Comprehensive Online Research Articles

Is there Anything Good about the COVID-19 Pandemic? Perceptions of the Positive Consequences at the Beginning of the Pandemic

The aim of this paper was to investigate the experience of possible positive consequences of the COVID-19 pandemic and their connection with indicators of mental health and well-being, and to identify themes by which people describe the positive consequences of the pandemic. As part of a broader longitudinal project, participants completed a comprehensive online survey on various aspects of the pandemic. This paper presents the results obtained from 1,201 adult participants (50.1% women) on a quantitative measure of the experienced positive consequences, and on the qualitative answers to an open question about the positive aspects of the pandemic. The quantitative measure was created for the purposes of this research. Measures of sociodemographic factors, mental health (DASS-21) and well-being (WHO-5) were also used. The results show that participants experience positive consequences of the COVID-19 pandemic through three factors: Awareness of life values, More time for oneself, and New job opportunities. Awareness of life values was ranked as the most important, then More time for oneself, and finally New job opportunities. Participants who were more aware of these three aspects of the positive effects of COVID-19 also showed significantly greater subjective well-being and resilience, while associations with depression, anxiety, and stress were negligible or low. Women were more aware of changes in their life values than men, while men had a greater experience of new job opportunities. The results of the qualitative responses show that 83.4% of participants recognised some form of positive consequences of the pandemic on their lives, on the lives of other people, and on society. Analyses revealed seven themes: better family relationships, reflection and personal growth, social well-being, digitalisation of work and education, improved personal life, environmental effects, and competent pandemic management. Together, the results point to the importance of thinking about and exploring positive consequences of crisis events in the context of individual resilience and well-being.

Comparison of Intraductal RFA Plus Stent versus Stent-Only Treatment for Unresectable Perihilar Cholangiocarcinoma-A Systematic Review and Meta-Analysis.

Simple SummaryIn patients with unresectable perihilar cholangiocarcinoma, adequate biliary drainage is essential. Stent patency remains a challenge in these complex patients, as both plastic and metal stent occlusion may occur, necessitating additional drainage procedures. Radiofrequency ablation (RFA) is a promising local treatment that has already proven its usefulness in other malignancies, such as hepatocellular carcinoma. In this meta-analysis and systematic review, we aimed to compare intraductal RFA with stent placement to stent placement alone in patients with unresectable perihilar cholangiocarcinoma. We found that RFA + stent treatment showed a significantly longer overall survival, in comparison to stent-only treatment. Further research is necessary in order to validate these findings to support the implementation of this promising strategy in clinical practice.Background: One of the cornerstones of palliative treatment for unresectable perihilar cholangiocarcinoma is biliary stent placement in order to restore biliary drainage. In this review, the potential added value of RFA with stent placement in comparison to stent placement alone in patients with unresectable perihilar cholangiocarcinoma is analyzed. Methods: We performed a comprehensive online search for relevant articles in November 2021 (PROSPERO ID: CRD42021288180). The primary endpoint was difference in overall survival. Secondary endpoints included overall survival, stent patency and complications. Only studies comparing survival after RFA + stent placement with stent placement alone were included in the meta-analysis. Non-comparative studies or comparative studies describing stent patency only were included in the systematic review. Results: A total of nine studies, including 217 patients with pCCA who underwent RFA + stent placement and 294 patients who underwent stent-only treatment, met the inclusion criteria for the primary endpoint analysis. Direct comparison between the two treatment groups showed a significantly longer overall survival for RFA + stent treatment, with a pooled HR of 0.65 [95% CI, 0.50–0.84, I2 = 38%]. When all eligible studies were included, RFA + stent treatment revealed an overall survival of 9.5 months [95% CI, 6.3–12.6], whereas survival for stent-only treatment was 7.0 months [95% CI, 5.7–8.2]. Due to the heterogeneity of the data, no pooled data analysis could be performed on stent patency or complications. Conclusions: RFA + stent placement displays promising potential to prolong survival. However, further research incorporating confounding factors like use of palliative chemotherapy is necessary in order to validate these findings.

