High Sugar Research Articles

Evaluation of Errors on Death Certificates.

Death certificates provide vital data for disease surveillance and health policy. However, errors are common globally, undermining data reliability. This study analyzed prevalence and types of errors in death certificates at a tertiary hospital in Nepal. A cross-sectional study reviewed all death certificates issued at Lumbini Medical College, Nepal from April 2020 to April 2022. Certificates were assessed for errors including improper sequencing, absent time intervals, abbreviations, illegible writing, and inaccurate immediate, antecedent, and underlying causes of death as per international guidelines. Errors were classified as major or minor. Of 139 certificates, none were error-free. The most common error was incorrectly or incompletely filling the immediate cause of death (77.7%). Other errors included absent time of death (17.3%), abbreviations (57.6%), illegible writing (22.3%), and omitting the hospital stamp/medical council registration number (8.6%). Based on international criteria, 76.3% had minor errors, 23% had both major and minor errors. This study found a high rate of errors in death certification at a tertiary hospital in Nepal, undermining data accuracy. Regular training and monitoring with feedback are recommended to improve certification practices. Accurate cause-of-death data is vital for healthcare policy and decision-making in Nepal.

Problem-solving difficulties, performance, and differences among preservice teachers in Western Philippines University

The ability to solve problems is a prerequisite in preparing mathematics preservice teachers. This study assessed preservice teachers’ problem-solving difficulties and performance, particularly in worded problems on number sense, measurement, geometry, algebra, and probability. Also, academic profile differences in the preservice teacher’s problem-solving performance and common errors were determined. A descriptive-comparative research design was employed with 158 random respondents. Data were gathered face-to-face during the first semester of the school year 2022-2023, and data were analyzed with the aid of jamovi software, ensuring ethical measures. Overall findings revealed that the preservice teachers experienced average difficulty in solving problems. The low performance of the preservice teachers on the given problems was also demonstrated. Further analysis revealed a significant difference between the preservice teachers’ problem-solving performance based on their subject preference and program. Moreover, the error analysis revealed that the preservice teachers incurred comprehension errors in misrepresentation, misinterpretation, and miscalculation. These results will serve as a measure for policymakers and curriculum developers of the teacher education institution concerned to make relevant enhancements to the math courses offered in the elementary and secondary education programs.

AN ERROR ANALYSIS OF STUDENTS’ GRAMMATICAL STRUCTURES IN TRANSLATING NARRATIVE TEXT

This research aims to discover the errors in students’ narrative text translation based on the Surface Strategy Taxonomy. The descriptive qualitative method was used in this research. The populations were the ninth-grade students of SMP Negeri 1 Ambarawa in the academic year 2022/2023. Specifically, 10 students from the IX A class were randomly chosen as the subject. The instrument used was a translation task entitled Kancil dan Buaya. The data was collected by administering the translation test in 90 minutes. Surface Strategy Taxonomy was used to identify the errors in analyzing the data. The results showed that the most frequent error made by students was misformation, while the least common error was misordering. In addition, the component of misformation in which the students made errors the most was the alternating form. Hence, this indicates that the student’s English proficiency, mainly in grammar, is still poor. Further researches are suggested to investigate more the causes of errors that occur in students’ translation through interviews or questionnaires in order to achieve more in-depth data.

The automation of the processes of students’ reporting documentation standard control: The software solution concept

Reporting documentation is one of the assessment tools used to verify the students’ mastery of several universal, general professional, and vocational competencies, reflecting the ability to search, critically analyze, and synthesize information, as well as the ability to design methodological materials and develop technical documents related to professional activities. Mastering the relevant competencies can be assessed by the results of analyzing the report text and controlling the compliance of documents with requirements to the design, accompanied by a set of standard checks. Such standard control does not imply any variability in the assessment and therefore has prospects for automation. The introduction of a software solution aimed at automating the processes of standard control will reduce the time spent on checking the reporting documentation and the formation of recommendations for students to correct the detected inconsistencies.The article analyzes the most common errors in the design of students’ reporting documentation on the results of internships, compiles a classification of errors, and suggests methods for detecting each type of non-compliance with the requirements to the design of documents. The concept of the software solution for automation of standard reporting documentation control, which offers a realization of the proposed methods and creates interfaces for interaction with users, is created using the principle of modularity. The results of the research presented in the article demonstrate the potential of applying automation methods to the tasks of checking students’ reporting documents.

