Conflicting Research Findings Research Articles

Caffeine and Vision: Effects on the Eye.

Caffeine, commonly found in coffee and tea, affects various aspects of eye health as it blocks adenosine receptors, impacting tear production, intraocular pressure, macular perfusion, and choroidal thickness. However, its connection with eye conditions like glaucoma and cataracts remains uncertain due to conflicting research findings. Some studies suggest potential benefits for cataracts, while others warn against frequent caffeine intake in glaucoma and surgical scenarios due to possible increases in intraocular pressure. Conflicting evidence also exists regarding its effects on dry eye, macular degeneration, myopia/hyperopia, diabetic retinopathy, retinopathy of prematurity, and central serous retinopathy. Caffeine does not seem to be a risk factor for dry eye, although studies have shown that caffeine may offer protection against wet age-related macular degeneration, and the metabolite 7-methylxanthine could be a more promising treatment for myopia. Moreover, caffeine can potentially cause tremors and might hinder surgical performance, especially in less experienced surgeons. Recommendations from experts vary, highlighting the need for further research to fully understand how caffeine affects the eye. Individuals genetically predisposed to glaucoma should be cautious due to the possibility of clinically significant elevations in intraocular pressure with caffeine consumption. For delicate procedures like microsurgery, where tremors can be detrimental, caution should be exercised with caffeine. This review underscores the importance of additional studies to provide clearer insights and prudent recommendations regarding caffeine's impact on eye health.

Plasma metabolites as mediators in immune cell-pancreatic cancer risk: insights from Mendelian randomization.

Immune cells play a crucial role in the development and progression of pancreatic cancer, yet the causal relationship remains uncertain due to complex immune microenvironments and conflicting research findings. Mendelian randomization (MR), this study aims to delineate the causal relationships between immune cells and pancreatic cancer while identifying intermediary factors. The genome-wide association study (GWAS) data on immune cells, pancreatic cancer, and plasma metabolites are derived from public databases. In this investigation, inverse variance weighting (IVW) as the primary analytical approach to investigate the causal relationship between exposure and outcome. Furthermore, this study incorporates MR-Egger, simple mode, weighted median, and weighted mode as supplementary analytical approaches. To ensure the reliability of our findings, we further assessed horizontal pleiotropy and heterogeneity and evaluated the stability of MR results using the Leave-one-out method. In conclusion, this study employed mediation analysis to elucidate the potential mediating effects of plasma metabolites. Our investigation revealed a causal relationship between immune cells and pancreatic cancer, highlighting the pivotal roles of CD11c+ monocytes (odds ratio, ORIVW=1.105; 95% confidence interval, 95%CI: 1.002-1.218; P=0.045), HLA DR+ CD4+ antigen-presenting cells (ORIVW=0.920; 95%CI: 0.873-0.968; P=0.001), and HLA DR+ CD8br T cells (ORIVW=1.058; 95%CI: 1.002-1.117; P=0.041) in pancreatic cancer progression. Further mediation analysis indicated that oxalate (proportion of mediation effect in total effect: -11.6%, 95% CI: -89.7%, 66.6%) and the mannose to trans-4-hydroxyproline ratio (-19.4, 95% CI: -136%, 96.8%) partially mediate the relationship between HLA DR+ CD8br T cells and pancreatic cancer in nature. In addition, our analysis indicates that adrenate (-8.39%, 95% CI: -18.3%, 1.54%) plays a partial mediating role in the association between CD11c+ monocyte and pancreatic cancer, while cortisone (-26.6%, 95% CI: 138%, -84.8%) acts as a partial mediator between HLA DR+ CD4+ AC and pancreatic cancer. This MR investigation provides evidence supporting the causal relationship between immune cell and pancreatic cancer, with plasma metabolites serving as mediators. Identifying immune cell phenotypes with potential causal effects on pancreatic cancer sheds light on its underlying mechanisms and suggests novel therapeutic targets.

Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic-pharmacodynamic model of uterine contraction frequency.