Development of COVID-19 Health-Risk Assessment and Self-Evaluation (CHaSe): a health screening system for university students and staff during the movement control order (MCO).

COVID-19 has triggered a global health crisis. Death from severe respiratory failure and symptoms, including fever, dry cough, sore throat, anosmia, and gastrointestinal disturbances, has been attributed to the disease. Development of screening and diagnosis methods prove to be challenging due to shared clinical features between COVID-19 and other pathologies, such as Middle Eastern respiratory syndrome, severe acute respiratory syndrome, and common colds. This study aims to develop a comprehensive one-stop online public health screening system based on clinical and epidemiological criteria. The immediate target populations are the university students and staff of University Sultan Zainal Abidin and the civil servants of the Malaysian Ministry of Science, Technology, and Innovation. Forty-nine (49) clinical and epidemiological factors associated with COVID-19 were identified and prioritized based on their prevalence via rigorous review of the literature and vetting sessions. A pilot study of 200 volunteers was conducted to assess the extent of risk mitigation of COVID-19 infection among the university students and civil servants using the prototyped model. Consequently, twelve (12) clinical parameters were identified and validated by the medical experts as essential variables for COVID-19 risk-screening. The updated model was then revalidated via real mass-screening of 5000 resulting in the final adopted CHaSe system. Principal component analysis (PCA) was used to confirm the weightage of risk level toward COVID-19 to procures the optimal accuracy, reliability, and efficiency of this system. Twelve (12) factor loadings accountable for 58.287% of the clinical symptoms and clinical history variables with forty-nine (49) parameters of COVID-19 were identified through PCA. The variables of the clinical and epidemiological aspects identified are the C6 (History of joining high-risk gathering (where confirmed cases had been recorded), CH11 [History of contact with confirmed cases (close contact)], CH13 [Duration of exposure with confirmed cases (minutes)] with substantial positive factors of 0.7053, 0.706 and 0.5086, respectively. The contribution toward high-risk infection of COVID-19 was firmly attributable to the variables CH14 [Last contact with confirmed cases (days)], CH13 [Duration of exposure with confirmed cases (minutes)], and S1 (Age). The revalidated PCA for 5000 respondents also yielded twelve significant PCs with a cumulative variance of 58.288%. Importantly, the medical experts have revalidated the CHaSe system for accuracy of all clinical aspects (clinical symptoms and clinical history) and epidemiological links to COVID-19 infection. After revalidating the model for 5000 respondents, the PC variance for PC1, PC2, PC3, and PC4 was 27.36%, 11.79%, 10.347%, and 8.785%, respectively, with the cumulative explanation of 58.288% in data variability. The level of risks detected using the CHaSe system toward COVID-19 provides optimal accuracy, reliability, and efficiency to conduct mass-screening of students and government servants for COVID-19 infection.

The Youth Wellness Quest: A Comprehensive Online Mental Health Literacy and Self-Advocacy Resource Developed by Youth for Youth.

A lack of mental health literacy may impact youths' ability to advocate for themselves as they seek to access and navigate the mental healthcare system. Recognizing this, members of the National Youth Action Council at the Centre for Addiction and Mental Health in Toronto, ON, developed the Youth Wellness Quest resource. This health literacy resource informs youth of possible available services, increasing their capacity to make informed mental healthcare decisions. The youth-led process of creating this resource, from development to dissemination, is described within this paper, showcasing how youth can lead the development of tools designed for youth.

