Commercial Plant Extracts Research Articles

Effectiveness of Commercial Plant Extracts in Management of Plutella xylostella (Lepidoptera: Plutellidae) on Broccoli in Mexico1

Plutella xylostella (L.) (Lepidoptera: Plutellidae) is the primary pest of broccoli (Brassica oleracea var. italica von Plenck), and it holds the distinction of having the highest number of documented cases of insecticide resistance among insect pests, which complicates its management. The utilization of plant extracts is considered an alternative approach. Therefore, this study aimed to determine the efficacy of commercial plant extracts for the control of P. xylostella. Nine commercial extract products were evaluated, and their effects were compared with Inex-A® + distilled water (control group) and Exalt® (commercial control). Toxicity assays were conducted using third-instar larvae by topical application bioassay. Oviposition inhibition was assessed along with adult female repellency by exposing females to treated surfaces. To determine the residual effect on feeding and oviposition inhibition, third-instar larvae and 3- to 6-d-old adult females were used, respectively, with residual effects measured at 2, 4, 6, 8, and 10 d postapplication. Nimicide 80 (Ultraquimia, Morelos, Mexico) exhibited a mortality rate of 35% of third-instar larvae. Garlimax (Plant Health Care, Azcapotzalco, Mexico) inhibited oviposition by 80%, and demonstrated 85% repellency. The residual effect of Garlimax persisted for 4 d, resulting in a reduced percentage of the consumed area and egg oviposition. The findings of this research highlight the effectiveness of these two products, Nimicide 80 and Garlimax; however, field evaluations are recommended to verify the consistency of their biological effects.

Effect of Lignin and Commercial Plant Extract on the Fractionation of Heavy Metals in Multi-Metal Contaminated Soil

Effect of Lignin and Commercial Plant Extract on the Fractionation of Heavy Metals in Multi-Metal Contaminated Soil

Evaluation of In-vitro Anticandidal Activity of 99 Different Commercial Plant Extract, Fixed and Essential Oils against Vaginal Candida albicans Isolates

Plant extracts (PE), fixed oils (FO) and essential oils (EO) are used in traditional medicine to treat various diseases. This study evaluated the anticandidal activity of 100 different commercially available PEs, FOs, and EOs against 19 Candida albicans vaginal isolates and C. albicans ATCC 10231. It was determined that 20 EOs and FOs had anticandidal activity. Piper nigrum FO, pine turpentine EO, pine tar EO, and Eugenia caryophyllata EO showed the highest anticandidal activity. The minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) values of these FO and EOs were between 0.125 and 2 µL mL-1. The volatile components of these FOs and EOs were determined by GC-MS analysis. There were six components in E. caryophyllata EO, 38 in Pine turpentine EO, 39 in P. nigrum FO, and 119 in Pine tar EO. In conclusion, this FOs and EOs can be used to treat vulvovaginal candidiasis.

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity.

Melatonin is a tryptophan derivative synthesized in plants and animals. In humans, melatonin acts on melatonin MT1 and MT2 receptors belonging to the G protein-coupled receptor (GPCR) family. Synthetic melatonin receptor agonists are prescribed for insomnia and depressive and circadian-related disorders. Here, we tested 25 commercial plant extracts, reported to have beneficial properties in sleep disorders and anxiety, using cellular assays (2─[125I]iodomelatonin binding, cAMP inhibition, ERK1/2 activation and β-arrestin2 recruitment) in mock-transfected and HEK293 cells expressing MT1 or MT2. Various melatonin receptor-dependent and -independent effects were observed. Extract 18 (Ex18) from Pistacia vera dried fruits stood out with very potent effects in melatonin receptor expressing cells. The high content of endogenous melatonin in Ex18 (5.28 ± 0.46 mg/g extract) is consistent with this observation. Ex18 contains an additional active principle that potentiates the effect of melatonin on Gi protein-dependent pathways but not on β-arrestin2 recruitment. Further active principles potentiating exogenous melatonin were detected in several extracts. In conclusion, we identified plant extracts with various effects in GPCR-based binding and signalling assays and identified high melatonin levels and a melatonin-potentiating activity in Pistacia vera dried fruit extracts that might be of therapeutic potential.

