While religion and spirituality (R/S) are generally considered protective factors in mental well-being in adults, there is limited research in youth. Further understanding this relationship may allow providers to integrate R/S into treatment to enhance effectiveness. This study explores the impact of R/S on mental health in youth with mild-to-severe mental health symptoms during the global pandemic of COVID-19. We hypothesize that R/S has a positive impact on mental health and can be a protective factor in how youth cope with mental health symptoms, especially during a global crisis. We developed a Religion and Spirituality Questionnaire (RASQ), an online questionnaire that included demographic questions, 27 questions on attitudes and practices regarding R/S and mental health, 6 items related to R/S and mental health during COVID-19, and 3 optional free response questions related to R/S and COVID-19. Participants were current patients of a community mental health clinic in the San Francisco Bay Area who were between 13 and 26 years old. Data from 74 questionnaires were analyzed (46 females, 3 transgender, 6 genderqueer, and 15 males). The average age was 18.1 years old. We found an inverse correlation between those who are not religious and worsening mental health during COVID-19 (R = –0.2547; p < 0.05). We also found that those who turn to their faith in crisis and those whose religious beliefs help guide them in difficult situations have had their faith strengthened during COVID-19 (R = 0.803, p < 0.00001; and R = 0.7849, p < 0.00001). Other comparisons including assessing for differences in age, ethnicity (White/non-White), and sex (male/female) did not reveal significant associations. These preliminary data highlight some significant associations between R/S and mental health during a pandemic, as part of a larger continuing study. Further research is needed. As we move forward with this project, we hope the outcomes can inform and improve clinical care.