Development and evaluation of an online questionnaire to identify women at high and low risk of developing gestational diabetes mellitus

BackgroundEstablished risk factors for Gestational Diabetes Mellitus (GDM) include age, ethnicity, family history of diabetes and previous GDM. Additional significant influences have recently been demonstrated in the literature. The oral glucose tolerance test (OGTT) used for GDM diagnosis has sub-optimal sensitivity and specificity, thus often results in GDM misdiagnoses. Comprehensive screening of risk factors may allow more targeted monitoring and more accurate diagnoses, preventing the devastating consequences of untreated or misdiagnosed GDM. We aimed to develop a comprehensive online questionnaire of GDM risk factors and triangulate it with the OGTT and continuous glucose monitoring (CGM) parameters to better evaluate GDM risk and diagnosis.MethodsPregnant women participating in two studies on the use of CGM for GDM were invited to complete the online questionnaire. A risk score, based on published literature, was calculated for each participant response and compared with the OGTT result. A total risk score (TRS) was then calculated as a normalised sum of all risk factors. Triangulation of OGTT, TRS and CGM score of variability (CGMSV) was analysed to expand evaluation of OGTT results.ResultsFifty one women completed the questionnaire; 29 were identified as ‘high-risk’ for GDM. High-risk ethnic background (p < 0.01), advanced age, a family diabetic history (p < 0.05) were associated with a positive OGTT result. The triangulation analysis (n = 45) revealed six (13%) probable misdiagnoses (both TRS and CGMSV discordant with OGTT), consisting of one probable false positive and five probable false negative by OGTT results.ConclusionsThis study identified pregnant women at high risk of developing GDM based on an extended evaluation of risk factors. Triangulation of TRS, OGTT and CGMSV suggested potential misdiagnoses of the OGTT. Future studies to explore the correlation between TRS, CGMSV and pregnancy outcomes as well as additional GDM pregnancy biomarkers and outcomes to efficiently evaluate OGTT results are needed.

Pocket Certificates using Double Encryption: A Survey

Abstract: Documents are items that convey information, can be used to certify someone, or can constitute a legal report. Theft of such crucial documents/certificates can obstruct or hinder an individual's or organization's ability to execute their work effectively, as well as result in the loss of personal belongings. "Pocket Certificates" - a traditional document archive with the possibility of securely preserving such papers - is provided in this text. The answer is to utilise a Double Encryption system that combines the AES and 3DES encryption standards. The use of improved security can be considered of as a tradeoff in a system's stability and smooth operation, however there are specific limitations that must be imposed so that the Encryption/Decryption process does not obstruct usability. This work considers such characteristics and strikes a balance between them all. Other Hashing methods are also used, such as bycrypt for securely storing user login data and passport middleware for each application stage's specific user authentication needs. The paper comprises of a comprehensive online application for the safe archiving of essential documents or data. Keywords: 3DES, AES, Cryptography, Decryption, Encryption

A Library for fMRI Real-Time Processing Systems in Python (RTPSpy) With Comprehensive Online Noise Reduction, Fast and Accurate Anatomical Image Processing, and Online Processing Simulation.

Real-time fMRI (rtfMRI) has enormous potential for both mechanistic brain imaging studies or treatment-oriented neuromodulation. However, the adaption of rtfMRI has been limited due to technical difficulties in implementing an efficient computational framework. Here, we introduce a python library for real-time fMRI (rtfMRI) data processing systems, Real-Time Processing System in python (RTPSpy), to provide building blocks for a custom rtfMRI application with extensive and advanced functionalities. RTPSpy is a library package including (1) a fast, comprehensive, and flexible online fMRI image processing modules comparable to offline denoising, (2) utilities for fast and accurate anatomical image processing to define an anatomical target region, (3) a simulation system of online fMRI processing to optimize a pipeline and target signal calculation, (4) simple interface to an external application for feedback presentation, and (5) a boilerplate graphical user interface (GUI) integrating operations with RTPSpy library. The fast and accurate anatomical image processing utility wraps external tools, including FastSurfer, ANTs, and AFNI, to make tissue segmentation and region of interest masks. We confirmed that the quality of the output masks was comparable with FreeSurfer, and the anatomical image processing could complete in a few minutes. The modular nature of RTPSpy provides the ability to use it for a simulation analysis to optimize a processing pipeline and target signal calculation. We present a sample script for building a real-time processing pipeline and running a simulation using RTPSpy. The library also offers a simple signal exchange mechanism with an external application using a TCP/IP socket. While the main components of the RTPSpy are the library modules, we also provide a GUI class for easy access to the RTPSpy functions. The boilerplate GUI application provided with the package allows users to develop a customized rtfMRI application with minimum scripting labor. The limitations of the package as it relates to environment-specific implementations are discussed. These library components can be customized and can be used in parts. Taken together, RTPSpy is an efficient and adaptable option for developing rtfMRI applications.Code available at: https://github.com/mamisaki/RTPSpy