Evaluation of the Efficacy of Commercial Plant Extracts of Palazin and Tondxier Against the Red Flour Beetle Tribolium castaneum (Herbest) Under Laboratory Conditions

Al-Fatlawi, N.C.H. and S. Al-Zurfi. 2023. Evaluation of the Efficacy of Commercial Plant Extracts of Palazin and Tondxier Against the Red Flour Beetle Tribolium castaneum (Herbest) Under Laboratory Conditions. Arab Journal of Plant Protection, 41(1): 54-57. https://doi.org/10.22268/AJPP-41.1.054057 The Effect of Tondxier and Palazin plant extracts on the mortality of the flour beetle T. castaneum (Herb) was investigated. Plant extracts were separately tested under laboratory conditions against the beetles using a topical spray. Beetles were sprayed with plant suspensions at different concentrations (1, 2 and 3 ml/L) for both Tondxier and Palazin. Mortality was recorded daily for 15 days while beetles were kept on wheat flour. Both Tondxier and Palazin had an impact on T. castaneum. Commercial Tondxier was more effective than Palazin at the same concentrations tested. Nevertheless, significant differences in the mortality rate at the end of the experiments between second, and 5 th instar larvae and adults treated with Palazin and Tondxier extracts were observed. Second and 5 th instar larvae were more susceptible, and adults were more resistant to Palazin and Tondxier treatments. This study showed that mortality rate increases with increased concentration and length of exposure times. Results obtained suggested that the two plant extracts of Palazin and Tondxier used in this study can be used as potent insect control agents. Keywords: Palazin, Tondxier, Tribolium castaneum, larvae

Beneficial Bacteria and Plant Extracts Promote Honey Bee Health and Reduce Nosema ceranae Infection

The research aims to give new insights on the effect of administering selected bacterial strains, isolated from honey bee gut, and/or a commercial plant extract blend (HiveAlive®) on Nosema ceranae. Analyses were first performed under laboratory conditions such as different infective doses of N. ceranae, the effect of single strains and their mixture and the influence of pollen administration. Daily survival and feed consumption rate were recorded and pathogen development was analysed using qPCR and microscope counts. Biomarkers of immunity and physiological status were also evaluated for the different treatments tested using one bacterial strain, a mixture of all the bacteria and/or a plant extract blend as treatments. The results showed an increase of abaecin transcript levels in the midgut of the honey bees treated with the bacterial mixture and an increased expression of the protein vitellogenin in the haemolymph of honey bees treated with two separate bacterial strains (Bifidobacterium coryneforme and Apilactobacillus kunkeei). A significant effectiveness in reducing N. ceranae was shown by the bacterial mixture and the plant extract blend regardless of the composition of the diet. This bioactivity was seasonally linked. Quantitative PCR and microscope counts showed the reduction of N. ceranae under different experimental conditions. The antiparasitic efficacy of the treatments at field conditions was studied using a semi-field approach which was adapted from research on insecticides for the first time, to analyse antiparasitic activity against N. ceranae. The approach proved to be reliable and effective in validating data obtained in the laboratory. Both the mixture of beneficial bacteria and its association with Hive Alive® are effective in controlling the natural infection of N. ceranae in honey bee colonies.

Effect of commercial plant extracts on the oxidative stability of mechanically deboned poultry meat during chilled storage

The effect of commercial plant extracts (grape, rosemary, pomegranate, green tea, and mate) at 0.125, 0.25, 0.50, and 1 % w/w concentrations as a natural antioxidant in mechanically deboned poultry meat (MDPM) was evaluated. The extracts were characterized for the content of phenolic compounds, total flavonoids, and antioxidant activity. Lipid oxidation (TBARS), instrumental color (L*, a*, and b* values), and pH of MDPM were evaluated on days 0, 2, 4, 6, 8, and 10 of chilled storage (2 °C). All commercial extracts showed antioxidant activity in the following order: grape > green tea > mate > rosemary > pomegranate, the latter addition promoted the highest TBARS values in MDPM during storage. The levels of 0.5, 0.25, and 0.125 % of grape, green tea, mate, and rosemary extracts showed the same positive effect in decelerating lipid oxidation in MDPM. The pH values of the MDPM decreased with increasing the extract concentrations. The commercial extracts led to a decrease in L* and b* values, and the grape extract provided the highest a* values in MDPM during chilled storage. The addition of commercial plant-derived extracts has proven to be an effective natural antioxidant to extend the shelf life of MDPM and consequently healthier and quality meat products can be produced.

