Coarse Powder Research Articles

Powder-size driven facile microstructure control in powder-fusion metal additive manufacturing processes

Microstructure control in metal additive manufacturing is highly desirable for superior and bespoke mechanical performance. Engineering the columnar-to-equiaxed transition during rapid solidification in the additive manufacturing process is crucial for its technological advancement. Here, we report a powder-size driven melt pool engineering approach, demonstrating facile and large-scale control in the grain morphology by triggering a counterintuitive response of powder size to the additively manufactured 316 L stainless steel microstructure. We obtain coarse-grained (>100 μm) or near-monocrystalline microstructure using fine powders and near-equiaxed, fine-grained (<10 μm) microstructure using coarse powders. This approach shows resourceful adaptability to directed energy deposition and powder-bed fusion with no added cost, where the particle-size dependent powder-flow preheating effects and powder-bed thermophysical properties drive the microstructural variations. This work presents a pathway for leveraging feedstock particle size distribution towards more controllable, cost-effective, and sustainable metal additive manufacturing.

Bimodal powder optimization in SiC binder jetting for mechanical performance

Binder jetting (BJ) additive manufacturing has emerged as a promising technique for batch production of complex silicon carbide (SiC) ceramic components. However, the utilization of coarse powder in BJ often leads to lower density and strength in green parts and final composites compared to conventional fabrication methods. This study aims to enhance the mechanical performance of SiC ceramics through a novel bimodal SiC powder formulation for BJ, complemented by phenolic resin impregnation and pyrolysis (PRIP) and liquid silicon infiltration (LSI). The optimal ratio of bimodal powder, comprising 75 % coarse and 25 % fine powder, was determined through a comprehensive analysis of the microstructure and properties at various stages of the preparation process. The bimodal powder achieves a packing density of 48.3 % and exhibits satisfactory flowability. Notably, the density of the green part reaches 1.78 g/cm3, which is 31 % and 4.7 % higher than that of unimodal fine and coarse powders, respectively. Following the LSI process, the final Si-SiC composites display a high flexural strength of 276.6 ± 13.3 MPa and fracture toughness of 3.52 ± 0.12 MPa·m1/2. These values represent increases of 42.4 % and 25.3 %, respectively, compared to the composites derived from unimodal coarse powder. The material compositions and fabrication strategies proposed in this work offer an effective pathway for creating high-performance SiC ceramic composites via binder jetting.

Pressureless sintered lithium disilicate glass-ceramics: Influence of particle size and crystallization state

The pressureless sintering process is essential to densify near net shaped parts with good shape fidelity. In this work, the impact of the particle size distribution and crystallization state on the processing and properties of final sintered multicomponent lithium disilicate (SiO2-Li2O-K2O-P2O5-Al2O3-ZnO) was evaluated. Higher densification was achieved by pressureless sintering at lower temperatures for samples prepared with fine glass-based powders (825 °C; ≈96%) rather than coarse crystallized powders (975 °C; 92.9%). However, samples based on fine powders presented a microstructure characterized by low aspect ratio crystals, while those based on coarse powders presented needle-like crystals with high aspect ratio. Best mechanical properties were found in samples prepared with coarse glass powders (relative density≈ 95.1%; Vickers Hardness≈ 5.2 GPa; indentation fracture toughness≈ 2 MPam0.5; flexural strength≈ 317 MPa) sintered at 875 °C-1 h. These results can provide valuable orientations for the post-processing of lithium disilicate glass-ceramics prepared by additive manufacturing techniques.

Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice

Abstract The majority of natural diabetic medications come from fruits and vegetables. These natural medications help protect humans from negative impacts of chemical antidiabetics by scavenging free radicals. The present study aimed to explore the antioxidant and antidiabetic properties of methanolic extract of fruits of Hibiscus sabdariffa Linn. (MEHSF) in alloxan-induced Swiss albino diabetic mice. The dried coarse powder of Hibiscus sabdariffa Linn. fruits was subjected to methanol extraction. The antidiabetic activity was determined by using alloxan-induced (80 mg/kg body weight) diabetic mice. Following a 15-day treatment period, serum biochemical parameters including total cholesterol (TC), triglyceride (TAG), LDL-cholesterol (LDL), HDL-cholesterol (HDL), serum glutamic pyruvic transaminase (SGPT), and serum glutamic-oxaloacetic transaminase (SGOT) enzymes were estimated. The antioxidant activity was evaluated through a DPPH and ABTS free radical scavenging assay. Total phenolic content and total flavonoid content were assessed using established methods. MESHF, containing polyphenolic and flavonoid compounds, exhibited antioxidant properties. A 100 and 200 mg/kg significantly (p &lt; 0.05) lowered the blood glucose levels and improved biochemical parameters such as TC, TAG, LDL, and HDL in diabetic mice. Further, MESHF significantly (p &lt; 0.05) reduced the activity of the SGPT and SGOT in diabetic mice compared to untreated diabetic mice. These results suggest that MEHSF with promising antioxidant and antidiabetic potentials can be considered to be a probable new resource of the antidiabetic agent.