Visual and Ocular Characteristics of Anisometropic Children.

To compare the demographic and ocular characteristics of patients with low and high levels of anisometropia compared with non-anisometropic individuals. This cross-sectional study was conducted on 1803 individuals (age range, 1 to 30 years) examined at strabismus clinics between January 2019 and December 2020. Of these, 203 subjects had anisometropia (11.2%); 66 cases were excluded due to the history of prior ocular surgery except from strabismus surgery. Finally, data from 137 subjects were analyzed. Spherical or cylindrical differences of 1.50 or 3.00D between the two eyes were defined as low or high anisometropia, respectively, and isometropic subjects (n = 1600) served as controls. No significant difference was observed between cases and controls regarding age (10.25 8.41 vs. 9.2 1.7 years; P = 0.133) and sex (P = 0.051). History of ocular surgery was present in 33% of anisometropic patients versus 0.8 % of isometropic cases. The rate of amblyopia was 83% and 2.3% in anisometropic and non-anisometropic groups, respectively. Best corrected visual acuity (BCVA) was comparable in amblyopic eyes in both study groups, while BCVA of non-amblyopic eyes of non-anisometropic subjects was better (non-anisometropic: 0.01 0.01 vs. anisometropic: 0.06 0.17 LogMAR; P = 0.001). Eye deviation was significantly more prevalent among anisometropic patients (36.5% vs. 3.25%, P 0.001) and exotropia was the common type of deviation. Anisohyperopia and anisomyopia were the most common refractive errors under low and high anisometropia categories, respectively. Simultaneous manifestation of amblyopia and strabismus were observed in 30.6% of anisometropic cases, while only 0.7% of subjects with isometropia had a similar status (P 0.001). High rates of amblyopia and strabismus in anisometropic subjects, especially with higher degrees of anomaly, indicate the necessity of early visual acuity and refractive error screening to improve detection and enhance the outcomes of treatment.

Common Consumer Misconceptions about Eggs

This publication provides information to consumers of eggs and explains a few of the common consumer misconceptions about eggs. Written by Gary D. Butcher and published by the UF College of Veterinary Medicine, May 2024.

Use of baby food products during the complementary feeding period: What factors drive parents' choice of products?

It is recommended that infants are introduced to complementary foods from 6 months old, moving from a solely milk diet to eating a family diet by 12 months old. Although home cooking of family foods is recommended, a rapidly growing market producing baby food products (BFP) such as jars, pouches and snacks has developed. These are often accompanied by marketing claims around nutritional, health and developmental impacts despite research highlighting high sugar content. Although numerous studies have explored drivers of infant formula choice and use, little research has examined the drivers of BFP use. This study used an online survey for United Kingdom parents of infants aged 4-12 months to explore use of BFP alongside perceptions and drivers to purchase products. Overall, 271 parents participated (173 used BFP and 98 did not), with a descriptive analysis of closed items and a thematic analysis for open ended text conducted. The top motivators for using BFP were convenience, time saving, and baby's perceived enjoyment of products. The most purchased puree was fruit based and the most purchased baby snacks were vegetable puffs/sticks, with snack purchases being more common than purees in this sample. Aspects such as perceived healthiness drove choice, with snack foods being seen to enhance self-feeding skills, appetite regulation and motor development. Those who did not use BFP did not trust them and preferred to feed their baby home cooked foods. The findings are important for professionals working with parents, to support them through the transition to solid foods, particularly around raising awareness of marketing techniques and how to check content of foods to make a more informed choice.