Simultaneous Estimation of Rhein and Aloe-Emodin in Traditional and Ultrasound-Based Extracts of Rheum palmatum L. (Rhubarb) Using Sustainable Reverse-Phase and Conventional Normal-Phase HPTLC Methods

The greenness indices of literature analytical procedures for the simultaneous measurement of rhein and aloe-emodin have not been determined. As a consequence, the first goal of this study was to design and validate a sensitive and sustainable reverse-phase high-performance thin-layer chromatography (HPTLC) method for the simultaneous estimation of rhein and aloe-emodin in a traditional extract (TE) and ultrasound-based extract (UBE) of commercial Rhubarb and Rhubarb plant extracts in comparison to the conventional normal-phase HPTLC method. The second goal was to determine the greenness indices for both methods using the AGREE approach. For the sustainable reverse-phase HPTLC approach, the method was linear in the 50–1000 ng/spot range for rhein and 25–1000 ng/spot range for aloe-emodin. However, for the conventional normal-phase HPTLC approach, the method was linear in the 50–600 ng/spot range for rhein and 100–600 ng/spot range for aloe-emodin. The limit of detection (LOD) for rhein and aloe-emodin was 16.81 ng/spot and 8.49 ng/spot, respectively, using the sustainable analytical method. However, the LOD for rhein and aloe-emodin was 18.53 ng/spot and 39.42 ng/spot, respectively, using the conventional analytical method. For the simultaneous determination of rhein and aloe-emodin, the sustainable analytical method was more sensitive, accurate, precise, and robust than the conventional analytical method. The amount of rhein and aloe-emodin was higher in the UBE of commercial Rhubarb and Rhubarb plant extract over their TE. For the simultaneous quantification of rhein and aloe-emodin in the TE and UBE of marketed Rhubarb and Rhubarb plant extract, the sustainable analytical method was superior to the conventional analytical method. The AGREE index for the sustainable reverse-phase and conventional normal-phase HPTLC methods was determined to be 0.78 and 0.49, respectively, indicating an excellent greenness profile of the sustainable reverse-phase HPTLC method over the conventional normal-phase HPTLC approach. The sustainable analytical method was found to be superior to the conventional analytical method based on these results.

Bioactive compounds of corn silk and their role in management of glycaemic response.

Management of glycaemic response is perhaps the most critical part of antidiabetic therapy. Hypoglycaemia is an avoidable complication caused by conventional drugs used in the treatment of diabetes. It triggers commonly during the intensification of anti-hyperglycemic therapy used to render glycemic control in diabetic patients. The commercial oral hypoglycaemic drugs, insulin, herbal medicines and plant extracts are therefore used as a part of the treatment of diabetes. The demand for treating diabetes, through herbal and plant resources is due to their lesser adverse reactions and better phytochemical benefits. Corn silk has been shown to have anti-allergic, anti-inflammatory, and anti-hypertensive effects when extracted in various solvents. Corn silk has medicinal characteristics and has long been used as a traditional medicine in many nations, although the mechanism of action is unknown. The hypoglycaemic effects of corn silk are investigated in this review. The phytochemical components present in corn silk-like flavonoids, phenolics, terpenoids, tannins, sterols, and alkaloids are phytochemical components that have hypoglycemic activity and a mechanism for lowering blood glucose levels. There is a lack of a homogenized database on the hypoglycemic properties of corn silk thus the present review attempts to critically analyse it and provide specific recommendations of its doses.

Effects of aromatic plant extract mixture on laying efficiency, egg quality and antioxidant status in laying quails

