Consent Statement Research Articles

Dose Effects of Co-Exposure to Polycyclic Aromatic Hydrocarbon and Phthalates on Blood-Cell-Based Inflammatory Indices in Children

Evidence surrounded the effect of co-exposure to polycyclic aromatic hydrocarbons (PAHs) and phthalates (PAEs) on blood-cell-based inflammatory indices was largely unknown. We conducted a panel study among 149 children aged 4-12 years with repeated morning urine collecting over 4 consecutive days prior to blood drawing across 3 seasons. We developed a gas chromatography/tandem mass spectrometry method for simultaneous determination of 10 PAHs metabolites (OH-PAHs) and 10 PAEs metabolites (mPAEs) in the urine sample. We employed the linear mixed-effects model to evaluate the independent effects of urinary OH-PAHs and mPAEs on blood-cell-based inflammatory indices over different lag days. Bayesian kernel machine regression (BKMR) and quantile g-computation were used to evaluate the overall effect of OH-PAHs and mPAEs mixture on blood-cell-based inflammatory indices. After multiple adjustments, we found positive dose-response associations of hydroxynaphthalene (∑OHPHE), hydroxyfluorene, hydroxyphenanthrene, summed OH-PAHs, mono-n-butyl phthalate and summed mPAEs with inflammatory indices such as neutrophil count, neutrophil to lymphocyte ratio, platelet-to-lymphocyte ratio, and the systemic immune-inflammation index at lag0. A 1% increase of ∑OHPHE was related to a 0.18% (95%CI: 0.11%, 0.25%) increment in the systemic immune-inflammation index, which was the strongest among the above associations. Results of Bayesian kernel machine regression (BKMR) and quantile g-computation suggested that co-exposure to OH-PAHs and mPAEs mixture was associated with elevated white blood cell count, neutrophil count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index to which ∑OHPHE and 1-hydroxypyrene (1-OHPYR) might be the major contributors. Besides, gender and age modified the associations of ∑OHPHE and 1-OHPYR with inflammatory indices where girls and younger children might be more susceptible. Totally, OH-PAHs and mPAEs were dose-responsively associated with elevated inflammation in children, in which ∑OHPHE and 1-OHPYR might play important roles. Funding: This work was supported by the National Key Research and Development Program of China (2016YFC0206505). Declaration of Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ethics Approval Statement: This study was approved by the Medical Research Ethics Committee of Tongji Medical College, Huazhong University of Science and technology. Informed consent was obtained from all individuals before the study. The consent statement was signed by the child' legal guardian at enrollment.

Bean Extract-Based Gargle as Promising Tool for Efficient Diagnosis of COVID-19 at Early Stage Using Rapid Antigen Tests: A Clinical, Prospective, Diagnostic Sensitivity Study

Background: Antigen based rapid diagnostic test (Ag-RDT) is faster and applicable for self-testing of SARS-CoV-2. Nasopharyngeal swab (NPS) is not technically feasible for self-testing due to requirement of heath professional and risk of contaminated aerosol during sample collection. Thus, saliva specimen can be appropriate for self-sampling technique required for Ag-RDT. However, the detection of virus by Ag-RDT in saliva could be less sensitive. Therefore, we aimed to evaluate novel Beanguard gargleTM (BG)-based virus collection method that can be applied to antigen-rapid detection test (Ag-RDT) as an alternative to the current RT-PCR with a nasopharyngeal swab (NPS) for early diagnosis of COVID-19. Methods: Paired BG-based saliva and NPS specimens were collected from 102 patients with COVID-19 and 100 healthy subjects. The diagnostic performance of Ag-RDT (BG-Ag-RDT) and RT-PCR (BG-RT-PCR) of BG-based saliva specimens for SARS-CoV-2 detection was compared to NPS-RT-PCR. Physical interactions between the bean extract (BE) in BG and SARS-CoV-2 were evaluated using cryo-electron microscopy (cryo-EM), isothermal titration calorimetry, and ELISA.Findings: BG-Ag-RDTs showed high sensitivity (97·8%) and specificity (100%) in all patients within 6 days of illness associated with the infection of SARS-CoV-2 along with Alpha and Delta variants. Notably, in 11 asymptomatic early-stage cases, both BG-Ag-RDTs and BG-RT-PCR showed excellent performance with sensitivity and specificity of 100%. The interaction between SARS-CoV-2 spike proteins and truncated canavalin, an active ingredient from BE, was shown by calorimetry. The ultrastructural features of SARS-CoV-2 particles coated by BE were well observed in cryo-EM, and the detachment of the receptor binding domain of SARS-CoV-2 from hACE2 was increased with increasing concentration of BE in ELISA, allowing us to apply for releasing the virus from hACE2 in the oral cavity to early diagnosis.Interpretation: BG-based saliva specimens applied to Ag-RDT can be an alternative to NPS-RT-PCR for early diagnosis of COVID-19. The method can facilitate self-testing without trained healthcare workers for mass screening, surveillance, and efficient quarantine.Funding: BIO3S, Inc., Korea Basic Science Institute, and Jeonbuk National University Hospital.Declaration of Interest: DSK received grant support for clinical study from BIO3S, Inc. DK, JK and BV were involved in developing Beanguard gargleTM. All disclosures are unrelated to present clinical study. All other authors declare no competing interests.Ethical Approval: Ethical approval for the study was granted by the Institutional Review Board of Jeonbuk National University Hospital (CUH 2021-04-036-002) and written informed consent statements were obtained from all participants.

