Chinese learners are poor at oral English owing to a lack of practice. There is a high demand for opportunities to practice oral English effectively. This study investigates the use of three educationally significant ways of talking to Chinese learners’ meaningful oral English development in one-to-one Computer- and Internet-Based Virtual Classes (CIBVC). It is a qualitative case study including two sets of data that contain 64 video-recorded lessons. One set of data are 32 class recordings from one participant as the primary data and the other are from another four participants as the supplementary data. Thematic analysis is employed to carry out this study and computer-assisted qualitative data analysis software is utilized to assist. The findings of this study discover effective ways of using the three ways of talking to conduct oral English teaching and learning practice. The results contribute to research into relating authentic communication in CIBVC to the discovery of effective oral English practice. Obtained practical implications are valuable references as predictors of successful teaching and learning outcomes.