Ti–6Al–4V alloy prepared by laser powder bed fusion of a coarse powder

ABSTRACT A Ti–6Al–4V (wt%) alloy was prepared by laser powder bed fusion (LPBF) of a coarse powder with particle sizes in the range of 50–200 μm. The effect of volume energy density (VED) on cavities/pores, microstructure and mechanical properties of the LPBF-fabricated samples was investigated. The results showed that with the increase of VED, the content of cavities/pores decreased. When the VED was 100 J/mm3 and above, the content of cavities/pores decreased to below 0.3%, and the yield strength (YS), ultimate tensile strength (UTS) and elongation to fracture reached 1032, 1052 MPa and 7.0%, which are close to the tensile properties of Ti–6Al–4V alloy prepared by LPBF of a fine powder (particle sizes: 15–53 μm). The microstructure of the samples consisted of β-columnar crystals containing acicular α′ martensite. After vacuum annealing at 800°C and 900°C respectively, the microstructure of the fabricated samples changed to an α+β lamellar structure, with a substantial decrease in YS and UTS to 836 and 919 MPa, respectively, but a significant increase in elongation to fracture to 15.9%, resulting in very good overall tensile properties. This study shows that with a sufficient VED and proper heat treatment, a Ti–6Al–4V alloy with good metallurgical quality and excellent overall tensile properties can be fabricated by LPBF of a coarse powder.

Superior mechanical properties of a Zr-based bulk metallic glass via laser powder bed fusion process control

Additive manufacturing has made the fabrication of large-dimensioned bulk metallic glasses (BMGs) achievable; however, questions remain regarding how to control the processing parameters to obtain dense and fully amorphous BMGs with desirable mechanical properties. Here, laser powder bed fusion (LPBF) was used to produce dense and fully amorphous Zr59.3Cu28.8Nb1.5Al10.4 BMG samples from two different starting powders within a large processing window of laser powers and scanning speeds. X-ray diffraction (XRD) revealed that fully amorphous XRD patterns were obtained for samples with high relative densities (>99 %) when the LPBF energy density ranged from ∼20 J/mm3 up to ∼33 J/mm3 for coarse powder with low oxygen and up to ∼30 J/mm3 for fine powder with higher oxygen. For the fully XRD amorphous samples, strength and hardness increased with increasing energy density while the relaxation enthalpy and ductility decreased. Transmission electron microscopy revealed that the softer samples contain larger medium range order clusters within the amorphous matrix. With higher LPBF energy density, high relative density was still achieved along with devitrification and embrittlement. While lower energy densities below ∼20 J/mm3 could retain a fully XRD amorphous structure, such samples had relative densities <99 %. When comparing the two powders, the coarse powder with four times lower oxygen content gave better glass forming ability, compression ductility up to 6 % plastic strain, and fracture toughness up to ∼38 MPa√m. These findings demonstrate that it is possible to tailor the structure and mechanical properties of BMGs by tuning the LPBF process parameters within a wide processing window.

Adaptive powder nozzle setup for enhanced efficiency in laser metal deposition

Laser metal deposition (LMD) is a blown powder process used for the additive manufacturing of large and/or complex parts. The laser spot size is determined by the fiber optic cable and the imaging ratio of the process optics. Spot sizes typically used in LMD can range from 200 μm to several millimeters, whereby zoom optics can be employed to change the laser spot focus within seconds during the process. However, industrial powder nozzles are still static in terms of powder spot size. Changing the powder spot size in line with the laser spot size could ensure the favorable dual outcome of time savings when printing large volumes while also generating fine near-net-shape features. To help overcome the current limitations in the LMD process, this work examines an adaptive powder nozzle setup. In this discrete coaxial layout of three single lateral powder injectors, the individual powder injectors can be adjusted closer to or further from the process to, respectively, dilate or shrink the powder stream focus. Different inner diameters of powder injectors are hereby examined. The resulting powder propagation behavior is characterized for different setups of the single powder nozzles. Single beads are welded with different nozzle setups for fine and coarse powder spots, while the laser spot size is changed accordingly using zoom optics. The laser power is a closed-loop controlled by a two-color pyrometer to achieve comparative process temperatures. The single beads are evaluated with regard to their geometry. High-speed imaging provides supplementary information on weld bead generation.

