Objectives When developing smart-based continuing nursing educational (SCNE) program, it is necessary to examine the intention to use of nurse education managers and staff nurses. This study was conducted to identify the level of perceived positive and negative attitude of SCNE among nurse education managers and to define perceived ease to use and perceived usefulness among staff nurses. And we compared the factors influencing intention to use SCNE of nurse education managers and staff nurses. Methods The data were collected by questionnaires from October 24 to November 20 of 2014. A total of 71 nurse education managers from 71 institutions and 486 staff nurses from 14 institutions participated in this study. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation, and stepwise multiple regression. Results The mean scores of intention to use SCNE of nurse education managers and staff nurses were 5.86 vs. 6.67 (t=-3.44, p=0.001). The factors influencing intention to use SCNE of nurse education managers were perceived effectiveness of on-line education (β=0.19, p=0.044), perceived positive attitude (β=0.34, p=0.002) and perceived negative attitude (β=0.40, p<0.001)(Adjusted R²=0.60) Perceived effectiveness of on-line education (β=0.13, p=0.028), perceived ease to use (β=0.50, p<0.001) and perceived usefulness of staff nurses (β=0.20, p=0.010) were influencing factors for staff nurses (Adjusted R²=0.55). Conclusions Staff nurses had more positive perceptions and intention to use than nurse education managers for SCNE. Based on the result of this study, SCNE must be developed for staff nurses using strength such as ubiquity and freedom from the limitation of space and time. Key words: Continuing nurse education, Smartphone, Nursing informatics, Intention, Perception