Development and Characterization of a Quantitative ELISA to Detect Anti-SARS-CoV-2 Spike Antibodies

A novel clinical assay for the detection and quantitation of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was adapted from an in-house, research-based enzyme-linked immunosorbent assay (ELISA). Development and validation were performed under regulatory guidelines, and the test obtained emergency use authorization (EUA) from the New York State Department of Health (NYSDOH) and the Food and Drug Administration (FDA). The Mount Sinai COVID-19 antibody assay is an orthogonal, quantitative direct ELISA test which detects antibodies reactive to the receptor binding domain (RBD) and the spike protein of the novel SARS-CoV-2. The assay is performed on 96-well plates coated with either SARS-CoV-2 recombinant RBD or spike proteins. The test is divided into two stages, a qualitative screening assay against RBD and a quantitative assay against the full-length spike protein. The test uses pooled high titer serum as a reference standard. Negative pre-COVID-19 and positive post-COVID-19, PCR-confirmed specimens were incorporated in each ELISA test run, and the assays were performed independently at two different locations. The Mount Sinai COVID-19 serology performed with high sensitivity and specificity, 92.5% (95% CI: 0.785 – 0.980) and 100% (CI: 0.939 – 1.000) respectively. Between-run precision was assessed with a single run repeated over 22 days; and within-run precision was assessed with 10 replicates per day over 22 days. Both were within reported acceptance criteria (CV ≤20%). This population-based study reveals the applicability and reliability of this novel orthogonal COVID-19 serology test for the detection and quantitation of antibodies against SARS-CoV-2, allowing a broad set of clinical applications, including the broad evaluation of SARS-CoV-2 seroprevalence and antibody profiling in different population subsets.Funding: This work was partially supported by the JPB foundation, the Open Philanthropy Project (#2020-215611) and other philanthropic donations.Declaration of Interests: Mount Sinai has licensed serological assays to commercial entities and has filed for patent protection for serological assays. The Icahn School of Medicine at Mount Sinai has filed patent applications relating to the COVID-19 serological assay (“Serology Assay”) and NDV-based SARS-CoV-2 vaccines which list Florian Krammer (“Serology Assay”, vaccines), Daniel Stadlbauer (“Serology Assay”), Damodara Rao Mendu (“Serology Assay”), and Carlos Cordon-Cardo (“Serology Assay”) as co-inventors. The foundational “Serology Assay” intellectual property (IP) was licensed by the Icahn School of Medicine at Mount Sinai to commercial entities including Kantaro Biosciences, a company in which Mount Sinai has a financial interest. Florian Krammer consulted for Merck, Curevac, and Pfizer in the past (before 2020) and is currently consulting for Pfizer, Seqirus, and Avimex. The Krammer laboratory is collaborating with Pfizer on animal models of SARS-CoV-2.Patient Informed Consent Statement: Informed consent was obtained from all individuals included in this study.

