Largely unknown just a few decades ago, computational systems biology is now a central methodology for biological and medical research. This amazing ascent raises the question of what the community should do next. The article outlines our personal vi... Read More
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What’s next for computational systems biology?
- Frontiers in Systems Biology
- VOL. 3
on Sep 19, 2023
- Computational Biology
- Computational Systems Biology
- Synthetic Biological Systems
- Issues In Agriculture
- Digital Twins
- Educational Efforts
- More +
Non‐similar analysis of chemically reactive bioconvective Casson nanofluid flow over an inclined stretching surface
- ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik
on Sep 18, 2023
- Casson Fluid Model
- Dissipation Of Viscosity
- System Of Partial Differential Equations
- Casson Nanofluid
- Graphical Configuration
- Finite Difference Code
- More +
AbstractBioconvection in non‐Newtonian nanofluids has a wide range of contemporary applications in biotech, biomechanics, microbiology, computational biology, medical science, etc. Considering the Casson fluid model and inclined stretching geometry a... Read More
Computation to Fight SARS-CoV-2 (COVID-19)
- Computation
- VOL. 11
on Sep 18, 2023
- Computational Biology
- Pandemic Health Emergency
- Pandemic Emergency
- Pandemic Health
- Health Emergency
- Special Issue
- More +
In April 2020, during the last pandemic health emergency, we launched a Special Issue hosted by Computation—section Computational Biology, entitled “Computation to Fight SARS-CoV-2 (COVID-19)” [...]... Read More
State-of-the-art strategies to prioritize Mycobacterium tuberculosis drug targets for drug discovery using a subtractive genomics approach
- Frontiers in Drug Discovery
- VOL. 3
on Sep 18, 2023
- Subtractive Genomics Approach
- Inappropriate Use Of Antibiotics
- Drug Development Pipeline
- Subtractive Approach
- anti-TB Drugs
- Evolution Of Technology
- More +
Tuberculosis remains one of the causes of death from a single infectious bacterium. The inappropriate use of antibiotics and patients’ non-compliance among other factors drive the emergence of drug-resistant tuberculosis. Multidrug-resistant and exte... Read More
SYSTEMATIC IDENTIfiCATION OF CONTEXT-DEPENDENT GENE-ESSENTIALITY IN GLIOBLASTOMA: THE GBM-CODE PLATFORM
- Neuro-Oncology
- VOL. 25
on Sep 16, 2023
- Computational Biology
- Scale Biological Data
- Subfield Of Mathematics
- Causal Machine Learning
- Functional Genomics Data
- GBM Tumours
- More +
Abstract AIMS Glioblastoma (GBM) is a heterogeneous and aggressive brain tumour that is invariably fatal despite maximal treatment. GBM-relevant ‘biomarkers’ (such as known driver-mutations or cell-... Read More
Quantum gate algorithm for reference-guided DNA sequence alignment.
- Computational biology and chemistry
- VOL. 107
on Sep 14, 2023
- Number Of Available Qubits
- Algorithm For Sequence Alignment
- Quantum Computers
- MB Of Storage
- DNA Sequencing
- Computational Molecular Biology
- More +
Reference-guided DNA sequencing and alignment is an important process in computational molecular biology. The amount of DNA data grows very fast, and many new genomes are waiting to be sequenced while millions of private genomes need to be re-sequenc... Read More
Identification of a novel Sorcin isoform with a different C-terminal but intact dimerization property
- Scientific Reports
- VOL. 13
on Sep 14, 2023
- C-terminal Domain
- Maintaining Calcium Homeostasis
- Molecular Biology Techniques
- Vesicular Trafficking
- Computational Biology Techniques
- Bioinformatics Tools
- More +
Sorcin (Sri), a member of penta EF-hand protein family plays a diverse role in maintaining calcium homeostasis, cell cycle and vesicular trafficking. Sri is highly conserved amongst mammals and consists of N-terminal glycine rich domain and C-termina... Read More
Progress with Repository-based Annotation Infrastructure for Biodiversity Applications
- Biodiversity Information Science and Standards
- VOL. 7
on Sep 14, 2023
- IIIF
- Editing Of Annotations
- GBIF
- FOSS
- International Society For Computational Biology
- Biodiversity Literature
- More +
Rapid development since the 1980s of technologies for analysing texts, has led not only to widespread employment of text 'mining', but also to now-pervasive large language model artificial intelligence (AI) applications. However, building new, concis... Read More
Monitoring environmental microbiomes: Alignment of microbiology and computational biology competencies within a culturally integrated curriculum and research framework.
