Combined Research Articles

Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: reversal learning and set-shifting in rats.

Within one experiment and one T-maze, we examined the consequences of (i) bilateral lesions of the anteromedial prefrontal cortex (PFC), (ii) bilateral transections of the fimbria-fornix (FF), or (iii) combined lesions of both PFC and FF (COMB) on rats' ability to perform reversal or set-shifting. Postoperatively, the animals were trained to perform a spatial discrimination go-right task. This was followed by (1) a spatial reversal go-left task (reversal learning), or (2) a visual pattern discrimination task (set-shift). Neither single (PFC or FF) lesion nor combined (COMB) lesions affected the animals' ability to acquire the original spatial discrimination task. Regarding the reversal learning, the performance of the PFC and the FF groups was not significantly different from that of the sham operated control animals (Sham). In contrast, animals with combined lesion of both structures were impaired on both error rate and acquisition speed relative to all other groups. Regarding the set-shifting, all lesioned groups were impaired relative to the Sham group both regarding the error rate and the acquisition speed. There was, however, no difference in the degree of impairment between the lesioned groups. We conclude that both the PFC and the hippocampus contributed to the mediation of the reversal learning and set-shifting. During functional recovery of reversal learning, these two structures exhibited a mutual dependency, whilst the functional recovery of set-shifting was mediated by a substrate outside these two structures.

The Relationship Between Muscle Action and Repetition Maximum on the Squat and Bench Press in Men and Women

The relationship between muscle action and fatigue is not well understood, especially in terms of potential sex-specific differences. The purpose of this investigation was to determine whether a different number of repetitions could be performed on the individual muscle actions of the bench press and squat in men and women. Ten resistance-trained men (n = 10; age, 25.2 ± 1.2 years; height, 178.6 ± 8.8 cm; weight, 91.4 ± 18.1 kg; body fat, 12.7 ± 3.6%) and women (n = 10; age, 25.4 ± 2.4 years; height, 164 ± 4.0 cm; weight, 58.45 ± 3.3 kg; body fat, 20.8 ± 1.5%) participated in this balanced and randomized within-group study. Using 85% of a 1 repetition maximum, over the course of 3 visits, subjects performed 1 eccentric (ECC), concentric (CON), or combined (COMB) set to failure on the squat and bench press. Differences in muscle action and sex-specific number of repetitions to failure were compared on the squat and bench press, where significance was p ≤ 0.05. Across both exercises and sex, we observed significant differences between each of the 3 muscle actions, where the number of repetitions decreased from ECC to COMB to CON. While no sex-specific differences were observed in the squat, women performed significantly more repetitions on the ECC and CON muscle actions of the bench press. Men performed more combined repetitions, however, indicating a greater reliance on the stretch-shortening cycle. Different muscle actions contribute uniquely to the successful performance of a lift and fatigue. These contributions appear to differ in men and women.

The effects of strength, aerobic, and concurrent exercise on skeletal muscle damage in rats

In this study we examined oxidative stress and skeletal muscle damage resulting from acute strength, aerobic, or concurrent exercise in rats. The animals were divided into control (C), strength (SE), aerobic (AE), and combined (CE) exercise groups. They were euthanized at 3 different time-points (6, 24, and 48 h) after acute exercise. SE exercise rats had increased dichlorofluorescein oxidation at 6 h post-exercise and decreased superoxide dismutase activity at all time-points. Glutathione peroxidase activity and sulfhydryl levels were increased in the AE group at 48 h post-exercise. Serum lactate dehydrogenase activity was increased in the SE and CE groups at 24 h and in the AE group at 48 h. Echo intensity was elevated at 24 h for all groups. Forty-eight hours was sufficient for complete recovery from oxidative stress and muscle damage in the SE and CE groups, but not in the AE group.