Intravenous oxytocin is commonly used for labor induction. However, a consensus on the initial dosing regimen is lac with conflicting research findings and varying guidelines. This study aimed to develop a population kinetic-pharmacodynamic (K-PD) model for oxytocin-induced uterine contractions considering real-world data and relevant influencing factors to establish an optimal starting dosing regimen for intravenous oxytocin. This retrospective study included pregnant women who underwent labor induction with intravenous oxytocin at Peking University Third Hospital in 2020. A population K-PD model was developed to depict the time course of uterine contraction frequency (UCF), and covariate screening identified significant factors affecting the pharmacokinetics and pharmacodynamics of oxytocin. Model-based simulations were used to optimize the current starting regimen based on specific guidelines. Data from 77 pregnant women with 1095 UCF observations were described well by the K-PD model. Parity, cervical dilation, and membrane integrity are significant factors influencing the effectiveness of oxytocin. Based on the model-based simulations, the current regimens showed prolonged onset times and high infusion rates. This study proposed a revised approach, beginning with a rapid infusion followed by a reduced infusion rate, enabling most women to achieve the target UCF within approximately 30 min with the lowest possible infusion rate. The K-PD model of oxytocin effectively described the changes in UCF during labor induction. Furthermore, it revealed that parity, cervical dilation, and membrane integrity are key factors that influence the effectiveness of oxytocin. The optimal starting dosing regimens obtained through model simulations provide valuable clinical references for oxytocin treatment.

Can venture capital shareholding improve M&A performance? An empirical study based on Chinese GEM-listed companies.

Existing studies have explored the impact of venture capital shareholding on the GEM-listed companies before and after listing from multiple perspectives. However, there has been limited research on the influence of venture capital shareholding on these companies' mergers and acquisitions(M&A) activities and performance. Additionally, two conflicting research findings have been presented in limited relevant studies. In order to clarify the mechanism by which venture capital shareholding affects M&A activities and performance of GEM-listed companies and verify existing research conclusions, this paper takes 468 M&A events completed by the acquirer of China's GEM-listed companies between 2014 and 2016 as samples to explore venture capital shareholding's effects on the M&A performance of GEM-listed enterprises. The empirical findings demonstrate that GEM-listed enterprises with venture capital shareholding perform significantly better in terms of short-term and long-term M&A performance than those without; with the increase in venture capital shareholding ratio, the short-term M&A performance of GEM-listed enterprises has remarkably improved, but the long-term M&A performance does not show obvious correlation; joint investment of venture capital can significantly improve the short-term M&A performance of GEM-listed enterprises, but it has no substantial influence on long-term M&A performance. Based on further analysis of the empirical study, it is concluded that the common one-share ownership structure of GEM-listed enterprises is not conducive to the play of the monitoring function of venture capital, and the insufficient incentives and free-riding thinking also weaken the motivation and input of some venture capital shareholders to provide value-added services. This study systematically elucidates the mechanism and impact of venture capital shareholding on the M&A performance of GEM-listed companies, addressing the shortcomings in existing research. It is conducive for GEM-listed companies to gain a rational understanding and effectively leverage the active role of venture capital shareholders in M&A activities.

Decisive role of electrostatic interaction in rheological evolution of graphene oxide under ultrasonic fragmentation.

The aqueous dispersibility and processability of graphene oxide (GO) are pivotal for various applications, including the fluid assembly of macroscopic materials and nanofluidic systems. Despite the widespread utilization of ultrasonic treatment to achieve homogeneous dispersions, the rheological changes of GO during sonication have remained relatively unexplored, leading to conflicting research findings. In this study, we demonstrate that the viscoelastic evolution of GO can significantly differ under ultrasonic fragmentation depending on the balance between repulsion force and attraction force at the initial state before fragmentation. When electrostatic repulsion is in delicate equilibrium with attractive forces, gelation occurs under ultrasonic fragmentation, leading to increased viscosity under sonication. Conversely, when electrostatic repulsion predominates, viscosity decreases during sonication. This study reconciles conflicting observations on the rheological evolution of GO dispersions under ultrasonic fragmentation and provides valuable guidance and insights for the rheological engineering of GO colloidal systems.

The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation.

