P-065 Introduction: In studying the temporal relationship between ambient air pollution levels and health outcomes, choosing an appropriate daily pollution metric may not be straightforward. The use of a given time metric in an epidemiologic analysis may be justified by biological plausibility, spatial representativeness, human time-activity patterns or data availability. In order to describe the variability of epidemiologic results attributable to the use of different pollutant metrics, we conducted a comparative time-series analysis using multiple daily pollutant metrics for the same pollutant. Methods: We obtained hourly measurements of ambient particulate and gaseous air pollutants (i.e., NO2, O3, PM10, ultrafine PM, PM2.5, PM2.5 sulfate, PM2.5 total carbon, PM2.5 elemental carbon, CO, and SO2) from existing air monitoring networks for the time period 1993–2004. Data on emergency department visits for cardiorespiratory outcomes were available from 41 hospitals in the study area. For an initial analysis, we investigated NO2, a primary pollutant exhibiting diurnal and spatial variation, and cardiovascular disease (CVD), which were associated in our previous epidemiologic investigation using a 1-hour maximum metric. The following temporal metrics were created: 1) a 1-hour daily maximum; 2) a 24-hour average; 3) a “rush hour” period, defined as the average pollution between 7-9am and 4-6pm; 4) a day-time (8am-6pm) period; and 5) a night-time (12am-5am) period. In addition, NO2 levels in each hour of the day were examined separately. Using Poisson generalized linear models, we examined the association of these NO2 metrics with daily counts of cardiovascular disease visits. Results: Ongoing analyses of multiple pollutants will be presented; here we present the NO2 metric comparison. Correlations between the metrics were:TableRisk ratios for an interquartile range increases in metric-specific NO2 were 1.022 (χ2=28.2) for 1-hour maximum, 1.021 (χ2=23.6) for 24-hour average, 1.018 (χ2=16.2) for rush hour, 1.018 (χ2=16.2) for night-time, and 1.013 (χ2=8.5) for day-time. Individual hour NO2 risk ratios for a 20ppb increase ranged from 0.99 (χ2=0.48) at 3pm to 1.022 (χ2=25.32) at 5am. No associations were observed with individual hours between 1pm and 5pm, hours with typically low NO2 concentrations. Discussion: Effect estimates varied according to the choice of time metric used to characterize daily NO2 pollution levels. Implications of this heterogeneity and results from similar analyses of other pollutants and outcomes will be discussed.
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