You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011761 THE COOLIDGE EFFECT ON THE ERECTILE FUNCTION FOLLOWING CAVERNOUS NERVE INJURY IN RATS Shin-ichi Hisasue, Kohei Hashimoto, Yohei Matsuda, Hisanori Taniguchi, Masahide Kanaya, Satomi Fujii, Satoshi Takahashi, and Taiji Tsukamoto Shin-ichi HisasueShin-ichi Hisasue Sapporo, Japan More articles by this author , Kohei HashimotoKohei Hashimoto Sapporo, Japan More articles by this author , Yohei MatsudaYohei Matsuda Sapporo, Japan More articles by this author , Hisanori TaniguchiHisanori Taniguchi Osaka, Japan More articles by this author , Masahide KanayaMasahide Kanaya Sapporo, Japan More articles by this author , Satomi FujiiSatomi Fujii Kutchan, Japan More articles by this author , Satoshi TakahashiSatoshi Takahashi Sapporo, Japan More articles by this author , and Taiji TsukamotoTaiji Tsukamoto Sapporo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1786AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The existence of the partner is suggested to play an important role in the recovery from erectile dysfunction (ED) following radical prostatectomy. It is also suggested that change of female partner affect the frequency of ejaculation. And it is known as Coolidge effect. This behavior leads to the increase of the attempt for sexual intercourse, which might be potentially appropriate as the animal model for the penile rehabilitation. The aim of this study is to investigate the impact of the cohabitation with female and Coolidge effect on the recovery from the ED following cavernous nerve (CN) injury. METHODS We investigated Sprague-Dawley rats aged 8 weeks. We divided the rats into 4 groups; vehicle group (n=5), CN crush group (n=5), female cohabitation group (n=5), and cohabitation/rotation group (n=5). All rats were vasectomized, and cavernous nerves were crushed simultaneously in the experimental groups on day 1. Female rats were introduced into the cage 1 week after the surgery. In the cohabitation/rotation group, each female rat was rotated from a cage to cage every week. We sacrificed the animals at 4 weeks after surgery and investigated the intracavernous pressure / blood pressure (ICP/BP) elicited by the unilateral pelvic nerve electrical stimulation. RESULTS ICP/BP was revealed to be 0.513±0.070 (Mean±SEM) in the vehicle group and 0.153±0.022 in the CN crush group (p=0.001). That in the cohabitation group was 0.196±0.033 without a significant difference compared with the CN crush group (p=0.315). However, that in the cohabitation/rotation group showed a significant difference (0.247±0.013; p=0.007). CONCLUSIONS This study indicated that the cohabitation with female rats with rotation (Coolidge effect) induces the recovery from ED following CN injury. This model is applicable for the study for the penile rehabilitation after CN injury. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e306 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shin-ichi Hisasue Sapporo, Japan More articles by this author Kohei Hashimoto Sapporo, Japan More articles by this author Yohei Matsuda Sapporo, Japan More articles by this author Hisanori Taniguchi Osaka, Japan More articles by this author Masahide Kanaya Sapporo, Japan More articles by this author Satomi Fujii Kutchan, Japan More articles by this author Satoshi Takahashi Sapporo, Japan More articles by this author Taiji Tsukamoto Sapporo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...