Plant Public RNA-seq Database: a comprehensive online database for expression analysis of ~45 000 plant public RNA-Seq libraries.

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Rizoma: a new comprehensive database on traditional uses of Chilean native plants.

BackgroundWe describe Rizoma, a new comprehensive online database on traditional uses of Chilean flora. The Rizoma database was built by reviewing multiple data sources on the uses of native plants and integrating phytogeographic and ecological aspects of plant species. This database attempts to safeguard traditional knowledge by making it available and visible to society, providing 1380 use records from 736 vascular plant species native to Chile. In addition, it contributes to a better understanding of the use patterns of Chilean native plants.New informationThe Rizoma database includes 1380 use records from 736 vascular plant species native to Chile, representing 399 genera and 128 families. Each species record provides information on geographic distribution, phytogeographic origin, life form, life span and use category. In addition, the online version includes information on the mode of use of each species, as well as common names and photographs. The database serves as a traditional knowledge repository that contributes to preserving local biological and cultural diversity for future generations.

E-Learning Process in Elementry School: Bibliometrics Approach

In the transition to entirely online learning for Covid-19, the learning management system (LMS) plays a critical role in higher educational institutions around the world. The Nvivo plus 12 system and the Vosviewer program were utilized in the qualitative research. The goal of this research paper is to look into the e-learning process among students who are familiar with the internet. The development of an online education model (Zoom, WA, LMS), platform, and comprehensive online e-Learning would have a big impact. Full e-learning is a term used to describe fully online learning that occurs between traditional campus education and online learning (e-learning) that occurs outside of the campus facing covid-19. The use of a virtual learning management system (LMS) allowed for the promotion of online learning (e-learning). The new research on virtual Learning management systems has the potential to transform essential components of classrooms by utilizing forms that can have a substantial impact on teaching and learning. According to the findings, technology affects librarians' perspectives of their jobs, students' needs, and faculties that might help them develop. In order to produce a selection and motivate pupils to think about it, full e-learning must collaborate with them. Despite the fact that comprehensive e-learning is becoming a viable strategy for various institutions in the country, some universities, particularly in developing countries, are opposing the transition.