Medication errors involving intravenous paracetamol in children: experience from enquiries to the National Poisons Information Service

IntroductionChildren are at higher risk of medication errors due to the complexity of drug prescribing and administration in this patient group. Intravenous (IV) paracetamol overdose differs from overdose by ingestion...

(131) EFFECTIVENESS OF AN INTERACTIVE PATIENT LEARNING MODULE: INTIMACY IN PREGNANCY

Abstract Introduction Two-thirds of women experience negative sexual symptoms during their pregnancy. Women suffer with dyspareunia, arousal issues, decreased libido, and anorgasmia frequently throughout pregnancy, with a significant worsening of symptoms during the third trimester. Also, many women restrict their sexual activity due to fear and misconceptions of inducing preterm labor or harming the fetus and social parameters of sexual conduct during pregnancy. Due to the lack of readily available medical education regarding sexual function in pregnancy, many women of various religious backgrounds may feel lack of trusting asking family members or medical professionals regarding sexual wellness. Objective Patient education given during pregnancy will increase patient knowledge of intimacy during pregnancy as well as improve sexual satisfaction and relationship quality and mental health in pregnancy. Moreover, this module will address gaps in common misconceptions by introducing supportive literature findings regarding benefits of intercourse during pregnancy dispensing the social stigma. Methods This prospective study is a single group before and after pilot study. This study recruited 25 patients beyond 12 weeks’ gestation. We approached 34 of patients and 25 agreed to participate in review an educational module titled “Sexual Intimacy and Pregnancy” build from ACOG guidelines. This module was created at an 8th grade reading level. Patients completed a presurvey, used the module on an electronic device and then completed a post-module assessment. Results 68% of women currently experience sexual dysfunction as either one of more of the following: pain with sex, decreased libido, anorgasmia, or vaginal dryness. Compared to their pre-module response, more women correctly answered the items “What percentage of pregnant women experience sexual dysfunction?” (28.0% versus 76.0%; p = .001) and “Having sex will cause labor” (28.0% versus 4.0%; p = .03). Additionally, women were more comfortable asking their doctor about sex while pregnant following the module (OR = 2.26, 95% CI: 1.06 – 4.83; p = .04). Through the recruitment process, we noticed that patients more likely to participate based on age, level of education received and most significant gravidity. The key for this recruitment was to create an environment in the exam room where both parents were able to see and engage with the module. During the module, partners spoke about current sexual dysfunction initially followed by confirmation by the pregnant patient. Prior to viewing this module, most participants predicted a much smaller percentage of women would be afflicted by sexual dysfunction in pregnancy which illustrating the broad deficits in sexual health education. Conclusions All participants would recommend this educational module to fellow pregnant women and all participants rated the completion and content of this module at easy or very easy to follow. This education module demonstrates baseline improvement in knowledge of sexual function in pregnancy and increases comfort level of discussing sexual function during prenatal care. Future direction of this study aims to target education in various socioeconomic cultures where intimacy education is not discussed in the clinical setting. Disclosure No.

Avoiding critical entrepreneurial cognitive errors through linear/nonlinear thinking style balance

ABSTRACT This study provides empirical evidence for why linear (for example, analytical, logical) and nonlinear (for example, intuitive, creative) thinking style balance is associated with effective entrepreneurial decision making and essential for cultivating organizational innovation. This study examined the relationship between linear and nonlinear thinking style and two common detrimental cognitive biases or errors that often interfere with effective entrepreneurial decision-making: representativeness bias and status quo bias. A sample of 261 business professionals completed a survey measuring linear/nonlinear thinking style profile and decision-making scenarios that assess each cognitive bias. The results provided evidence that linear thinking style is helpful in avoiding the representativeness bias, nonlinear thinking style is beneficial for lessening the status quo bias, and linear/nonlinear thinking style balance is effective in averting both cognitive biases. We discuss the implications of these results and future research directions for advancing theory and practice, and particularly for guiding the design of entrepreneurship education.