Differential Oscillatory Electroencephalogram Between Attention-Deficit/Hyperactivity Disorder Subtypes and Typically Developing Adolescents

A neurobiological-based classification of attention-deficit/hyperactivity disorder (ADHD) subtypes has thus far remained elusive. The aim of this study was to use oscillatory changes in the electroencephalogram (EEG) related to informative cue processing, motor preparation, and top-down control to investigate neurophysiological differences between typically developing (TD) adolescents, and those diagnosed with predominantly inattentive (IA) or combined (CB) (associated with symptoms of inattention as well as impulsivity/hyperactivity) subtypes of ADHD. The EEG was recorded from 57 rigorously screened adolescents (12 to 17 years of age; 23 TD, 17 IA, and 17 CB), while they performed a cued flanker task. We examined the oscillatory changes in theta (3-5 Hz), alpha (8-12 Hz), and beta (22-25 Hz) EEG bands after cues that informed participants with which hand they would subsequently be required to respond. Relative to TD adolescents, the IA group showed significantly less postcue alpha suppression, suggesting diminished processing of the cue in the visual cortex, whereas the CB group showed significantly less beta suppression at the electrode contralateral to the cued response hand, suggesting poor motor planning. Finally, both ADHD subtypes showed weak functional connectivity between frontal theta and posterior alpha, suggesting common top-down control impairment. We found both distinct and common task-related neurophysiological impairments in ADHD subtypes. Our results suggest that task-induced changes in EEG oscillations provide an objective measure, which in conjunction with other sources of information might help distinguish between ADHD subtypes and therefore aid in diagnoses and evaluation of treatment.

The water footprint of the EU for different diets

In this paper, the EU28 (EU27 and Croatia) water footprint of consumption (WFcons) for different diets is analysed: the current diet (REF, period 1996–2005), a healthy diet (DGE), a vegetarian (VEG) and combined (COM) diet. By far the largest fraction of the total WFcons (4815lcd) relates to the consumption of edible agricultural goods (84%). The average EU28 diet is characterised by a too high energy intake and a too high ratio of animal to vegetal protein intake. For a healthy diet, the intake of some product groups should be reduced (sugar, crop oils, meat and animal fats) and of other product groups increased (vegetables and fruit). Especially the consumption of animal products accounts for high WF amounts. The three alternative diets result in a substantial reduction (−974lcd or −23% for DGE, −1292lcd or −30% for COM, −1611lcd or −38% for VEG) of the WFcons for agricultural products with respect to the existing situation (REF, 4265lcd). The reduction in meat intake contributes most to the WF reduction. Each of the specific WF components (green, blue and grey) shows a reduction similar to the observed reduction in the total WFcons. Regarding the total WFcons (green, blue and grey WFcons) as well as the WFcons without the grey WF component (green+blue WFcons) for agricultural products, the EU28 shifts from net virtual water (VW) importer for the REF and DGE diets to net exporter for the COM and VEG diets.

Evaluation of the Duration of Action and Comparative Effectiveness of Lisdexamfetamine Dimesylate and Behavioral Treatment in Youth With ADHD in a Quasi-Naturalistic Setting

Objective: This study compared the relative effects of three treatment conditions: long-acting stimulant medication (MED), behavior modification, and medication/behavioral treatments combined (COM) in children with ADHD. Method: A total of 25 children, aged 6 to 12 years, received the three treatment conditions during a 7-week Summer Treatment Program in an alternating treatments design. Counselors completed behavioral ratings from 0.5 to 12.5 hr post dose, and parents completed nighttime ratings. Results: Ratings for SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) and for following instructions indicated COM and MED improved symptoms over BEH treatment beginning 3 hr post dose (p = .008), with ratings maintained 12.5 hr post dose (p = .001 and .006). Results for frustration tolerance indicated significant improvement in all three conditions until 9 hr post dose. Conclusion: MED and COM separated from BEH at 3 hr post dose, and sustained benefit was observed across the day for two of three measures. BEH appears to have an additive effect, extending the duration of frustration tolerance.