Exploring the Stress Coping Strategies of Frontline Healthcare Workers During the Outbreak of COVID-19 in Pakistan

Background: Amidst several crises arising due to an entirely empirical threat of global nature, the pandemic of Covid-19; one which proved to be extraordinarily difficult to deal, with was the declining mental status of the healthcare workers (HCWs). There has been an increasing need for interventions to be made in order to combat this dilemma.Methodology: A secondary analysis was conducted to assess the impact of various coping strategies among frontline health care workers on their negative feelings and emotions working in a tertiary care hospital. An analysis was conducted using Linear regression firstly by univariate analysis. In final model for multivariable analysis, variable significant in first step were used. Assumptions of normality of data and Homoscedasticity were assessed also after multivariable analysis.Results: A total of 202 individuals participated in the survey. In a multivariable analysis, sharing feelings with friends and family (95% CI: 0.51-2.99) and seeking psychological help 1.76 (95% CI: 0.16-3.36) was significantly associated with positive feelings.Conclusion: Healthcare workers and the front liners, who, albeit of the risk associated with being around the patients of an unknown disease faced the challenge head on, ultimately found themselves drained of the mental stamina to deal with the effects.Funding: None.Declaration of Interests: The authors declare no conflict of Interest.Patient Informed Consent Statement: Verbal informed consent was obtained from all participants as well as participants consented for the results to be published before the commencement of the survey.

The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods.

SummaryThe reproducibility crisis is a multifaceted problem involving ingrained practices within the scientific community. Fortunately, some causes are addressed by the author's adherence to rigor and reproducibility criteria, implemented via checklists at various journals. We developed an automated tool (SciScore) that evaluates research articles based on their adherence to key rigor criteria, including NIH criteria and RRIDs, at an unprecedented scale. We show that despite steady improvements, less than half of the scoring criteria, such as blinding or power analysis, are routinely addressed by authors; digging deeper, we examined the influence of specific checklists on average scores. The average score for a journal in a given year was named the Rigor and Transparency Index (RTI), a new journal quality metric. We compared the RTI with the Journal Impact Factor and found there was no correlation. The RTI can potentially serve as a proxy for methodological quality.

Correlation of the modified dental anxiety scale value with salivary alpha-amylase in pre-odontectomy patients

Introduction: Odontectomy is a minor surgical procedure that often results in dental anxiety. Dental anxiety can interfere during odontectomy treatment. Dental anxiety can be examined using the Modified Dental Anxiety Scale (MDAS) and through the level of the salivary alpha-amylase enzyme, both of which are dental anxiety biomarkers. The objective of this study was to analyse the correlation between anxiety values with salivary alpha-amylase levels using MDAS as an indicator of anxiety in pre-odontectomy patients. Methods: This study was conducted on 60 research samples of women aged 18-40 years who came to the minor surgery clinic of Department of Oral and Maxillofacial Surgery, Universitas Padjadjaran Dental Hospital, to have odontectomy treatment of maxillary or mandibular third molars impaction, not having systemic and oral diseases, and willing to participate in this study. Patients who met the inclusion criteria then required to sign the research consent statement; afterwards, the MDAS data was taken. The salivary alpha-amylase enzyme data was taken using the Cocoro meter (Nipro, Japan) tip which was kept under the tongue for 30 seconds, then the tip was inserted into the monitor, and the enzyme levels would be counted. The data obtained will be analysed using the Spearman rank correlation test. Results: The results showed that there was a significant relationship (p < 0.01) with a strong positive correlation (r = 0.85). Conclusion: There is a correlation between MDAS value and salivary alpha-amylase enzyme as an indicator of dental anxiety.

Letter: Strategies for Prevention and Control of 2019 Novel Coronavirus Infection Among Medical Staff.

Letter: Strategies for Prevention and Control of 2019 Novel Coronavirus Infection Among Medical Staff.

Study of the infl uence of information and communication tools on the psychophysiological state of schoolchildren on the basis of subjective evaluation

The relevance of the article is determined by the existence of contradictions between the need to introduce innovative technologies into the educational process at school, as an integral attribute of modern education, and the negative influence of factors on the physical and psycho-emotional state of health of students related to the use of information and communication tools (computers, phones, headphones). The goal of the study was to assess the relationship between the timing of the use of information and communication tools and the frequency of functional and psycho-emotional complaints in groups of middle and high school schoolchildren. 400 schoolchildren of the Saratov Region, the Moscow Region, Leningrad Region and the Republic of Dagestan were surveyed, who made up two groups of research: middle-school schoolchildren (grades 5–6) and high-school schoolchildren (grades 10–11 The survey was carried out by means of the standardized formalized cards which included the questions considering usage time of computers and mobile phones, complaints to a headache, hands pain, other pain and/or feeling of discomfort from visual organ and the organs of hearing, as well as a psycho-emotional state. Statistical analysis of the data was performed using the STATISTICA application software program by StatSoft Inc (USA). To compare the frequencies of a binary feature, a fourfold table of absolute frequencies was constructed and the level of statistical significance for the exact Fisher’s two-tailed test criterion was determined. The study was conducted according to the requirements of bioethics, after signing informed consent statement by teenagers and their parents. The study examined the relationship between the timing of the use of information and communication tools and the frequency of complaints in groups of schoolchildren. The results of the study should be taken into account when developing and implementing preventive measures to prevent negative effects of computers and mobile devices on the body of students.