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, and DNA integrity, leading to male infertility. Antioxidants play a crucial role in maintaining reproductive health by neutralizing ROS and protecting sperm cells from oxidative damage. This review article explores the impact of oxidative stress on male reproductive function and investigates the potential benefits of antioxidant supplementation in mitigating its detrimental effects. A comprehensive literature search was conducted to gather relevant studies examining the effects of oxidative stress on male fertility and the outcomes of antioxidant supplementation. The findings reveal that antioxidant supplementation can improve sperm quality, DNA integrity, and fertility outcomes in some individuals. However, conflicting research findings and limitations in study design highlight the need for further investigation. Factors such as individual variations, underlying causes of infertility, dosage, and duration of supplementation should be carefully considered. Lifestyle modifications, including a healthy diet and exercise, are crucial in reducing oxidative stress and optimizing male reproductive health. This review article provides valuable insights into the complex relationship between oxidative stress and male reproductive function, emphasizing the potential role of antioxidant supplementation as a supportive strategy. Further research is warranted to establish optimal protocols, identify specific subgroups that may benefit the most, and explore advancements in antioxidant therapies to improve male fertility outcomes.

Computer-Mediated Communication and Well-Being in the Age of Social Media: A Systematic Review

The association between computer-mediated communication (CMC) and well-being is a complex, consequential, and hotly debated topic that has received significant attention from pundits, researchers, and the media. Conflicting research findings and fear over negative outcomes have spurred both moral panic and further research into these associations. To create a more comprehensive picture of trends, explanations, and future directions in this domain of research, we conducted a systematic meso-level review of 366 studies across 349 articles published since 2007 that report associations between CMC and well-being. Although most of this research is not explicitly theoretical, several potential theoretical mechanisms for positive and negative effects of CMC on well-being are utilized. The heterogeneity of effects in the studies we reviewed could be explained by the discipline in which the research is conducted, the methodology used, the types of CMC and well-being examined, and the population studied. Our evaluation of this body of research highlights the importance of attending to how we conceptualize communication and well-being, the questions we ask, and the populations and contexts we study when both reading and producing research on CMC and well-being.

How personality moderates the relationships between childhood environment, flow metacognitions, and creative ideational behavior: A preliminary study

There seems to be conflicting research findings about the role that personality and childhood environment play in predicting creativity. This study aims to fill this gap and explore through moderation analysis how personality, childhood environment, and their interaction affect two constructs that impact creativity outcomes: flow metacognitions and creative ideational behaviors. A sample of 59 adolescents from the midwestern region of the United States who were identified as creative through a profiling approach participated in the study. Results indicated that neuroticism significantly moderated the relationship between childhood environment and flow metacognitions. Openness to experience significantly predicted belief that flow fosters achievement and creative ideational behaviors, but it did not significantly moderate any proposed relationships. The significance of the findings to creativity is discussed.

Navigating challenging contexts: Costs and benefits of codified acquisition experience

Despite its intuitive appeal, acquisition experience has not shown a clear benefit to acquirers, and we argue the applicability of acquisition experience depends on goals and context. Using survey data, we consider the effects of applying codified experience for two common acquisition goals involving knowledge transfer and market expansion. Our findings reveal a ‘double-edged sword’ effect, where on one hand, codification mitigates negative effects of industry rivalry on knowledge transfer. However, on the other hand, codification amplifies negative effects of industry rivalry on market expansion and internal turmoil on knowledge transfer. Beyond demonstrating the importance of goals and context contingencies for determining acquisition experience effect, our results reconcile conflicting research findings to identify when codified experience is beneficial in acquisitions.

Metaphors in the Making: Illuminating the Process of Arts-Based Health Research Through a Case Exemplar Linking Arts-Based, Qualitative and Quantitative Research Data

