Currently several studies show the relevance of video games in neuropsychological processes of students. The purpose of this research study is to determine if there are differences in attention and executive function (specifically, cognitive flexibility and cognitive interference) between commercial video game players and non-players of commercial video games. Method: The sample (N=60, M=21.18, SD=1.47) is composed of university students in the Psychology Program in the Community of Madrid. The tests administered were the D2 test, Changes and Stroop. Results: The analysis shows that the group of players of commercial video games obtained scores significantly higher in attention, cognitive flexibility and cognitive interference than the group of non-players of commercial video games. Conclusions: These results are relevant for the use of commercial video games as novel and attractive tools to enhance attentional and executive cognitive abilities.