Evaluation of the Effect of Pistacia atlantica Oleoresin on Blood Sugar, Pressure and Lipids in Patients With Type 2 Diabetes: A Single-Blind, Placebo-Controlled Trial.

Diabetes mellitus (DM) is a chronic metabolic disorder characterised by high blood sugar (BS) levels due to impaired insulin production or insulin resistance. It is a global health concern with significant implications for morbidity and mortality. Persian medicine has long utilised natural remedies, such as Pistacia atlantica Desf., for various diseases. In this randomised clinical trial, the effects of P. atlantica oleoresin in the improvement of lipid profiles, glucose indices and blood pressure (BP) were assessed in patients with Type 2 DM. In this randomised, single-blind, placebo-controlled study, 42 patients with Type 2 DM were randomly allocated to receive either P. atlantica oleoresin or placebo capsule for 3 months. Patients were evaluated prior to and 12 weeks after the beginning of the intervention, in terms of changes in lipid profiles, glucose indices and BP. After 3 months, the mean BP in patients with DM receiving P. atlantica oleoresin was significantly reduced compared with the baseline (p = 0.001). Also, these changes were significantly higher than those of the control group. The mean of total cholesterol (p = 0.89), low-density lipoprotein (LDL) (p = 0.43) and triglyceride (TG) (p = 0.98) in the intervention group after 3 months was lower than that in the control group, but this difference was not statistically significant. After 3 months, there was no significant difference between the P. atlantica and control groups in terms of blood sugar and lipid profiles. The mean BP in patients with DM receiving P. atlantica oleoresin was significantly reduced compared with that in the beginning of the study. Also, these changes were significant compared with the control group.

Metabolic reasons of diabetes mellitus: An update

Diabetes Mellitus (DM) goes beyond just a lack of insulin. Type 2 Diabetes Mellitus (T2DM) is heavily influenced by insulin resistance. Cells become less responsive to insulin’s signal to absorb glucose, leading to high blood sugar levels. Excess body fat, particularly around the abdomen, and a sedentary lifestyle are ley culprits for this resistance. The pancreas struggles to keep up with the demand for insulin in T2DM. Initially, it compensates by producing more, but over time, this ability declines due to factors like genetics and high blood sugar levels. Glucagon, normally working opposite insulin becomes imbalanced in T2DM. Its levels rise, further promoting glucose production and worsening hyperglycemia. The contributing factors include fasting, high protein diet, and pancreatic issues. The liver’s ability to regulate glucose production is impaired in T2DM. This dysregulation leads to the excessive release of glucose into the bloodstream, contributing to chronic hyperglycemia. Certain genetic disorders affecting carbohydrate metabolism can increase the risk of diabetes. These disorders can lead to changes that mimic pre-diabetes, further contributing to insulin resistance. In T2DM, increased lipolysis releases excessive free fatty acids (FFAs) into the blood stream. These FFAs worsen insulin resistance and damage insulin-producing cells, further exacerbating hyperglycemia. Obesity, with its high fat stores and increased lipolysis, is a major risk factor. The kidneys play a crucial role in reabsorbing filtered glucose from the urine. In T2DM, this reabsorption might be heightened contributing to hyperglycemia. Additionally, chronic kidney disease can impair glucose metabolism, potentially impacting diabetes management. While insulin deficiency plays a role, diabetes is a complex interplay of factors. Unravelling the intricate dance between insulin, glucagon, the liver and cellular responses is crucial for effective management and prevention of diabetes-related complications. This review delves into the intricate metabolic reasons behind this condition, focusing in Type 2 Diabetes Mellitus (T2DM).