Background: The potentials of arts-based health research are increasingly being realized as an approach to understanding and communicating the complexities of the human experience of health and illness. Despite this, arts-based health research often remains shrouded in obscurity, limiting its potential utility. Arts-based health research offers unique opportunities to integrate evidence of patients’ lived experience with other forms of research evidence to improve understanding and knowledge translation, but transparent descriptions of this praxis are generally lacking. In response, this article offers methodological insight and guidance through an in-depth case exemplar of an arts-based health research process linking qualitative research with diverse evidence sources in the context of frailty research. Methods: Responding to research data generated within a Centre of Research Excellence in Frailty and Healthy Ageing, we adopted a researcher-as-practitioner stance to produce research-based artworks to integrate and communicate conflicting research findings. We structure this process according to Ecker’s seven domains of qualitative inquiry, demonstrating parallels between the arts-based research and qualitative inquiry processes and offering opportunities for engaging with “evidence misalignments” resulting from incongruent evidence sources. Findings: Arts-based health research can enable meaningful reflection upon, integration, and communication of “evidence-misalignments” in research spanning the health and social sciences. Such misalignments are problematic when the lived experience of health and illness conflicts with other empirical evidence, including gold standard evidence guiding treatment decisions. These in turn, can function as plausible barriers to self management and to achievement of health outcomes. Interpretation: Through the researcher-as-practitioner lens, and with an orientation to production, this work engaged with a new means of materiality—one that extends beyond text and numerical representations—and whose meaning and connections may not be immediately apparent. These relationships change how the researchers-practitioner engages with, understands, explores, and represents concepts, enabling epistemological and ontological gains of benefit to the health and social sciences.

The role of eosinophils in parasitism and allergies: A review.

Eosinophils are bone marrow produced granulocytes known to play key roles in mammalian host’s defence against parasitic infections and allergic reactions. Although a lot of studies were carried out to establish these roles, conflicting research findings rendered the long-established relationship between eosinophils and the induction of allergic sensitivity and their roles in helminth infections controversial. Emerging evidence from recent research efforts showed that eosinophils stimulated airway remodelling and also served to control the immune response in allergic reactions. Research was conducted using databases such as Google, Google Scholar, Research gate, Scopus, Science Direct and Pub Med. The key words used for the search were eosinophils and eosinophilia, then the relevant articles were selected. This article explains the mechanism of eosinophilia in parasitism as well as allergic reactions. In this article, the concept of eosinophilia, its different classes and the role it plays in parasitism and allergies are reviewed and discussed.

COVID-19, neutrophil extracellular traps and vascular complications in obstetric practice.

An issue of the novel coronavirus infection spreading is currently in the first place among others in the list of the international medical community. Due to lack of information, conflicting research findings, multicomponent effect of the virus on the body host, as well as various consequences that the virus triggers in the body, now every medical specialty does study the viral attack pathogenesis. Recent months showed that vascular complications are the most severe in the Coronavirus Disease 2019 (COVID-19) and are the main cause of death in the patients. The mechanisms of vascular complications are complex and affect both the hemostatic system and immune responses, "inflammatory storm", disorders of the renin-angiotensin-aldosterone system, endotheliopathy, etc. Due to the leading role of vascular complications in the viral infection pathogenesis, several groups of patients are at extra risk, including pregnant women, patients with a burdened obstetric history, with hereditary thrombophilia and antiphospholipid syndrome, and patients after in vitro fertilization (IVF). In this category of pregnant women, use of low-molecular-weight heparins (LMWH) is particularly important for both prevention of vascular and obstetric complications, and for pathogenetic therapy of COVID-19.

Experimental evidence on structural adequacy of high strength S690 steel welded joints with different heat input energy

Quenching and tempering is a highly developed heat treatment method to produce high strength steels with certain quantities of expensive alloy elements. This process has been highly industrialized and widely adopted in modern steel mills to produce high strength S690 steels. However, a heating/cooling cycle induced during welding may initiate phase transformation, re-crystallization and grain growth in microstructures of these steels. This will cause a significant reduction in their mechanical properties if both the maximum temperatures during welding and the cooling rates after welding are not properly controlled. Over the past twenty years, conflicting research findings have been reported on mechanical properties of these S690 welded sections due to different welding procedures and parameters adopted during welding.In order to quantify adverse effects on mechanical properties of the S690 steel welded joints under static loads, a series of pilot tests on a total of 18 coupons of S690 steel plates, welded joints and weld metals with different heat input energy during welding have been conducted to examine their deformation characteristics under tension. Moreover, 12 reference and 12 spliced S690 welded H-sections with different heat input energy adopted in the welding processes have been conducted to examine their deformation characteristics under compression, in particular, their section resistances under compression. It is demonstrated that by a proper control on the heat input energy during welding, it is possible to control or even eliminate any reduction in the mechanical properties of these S690 welded joints under either tension or compression. Consequently, experimental evidence on structural adequacy of these high strength S690 steel welded joints with different heat input energy adopted in the welding processes is provided scientifically to confirm applications of these high strength S690 steels in construction.