IMPACT OF COVID-19 ON THE UNIVERSITY EDUCATION SYSTEM IN JORDAN

The rampant spread of COVID-19 effects spared none of the sectors, and this holds true for the education sector. In Jordan, the Ministry of Education and Culture has been disseminating information regarding the protocols that have to be followed during the pandemic, primarily motivating students to learn through online means. Recently declared to be a pandemic, COVID-19 is an acute respiratory illness caused by Coronavirus Sars-Cov-2, and its impact on the education systems worldwide is evident. Universities-provided training was also affected by the numerous challenges brought on by the pandemic. In this paper, the authors focused on how COVID-19 has caused the shift to the use of digital platform in the Jordanian universities. The outbreak of COVID-19 has generally affected education systems all over the globe, with efforts directed towards its containment leading to unscheduled schools’ closures in over 100 countries, and to over 1 billion learners out of school. This study is the first to examine the effect of COVID-19 on the education system in the context of Jordanian universities sector and develops a comprehensive online learning model. It also contributes to practice by identifying the factors that influence e-learning adoption and highlighting the significant relationships, all of which will assist students in the Jordan universities to summarize the students’ perceptions and needs. The study findings provide practical contributions in the form of guidelines to Jordanian universities involving stakeholders, policymakers, professionals and experts. These stakeholders can use the findings to improve their understanding of the variables, to assist in making wise decisions and enhancing the rate of online learning in the Jordanian universities. They also help the managers to develop the suitable websites and formulate effective strategies that can boost the use of e-learning among universities. The data was collected using structured questionnaires from 200 respondents comprising teachers, students, parents, and policymakers. The study used STATA/Regression analysis to analyze the collected data. The results demonstrated that COVID-19 negatively affects education in the form of learning disruptions and decreased access to education and research institutions, losses of job positions, all of which increased the students’ debts. The findings also showed that educators and students had to depend mainly on technology to continue learning online during the pandemic. In this regard, online education has been constantly hindered by several factors including poor infrastructures leading to issues in network, power, inaccessibility and unavailability of service and lack of digital skills on the part of the users. The study underlines the adverse COVID-19 effects on the realm of education and the technology adoption requirement in educational institutions, by educators and learners, enhancements of digital skills and more importantly, the highlighted current global trends and realities in the education field.

Publishing during a pandemic

Scientific knowledge has a well-established cycle of generating hypotheses, testing them in experiments with proper discussion, and submitting it to the scientific community analysis through publications. It takes time to establish sample size for biomedical studies, especially concerning the effect of medicines and vaccines. The World Health Organization’s protocol estimates that more than 19 months of experiments are necessary to approve a vaccine, for example. As the world has witnessed, a pandemic with immediate impact on human lives urges scientific methods to speed up finding solutions. Here it was assessed the speed and volume of information generated by the Academia to tackle the COVID-19 compared to the Swine Flu pandemic. Were considered papers published in journals indexed in PubMed, the most comprehensive biomedical scientific database available online. The number of publications about COVID-19 was 11 times higher than the number of publications about Swine Flu in a one-year timeframe. Though the expectation were finding more international collaborations and studies focusing on vaccines for COVID-19, papers were mostly concentrated in China and studying symptoms, managing the pandemic, reviewing knowledge, or establishing clinical trials. For sure, science is working faster every day for solutions in biomedical critical situations. However, the fast volume of information might blurry decisions on public health management. This paper’s results show it is mandatory before using papers to take actions, waiting for the scientific community to first progress on its scientific knowledge cycle and mature discussions on the generated knowledge.

Determinants of birth asphyxia among preterm newborns in Ethiopia: a systematic review and meta-analysis of observational studies protocol

BackgroundBirth asphyxia accounted for nearly 50% of neonatal mortality in Sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia. Moreover, studies conducted in Ethiopia were highly variable and inconclusive to estimate the pooled prevalence and determinants of perinatal birth asphyxia among preterm babies.ObjectiveThis study aimed to estimate the pooled prevalence of birth asphyxia and its determinants among preterm newborns in Ethiopia.MethodsThe protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive online databases (PubMed, HINARI, Scopus, EMBASE, Science direct, and Cochrane library database), Google Scholar, African Journals online, other gray and online repository accessed studies will be searched using different search engines. In addition, maternity and infant care databases uploaded at Ethiopian Health Development Journal and Ethiopian Journal of Health Sciences will be searched until 30 June 2020. Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for critical appraisal of studies. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 11.0. We will demonstrate pooled estimates and determinants of birth asphyxia with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q test statistics and I2 test. Publication bias will be checked using funnel plot and Egger’s test. Finally, statistical significance level will be declared at a p value of less than 0.05.DiscussionThe result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.

Concussion in Women's Flat-Track Roller Derby.