This study aimed to evaluate the effects of commercial plant extract mixture added to laying quail rations on performance, egg quality, plasma antioxidant and blood biochemical parameters. In this experiment, 160 Japanese quails aged twelve weeks were equally divided into four groups of 40 (five replicates of 8 quails each). The study included a control and three treatment groups. The treatment groups were as follows: (1) 100 mg/kg aromatic plant extract mixture-group 1; (2) 150 mg/kg aromatic plant extract mixture-group 2 (3) 200 mg/kg aromatic plant extract mixture-group 3, respectively. When examined the egg parameters at the end of the study, significant differences (P<0.05) were found in the parameters of egg weight, Haugh unit (HU), albumen index, egg yolk color and eggshell thickness. Egg weight and eggshell thickness values were measured the highest (P<0.05) in group 1. HU, egg yellow color and albumen index values were found significantly higher (P<0.05) in all experimental groups compared to the control group. Significant differences (P<0.05) were determined in superoxide dismutase (SOD) and malondialdehyde (MDA) values of plasma antioxidant parameters in the study. In the study, High density lipoprotein (HDL) value, one of the blood (plasma) parameters, was found to be higher (P< 0.001) in the experimental groups. Consequently, we can say that the addition of herbal extract mixture to quail diets increases egg quality and has a positive effect on cholesterol and plasma antioxidant parameters

Antimicrobial activity of essential oils and natural plant extracts against Listeria monocytogenes in a dry-cured ham-based model.

Listeria monocytogenes is a widespread common contaminant in food production facilities during preparation, storage, and distribution, and minimally processed ready-to-eat products are considered at high risk of contamination by this bacterium. Increased antibiotic resistance has led researchers to search for plant-based natural alternatives to control pathogenic microorganisms. Among these products, essential oils and plant extracts have previously shown antimicrobial activity and are possible alternatives to manage food pathogens. In this study, commercial essential oils (cinnamon, clove, oregano, ginger, and thyme) and plant extracts (pomegranate, acorn, olive, strawberry tree, and dog rose) were tested against L. monocytogenes in a dry-cured ham-based model. Essential oils and plant extracts were screened by agar diffusion and minimum inhibitory concentration for anti-L. monocytogenes activity. Cinnamon, pomegranate, and strawberry trees returned the strongest results and were therefore evaluated in a dry-cured ham-based medium assay with water activity of 0.93 or 0.95. The 10% essential oil of cinnamon was capable of completely inhibiting bacterial growth, while strawberry tree and pomegranate extract also showed antilisterial activity (P > 0.05). Water activity influenced the bacterial count of L. monocytogenes in a dry-cured ham-based medium. There was a reduction in L. monocytogenes with the application of cinnamon essential oil but, because of the negative sensory impact of this particular compound in meat products, we suggest the use of pomegranate or strawberry tree for the biocontrol of Listeria in ready-to-eat products. © 2021 Society of Chemical Industry.

Effects of Dietary Supplementation of Two Commercial Plant Extracts on the Growth Performance and Ileal Inflammation Score in Broiler Chickens

Effects of Dietary Supplementation of Two Commercial Plant Extracts on the Growth Performance and Ileal Inflammation Score in Broiler Chickens

Green Tea and Pomegranate Extract Administered During Critical Moments of the Production Cycle Improves Blood Antiradical Activity and Alters Cecal Microbial Ecology of Broiler Chickens.

Phytobiotics are usually tested in feed and throughout the production cycle. However, it could be beneficial to evaluate their effects when administered only during critical moments, such as changes in feeding phases. The aim of the trial was to investigate the effect of a commercial plant extract (PE; IQV-10-P01, InQpharm Animal Health, Kuala Lumpur, Malaysia) on growth performance, blood antiradical activity and cecal microbiome when administered in drinking water to broiler chickens during the post-hatching phase and at each change of diet. In the experiment, 480 1-day-old male broiler chicks were assigned to two groups in a 50-day trial. Broilers received drinking water (C) or drinking water plus PE (T) at a rate of 2 mL/L on days 0 to 4, 10-11 and 20-21. PE did not affect performance and water intake, while total antiradical activity was improved (p < 0.05). A greater abundance of lactic acid bacteria (false discovery rate (FDR) < 0.05) was found in the T group and the result was confirmed at a lower taxonomic level with higher Lactobacillaceae abundance (FDR < 0.05). Our findings suggest that PE administration during critical moments of the production cycle of broiler chickens may exert beneficial effects at a systemic level and on gut microbial ecology.

Plants: A natural solution to enhance raw milk cheese preservation?