Corporate Governance and the Financial Crisis: What Have We Missed?

The need for efficient corporate governance mechanisms, to restore the public’s trust in U.S. financial markets, increased after the latest round of corporate fraud cases that wiped out $8 trillion from the US market. Proponents of efficient governance argue that current mechanisms need revamping. This study explores the role of corporate governance in regulating the US market and sets forth corporate governance improvement recommendations. These recommendations address the need for proactive corporate governance, using meta analysis to reconcile conflicting research findings, employing alternative theoretical underpinnings that go beyond agency theory, thinking blockchains, and developing an agenda for corporate governance convergence.

A child of two mothers: what about the father? Italian overview.

Surrogacy techniques allow for the birth of children who are then raised by parents who may have no genetic or biological connection with them at all. Italian legislation on medically assisted procreation bans such practices, under national criminal codes, and yet the intended parents’ ability to legally register children born abroad via surrogacy has not been affected by such legislation. Italian jurisprudence has acknowledged the parental status of same-sex couples, following the same path outlined by the European Court of Human Rights. The paper’s author elaborates on court decision n. 145/2018, from the Naples Court of Appeals, which has stated that surrogacy children may be connected to their intended parents merely by virtue of “mental” elements, based on affection, harmony and listening enjoyed by the child within the family setting. The author is critical of that view, in light of conflicting research findings on children growing up in same-sex families. In that regard, the author argues that even though homosexual couples may well turn out to be good parents, families made up of fathers and mothers still constitute the best scenario for the children, from a social perspective. It is however necessary for lawmakers to step in and better regulate an utterly sensitive area of law, one that might engender adverse repercussions on the children’s well-being, in terms of growth and psychological development, following their becoming part of homosexual families. (www.actabiomedica.it)

Approximate number system task performance: Associations with domain-general and domain-specific cognitive skills in young children

We investigated the associations between young children’s domain-general executive functioning (EF) skills and domain-specific spontaneous focusing on number (SFON) tendencies and their performance on an approximate number system (ANS) task, paying particular attention to variations in associations across different trial types with either congruent or incongruent non-numerical continuous visual cues. We found that children’s EF skills were strongly related to their performance on ANS task trials in which continuous visual cues were incongruent with numerosity. Novel to the current study, we found that children’s SFON tendencies were specifically related to their performance on ANS task trials in which continuous visual cues were congruent with numerosity. Children’s performance on ANS task trials in which children can use both congruent numerical and non-numerical continuous visual cues to approximate large quantities may be related to their unprompted tendency to focus on number in their early environment when there are not salient distractors present. On the other hand, children’s performance on incongruent ANS trials may be less a function of number-specific knowledge but more of children’s domain-general ability to inhibit salient but conflicting or irrelevant stimuli. Importantly, these effects held even when accounting for global math achievement and children’s cardinality knowledge. Overall, results support the consideration of both domain-specific and domain-general cognitive factors in developmental models of children’s early ability to attend to numerosity and provide a possible means for reconciling previous conflicting research findings.

Oat safety for celiac disease patients: theoretical analysis correlates adverse symptoms in clinical studies to contaminated study oats

Inclusion of oats in a gluten-free (GF) diet can provide whole grain nutritional benefits to celiac disease (CD) patients, but there has been debate regarding oat safety for these individuals. This is because of conflicting research findings, with inconsistencies attributed to varying CD subject's sensitivities to “pure” oats. Clinical trials to date have assumed oats provided to subjects to be lightly contaminated, if at all. This assumption is challenged here since oat's propensity to be “kernel” contaminated with gluten sources like wheat and barley has recently been shown to significantly complicate confirmation of a GF state. We therefore hypothesize that clinical studies may have inadvertently provided pill-like gluten kernels intermittently to study subjects, leading to adverse outcomes that could potentially explain inconsistencies between study conclusions. To test this theory, potential gluten contamination of oats used in a cross-section of 12 important oat feeding studies has been estimated, done according to descriptions of oats used, published contamination rates for various oat types, and study oat dosages. Expected gluten exposures were found to be at levels to elicit clinical effects in a large portion of CD patients, correlating with observed clinical reaction rates in those studies (P value = .0006). Estimated gluten doses were found insufficient, however, to affect morphological outcomes, whereas only 1 study had 1 case. Our analysis provides a new perspective with which to view oat safety study conclusions and justifies new clinical trials using today's higher-purity GF oats to settle the oat safety for CD patient debate.