Size effect configuration modeling for the high-performance hybrid Fe-Si directional alloyed soft magnetic material (DASMM)

This work presents a novel hybrid gas/water atomized Fe-Si directional alloyed soft magnetic materials (DASMM), they have a combination of low core loss (Pcv), constant permeability (μ) and high compatibility. The particle size has a big influence upon the Fe-Si DASMP magnetic properties, the study result revealed that the coarse powder DASMM merely have a steady permeability of 60 in the frequency range between 10 and 100 kHz; while the fine particle (≥200 meshes) DASMM could maintain its constant permeability of 40 in the whole range between 10 and 500 kHz. The Pcv of Fe-Si DASMM rapidly decreased as the consisting powder particle size decrease, dramatically decreased from 277.36 W/kg for the 100 mesh to 62.00 W/kg for the 300 mesh Fe-Si DASMM. While the resistivity (Rs) sharply increased, it increased 9 times from 5.93 mΩ·cm for the 100 mesh to 54.33 mΩ·cm for the 300 mesh Fe-Si DASMM.

ХИМИЧЕСКОЕ ОСАЖДЕНИЕ ИЗ ГАЗОВОЙ ФАЗЫ ПИРОУГЛЕРОДНЫХ ПОКРЫТИЙ НА ПОРОШКАХ В ПСЕВДООЖИЖЕННОМ СЛОЕ. II. ПОЛУЧЕНИЕ ПОКРЫТИЙ

Pyrocarbon coatings of nanometer and submicron thickness were applied to coarse powders by Low Pressure Chemical Vapor Deposition (LPCVD), using a technical mixture of propane-butane. The nfluence of the nature of the carrier powder and CVD parameters on the deposition process was studied: total pressure (5 and 17 kPa), temperature (800, 900, 1000 °C), deposition time (0.5–3 h). The specific weight of the coatings was measured, the coatings thickness and the conversion degree of the reactant in the reactor were calculated, other engineering calculations were carried out. Design and technological solutions and research results are compared with those known from the literature

Pharmacological And Phytochemical Evaluation Of Urtica Dioica Against Staphylococcus -Aureus, Bacillus Cereus (Gram Positive And Gram Negative) Curing Dental Problem

Aim: - Pharmacological and phytochemical evaluations of Urtica dioica against (gram positive and gram negative) Curing dental problem. Method: - Shade dried Urtica dioica plant and stored leaves in this extraction plant leaves a coarse powder formed then aqueous done from 50 gm to obtain leaves powder using 500ml of ethanol and aqueous using Soxhlet Apparatus. Result and conclusion: - Urtica dioica leaves have shown great anti-bacterial activity toward both bacteria (staphylococcus Aureus and bacillus cereus). As an extract of Urtica dioica of leaves (Ethanolic and Aqueous) were used among be to, ethanolic extract has highly percentage in comparison to aqueous extract. Due to high percentage, ethanolic extract was used for the phytochemical screening and show positive result for percentage of alkaloids, flavonoids, tannins, phenolic compounds and Resins but shown slight negative result for Iodine test.during measurement of zone of inhibition, both the extract (ethanolic and aqueous) has shown grater activity toward Bacillus cereus and among the both extract, ethanolic extract was found to be more effective.

Computational fluid dynamics simulation and performance study of a three-separation combined air classifier

This paper mainly uses ANSYS-FLUENT 19.2 software to simulate the movement of the air-flow in a three-separation combined classifier. The simulation results indicate that the air-flow is uniformly distributed in the V-classifier under the action of dispersion plates and baffles. As the air-flow enters the rotor channel, the tangential velocity of the air-flow increases uniformly and remains stable in the axial direction, providing a stable centrifugal force field for particle classification. From the analysis of the flow field and particle trajectories, the separation interface between the upward path for particles and the downward path for coarse particles is relatively clear. The experimental results with sodium bicarbonate show that the V-classifier has a good pre-classification effect. The rotor cage speeds of 300 rpm and 500 rpm are the best working conditions for the coarse powder and fine powder collection, respectively. This study not only provides a new strategy for the design and development of air classifier, but also provides theoretical guidance for its application in industrial production.