Hot Water Treatment Preserves Chinese Chestnut (Castanea mollissima Blume) Quality during Storage by Increasing Its Sugar Accumulation and ROS-Scavenging Ability

Heat treatment is a widely used physical technology for postharvest fruit and crops. The Chinese chestnut cultivar “Kuili” has high sugar and amylose contents, and is popular among people. However, the chestnut quality decreases quickly after harvest. In order to maintain the chestnuts’ quality during storage, this study explores five hot water treatments for chestnuts: T1 (control, no treatment), T2 (50 °C), T3 (65 °C), T4 (75 °C), and T5 (90 °C) for 45 min. T1 was dried at ambient temperature, while the other heat treatments were dried at 30 °C for 30 min. After treatment, chestnuts were placed in plastic trays, covered with a 15 μm thick PVC film, and stored at 4 °C with 70% relative humidity; they remained in the same air for 120 days. Results indicated that T3 and T4 showed slight color changes while maintaining shell and kernel firmness, and their weight loss was reduced (+5–8%), as well as their decay rate (limited to within 20%). The T3, T4, and T5 treatments (from days 60 to 120) decreased their pest survival rates to <2%. Additionally, heat treatments facilitated the accumulation of total soluble sugar and increased the expression of sugar biosynthesis-related genes. Meanwhile, T3 and T4 delayed starch reduction (they maintained relatively higher contents, from 288 to ~320 mg g−1 DW) and altered some starch biosynthesis genes. Furthermore, T2, T3, and T4 exhibited higher antioxidant activity and lower hydrogen peroxide (H2O2) and superoxide anions (O2−) contents than T1. At the end of storage, the scores of T3 and T4 treatments were 55.1 and 52.3, and they ranked first and second among the five treatments, respectively. Therefore, these findings provide valuable insights for controlling postharvest losses in chestnuts.

The role of arabinoxylan purified from wheat bran in bread and biscuits: Impacts on digestibility and colonic fermentability in vitro

In this study, arabinoxylan (AX) isolated from wheat bran was used to prepare AX-fortified bread and biscuits, and the effects of the amount and method of AX addition on the nutritional properties of baked products were investigated through simulated digestibility and colonic simulated fermentability analysis in vitro. The purified AX demonstrated a high total sugar content (92.75%), high molecular weight (Mw) (669.8 kDa), low polymer dispersity index (PDI) and low arabinose to xylose (A/X) ratio (1.21). In vitro digestibility test indicated that AX addition could dose-dependently inhibit the starch digestibility in both bread and biscuits. Most importantly, it could also dose-dependently transfer more starch and protein into the colon through the gastrointestinal tract, leading to the changes in total amount and chemical composition of food residues. Results from the in vitro fermentability test showed that alterations in the composition of food residue affected its fermentability: a high relative ratio of carbohydrate to protein could enhance its prebiotic effect. This study provides valuable insights into the role of dietary fibres in baked foods, aiming to achieve precise nutrition for high-fibre food products.

Analysis of Junior High School Students’ Misconceptions About the Human Excretion Using a Four-Tier Diagnostic Test

This study aimed to measure middle school students’ conceptions and misconceptions related to human excretion using a four-tiered diagnostic test. Using a cross-sectional survey design, responses of 113 eighth-grade students, convenience sampled from two schools in Bandung were collected. A four-tiered instrument was developed specifically for the focus of this study and the data analyzed below consists of test results and interviews with teachers. The findings indicate that students’ conceptions of the human excretory system fall into several categories: scientific knowledge (SK) at 46.90%, false positive (FP) at 13.09%, false negative (FN) at 6.13%, misconception (M) at 20.45%, and lack of knowledge (LK) at 13.43%. The most common misconceptions relate to diseases and disorders (38%) and sweating and body thermoregulation (31%). These misconceptions may arise due to factors such as students’ lack of enthusiasm for learning and limited engagement during the learning process. Consequently, there is a need for improved teaching approaches to address misconceptions associated with human excretion and to foster a more comprehensive scientific understanding among students.

