Weeds are one of the most serious causes of economic losses in agricultural production. As a result weed completions contributes 60 to 80% yield losses in coffee under Jimma condition. Currently, expensiveness of weed management has been a principle issue in economic analysis of coffee production particularly in large scale farm in Ethiopia. Hence, evaluation of systemic herbicide with different mode of action is essential to effectively control dangerous weeds in coffee production system. The study was conducted in Jimma Agricultural Research Center in 2021 cropping season at Jimma Agricultural Research Center on Station to evaluate the efficacy of newly introduced herbicides (Fascinate 280SL at 3.3l/h, Jimila 480% SL at 3.0l/h and Proper 360 SL at 3.0l/ha) against major weeds in coffee. Tested herbicides (Fascinate 280SL, Jimila 480% SL and Proper 360 SL) were effectively controlled the noxious weeds infested coffee experimental plots. These herbicides also showed significant effect on inhibiting weed density over standard check. The herbicide were effective in controlling weeds in coffee safe for crops if applied at active growth stage of weeds following the instructions on technical guide line of herbicides properly. Therefore, the herbicides were recommended used as management option against weeds in coffee with the application rate mentioned above
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