Udgharshana (an Ayurvedic therapeutic intervention) in improving vibration perception threshold in diabetic distal symmetric polyneuropathy: An observation

Diabetic Distal Symmetrical Polyneuropathy (DSPN), affects the sensation of vibration, a major risk factor for diabetic foot ulcers that raises the likelihood of lower limb amputation among the diabetic population. The effectiveness of existing therapeutic approaches in its management is limited, necessitating exploring alternative therapy approaches. A 61-year-old female, a known Type 2 Diabetic for five years, presented with complaints of numbness and tingling sensation in bilateral lower limbs below the knee joint associated with aching pain in the bilateral foot region for the last two years. On assessment, she was found to be positive on the Michigan Neuropathy Screening Instrument that indicates the probable diagnosis of diabetic DSPN. The patient was treated with an Ayurvedic topical therapeutic intervention, Udgharshana (~therapeutic coarse powder massage) with a combination of Triphala (~a polyherbal Ayurvedic formulation) powder and Dhanyamla (~fermented sour liquid prepared from gruel of husked grains). Improvement in clinical features was observed on Neuropathy Total Symptom Score-6 and in Semmes-Weinstein monofilament reading in the bilateral foot (right 7/10 vs. 9/10 and left 7/10-10/10). The intervention also improved the vibration perception threshold bilaterally (right 31.5V vs. 20.1V; left 30.5V vs. 22.8V). Inferring the observations, it is suggested that early disease management of diabetic DSPN with Ayurveda might arrest further disease progression and help in reversing the pathogenesis, with a positive effect on improving vibration perception threshold.

Glutaraldehyde Crosslinked Alginate-Chitosan Nanoparticles as Paracetamol Adsorbent

Paracetamol contained in wastewater can cause adverse effects on animal ecosystems, such as fish living in waters and cause harmful effects on humans. Adsorption techniques are used to remove these pharmaceutical compounds. Alginate-chitosan nanoparticles are non-toxic and effectively used as adsorbents to remove pharmaceutical compounds in wastewater. Research on glutaraldehyde crosslinked alginate-chitosan nanoparticles as paracetamol adsorbent has been carried out. This research used the ionic gelation method. Nanoparticles were characterized using transmission electron microscopy (TEM), scanning electron microscope (SEM-EDX) and Fourier transform infra-red spectrophotometer (FTIR). Furthermore, the nanoparticles were used for paracetamol adsorption. The results showed that the form nanoparticles are coarse solid powder and brownish yellow. The TEM image shows an average nanoparticle size of 8.22 nm. Glutaraldehyde crosslinked alginate-chitosan nanoparticles adsorbed paracetamol with adsorption kinetics followed a pseudo-second-order or Ho-McKay model, the adsorption rate constant of 0.0324 g mg−1 min−1. The isotherm study of paracetamol adsorption by glutaraldehyde cross-linked alginate-chitosan nanoparticles followed the isotherm Dubinin-Radushkevich isotherm model with a free energy value of 707.1068 kJ mol−1, and this value indicates the adsorption process by chemically or chemisorption.

Refractory ceramics based on magnesium–aluminate spinel and periclase of the Satka deposit

The article is aimed at evaluating the promising approach to the management of the performance characteristics of ceramic refractories based on magnesia-aluminate spinel and periclase made from natural components extracted from the Satka deposit. The essence of the approach is the mechanical activation of initial coarse powders to decrease the mean particle size and dispersion, as well as to clean particle surfaces, and the variation of sintering parameters to improve the quality of adhesion between particles during sintering. It is shown that these changes in production technology allow for achieving a significant superiority of refractories obtained from activated powders over industrial samples made of powders not subjected to this kind of treatment. The obtained materials particularly have multiple higher strengths and fracture toughness. The thermal conductivity and thermal shock resistance of the obtained materials are not inferior to or superior to the corresponding characteristics of industrial refractories of similar phase composition. The analysis showed that the mechanical and thermophysical characteristics of ceramics synthesized from mechanically activated natural powders are not inferior to those of ceramics synthesized in laboratory conditions from pure precursors. The results of the study indicate a possibility of significant improvement of the mechanical and thermal characteristics of industrial periclase-spinel refractories by additional mechanical activation of mixtures of coarse powders obtained from mined natural components.