How Annals of Dermatology Has Improved the Scientific Quality and Ethical Standards of its Articles in the Two-Year Period since October 2018.

Annals of Dermatology has not been deposited in PubMed Central (PMC) since October 2018 due to inadequate scientific quality, including the absence of informed consent in three case reports with patients' photos. This study examined the readiness of Annals of Dermatology to be deposited in PMC again by analyzing the 13 issues published from October 2018 to August 2020. The journal's scientific quality and ethical standards were assessed, and adherence to these standards was documented. In total, 259 articles were analyzed for ethical standards, including institutional review board (IRB) approval, an informed consent statement, and disclosure of conflicts of interest. Scientific quality was also checked for each article. Of the 129 original articles or brief reports presenting research on human subjects or human-derived materials, 111 studies received IRB approval and/or obtained informed consent. The other seven studies were data analyses or studies of purchased cultured cells. One study that used a post-circumcision foreskin sample contained no statement describing permission from the patient's family, but the researchers were found to have obtained informed consent. In all 152 case presentations, the authors obtained informed consent. All seven animal experiments received Institutional Animal Care and Use Committee approval. One review article did not disclose conflicts of interest, but this was an editorial error. Two systematic reviews adopted the PRISMA guidelines. In conclusion, the present publication policies, scientific quality, and ethical standards of the journal are top-tier internationally. Annals of Dermatology may be ready to apply to PMC again.

Utilization of a Parental Approach to Informed Consent in Intravenous Tissue Plasminogen Activator Administration Decision-Making: Patient Preference and Ethical Considerations.

Objective While administration of intravenous tissue plasminogen activator (IV-tPA) is the standard of care in acute ischemic stroke and has been shown to have statistically significant benefit, there can also be potentially life-threatening complications; however, there is no standard informed consent approach. The purpose of this study was to present a parental, technical, and general model of informed consent for IV-TPA and to determine which approach was preferred. Methods Survey respondents were asked to hypothetically decide whether or not to provide consent for their family member to receive IV-tPA. Respondents were presented with 3 informed consent models: one emphasizing parental qualities, one emphasizing statistical data, and one representing a general consent statement. After being presented each model, the respondents had to select their preferred consent model, as well as rate their level of agreeability toward their family member receiving the medication following each approach. Results The results of 184 surveys showed respondents were equally as likely to give consent for their family member to receive IV-TPA following all three approaches; however, respondents were significantly more likely to prefer the parental approach compared to a technical or general approach. Conclusion Our results indicate that while paternalism is generally discouraged in the medical community, some degree of parental language may be preferred by patients in tough decision-making situations toward consent to receive medical interventions.

Prognostic Biomarkers for Predicting Survival Outcome in Adult Patients with Sepsis, Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

Background: Sepsis is an important cause of neonatal morbidity and mortality; therefore, patients with high early risk of death need to be identified early through readily available laboratory parameters that can be quickly assessed. Method: The objective of this study was to explore prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) as prognostic biomarkers for predicting survival outcome in adult patients with sepsis, severe sepsis and septic shock. We searched six databases to identify studies that met the inclusion criteria. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under curve (AUC), and corresponding 95% credible interval (95% CI) were calculated using a bivariate regression model. Results: A total of 43 studies enrolling 6974 patients were included in our meta-analysis. The pooled sensitivity, specificity, PLR, NLR of CRP is weaker than that of Presepsin, and sTREM-1, and the pooled specificity, PLR, NLR of PCT is less than Presepsin, and sTREM-1. The AUC of Presepsin, PCT, IL-6 and sTREM-1 are greater than CRP, and the AUC of Presepsin and sTREM-1 are greater than PCT and IL-6. The results of the subgroup analysis showed that 2-5 ng/mL, > 10 mg/L, ≤1500 pg/ml, ≤200 pg/ml may be the appropriate cut-off interval for PCT, CRP, Presepsin, and sTREM-1, respectively. In addition, PCT was measured on day 5 to predict mortality with the highest sensitivity, while on day 7 it had the best specificity. sCD14 was measured on day 1 to predict mortality with the high sensitivity, while on day 7 it had the best specificity. Conclusions: Presepsin and sTREM-1 can be used as prognostic biomarkers for predicting survival outcome in adult patients with sepsis, severe sepsis and septic shock. Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Declaration of Interest: The authors declare that they have no conflict of interest. Ethical Approval: This article is meta-analysis and does not require Ethics Committee ethics approval and consent statement.

