Objective: To determine the association between the consumption of psychotropic drugs and the capabilities of self-care in women. Materials and Methods: a non-experimental, quantitative, applied, simultaneous, and cross-sectional study was carried out. The sample was made up of 33 women that consume psychotropic drugs in the Tierra and Libertad neighborhoods in Tepic, Nayarit. Results: Of those studied, 73% were single, 51.5% suffer with depression, 21.2% suffer with insomnia and 15.2% with anxiety. More than half (69.7%) reported a duration of psychotropic drug consumption of between 1 and 5 years. The majority (75.8%) did not use any techniques to control depression, stress, nor anxiety, and 78.8% did not do any exercise. Just over half (54.5%) were not aware of the consequences of psychotropic drug use, 48.5% do not resolve daily life problems, and 36.4% do not like living with friends and family. We found a high level of knowledge (64%) and a low level of skills and attitudes (82% and 53% respectively). By applying the eta (η) index with p<0.05 between the self-care skills and the consumption of psychotropic drugs, an association and difference between these variables was find, leading to the acceptance of the hypothesis and the alternative hypothesis. Conclusions: There are significant associations and differences between the variables in the self-care ability and the consumption of psychotropic drugs.