Evaluation of TRMM Rain Estimates Using Ground Measurements over Central Florida

AbstractThis study evaluates space-based rain estimates from the Tropical Rainfall Measuring Mission (TRMM) satellite using ground-based measurements from the radar (GR) and tipping-bucket rain gauges (TG) over the TRMM Ground Validation (GV) site at Melbourne, Florida. The satellite rain products are derived from the TRMM Microwave Imager (TMI), precipitation radar (PR), and combined (COM) rain algorithms using observations from both instruments. The TRMM satellite and GV rain products are spatiotemporally matched and are intercompared at multiple time scales over the 12-yr period from 1998 to 2009. On monthly and yearly scales, the TG agree excellently with the GR because the GR rain rates are generated using the TG data as a constraint on a monthly basis. However, large disagreements exist between the GR and TG at shorter time scales because of their significantly different spatial and temporal sampling modes. The yearly biases relative to the GR for the PR and TMI are generally negative, with a few exceptions. The COM bias fluctuates from year to year over the 12-yr period. The PR, TMI, and COM are in good overall agreement with the GR in the lower range of rain rates, but the agreement is notably worse at higher rain rates. The diurnal cycle of rainfall is captured well by all products, but the peak satellite-derived rainfall (PR, TMI, and COM) lags the peak from the ground measurements (GR and TG) by ~1 h.

Muon reconstruction efficiency measurement in the ATLAS experiment

The measurement of the muon reconstruction effi ciency in the ATLAS experiment based on the and method using decay muons from J/ψ and Z resonances is presented. The effi ciency measurement is compared to its value as estimated from simulations in order to provide scaling factors to correct the residual mis-modeling of the ATLAS muon identification performance. This paper describes the measurement of the muon iden- tification e ffi ciency as determined by using the so-called and method at the J/ψ and Z resonances; a detailed description of these studies can be found in (1) and (2). The method allows to select an unbiased sample of muons by searching for an Inner Detector (ID) track (the probe) that, along with a well reconstructed muon (the tag) forms a system with invariant mass consistent with a di-muon resonance. By this procedure a sample of low pT probes (from the J/ψ !� + � decay) and high pT probes (coming from Z ! � + � decay) are selected in- dependently of the ATLAS Muon Spectrometer (MS) and can be used to measure the effi ciency for reconstructing a muon with MS measurement. Two categories of muons are reconstructed in ATLAS using the Muon Spectrometer data: Combined (CB) muons, that require the reconstruction of consistent tracks in the MS and in the ID, and Segment tagged (ST) muons, that give additional effi ciency as they can recover muons, typ- ically of low pT , which did not cross enough precision chambers to allow an independent momentum measure- ment in the MS. The two classes of muons are implemented in two different reconstruction chains, hereafter referred as chain 1 (Staco) and chain 2 (MuId). At the J/ψ resonance the tag and probe method suf- fers from a large background from muons originating from light meson decays in flight or from b and c semi-leptonic decays identified as tags that, associated to ID tracks, form a system with invariant mass close to the J/ψ mass. By re- quiring the probe to be associated with an energy deposit in the calorimeter consistent with a minimum ionizing par- ticle, a sample with low background contamination can be selected. These Calorimeter-tagged probes (CT probes) allow a measurement of the identification e ffi ciency in the MS al- most free from the biases induced by the background sub- traction procedure. The background contamination in the tag and probe selection at the Z resonance is very low and well understood theoretically, thus allowing for a simple signal yield extraction.