Debunking the Myth: Do MFM Fellows Negatively Impact Resident Obstetrical Skills [15H

INTRODUCTION: Residents often express concern that fellows negatively impact surgical opportunities. We described the impact of MFM fellows on resident surgical opportunities. METHODS: After IRB approval, anonymous 27-question e-survey sent to OBGYN residents in US and Puerto Rico in 3/2018. Survey included consent statement, and questions included experience as primary surgeon (PS), for 4th year residents only, comfort performing procedures post-residency (CPPR), and demographics. Residents from programs with MFM fellows (pMFM) were compared to those without (nMFM). Descriptive statistics used as appropriate. Regression performed, controlling for significant variables. RESULTS: 417 residents completed the survey; 275 (66%) from nMFM and 142 (33%) from pMFM. PMFM residents were more likely to have >7 residents/year, be from an academic residency, and less likely to be planning to practice obstetrics post-residency (all P<0.01). Plan to pursue MFM fellowship did not differ. NMFM residents were more likely to have been PS on a vacuum assisted delivery (VAVD; 77% vs 63%, p<0.01), but equally likely to have been PS at forceps delivery (FAVD; 48% vs 57%, P=0.09). No difference in PS experience was seen for breech deliveries, 3rd or 4th degree repairs, cerclage or cesarean hysterectomy. With regards to CPPR, VAVD was more likely among nMFM trainees, no other differences seen. In regression models, no differences in likelihood of CPPR for any procedures based on the presence of MFM fellows were seen. Among pMFM residents, 94% stated fellows positively impacted their learning. CONCLUSION: MFM fellows do not appear to impact residents' competency in obstetric procedures, larger studies are needed to confirm these findings.

Hikmah Behind The Academic in The Islamic Economy

The relationship between one human being and another in fulfilling needs (min min al-Nas), there must be a rule that explains both rights and obligations based on agreement (contract). Humans are never separated from the contract (contract / agreement) in their lives. A contract is a bond of consent (statement of acceptance of a bond) and Kabul (statement of acceptance of a bond) in accordance with the will of the Shari'a which affects the object of engagement (contract). Because of the importance of the contract in human life, of course every thing has wisdom, then what is the nature of wisdom and how are the wisdom of the contract in Islamic economics. The essence of wisdom is an expression that refers to a solid knowledge, which includes (can lead to) makrîfah (recognition) to Allah, which comes from the pure inner eye, and the ability of the knowledge to learn and understand the nature of things in their objective state the realm of reality is limited to the supreme ability of humans in finding and discovering the secrets of the shari'a religion (law) and the purpose of Islamic law. While the wisdom of the contracts in Islamic economics are: 1). Moral and material accountability of both parties emerged; 2). The emergence of a sense of tranquility and satisfaction from both parties; 3). Avoidance of disputes from both parties; 4). Avoid legitimate ownership of property; 5). Ownership status of property becomes clear; 6). There is a strong bond between two or more people in transacting or having something; 7) It cannot be arbitrary in canceling an agreement, because it has been set in shar'i; 8). A contract is a "legal umbrella" in possession of something, so that the other party cannot sue or have it. In simple terms the wisdom of the Covenant is an attempt to uncover the truth, practice the truth and fight lust from all forms of evil and realize benefit and reject damage in the muamalah contract of Islamic economics.

Tyrosine and Glutamine-Leucine Are Metabolic Markers of Early-Stage Colorectal Cancers.

Tyrosine and Glutamine-Leucine Are Metabolic Markers of Early-Stage Colorectal Cancers.

Informed Consent Statement for Readers of This Column

Anthropology NewsVolume 60, Issue 2 p. e102-e104 March/April Online Content Informed Consent Statement for Readers of This Column First published: 25 February 2020 https://doi.org/10.1111/AN.1152AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume60, Issue2Special Issue: From 1969 to 2019March/April 2019Pages e102-e104 RelatedInformation

The effectiveness of an on-line training program for improving knowledge of fire prevention and evacuation of healthcare workers: A randomized controlled trial.