Plants have been traditionnally used for centuries in cheese manufacturing, either for their aromatic properties or as technological auxiliaries (e.g. milk-clotting enzyme preparations, cheese wrappers). Some of these plants are known to have antimicrobial and/or antioxidant properties and could also act as natural preservatives for raw milk and derived dairy products. This review examined the traditional uses of plants in dairy processing, and then focuses on known antimicrobial and antioxidant properties of their extracts (e.g. maceration, decoction, essential oil). Known effects of theses plants on technological flora (starter cultures and microorganisms implicated in cheese ripening) were also summarized, and the potential for plant extracts used in combination with hurdle technologies was explored. Then, legal restriction and bioactivity variations from a culture media to a food matrix was reviewed: non-toxic bioactive molecules found in plants, extract preparation modes suitable with foodgrade processing restrictions, the role of the food matrix as a hindrance to the efficiency of bioactive compounds, and a review of food legislation. Finally, some commercial plant extracts for milk preservation were discussed.

E. coli cultures expressing a synthetic sequence of ptz gene (stz) promoted in vitro direct organogenesis in Nicotiana tabacum L.

In vitro plant organogenesis requires plant regulator cytokinins to be exogenously supplied to the culture media. Cytokinins are either obtained from natural sources, from purified commercial plant extracts or by chemical synthesis. Besides plants, several species of plant pathogenic bacteria also naturally produce cytokinins. For example, Pseudomonas syringae pv. savastanoi (P. savastanoi) produces cytokinins by virtue of its isopentenyl transferase (ptz) gene. Therefore, we asked whether cell cultures of an Escherichia coli (E. coli) strain transformed with a synthetic sequence of the ptz gene (stz) may induce a morphogenetic response in vitro. To address this question, the stz gene was inserted into the pColdI™ DNA cold shock expression vector, and this clone was used to genetically transform cells of the E. coli TOP10 strain. The same strain transformed with an empty expression vector was used as the experimental control. Our results showed that cell-free media and methanolic fractions of the cell-free media prepared from the E. coli TOP10 strain overexpressing the stz gene combined with MS basal medium were able to induce in vitro organogenesis in tobacco bioassays. These cell-free media promoted shoot and root formation in tobacco leaf explants. We propose that these types of cell-free extracts could be used not only for in vitro plant propagation, but also for promoting plant rooting.

Mangifera indica Bark Essential Oil: Chemical Composition and Biological Activities in Comparison with Aqueous and Ethanol Extracts

Ethnobotanic surveys have revealed the use of Mangifera indica L. (Anacardiaceae) bark for the treatment of infectious diarrhea. The essential oil of M. indica bark is described for the first time for its chemical composition, radical scavenging activity (DPPH method) and antimicrobial properties. The total phenols content of its water and ethanol bark extracts as well as their radical scavenging and antimicrobial properties were also evaluated. Four commercial plant extracts were also studied for a comparison purpose. The antimicrobial activities were measured for all samples against three Gram (-): Escherichia coli, Salmonella enteritidis, Shigella and two Gram (+): Staphylococcus aureus and Bacillus cereus bacteria. The M. indica bark essential oil was characterized by the association of two major sesquiterpenes: ( E)-β-caryophyllene (60.3%) and α-humulene (36.7%). It presented the lowest ratio of concentration to inhibition zone diameter on all the strains. The aqueous and ethanol extracts of M. indica bark were characterized by high contents of total phenols compounds and high radical scavenging activity compared to the essential oil. Finally, the interesting combination of the antibacterial and antiradical activities of the aqueous M. indica bark extract justifies the traditional use of this plant part in decoction form for the treatment of diarrheal infections.

P-119 - Ex-vivo vasorelaxation induced by polyphenol-rich extracts from plant, fruits and berries on porcine coronary artery rings

The aim of the present study was to investigate if the polyphenol content of various commercial plant, fruits and berries extracts was linked to vasorelaxation properties. A total of 24 commercial extracts (including black currant fruit, green tea, grape seed, leucocyanidins of grape seed, pine bark, apple, pomegranate, bilberry, red vine, citrus pericarp, bitter orange, cocoa, aronia, raspberry leaf, hibiscus, olive leaf, olive fruit and a mix of olive fruit and leaf) was assessed on porcine coronary artery rings. Among all extracts, the most important endothelium-dependent vasorelaxation were obtained with grape seed (EC50=0.87 µg/ml and 2.0 µg/ml), leucocyanidins of grape seed (EC50=1.6 µg/ml), pine bark (EC50=2.2 µg/ml and 3.1 µg/ml), apple (EC50=2.2 µg/ml), cocoa (EC50=3.6 µg/ml), black currant (EC50=6.6 µg/ ml), pomegranate (EC50=6.6 µg/ml) and aronia EC50=12.7 µg/ml). The efficiency of all extracts (EC50) were significantly correlated with their content in total polyphenols (r=0.70; p=0.0002; n=23), in flavanols (r=0.65; p=0.031; n=11) and in flavonols (r=0.57; p=0.016; n=17). Our results suggest that some polyphenol-rich extracts could be potentially interesting to maintain a good cardiovascular health.