Effect of combined exercise training on physical and metabolic fitness in adults with intellectual disability: a controlled trial

Objective: Investigating the effect of combined aerobic and strength training on metabolic and physical fitness in adults with intellectual disabilities compared to endurance training and no training. Design: A controlled trial with patients receiving either combined (COM), endurance (END) or no training (C). Setting: Two centres for intellectual disabilities (Sterrenhuis, Brasschaat and Emiliani, Lokeren, Belgium). Subjects: Forty-five adults with intellectual disabilities (mean age: 42 (9,2), mean body mass index (BMI): 24 (3,9), mean IQ: 56 (5,6)). Intervention: Combined exercise training (n = 15) and endurance training (n = 15) twice a week for 70 minutes per session for 20 weeks and no training (n = 15). Groups were matched for age, sex and intellectual disability. Main measures: Lipid profile, physical fitness (primary); blood pressure and body composition. Results: Compared to no training, combined exercise training has significant positive effects on total cholesterol levels, aerobic capacity, muscle strength and resting systolic blood pressure, while endurance exercise training has significant effects on aerobic capacity and resting systolic blood pressure. Compared to endurance training, combined exercise training resulted in a significant better evolution of total cholesterol (mean differences: −18 versus −3 mg/dl), 1RM upper (+6 versus +1 kg) and lower limb (+25 versus +8 kg) and abdominal muscles (+15 versus +1 kg), hand grip strength (+9 versus +2 kg), muscle fatigue resistance (+11 versus +5 sec), sit-to-stand (+5 versus +2/30 sec) and systolic blood pressure (−15 versus −10 mmHg). Conclusion: This study revealed a tendency towards more beneficial effects of combined exercise training in adults with intellectual disability.

Ameliorating Children’s Reading-Comprehension Difficulties

Children with specific reading-comprehension difficulties can read accurately, but they have poor comprehension. In a randomized controlled trial, we examined the efficacy of three interventions designed to improve such children’s reading comprehension: text-comprehension (TC) training, oral-language (OL) training, and TC and OL training combined (COM). Children were assessed preintervention, midintervention, postintervention, and at an 11-month follow-up. All intervention groups made significant improvements in reading comprehension relative to an untreated control group. Although these gains were maintained at follow-up in the TC and COM groups, the OL group made greater gains than the other groups did between the end of the intervention and follow-up. The OL and COM groups also demonstrated significant improvements in expressive vocabulary compared with the control group, and this was a mediator of the improved reading comprehension of the OL and COM groups. We conclude that specific reading-comprehension difficulties reflect (at least partly) underlying oral-language weaknesses that can be effectively ameliorated by suitable teaching.

Stimulant Drug Response in the Predominantly Inattentive and Combined Subtypes of Attention-Deficit/Hyperactivity Disorder

This study compared the methylphenidate (MPH) dose-response profiles of children with the Predominantly Inattentive (PI) and Combined (CB) subtypes of attention-deficit/hyperactivity disorder (ADHD). It is the first such study to enroll a sample comprised exclusively of children, all but one of whom had no prior exposure to ADHD medications. The design was a double-blind crossover with 1-week exposures to placebo and low, medium, and high, fixed, three times daily (t.i.d.) dosage regimens of immediate-release MPH, administered in random order. Parents and teachers completed weekly behavioral questionnaires (Conners, Swanson, Kotkin, Agler, M-Flynn and Pelham Scale [SKAMP]) and a child psychiatrist provided weekly ratings of symptom severity (ADHD Rating Scale [ADHD-RS]), side effects (Side Effects Rating Scale), and a Clinical Global Impressions-Severity (CGI-S). In addition, laboratory measures of vigilance (Continuous Performance Test [CPT]) and resistance to cognitive interference (Stroop) were administered weekly. Twenty-five children (15 CB, 10 PI), who met rigorous diagnostic criteria for their ADHD subtype, completed the study. Groups did not differ on demographic variables or severity at baseline. Behavioral questionnaires and clinical ratings indicated significant improvement on MPH for both subtypes but no differences in response profiles of the two groups. Drug effects were predominantly linear for both subtypes. Effects of MPH were significant for the CPT, but not the Stroop, instrument with no differences between ADHD subtypes. Results support the clinical utility of MPH in the treatment of the PI subtype and provide no evidence of differences in response between the subtypes.