Sued, Subpoenaed or Sworn in: Use of a Flipped-Classroom Style Medicolegal Workshop for Emergency Medicine Residents.

It is an unfortunate truth that Emergency Medicine (EM) physicians will, at some point, have contact with the medicolegal system. However, most EM residency training programs lack education on the legal system in their curriculum, leaving EM physicians unprepared for litigation. To fill this gap, we designed a high-yield and succinct medical legal workshop highlighting legal issues commonly encountered by EM physicians. We aimed to determine the effectiveness of this curriculum by measuring pre and post knowledge questions. A two-hour session included a case-based discussion of common misconceptions held by physicians about the legal system, proper steps when interacting with the legal system and review of legal documents. This session was developed with the involvement of our hospital legal counsel and discussed real encounters. The effectiveness of the session was determined using pre- and post-session surveys assessing participant knowledge and comfort approaching the scenarios. A total of 34 EM residents had the opportunity to complete this workshop as a part of their conference curriculum. A total of 26 participants completed the pre-survey and 19 participants completed the post-survey. No participants had previous training in the legal aspects of medicine, including handling a subpoena, serving as a witness, or giving a deposition. The pre-survey demonstrated that there was significant uncertainty surrounding the processes, definitions, and the legal system interaction. Many participants stated they would not know what to do if they received a subpoena (85.71%), were called as a witness in a trial (96.43%) or receive correspondence from a lawyer (96.43%). The post survey revealed an increased knowledge base and confidence following the session. 100% of residents reported knowing what to do after receiving a subpoena, being called as a witness and understanding the process involved in giving a deposition. All residents reported that the session was beneficial and provided crucial information. EM residents have limited baseline understanding of how to approach common legal scenarios. Educational materials available for this curriculum topic are limited. Based on the rapid knowledge increase observed in our residents, we believe our workshop could be adapted for use at other residency programs.

Optimizing an Organic Method of Sugar Beet Cultivation and Yield Gap Decrease in Northern Poland

In the period of 2016–2018, two series of field studies on organic sugar beet growing (Beta vulgaris L.) were carried out in northern Poland on Luvisol loamy soil (medium–heavy) soil in Bałcyny and Płonne. The aim of this study was to decrease the yield gap between organic and conventional beets. Factors to increase the yield of organic beet were differentiated fertilization (cattle farmyard manure (FYM), compost, and Bioilsa) and choice of varieties (Eliska, Jampol, and Sobieski). The reference point was the conventional cultivation of the same sugar beet varieties, fertilized with manure and NPK mineral fertilizers, the prevailing standard of sugar beet cultivation in Poland. High sugar beet root yields exceeding the average yield in Poland by 25–30% were obtained in both studies, both in conventional and organic cultivation. Higher root and white sugar yields were obtained in the study conducted at Płonne (with similar soil conditions to those at Bałcyny), but they were characterized by higher temperatures during the growing season. The lowest root yields in both experiments were obtained by fertilizing the organic beet with compost (66.1 t per ha in Bałcyny and 78.13 t per ha in Płonne), which were 10.8% and 8.5% lower than the conventional crop, respectively. Higher root yields in organic cultivation were obtained by fertilizing the sugar beet with FYM, which reduced the differences from conventional beet to 7.7% in the study in Bałcyny and 2.1% in the study in Płonne. Thus, the results showed no need to convert cattle FYM to compost. The highest root yields in organic cultivation were obtained by fertilizing the sugar beet with Bioilsa N 12.5 supplemented with mineral fertilization of K, Mg, and S (Patentkali). This fertilization provided a yield of 78.1 t of roots per ha in Bałcyny, which is a reduction in the yield gap to 1.4%, a statistically insignificant value. Moreover, in the study at Płonne, organic sugar beet fertilized with Bioilsa and Patentkali yielded 86.7 t of roots per ha, compared to 85.6 t per ha of conventional beet, so a yield gap was not seen here. The choice of varieties was also of great importance for root and pure sugar yields in both farming systems. The lowest yields were obtained from the Eliska variety, and at Bałcyny, a change of beet cultivar to Jampol increased the organic root yield from 68.8 t per ha to 76.0 t per ha, while reducing the yield gap from 10.1% to 2.2%. At Płonne, replacing the Eliska variety with Jampol reduced the yield gap between organic and conventional roots from 6.6% to 0.3%.