Field evaluation of commercial plant extracts against Drosophila suzukii (Diptera: Drosophlidae) in raspberry

ABSTRACTDrosophila suzukii (Matsumura) (Diptera: Drosophilidae) was detected in 2008 in southern Europe and North America and it has spread rapidly throughout the two continents mainly affecting thin-skinned berries and stone fruits which constitute an important, economic and social driver in these regions. This study analyzes the potential control ability of four commercial plant-derived extracts, namely Sophora flavescens (shrubby sophora), Cinnamomum zeylanicum (cinnamon), Capsicum frutescens (chili) and Allium sativum (garlic), against D. suzukii, under raspberry high tunnel field conditions. Extracts were applied in a randomized complete block design using spinosad as positive control. As expected, spinosad treatment resulted in a satisfactory control, reducing significantly the number of larvae and adults emerged from treated fruits even ten days after application. Sophora flavescens extract produced a significant reduction of 60.7% in emerged adults, with no reduction in the number of larvae, six days after application. In addition, garlic extract caused significant reduction in the mean number of larvae (over 50%) and emerged adults (over 48%) six days after application. These findings suggest that garlic and S. flavescens affect egg viability and/or larvae development. Tentative explanations about the variability of the results and possible benefits of repetitive treatments are discussed.

In vitro cytotoxic activity of five commercial samples of Tribulus terrestris Linn in Espírito Santo (Brazil)

ABSTRACT The objective was to investigate the total saponin and protodioscin concentrations and the cytotoxicity in vitro, of five samples of the plant Tribulus terrestris, commercially available in the metropolitan region of Vitoria - Espirito Santo, Brazil, and to compare them with the aqueous extract of the plant. The chromatographic profile and quantification of protodioscin in commercial samples and plant extract were evaluated by LC-MS/MS. The percentage of total saponins were determined by the colorimetric method. Extracts and protodioscin cytotoxicity were analyzed by the MTT assay in three cell lineages: fibroblasts (L929), ovarian cancer (Ovcar3) and murine hepatoma (Hepa1c1c7). All extracts displayed high levels of total saponins (207.2 to 780.3 mg g-1 of dry extract). The chromatographic profile revealed a wide diversity of compounds, and the saponin protodioscin was detected in only two extracts. One extract displayed high cytotoxicity, with IC50 values of 157.0, 38.2 and 7.4 µg mL-1 for the Ovcar3, Hepa1c1c7 and L929 cell lines, respectively. The other extracts displayed cytotoxic effects only at concentrations equal to or greater than 125.0 µg mL-1. Surprisingly, the most cytotoxic extract displayed the highest protodioscin concentration. Therefore, it is suggested that these products be marketed with caution, and followed-up by a certified healthcare professional.

Evaluation of Phenolic Phytochemical Enriched Commercial Plant Extracts on the In Vitro Inhibition of α-Glucosidase.

Green tea (GT), cranberry (CR), and tart cherry extracts were evaluated for their ability to inhibit yeast α-glucosidase, relevant to glucose uptake. The total phenolic content (TPC), antioxidant activity, and in vitro inhibitory activity of yeast α-glucosidase were examined for the extracts in the present study. GT had higher TPC and antioxidant activity, but CR demonstrated a greater α-glucosidase inhibitory activity, on phenolic basis. CR was fractionated using LH-20 column chromatography into two fractions: 30% methanol (CME) and 70% acetone (CAE). TPC, antioxidant activity, and yeast α-glucosidase inhibitory activity were determined for the fractions. CAE had a greater TPC and antioxidant activity than CME, but the two fractions had a synergistic effect when inhibiting yeast α-glucosidase. Our findings suggest that CR has the greatest potential to possibly manage post-prandial blood glucose levels via the inhibition of α-glucosidase, and that the effect is through synergistic activity of the extract’s phenolic compounds.