Social Functioning in Predominantly Inattentive and Combined Subtypes of Children With ADHD

Objective: The objective of this study was to compare the social functioning of children with the Combined (CB) and Predominantly Inattentive (PI) subtypes of Attention Deficit/Hyperactivity Disorder (ADHD), controlling for comorbidity and medication-status, which may have confounded the results of previous research. Method: Parents and teachers of rigorously diagnosed unmedicated children with PI or CB subtypes of ADHD, and typical comparison children, rated them on the multidimensional Social Skills Rating Scale (SSRS). Results: After co-varying for oppositionality and anxiety, social impairment was substantial and equivalent in both ADHD groups whether rated by parent or teacher. In addition, when rated by teacher, the nature of the deficits varied by subtype: Children with PI were impaired in assertiveness, whereas children with CB were deficient in self-control. These findings indicate that AD/HD subtypes differ in the nature of their social dysfunction independent of comorbidity and highlight the need for interventions to target their divergent needs.

Multimodel estimates of intercontinental source‐receptor relationships for ozone pollution

Understanding the surface O3 response over a “receptor” region to emission changes over a foreign “source” region is key to evaluating the potential gains from an international approach to abate ozone (O3) pollution. We apply an ensemble of 21 global and hemispheric chemical transport models to estimate the spatial average surface O3 response over east Asia (EA), Europe (EU), North America (NA), and south Asia (SA) to 20% decreases in anthropogenic emissions of the O3 precursors, NOx, NMVOC, and CO (individually and combined), from each of these regions. We find that the ensemble mean surface O3 concentrations in the base case (year 2001) simulation matches available observations throughout the year over EU but overestimates them by >10 ppb during summer and early fall over the eastern United States and Japan. The sum of the O3 responses to NOx, CO, and NMVOC decreases separately is approximately equal to that from a simultaneous reduction of all precursors. We define a continental‐scale “import sensitivity” as the ratio of the O3 response to the 20% reductions in foreign versus “domestic” (i.e., over the source region itself) emissions. For example, the combined reduction of emissions from the three foreign regions produces an ensemble spatial mean decrease of 0.6 ppb over EU (0.4 ppb from NA), less than the 0.8 ppb from the reduction of EU emissions, leading to an import sensitivity ratio of 0.7. The ensemble mean surface O3 response to foreign emissions is largest in spring and late fall (0.7–0.9 ppb decrease in all regions from the combined precursor reductions in the three foreign regions), with import sensitivities ranging from 0.5 to 1.1 (responses to domestic emission reductions are 0.8–1.6 ppb). High O3 values are much more sensitive to domestic emissions than to foreign emissions, as indicated by lower import sensitivities of 0.2 to 0.3 during July in EA, EU, and NA when O3 levels are typically highest and by the weaker relative response of annual incidences of daily maximum 8‐h average O3 above 60 ppb to emission reductions in a foreign region (<10–20% of that to domestic) as compared to the annual mean response (up to 50% of that to domestic). Applying the ensemble annual mean results to changes in anthropogenic emissions from 1996 to 2002, we estimate a Northern Hemispheric increase in background surface O3 of about 0.1 ppb a−1, at the low end of the 0.1–0.5 ppb a−1 derived from observations. From an additional simulation in which global atmospheric methane was reduced, we infer that 20% reductions in anthropogenic methane emissions from a foreign source region would yield an O3 response in a receptor region that roughly equals that produced by combined 20% reductions of anthropogenic NOx, NMVOC, and CO emissions from the foreign source region.

Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.

Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores >1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and 11 at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW.