- Molecular ecology resources
on Sep 13, 2023
- Researchers In Microbiology
- Research Framework
- Environmental Microbiomes
- Curriculum Framework
- Microbiome Research
- Microbiome Analysis
- More +
We have developed a flexible undergraduate curriculum that leverages the place-based research of environmental microbiomes to increase the number of Indigenous researchers in microbiology, data science and scientific computing. Monitoring Environment... Read More
Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua)
- BMC Complementary Medicine and Therapies
- VOL. 23
on Sep 8, 2023
- Computational Biology
- Mechanisms Of Action In Cancer
- Artemisia Annua
- Protein-ligand Complexes
- Traditional Chinese Medicine
- Cancer Cell
- More +
BackgroundCancer is one of the leading causes of death worldwide. Recently, it was shown that many natural extracts have positive effects against cancer, compared with chemotherapy or recent hormonal treatments. A. annua is an annual medicinal herb u... Read More
Identification of natural lead molecules as potential Trypanosoma cruzi cruzipain inhibitors and decoding the interaction mechanism for the treatment of Chagas disease: a computational biology analysis
- Natural Product Research
- VOL. ahead-of-print
on Sep 4, 2023
- Cruzipain Inhibitor
- Drug Discovery Process
- Docking Protocol
- Public Health Threat
- Unwanted Side-effects
- Chagas Disease
- More +
Chagas disease has grown into a serious public health threat, with a high morbidity rate, major social impact, and global neglect. Therapeutic adhesion, unwanted side-effects, and resistance make its present therapy ineffective. Discovery of more ef... Read More
DeepGene Transformer: Transformer for the gene expression-based classification of cancer subtypes
- Expert Systems with Applications
- VOL. 226
on Sep 1, 2023
- Computational Biologists
- Use Of Precision Medicine
- Classification Of Cancer Subtypes
- Identification Of Cancer Biomarkers
- Multiple Cancer Subtypes
- Conventional Machine Learning
- More +
Cancer and its subtypes constitute approximately 30% of all causes of death globally and display a wide range of heterogeneity in terms of clinical and molecular responses to therapy. Molecular subtyping has enabled the use of precision medicine to o... Read More
Integrative gene expression analysis for the diagnosis of Parkinson's disease using machine learning and explainable AI.
- Computers in biology and medicine
- VOL. 163
on Sep 1, 2023
- Computational Biologists
- Diagnosis Of PD
- LASSO
- SHAP
- Integrating Gene Expression Data
- Treatment Of PD
- More +
Parkinson's disease (PD) is a progressive neurodegenerative disorder. Various symptoms and diagnostic tests are used in combination for the diagnosis of PD; however, accurate diagnosis at early stages is difficult. Blood-based markers can support phy... Read More
Subspace learning using structure learning and non-convex regularization: Hybrid technique with mushroom reproduction optimization in gene selection.
- Computers in biology and medicine
- VOL. 164
on Sep 1, 2023
- Computational Biology
- Hybrid Feature Selection
- Hybrid Feature Selection Method
- Feature Selection
- Structure Learning
- Gene Selection
- More +
Gene selection as a problem with high dimensions has drawn considerable attention in machine learning and computational biology over the past decade. In the field of gene selection in cancer datasets, different types of feature selection techniques i... Read More
A systems and computational biology perspective on advancing CAR therapy
- Seminars in Cancer Biology
- VOL. 94
on Sep 1, 2023
- Computational Biology
- CAR Therapy
- CAR
- CAR Structure
- Use Of Systems Approaches
- Eliminate Tumor Cells
- More +
In the recent decades, chimeric antigen receptor (CAR) therapy signaled a new revolutionary approach to cancer treatment. This method seeks to engineer immune cells expressing an artificially designed receptor, which would endue those cells with the ... Read More
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability.
- iScience
- VOL. 26
on Sep 1, 2023
- Atherosclerotic Plaque Vulnerability
- Chronic Coronary Syndrome
- Quantification System
- Subtle Genetic Changes
- Biological Interpretability
- Subtle Pathological Changes
- More +
Acute myocardial infarction dominates coronary artery disease mortality. Identifying bio-signatures for plaque destabilization and rupture is important for preventing the transition from coronary stability to instability and the occurrence of thrombo... Read More
Rational peptide design for targeting cancer cell invasion.
- Proteins
on Aug 30, 2023
- Computational Biology
- Implantation Of Cancer Cells
- Field Of Computational Biology
- Inhibit Cancer Cell Invasion
- Computational Biology Approaches
- Anti-metastatic Potency
- More +
Cell invasion is an important process in cancer progression and recurrence. Invasion and implantation of cancer cells from their original place to other tissues, by disabling vital organs, challenges the treatment of cancer patients. Given the import... Read More
Sequence-based prediction model of protein crystallization propensity using machine learning and two-level feature selection.
- Briefings in bioinformatics
on Aug 30, 2023
- Computational Biology
- Protein Crystallization Propensity
- Recursive Feature Elimination
- Support Vector Machine Algorithm
- Hyperparameter Tuning
- Feature Selection Method
- More +
Protein crystallization is crucial for biology, but the steps involved are complex and demanding in terms of external factors and internal structure. To save on experimental costs and time, the tendency of proteins to crystallize can be initially det... Read More
Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells
- Stem Cell Research & Therapy
- VOL. 14
on Aug 30, 2023
- Transcriptomic Data
- Expression In Human ECs
- Gene Expression In Human ECs
- MCs
- Preferential Commitment
- ECs
- More +
BackgroundNative bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan. Moreover, BM-MSCs regulate hematopoiesis by contributing to the hematopoietic stem cell nich... Read More
A co-formulation of interferons alpha2b and gamma distinctively targets cell cycle in the glioblastoma-derived cell line U-87MG
- BMC Cancer
- VOL. 23
on Aug 29, 2023
- Proliferation Of U-87MG
- Cell Cycle
- Functional Enrichment
- Basal Cell Carcinomas
- GBM
- Clinical Superiority
- More +
BackgroundHeberFERON is a co-formulation of α2b and γ interferons, based on their synergism, which has shown its clinical superiority over individual interferons in basal cell carcinomas. In glioblastoma (GBM), HeberFERON has displayed promising prec... Read More