Potential of Coffee and Cocoa Shell Waste as An Energy Source: Analysis of Characteristics of Briquettes From Coffee and Cocoa Shell Waste Through The Carbonization Process

This research aims to compare the characteristics of briquettes as an energy source produced from coffee shell waste and cocoa waste. The briquette-making process involves carbonization to produce charcoal as the primary raw material for briquettes. Carbonization time varies, influenced by the type of waste and size of the material. After that, the charcoal is reduced and sifted into fine and coarse powder. Briquette molding uses pressure using a pipe as a mold. The characteristics of briquettes are analyzed through water content, density, burning rate, and ash content. The research results show differences in characteristics between coffee and cocoa waste. The carbonization process affects the time and mass difference of raw materials. Cocoa pod shells require the longest (±35 minutes), while cocoa bean shells require the shortest (±17 minutes). Next, making briquettes involves molding and pressing using a pipe as a mold. The results showed that waste cocoa pod shells and cocoa bean shells produced more briquettes than waste coffee pod shells and coffee bean shells. The moisture content of briquettes from all types of waste meets the standards, but the density of the raw material for coffee husk waste is low, while the briquettes have a high density. The burning rate of briquettes varies, with cocoa bean shell briquettes having the fastest burning rate and producing much smoke. The ash content of cocoa pod husk briquettes exceeds the standard, while cocoa bean husk briquettes have low ash content. The density of the raw material is correlated with the moisture content of the briquettes. The highest burning rate occurs in cocoa bean shell briquettes, influenced by low density and high water content. The ash content of the briquettes meets standards, except for cocoa shell briquettes. This research proves that cocoa and coffee shell waste can be processed into briquettes with different characteristics.

Cellulose Isolation and Characterization of Green Seaweed C. Lentillifera from Halmahera, Indonesia

Caulerpa lentillifera or known as sea grapes is a type of green seaweed which is rich of nutritional components and widespread in the tropical regions in Asia, including Indonesia. Moreover, C. lentillifera contains of polysaccharides, such as cellulose which has the potential to various applications. In this study, C. lentillifera collected from Halmahera, Indonesia was determined for its chemical compositions (moisture, ash, extractives, hemicellulose, α-cellulose contents) and was extracted to obtain cellulose. Isolation of cellulose from C. lentillifera was done by soxhlet extracted using ethanol-benzene solvent to remove extractives, boiling to increase the amount of cellulose extracted, H2O2 bleaching to eliminate any remaining pigments and other contaminants, and freeze drying to get coarse powder of cellulose. The moisture content, ash, extractives, hemicellulose, α-cellulose of C. lentillifera were 11.94%, 31.62%, 11.53%, 35.57%, and 7.95%, respectively. The yield of cellulose obtained was 31.13% based on seaweed dry weight. FE-SEM (Field Emission-Scanning Electron Microscopy) analysis of C. lentillifera showed colonies of diatoms in elliptical shapes. FTIR (Fourier Transform Infrared) measurements indicating cellulose purity after extraction process. X-Ray Diffraction (XRD) analysis resulted some peaks of salt crystals in C. lentillifera and cellulose of C. lentillifera in amorphous form. After extraction, the crystallinity index of cellulose obtained was 37.3%.

Characterization of polymer foam evolution in unpressurized melt systems

AbstractThe evolution of foam in unpressurized melt processing techniques, such as rotational molding, is different from high‐pressure processes like injection foam molding, making comparisons difficult. This has driven the need for a dedicated technique for studying these systems. A unique test procedure was developed to capture and characterize foam evolution in test tubes under unpressurized conditions. A validation study found the procedure to be reliable, producing repeatable samples (height average (AVG) 39.69 ± 1.70 mm and density AVG 0.319 ± 0.012 g/cm3) and delivering comparable results to samples produced using the industrial rotational foam molding process. A study examined the effect of polymer particle size on the foam structures produced. Finer (&gt;90 μm &lt;106 μm) polymer powders produced more desirable structures, achieving 38.6% lower foam density and 43.8% taller peak foam height than coarser powders (&gt;425 μm &lt; 500 μm). Cycle times were much shorter (~15 min) in comparison with the industrial rotational molding process (&gt;40 min) and required smaller amounts of materials, making it useful for rapid characterization. Future work is planned to apply the new procedure to investigate the effects of material and processing conditions on the foam structures produced under unpressurized conditions.Highlights Evaluation of existing unpressurized foam characterization methods. Rapid test procedure developed to characterize unpressurized foam evolution. Variability study of foam structures produced using the new procedure. Effect of rotational molding polymer powder and considerations for foaming. Results validated with industrial unpressurized rotationally molded samples.