Comparisons of Instantaneous TRMM Ground Validation and Satellite Rain-Rate Estimates at Different Spatial Scales

Abstract This study provides a comprehensive intercomparison of instantaneous rain rates observed by the two rain sensors aboard the Tropical Rainfall Measuring Mission (TRMM) satellite with ground data from two regional sites established for long-term ground validation: Kwajalein Atoll and Melbourne, Florida. The satellite rain algorithms utilize remote observations of precipitation collected by the TRMM Microwave Imager (TMI) and the Precipitation Radar (PR) aboard the TRMM satellite. Three standard level II rain products are generated from operational applications of the TMI, PR, and combined (COM) rain algorithms using rain information collected from the TMI and the PR along the orbital track of the TRMM satellite. In the first part of the study, 0.5° × 0.5° instantaneous rain rates obtained from the TRMM 3G68 product were analyzed and compared to instantaneous Ground Validation (GV) program rain rates gridded at a scale of 0.5° × 0.5°. In the second part of the study, TMI, PR, COM, and GV rain rates were spatiotemporally matched and averaged at the scale of the TMI footprint (∼150 km2). This study covered a 6-yr period (1999–2004) and consisted of over 50 000 footprints for each GV site. In the first analysis, the results showed that all of the respective rain-rate estimates agree well, with some exceptions. The more salient differences were associated with heavy rain events in which one or more of the algorithms failed to properly retrieve these extreme events. Also, it appears that there is a preferred mode of precipitation for TMI rain rates at or near 2 mm h−1 over the ocean. This mode was noted over ocean areas of Kwajalein and Melbourne and has been observed in TRMM tropical–global ocean areas as well.

Neurocognitive Functioning in AD/HD, Predominantly Inattentive and Combined Subtypes

The Predominantly Inattentive (PI) and Combined (CB) subtypes of AD/HD differ in cognitive tempo, age of onset, gender ratio, and comorbidity, yet a differentiating endophenotype has not been identified. The aim of this study was to test rigorously diagnosed PI, CB, and typical children on measures selected for their potential to reveal hypothesized differences between the subtypes in specific neurocognitive systems (anterior vs. posterior attentional systems) and processes (arousal vs. activation). Thirty-four CB and 26 PI children meeting full DSM-IV criteria for subtype both in school and at home, without confounding reading disability or emotional disorder, were enrolled along with 20 typically developing children. Neurocognitive functions measured included attention, inhibitory control, working memory, learning, and executive functions. Tasks included the Stroop, Wisconsin Card Sorting Test, Continuous Performance Test (CPT). Buschke Selective Reminding Test, ad the Tower of London (TOL), as well as instruments developed by Posner and Sternberg, and tasks assessing the impact on reaction time of [corrected] varying preparatory intervals and stimulus/response complexity. After co-varying for IQ, subtypes differed primarily on measures of impulsivity during tests of vigilance (CPT) and executive function (TOL), with the CB group showing greater impulsivity than both other groups. In addition, the PI group showed worse performance than CB and control groups on the WISC-III Processing Speed Index. Whether analyzed with or without an IQ co-variate, there was no support in the data for hypothesized differences between subtypes in functioning of the anterior vs. posterior attentional systems, nor in involvement of arousal vs. activation processes. The results indicate that the PI and CB subtypes are best differentiated by ratings, observations and tests of cognitive tempo and behavioral impulsivity. Neuropsychological methods have yet to identify critical neuropsychological [corrected] substrates of these differences.

Performance of a color-difference formula based on OSA-UCS space using small-medium color differences

An investigation of the color metrics and the complexity of the CIEDE2000 formula shows that CIELAB space is inadequate to represent small-medium color differences. The OSA-UCS (Uniform Color Space) Committee has shown that no space with uniform scale for large color differences exists. Therefore the practical way for color-difference specification is a color-difference formula in a nonuniform space. First, the BFD (Bradford University) ellipses are considered in the OSA-UCS space, and their very high regularity suggests a new and very simple color-difference formula at constant luminance. Then the COM (combined) data set used for the development of the CIEDE2000 formula is considered in the OSA-UCS space, and the color-difference formula is extended to sample pairs with a different luminance factor. The value of the performance factor PF/3 for the proposed OSA-UCS-based formula shows that the formula performs like the more complex CIEDE2000 formula for small-medium color differences.