Concussions are common among flat-track roller derby players, a unique and under-studied sport, but little has been done to assess how common they are or what players can do to manage injury risk. The purpose of this study is to provide an epidemiological investigation of concussion incidence and experience in a large international sampling of roller derby players. Six hundred sixty-five roller derby players from 25 countries responded to a comprehensive online survey about injury and sport participation. Participants also responded to a battery of psychometric assessment tools targeting risk-factors for poor injury recovery (negative bias, social support, mental toughness) and players' thoughts and feelings in response to injury. Per 1,000 athletes, 790.98 concussions were reported. Current players reported an average of 2.2 concussions, while former players reported 3.1 concussions. However, groups were matched when these figures were corrected for differences in years of play (approximately one concussion every 2 years). Other frequent injuries included fractures in extremities and upper limbs, torn knee ligaments, and sprained ankles. We found no evidence that players' position, full-contact scrimmages, or flooring impacted number of concussions. However, neurological history and uncorrected vision were more influential predictors of an individual's number of concussions during roller derby than years of participation or age, though all four contributed significantly. These findings should assist athletes in making informed decisions about participation in roller derby, though more work is needed to understand the nature of risk.

Design decisions for multidimensional digital and interactive basemaps of urban environments

ABSTRACT Multidimensional digital and interactive basemaps are of high interest for many different user groups coming from various domains. There are already some design principles available for creating digital 3D maps, many of them coming from classical 2D map design, but there is still a need for new design strategies and principles for digital and interactive 3D and 4D basemaps for urban environments. In this article, we present the results of a comprehensive online survey with 175 participants. The aim of this conducted survey was to find out more about the preferences of different user groups regarding the content of digital 3D and 4D basemaps for urban environments, the zoom levels at which different content (such as buildings, landmarks, vegetation, labels, live data) should be visible, the highest shown level of detail as well the overall design (with regard to color, classification and symbology) of these contents. In addition, we also deal with questions about desired map elements and functionalities for an interactive multidimensional basemap and present first assessments of a developed 4D basemap demonstrator. As a final result, we conclude with two tables that provide advice for specific design decisions for creating digital and interactive 3D and 4D basemaps of urban environments for orientation purposes.

Exploration and practice of blended teaching of cell biology experiments during the COVID-19 epidemic.

Since 2019, new coronavirus pneumonia has been widespread worldwide and has had a direct impact on human life. Meanwhile, it also has a huge impact on teaching in universities and hospitals, especially in experimental courses. Cell biology is not only an important part of biology but also one of the most dynamic frontier branches of modern life science, which is also a science based on experiments. It is necessary to promote the online and offline teaching during this special period. To explore and evaluate the blended teaching modes during the COVID-19 epidemic, we changed the previous single teaching mode of “teaching + experiment” and published courseware and learning requirements online before class, this kind of mode takes “theory + virtual demonstration experiment” in class as the main body and the reviewing and thinking after class as the summary. We also carried out offline practice on a small scale when the epidemic allowed and actively explored the comprehensive online and offline teaching modes, in and out of class. Through the hybrid teaching, the percentage distribution of students in high and moderate scores ranges were greatly increased, the blended teaching mode also greatly improves students’ subjective initiative and highlights the development of students’ personalized thinking and scientific research ability. The practice of this model not only ensures the health of teachers and students during the epidemic but also provides a new teaching exploration model and thinking for the development of experimental courses during the epidemic.

HIV-1 genetic diversity a challenge for AIDS vaccine development: a retrospective bibliometric analysis

ABSTRACT Background Despite recent advances in human immunodeficiency virus-1 (HIV-1) prevention, a fast, safe, and effective vaccine will probably be necessary to end the HIV/AIDS pandemic. This study was conducted to evaluate global research trends and map the key bibliometric indices in HIV-1 genetic diversity from 1998 to 2021. Methods A comprehensive online search was conducted in the Web of Science Core Collection database to retrieve published literature on HIV-1 genetic diversity. Key bibliometric indicators were calculated and evaluated using HistCiteTM, Bibliometrix: An R-tool, and VOSviewer software for windows. Results A total of 2,060 documents written by 9,201 authors and published in 250 journals were included in the final analysis. Year 2012 was the most productive year with 121 (5.87%) publications. The most prolific author was Shao Yiming (n = 74, 3.59%) from Chinese Center for Disease Control and Prevention. The United States of America was the highly contributing and influential country (n = 681, 33.05%). AIDS Research and Human Retroviruses was the most productive journal (n = 562, 27.2%). Network visualization shows that HIV-1 was the most widely used author keyword. Conclusion This study provides global research trends and detailed information on HIV-1 genetic diversity. The amount of scientific literature on HIV-1 genetic diversity research has rapidly increased in the last two decades. The maximum number of articles on HIV-1 genetic diversity was published in developed countries; therefore, a scientific research collaboration among researchers and institutes in low-income countries should be promoted and supported.