Anti-microbial and anti-cancer efficacy of acetone extract of Rosa chinensis against resistant strain and lung cancer cell line

BackgroundScreening of herbal plants for various therapeutic properties is the hour as it shows promising activity. Scientific evidence of the pharmacological activity of the plant strengthens the traditional application of plants.MethodsRose flowers (Rosa chinensis) were procured and grounded into a coarse powder. The DNA was isolated from rose flower and molecular identification was performed by rbcL-BF and rbcL-724R primers. Antibacterial activity was evaluated by using disc and agar diffusion methods and the anti-cancer effect of the rose flower extract (RE) was examined using MTT assay in lung cancer cell line. The mechanism of cell death induced by RE was qualitatively measured using Acridine orange/Ethidium bromide staining and Hoechst staining. GC-MS analysis was performed using GC-MS-5975C.ResultThe RE showed potent antimicrobial activity against various ATCC cultures. The rose extract strongly inhibits the growth of ESBL resistant organism along with inhibition of biofilm formation in the ESBL resistant organism. The extract caused apoptotic and necrotic cell death in lung cancer cells. GC-MS analysis demonstrated the presence of several biologically active compounds such as Clindamycin, Phytol, Octanoic acid, and Stigmasterol which might be the reason for the therapeutic properties of the plant.ConclusionThis study shows the antimicrobial and biofilm inhibition activity against the clinical isolates of Klebsiella pneumonia. The study shows the cytotoxic and apoptotic activity in A549 cancer cell line. Thus, the plant may act as a potent antimicrobial drug against resistant strains.

Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters

Current research investigates the abortifacient properties of Nigella sativa, a natural alternative to pharmaceutical abortifacients such as mifepristone. Abortion induced by mifepristone is often accompanied by distressing side effects, prompting the exploration of safer alternatives. Nigella sativa seeds were processed into coarse powder through grinding and subjected to ethanolic and aqueous extractions. Pregnant mice were administered extracts at 400 milligrams per kilogram of body weight, with a comparison group receiving 2.85 mg/kg p.o. of mifepristone. The study showed a significant decrease in fetal survival rates with nigella sativa extract treatment with the untreated control group exhibiting a 100% survival rate and the 400 mg/kg p.o. Dose groups showed rates of 26.66% for aqueous extract and 33.33% for ethanolic extract. Importantly, none of the fetuses in the mifeprin-treated group survived. The results indicate a promising 70% abortion rate with well-tolerated doses of Nigella sativa extracts, highlighting the potential for natural alternatives to mitigate the side effects associated with mifepristone administration. This research underscores the importance of exploring botanical sources for safer and more tolerable options in induced abortion.

Physicochemical, Heavy Metal Analysis, HPTLC, Gas Chromatography-Mass Spectrometry, Antibacterial, and Antioxidant Activity of an Ethanol Extract of Viola pilosa Blume Whole Plant

IntroductionQuality control of herbal products remains a big challenge. There needs to be more than the physicochemical parameters to authenticate and differentiate adulterants in medicinal plants. Viola pilosa is one of the herbs used to treat various bodily ailments. This study aims to evaluate the quality control, HPTLC, and gas chromatography-mass spectrometry (GC-MS) fingerprint profiles of the whole plant of V pilosa. The in-vitro antimicrobial and antioxidant activities of the ethanolic extract of V pilosa were also studied. MethodsThe physicochemical standardisation and the heavy metal analysis of the whole plant of V pilosa coarse powder were carried out using standard methods. High-performance Thin layer chromatography and Gas chromatography - Mass spectroscopy (HPTLC and GC-MS) analyses of the ethanol extract of V pilosa were performed using standard methods. The in-vitro antioxidant properties of the ethanolic extract on DPPH and its antimicrobial effects against different microbes were also investigated. ResultsThe physicochemical properties of V pilosa have shown that all the parameters were within the permissible limits. The HPTLC fingerprint profile of the ethanolic extract exhibited 14 peaks under UV 254 nm and seven peaks under UV 366 nm. The GC-MS analysis illustrated the presence of 10 bioactive compounds in the test sample. The ethanolic extract showed significant antimicrobial activity against certain organisms and promising antioxidant activity. ConclusionsThe quality control findings revealed that the test drug was free from adulterations. The physicochemical constants, HPTLC, and GC-MS profiles of V pilosa can be essential data in the future. This herb's ethanolic extract may treat infectious and inflammatory diseases.