Accuracy of drawing in a dual-task and resistance-to-distraction study: Motor or attention deficit?

To determine whether manual incoordination is caused by attention deficit or not, we used an accuracy drawing task as a primary task in dual-task and resistance-to-distraction studies, and examined if thus measured attention could differentiate inattention (IA) and combined (CO) subtypes of ADHD. The secondary tasks and distractions failed to lower the primary task performance in IA, CO and control groups. We also compared the impairment scores of the accuracy drawing tasks from the Movement Assessment Battery for Children [Henderson, S. E., & Sugden, D. A. (1992). Movement assessment battery for children. London: Psychological Corporation.] between the groups with attention deficit hyperactivity disorder (ADHD) and/or developmental coordination disorder-inaccurate drawing type (DCD-ID). There were no group differences in the impairment score between the control and the ADHD groups, and between ADHD and ADHD plus DCD-ID groups. We concluded that inaccurate drawing is not caused by attention deficit, but that it is a manifestation of a motor deficit as a separate entity from attention deficit.

Ground Validation for the Tropical Rainfall Measuring Mission (TRMM)

Abstract An overview of the Tropical Rainfall Measuring Mission (TRMM) Ground Validation (GV) Program is presented. This ground validation (GV) program is based at NASA Goddard Space Flight Center in Greenbelt, Maryland, and is responsible for processing several TRMM science products for validating space-based rain estimates from the TRMM satellite. These products include gauge rain rates, and radar-estimated rain intensities, type, and accumulations, from four primary validation sites (Kwajalein Atoll, Republic of the Marshall Islands; Melbourne, Florida; Houston, Texas; and Darwin, Australia). Site descriptions of rain gauge networks and operational weather radar configurations are presented together with the unique processing methodologies employed within the Ground Validation System (GVS) software packages. Rainfall intensity estimates are derived using the Window Probability Matching Method (WPMM) and then integrated over specified time scales. Error statistics from both dependent and independent validation techniques show good agreement between gauge-measured and radar-estimated rainfall. A comparison of the NASA GV products and those developed independently by the University of Washington for a subset of data from the Kwajalein Atoll site also shows good agreement. A comparison of NASA GV rain intensities to satellite retrievals from the TRMM Microwave Imager (TMI), precipitation radar (PR), and Combined (COM) algorithms is presented, and it is shown that the GV and satellite estimates agree quite well over the open ocean.

Selective effects of vagal deafferentation and celiac–superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients

The role of vagal afferents and splanchnic fibers in nutrient-induced flavor conditioning and feeding suppression was determined. Male rats were fitted with intraduodenal (ID) catheters and given subdiaphragmatic vagal deafferentation (SDA), celiac–superior mesenteric ganglionectomy (CGX), combined (COM) treatments, or sham surgery. In separate conditioning trials, they were trained to drink (30 min/day) flavored saccharin solutions paired with concurrent ID infusions of 8% maltodextrin or water and 3.55% corn oil or water. Experiment 1 revealed that SDA and sham rats showed equal preferences for the nutrient-paired flavors over the water-paired flavors. In contrast, SDA rats, unlike sham rats, failed to suppress their intake of a palatable fluid when infused intraduodenally with maltodextrin or corn oil. Experiment 2 revealed that CGX, COM and sham rats all developed preferences for the maltodextrin-paired flavor, although CGX alone or COM attenuated the conditioned preference. CGX and COM treatments also attenuated or blocked the feeding inhibitory actions of ID nutrient infusions. These findings along with prior data indicate that gut vagal afferents and splanchnic nerves are not essential for flavor–nutrient preference conditioning, whereas both vagal afferents and splanchnic nerves are implicated in carbohydrate- and fat-induced satiation.