Modified Xuan-Bi-Qing-Ying decoction alleviates septic liver injury by regulating autophagy and apoptosis via HIF-1α signaling pathway.

Total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] extract ameliorates diabetic liver injury: association with ferroptosis suppression and the PI3K/AKT/Nrf2 pathway.

Regulation of skeletal muscle development and metabolism in broiler chickens by Urolithin A through threonine kinase 1 pathway activation.

Berberine alleviates early brain injury after subarachnoid hemorrhage by inhibiting GSK3β-mediated CASP1-dependent pyroptosis.