Research on Problems and Countermeasures of Government Response to Online Public Opinion in the Era of Self-Media

With the advent of the era of self-media, the Internet has become the most important medium for citizens to share information and express their opinions. The continuous spread and fermentation of any social developments may form online public opinion, which may have a certain guiding effect on major social issues. Therefore, governments at all levels deepen online governance and attach importance to early warning and detection of online public opinion. A comprehensive central-local online public opinion response system needs to be built urgently. Based on the Life cycle theory, the main current situation of online public opinion at present is analyzed through the case study method and the comparative research method. It is possible to identify and summarize the shortcomings of government countermeasures for online public opinion in the era of self-media, such as the failure of early warning and monitoring mechanisms of local governments, the lack of coherence between central and local government departments and the lack of administrative work in the aftermath. Based on this, I attempt to construct an optimal path for government countermeasures for online public opinion, actively implement the central government’s emphasis on public opinion governance at all levels and establish a perfect online public opinion response mechanism.

Enterprise Blockchain Network Audit Mode and Application

In recent years, the continuous development of blockchain has not only spawned many emerging industries, but also changed the development mode of many original industries, but also had a certain impact on the audit work. This paper attempts to collide the unique characteristics of blockchain with the traditional online audit work. Based on the existing online audit mode of Zhiyuan technology company, this paper puts forward the idea of building a new blockchain online audit platform, which is based on four modules: blockchain technical support module, auditee basic data module, blockchain audit application service module and audit access module, Complete the four steps of audit information operation process: data collection, data preprocessing, collection of audit data and formation of audit report. Finally, it puts forward optimization suggestions for the existing blockchain online audit mode, such as improving the audit early warning mechanism, establishing a comprehensive and high-quality blockchain online audit talent training system, and improving relevant systems and laws, in order to provide reference for subsequent development and application.

Comprehensive Online Management Based on Cloud Platform for Breast Cancer Patients Using Dual-Targeted Therapy with Macromolecular Monoclonal Antibodies

Objective: The purpose of the study was to explore the application effects of the cloud platform-based comprehensive online management for breast cancer patients using dual-targeted therapy with macromolecular monoclonal antibodies. Methods: 120 breast cancer patients treated by dual-targeted therapy with macromolecular monoclonal antibodies were managed by a cloud platform from March to November 2019. Comprehensive online management included consultation about drugs and side effects and frequently asked questions in the dual-targeted therapy with macromolecular monoclonal antibodies. Results: In the consultation about drugs and side effects, there were five patients with fever, neutrophil, cough, and fatigue; 24 with diarrhea; 25 with nausea; 11 with oral mucosal inflammation; 10 with rashes and dry skin; 8 with insomnia; and 1 with palpitation. Moreover, 110 patients with anxiety about the missed or delayed treatment were properly handled. Conclusion: The comprehensive online management of dual-targeted therapy with macromolecular monoclonal antibodies based on the cloud platform is helpful to satisfy the at-home breast cancer patients’ needs, ensure the continuity of dual-targeted therapy with macromolecular monoclonal antibodies for breast cancer patients, prevent misinformation, alleviate patients’ negative psychological emotions, and reduce patients’ economic losses. The online cloud platform integrated management model is crucial for managing patients with breast cancer treated by dual-targeted therapy.