BackgroundHospitals are vulnerable to fires and the evacuation process is challenging. However, face-to-face fire prevention and evacuation training may take healthcare workers’ time away from patient care; therefore, effective on-line training may be warranted. We carried out and examined the effectiveness of an on-line education and training of fire prevention and evacuation training for healthcare workers in China by a randomized controlled trial using convenience sampling from five public hospitals in China.MethodsA total of 128 participants were recruited between December 2014 and March 2015. The authors built a webpage that included the informed consent statement, pre-test questionnaire, video training, and post-test questionnaire. After completing the pre-test questionnaire, participants were randomly assigned to watch the intervention video (basic response to a hospital fire) or the control video (introduction to volcanic disasters). A 45-item questionnaire on knowledge of fire prevention and evacuation was administered before and after the video watching. This questionnaire were further divided into two subscales (25-item generic knowledge of fire response and 20-item hospital-specific knowledge of fire prevention and evacuation). One point was awarded for each correct answer.ResultsHalf of the participants (n = 64, 50%) were randomized into the intervention group and the remaining 64 (50%) were randomized into the control group. For generic knowledge of fire prevention and evacuation, those in the intervention group improved significantly (from 16.16 to 20.44, P < 0.001) while the scores of those in the control group decreased significantly (from 15.27 to 13.70, P = 0.03). For hospital-specific knowledge of fire prevention and evacuation, those in the intervention group (from 10.75 to 11.33, P = 0.15) and the control group (from 10.38 to 10.16, P = 0.54) had insignificant change. For total score, those in the intervention group improved significantly (from 26.91 to 31.77, P < 0.001) while those in the control group decreased insignificantly (from 25.64 to 23.86, P = 0.07). After the intervention, the difference between the scores of the intervention group and the control group on all three knowledge areas of fire prevention and evacuation (generic, hospital-specific, and total) were significant (all Ps < 0.05).ConclusionsAn on-line fire training program delivered via educational video can effectively improve healthcare workers’ knowledge of fire prevention and evacuation.Trial registrationClinicaltrials.gov NCT02438150

IZIN POLIGAMI DARI ISTRI DI PENGADILAN DALAM PERSPEKTIF MASHLAHAH MURSALAH

This article would like to see the rule of law related the need of consent from a wife for her husband who will do polygamy from the perspective of mashlaha mursalah. One of the requirements in a court session is the need for the court to obtain a consent statement from the wife and need to check and confirm the wife’s consent. In this study, it was concluded that the consent of the wife conveyed before the trial is a fundamental need (mashlahah hajiyah) to protect the absolute need (mashlahah daruriyah) in the form of happiness in the household. Based on related studies focusing on the impact, most wives did not sincerely give their consent for polygamy. Therefore, the court must invite the wife to obtain direct information on the consent of polygamy given to her husband.

Effect of Cryotherapy on Proprioception and Throwing Accuracy In the Dominant Shoulder among Female Recreational Players

Throwing is one of the most complex activities within all athletic activity. The integrity of the receptors responsible for movement and proprioception with neural pathways plays a important role in maximizing the shoulder mobility in throwing skill. After an acute shoulder injury in sport, an athlete may return to practice or competition following a cryotherapy treatment to the injured shoulder. To find the effect of Cryotherapy on proprioception and throwing efficiency of shoulder in recreational players. 10 female basketball players will be selected as per the inclusion and exclusion criteria. The procedures were explained and an informed consent statement was obtained from the participants. Crushed ice with terry towels were employed to all the players included to the study. Treatment duration was 15 minutes, immediately at the end of the treatment, the post-test documentation on throwing efficiency was documented. Throwing performance index was used to assess the Functional ability of the shoulder joint. Paired t-test was used to compare in mean values of pre-test and post-test. There was a statistically significant changes obtained in the throwing accuracy after 15 minutes of cryotherapy application.

Design of a phase IV randomised, double-blind, placebo-controlled trial assessing the ImPact of Residual Inflammation Detected via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) patients (PREDICTRA)

IntroductionThe current American College of Rheumatology and European League Against Rheumatism treatment recommendations advise tapering biological disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) who achieve stable...

Clinical Supervision Contract & Consent Statement and Supervisee Rights and Responsibilities

(Adapted from Bernard & Goodyear, 2004 & McCarthy et al., 1995)The purpose of this form is to acquaint you with your clinical supervisor, to describe the supervision process, to involve you in stru...