CMONOC II Common Mode Error Analysis and Structural Region Division Research

CMONOC II Common Mode Error Analysis and Structural Region Division Research

Dementia and metabolic syndrome: a bibliometric analysis.

Dementia is a progressive neurodegenerative condition, while metabolic syndrome (MetS) is characterized by a combination of metabolic abnormalities such as hypertension, high blood sugar, and obesity. There exists a connection and overlap between the two conditions in certain aspects, and both are influenced to varying degrees by the process of aging. This study presents an overview of the current research landscape regarding dementia and MetS through bibliometric analysis. A systematic search was conducted to retrieve relevant literature on dementia and MetS published between 1 January 2000, and 30 November 2023, from the Web of Science Core Collection database. Various bibliometric tools, including VOSviewer, CiteSpace, and the R software package "bibliometrix," were utilized for analysis. A total of 717 articles were identified, showing an upward trend in annual publications. Leading contributors included the United States, Italy, and China, with institutions such as the University of California System at the forefront. The Journal of Alzheimer's Disease emerged as the top publisher, while research published in Neurology garnered significant citations. Noteworthy authors encompassed Panza, Francesco; Frisardi, Vincenza; and Feldman, Eva L, with Kristine Yaffe being the most cited author (280 citations). Recent studies have focused on themes like "gut microbiota," "neuroinflammation," "fatty acids," and "microglia." This bibliometric analysis summarizes the foundational knowledge structure in the realm of dementia and MetS from 2000 to 2023. By highlighting current research frontiers and trending topics, this analysis serves as a valuable reference for researchers in the field.

Endogenous opioids facilitate stress-induced binge eating via an insular cortex-claustrum pathway.

Stress has been shown to promote the development and persistence of binge eating behaviors. However, the neural circuit mechanisms for stress-induced binge-eating behaviors are largely unreported. The endogenous dynorphin (dyn)/kappa opioid receptor (KOR) opioid neuropeptide system has been well established to be a crucial mediator of the anhedonic component of stress. Here, we aimed to dissect the basis of dynorphinergic control of stress-induced binge-like eating behavior. We first established a mouse behavioral model for stress-induced binge-like eating behaviors. We found that mice exposed to stress increased their food intake of familiar palatable food (high fat, high sugar, HPD) compared to non-stressed mice. Following a brain-wide analysis, we isolated robust cFos-positive cells in the Claustrum (CLA), a subcortical structure with highly abundant KOR expression, following stress-induced binge-eating behavior. We report that KOR signaling in CLA is necessary for this elevated stress-induced binge eating behavior using local pharmacology and local deletion of KOR. In vivo calcium recordings using fiber photometry revealed a disinhibition circuit structure in the CLA during the initiation of HPD feeding bouts. We further established the dynamics of endogenous dynorphinergic control of this behavior using a genetically encoded dynorphin biosensor, Klight. Combined with 1-photon single-cell calcium imaging, we report significant heterogeneity with the CLA population during stress-induced binge eating and such behavior attenuates local dynorphin tone. Furthermore, we isolate the anterior Insular cortex (aIC) as the potential source of endogenous dynorphin afferents in the CLA. By characterizing neural circuits and peptidergic mechanisms within the CLA, we uncover a pathway that implicates endogenous opioid regulation stress-induced binge eating.