The impact of anonymous marking on students’ perceptions of fairness, feedback and relationships with lecturers

Anonymity in marking is a contentious issue within higher education. Conflicting research findings have identified issues surrounding gender bias, ethnicity bias and fairness in marking. However, the effects of anonymity upon feedback mechanisms have not been systematically explored. This study sought to understand the effects of anonymous marking and feedback upon students’ perceptions of its potential for future learning and relationship building with their lecturers. First year United Kingdom undergraduate business, politics, pharmacy and french students experienced anonymous and non-anonymous marking of coursework across different modules. Student performance data were collected, and a survey was administered following the completion of their modules. Results revealed that anonymous marking did not seem to advantage or disadvantage particular groups of students in terms of grade outcome. There was no significant difference in perceptions of fairness according to whether or not marking was anonymous. Furthermore, the results suggest that anonymous marking might undermine the learning potential of feedback, and minimise the strength of the relationship between lecturers and students, which may minimise the role of dialogue in the feedback process.

Posttraumatic Stress Disorder and Gastrointestinal Disorders in the Danish Population

Evidence for the association between posttraumatic stress disorder (PTSD) and gastrointestinal (GI) disorders is mixed, owing in part to methodologic differences across studies. Furthermore, studies which have combined GI disorders or symptoms for examination as one overall category may potentially obscure associations between PTSD and individual GI diagnoses. This nationwide cohort study examined the incidence of all major nonmalignant GI disorders in patients with a prior PTSD diagnosis (n = 4,076), compared with the general population incidence from 1995 to 2013, using Danish medical registry data. We examined differences by sex, age, marital status, psychiatric and somatic comorbidity, and follow-up time. Risks, standardized incidence rates (SIRs), and confidence intervals (95% CIs) were calculated. Risk of any GI disorder among PTSD patients was 25% (95% CI: 21%, 29%); the SIR for any GI disorder was 1.8 (95% CI: 1.7, 2.0). Risk and SIRs varied by disorder (e.g., no association with diverticula of the intestines [SIR: 1.1, 95% CI: 0.83, 1.5]; stronger association with peptic ulcer, site unspecified [SIR: 3.3, 95% CI: 1.8, 5.5]). Stratified analyses revealed that some associations were stronger for persons ages 16-39 or unmarried at PTSD diagnosis, persons with comorbid psychiatric diagnoses, and in the year following PTSD diagnosis. This study documents associations between clinician-diagnosed PTSD and all major nonmalignant GI disorders in an unselected nationwide cohort with long follow-up. Differences in associations across GI disorders and important modifiers may account for previous conflicting research findings.

Effects of Subtitles, Complexity, and Language Proficiency on Learning From Online Education Videos

Abstract. Open online education has become increasingly popular. In Massive Open Online Courses (MOOCs) videos are generally the most used method of teaching. While most MOOCs are offered in English, the global availability of these courses has attracted many non-native English speakers. To ensure not only the availability, but also the accessibility of open online education, courses should be designed to minimize detrimental effects of a language barrier, for example by providing subtitles. However, with many conflicting research findings it is unclear whether subtitles are beneficial or detrimental for learning from a video, and whether this depends on characteristics of the learner and the video. We hypothesized that the effect of 2nd language subtitles on learning outcomes depends on the language proficiency of the student, as well as the visual-textual information complexity of the video. This three-way interaction was tested in an experimental study. No main effect of subtitles was found, nor any interaction. However, the student’s language proficiency and the complexity of the video do have a substantial impact on learning outcomes.